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Leukorrienes and prostanoids in health and disease
hr. J. Eiochem. Vol. 22, No. 12, pp. 1503-1504, Pergamon Press pk. Printed in Great Britain
1990
BOOK REVIEWS
An Introduction to the Physical Chemistry of Biological Organization-A. R. F%ACOCKE. 310 pp. 1989. Oxford University Press, Oxford. $92 cloth. $33.95 paperback.
physical appearance; crystal appearance; spectra; synthesis; pharmacology; toxicity; pharmacokinetics; methods of analysis. This volume deals with azintamide, chlorothiazide, clioquinol, clofazamine, etoposide, furosamide, nalorphine, nifedipine, physostigmine, prazocin, tetracaine, thiamine, thioridazine, thiothixene, cyloserine and fluorouracil.
This is a reprint of the 1983 edition with some corrections and additional references. The topics discussed are: thermodynamics of living systems; network thermodynamics; kinetics of biological self organization; selection and evolution of biological macromolecules; interpretation of biological complexity. The reader will get an insight into the way in which specific chemical structures can lead to apparently very complex systems by obeying relatively simple physicochemical laws. It might even solve embryonic differentiation in time.
and Lipoxygenases; Chemical, Biological and Clinical Aspects-Edited by J. ROKACH. 518 pp. 1989. Elsevier, Amsterdam. D.Fl 360. $189.50. Leukotienes
Who would have thought that Feldberg and Krayer’s work in 1939 on the slow releasing substance (SRS) that appeared from lungs perfused with cobra venom, and which could cause smooth muscle to contract, would lead to the prostaglandins, thromboxanes and prostacyclin? Later work showed that SRS-A was released during allergic reactions and that it was a series of metabolites of arachidonic acid. The enzymes carrying out this metabolism were lipoxygenases which insert molecular oxygen at different sites on arachidonic acid. This volume has chapters on the chemistry of leukotrienes (L); biochemistry of the L pathways; assay methods for L products; pharmacology and pathophysiology of L; L in diseased states; enzyme inhibitors and L receptor antagonists. The action of L on the respiratory system, cardiovascular system, skin, eyes and GI tract, and inflammation make them key chemicals in modern medicine and their role is well described in this volume.
Proteolytic Enzymes; a Practical ApproackEdited by R. J. BENYONand J. S. BOND.259 pp. 1989. IRL/Oxford University Press, Oxford. $59 cloth. $39 paperback. The topics dealt with: diversity of proteolytic enzymes (PE); purification of PE; protease assay methods; determination of protease mechanism; inhibition of PE; prevention of unwanted proteolysis; proteases in peptide synthesis; proteolysis for sequence analysis and peptide mapping; proteases as probes of conformation of soluble proteins; proteases as topological probes for membrane proteins; solubilization of membrane proteins; exogenous control of intracellular protein catabolism; proteases in protein maturation
Leukotrleuw and Prostanoids in Health and Disease-Edited by U. ZOR, Z. NAORand A. DANON.345 pp. 1989. Karger, Basel. S.Fr 329. $213.50.
Solid Phase Peptide Synthesis; A Practical ApproackE. ATHERTONand R. SHEPPARD.203 pp. 1989. IRL/Oxford University Press, Oxford. $59 cloth. $38 paperback.
The metabolites of arachidonic acid, leukotrienes (L) and prostanoids (P) are implicated as mediators in allergic and inflammatory responses, asthma, anaphylaxis, shock, myocardial infarction and stroke. Research on the cyclooxygenase, lipoxygenase and phospholipase A2 regulation by protein kinase C has led to the development of drugs that inhibit the biosynthesis of L and P and so can be used in the treatment of clinical conditions. This volume contains the proceedings of the 2nd International Conference held in Jerusalem.
This book gives details of the Merrifield original method and then gives full details of the more recent F-mot (fluorenyl methoxy carbonyl) polyamide synthesis (analytical and monitoring techniques; reaction procedures and operating techniques; resin cleavage and purification; illustrative synthesis of 6 different peptides) with information on laboratory constructed and commercial instruments An excellent handbook for this methodology. Protein Purification; principles, High Resolution Methods and Applications-Edited by J.-C. JANS~Nand L. RYDEN. 502 pp. 1989. VCH Weinheim, F.R.G. DM 124.
Antigenic Determinants and Immune ReguIaHo~Edited E. SERCARZ. 189 pp. 1989. Karger, Basel. $99.50.
The different methods of protein purification are discussed with accent on the principles and methodology. The topics discussed are: chromatography (C); gel filtration; ion exchange C; chromafocusing; high resolution reversed phase C; hydrophobic interaction C; immobilized metal ion affinity C; covalent C; affinity C; affinity partitioning of proteins; electrophoresis (E); gel E; isoelectric focussing; immunoE; two dimension polyacrylamide E; protein recovery and blotting techniques; capillary E.
Protein antigens are responsible for antigenicity (determinants reactive with the antibody) and immunogenicity (determinants that activate T cells). This volume deals with: the antigens; T clones and monoclonal antibodies; the major histocompatibility complex; insulin determinant recognition; encephalogenic epitopes of myelin basic protein; mammalian reovirus; murine alloantigens and their suppression; immune dominance. The balance between under reaction, reaction and over reaction of the immune response is described.
Analytical Profiles of Drug Substances, Vol. l%Edited by K. FLOREY. 646 pp. 1989. Academic Press, San Diego. $69.95.
Radiation Tolerance of Normal Tissue-Edited by J. M. VAE~ and J. L. MEYER. 443 pp. 1989. Karger, Basel. S.Fr 384. $256.
This series of volumes gives drug profiles. Each drug is described: name, formulae; chemical abstract registry number;
Radiation treatment for cancer depends on cancerous cells having a greater sensitivity to radiation than normal 1503
by
1990
BOOK REVIEWS
An Introduction to the Physical Chemistry of Biological Organization-A. R. F%ACOCKE. 310 pp. 1989. Oxford University Press, Oxford. $92 cloth. $33.95 paperback.
physical appearance; crystal appearance; spectra; synthesis; pharmacology; toxicity; pharmacokinetics; methods of analysis. This volume deals with azintamide, chlorothiazide, clioquinol, clofazamine, etoposide, furosamide, nalorphine, nifedipine, physostigmine, prazocin, tetracaine, thiamine, thioridazine, thiothixene, cyloserine and fluorouracil.
This is a reprint of the 1983 edition with some corrections and additional references. The topics discussed are: thermodynamics of living systems; network thermodynamics; kinetics of biological self organization; selection and evolution of biological macromolecules; interpretation of biological complexity. The reader will get an insight into the way in which specific chemical structures can lead to apparently very complex systems by obeying relatively simple physicochemical laws. It might even solve embryonic differentiation in time.
and Lipoxygenases; Chemical, Biological and Clinical Aspects-Edited by J. ROKACH. 518 pp. 1989. Elsevier, Amsterdam. D.Fl 360. $189.50. Leukotienes
Who would have thought that Feldberg and Krayer’s work in 1939 on the slow releasing substance (SRS) that appeared from lungs perfused with cobra venom, and which could cause smooth muscle to contract, would lead to the prostaglandins, thromboxanes and prostacyclin? Later work showed that SRS-A was released during allergic reactions and that it was a series of metabolites of arachidonic acid. The enzymes carrying out this metabolism were lipoxygenases which insert molecular oxygen at different sites on arachidonic acid. This volume has chapters on the chemistry of leukotrienes (L); biochemistry of the L pathways; assay methods for L products; pharmacology and pathophysiology of L; L in diseased states; enzyme inhibitors and L receptor antagonists. The action of L on the respiratory system, cardiovascular system, skin, eyes and GI tract, and inflammation make them key chemicals in modern medicine and their role is well described in this volume.
Proteolytic Enzymes; a Practical ApproackEdited by R. J. BENYONand J. S. BOND.259 pp. 1989. IRL/Oxford University Press, Oxford. $59 cloth. $39 paperback. The topics dealt with: diversity of proteolytic enzymes (PE); purification of PE; protease assay methods; determination of protease mechanism; inhibition of PE; prevention of unwanted proteolysis; proteases in peptide synthesis; proteolysis for sequence analysis and peptide mapping; proteases as probes of conformation of soluble proteins; proteases as topological probes for membrane proteins; solubilization of membrane proteins; exogenous control of intracellular protein catabolism; proteases in protein maturation
Leukotrleuw and Prostanoids in Health and Disease-Edited by U. ZOR, Z. NAORand A. DANON.345 pp. 1989. Karger, Basel. S.Fr 329. $213.50.
Solid Phase Peptide Synthesis; A Practical ApproackE. ATHERTONand R. SHEPPARD.203 pp. 1989. IRL/Oxford University Press, Oxford. $59 cloth. $38 paperback.
The metabolites of arachidonic acid, leukotrienes (L) and prostanoids (P) are implicated as mediators in allergic and inflammatory responses, asthma, anaphylaxis, shock, myocardial infarction and stroke. Research on the cyclooxygenase, lipoxygenase and phospholipase A2 regulation by protein kinase C has led to the development of drugs that inhibit the biosynthesis of L and P and so can be used in the treatment of clinical conditions. This volume contains the proceedings of the 2nd International Conference held in Jerusalem.
This book gives details of the Merrifield original method and then gives full details of the more recent F-mot (fluorenyl methoxy carbonyl) polyamide synthesis (analytical and monitoring techniques; reaction procedures and operating techniques; resin cleavage and purification; illustrative synthesis of 6 different peptides) with information on laboratory constructed and commercial instruments An excellent handbook for this methodology. Protein Purification; principles, High Resolution Methods and Applications-Edited by J.-C. JANS~Nand L. RYDEN. 502 pp. 1989. VCH Weinheim, F.R.G. DM 124.
Antigenic Determinants and Immune ReguIaHo~Edited E. SERCARZ. 189 pp. 1989. Karger, Basel. $99.50.
The different methods of protein purification are discussed with accent on the principles and methodology. The topics discussed are: chromatography (C); gel filtration; ion exchange C; chromafocusing; high resolution reversed phase C; hydrophobic interaction C; immobilized metal ion affinity C; covalent C; affinity C; affinity partitioning of proteins; electrophoresis (E); gel E; isoelectric focussing; immunoE; two dimension polyacrylamide E; protein recovery and blotting techniques; capillary E.
Protein antigens are responsible for antigenicity (determinants reactive with the antibody) and immunogenicity (determinants that activate T cells). This volume deals with: the antigens; T clones and monoclonal antibodies; the major histocompatibility complex; insulin determinant recognition; encephalogenic epitopes of myelin basic protein; mammalian reovirus; murine alloantigens and their suppression; immune dominance. The balance between under reaction, reaction and over reaction of the immune response is described.
Analytical Profiles of Drug Substances, Vol. l%Edited by K. FLOREY. 646 pp. 1989. Academic Press, San Diego. $69.95.
Radiation Tolerance of Normal Tissue-Edited by J. M. VAE~ and J. L. MEYER. 443 pp. 1989. Karger, Basel. S.Fr 384. $256.
This series of volumes gives drug profiles. Each drug is described: name, formulae; chemical abstract registry number;
Radiation treatment for cancer depends on cancerous cells having a greater sensitivity to radiation than normal 1503
by