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Lipid levels and coronary events
Thursday June 29, 2000: Read by 7TileAbstracts T:W37 Other Topics coronary events a mean follow-up of 32 4- 13 months was carried out. For statistical analysis the Chi-Square test with Fisher's test was applied. Results:
Hypertension Normal coronariography
Tchol/HDL < 5 (39)
TcholCT/HDL > 5 (190)
p
7 (18%) 6 (30%)
77 (40%) 7 (6%)
0.007 <0.005
No differences were found in the prevalence of diabetes or smoking habits in either group. No differences were seen during follow-up in the presence of angina, myocardial infarction, heart failure or need for revascularisation. Conclusions: Our group of patients younger than 50 years old with ischemic heart disease and showing a Tchol/HDL less than or equal to 5, present less prevalence of hypertension and show more frequently absence of significant coronary lesions in comparison with those patients with an altered lipid profile.
ThT5:W37 ] Early-onset single vessel coronary disease A. Batalla I , G.I. Cubero 2, J.J.R. Reguero2 , S. Hevia2, S. Braga2, E. Bustillo 2, E. Merino2, J.C. Sanmartin2, A. Cortina2. Department of Cardiology;
l Hospital de Cabuehes (Gij6n); 2Hospital Central de Asturias (Oviedo), Spain Purpose: To determine common characteristics of patients under 50 years of age with single vessel coronary disease. Methods: Consecutively, 119 male patients before 50 years of age (mean age 42 4- 4 years), who were admitted to our Coronary Care Unit as result of an episode of coronary disease and at least a coronary lesion greater than 70% in the coronariography, were prospectively studied. Smoking habits, arterial hypertension, diabetes and dyslipemia were determined during the acute phase by means of a questionnaire, physical examen and fasting analysis. The follow cutoff points were established: Total cholesterol (Tchol) 200 mg/dl; HDL cholesterol (HDL) 35 mg/dl; LDL cholesterol (LDL) 130 mg/dl; Tryglicerides (TG) 200 mg/dl and Lp(a) 30 mg/dl. In order to determine new coronary events, a mean follow-up of 32 5= 13 months was carried out. For statistical analysis the Chi-Square test with Fisher's test was applied. Results:
Lp(a) > 30 mg/dl
Single vessel disease (49)
Multivessel disease (70)
p
23 (47%)
46 (66%)
<0.05
No differences were found in the prevalence of hypertension, diabetes or smoking habits in either group. No differences were seen according to the cutoff points in Tchol, HDL, LDL and TG. Nor were any difference during follow-up in the presence of angina, myocardial infarction, heart failure, mortality or need for revascularisation. Conclusions: Patients with early onset of coronary disease and single vessel disease present normal Lp(a) levels more frequently than those with multivessel disease. I
ThT6:W371 The relationship of dyslipemia w i t h other coronary risk factors in males with early coronary disease A. Batalla I , G.I. Cubero 2, J.J.R. Reguero 2, S. Braga2, E. Bustillo 2 , S. Hevia2 , E. Merino 2, J.C. Sanmarffn 2, A. Cortina2. Department of Cardiology;
1Hospital de Cabuehes (Gij6n); 2Hospital Central de Asturias (Oviedo), Spain Purpose: To determine a possible association between dyslipemla and other coronary risk factors in early coronary disease. Methods: Consecutively, 229 male patients before 50 years of age (mean age 42 5= 4 years), who were admitted to our Coronary Care Unit as result of an episode of coronary disease were prospectively studied. Smoking habits, arterial hypertension, diabetes and dyslipemia were determined during the acute phase by means of a questionnaire, physical examen and fasting analysis. An attempt was made to determine a possible association between dyslipemia and other risk factors. We considered dyslipemia a Total cholesterol-HDL cholesterol ratio (Tchol/HDL) greater than 5. For statistical analysis the Chi-Square test was applied. Results are presented in the table. No differences were found in relation to smoking habits and diabetes Conclusions: In our study of males with early coronary disease an association was found between dyslipemla and arterial hypertension that the
323
Hypertension
No Hypertension
p
77 (40.5%) 7 (18%)
113 (59.5%) 32 (82%)
0.01
CT/HDL > 5 (n: 190) CT/HDL < 5 (n: 39)
prevalence of arterial hypertension is significantly greater in the group of patients with a Tchol/HDL greater than 5.
ThT7:W37 1 Lipid levels and coronary events A. Batalla I , G.I. Cubero 2, J.J.R. Reguero2, S. Hevia 2, S. Braga 2, E. Bustillo 2 , E. Merino 2, J.C. Sanmartin2 , A. Cortina2 . Dept. of Cardiology; 1Hospital de
Cabue~es (Gijdn ); 2Hospital Central de Asturias (Oviedo), Spain Purpose: To determine whether differences exist in the appearance of coronary events in patients with coronary disease before 50 years of age according to the levels of different lipoprotein fractions. Methods: Consecutively, 227 male patients (pts) before 50 years of age (mean age 42 + 4 years), who were admitted to our Coronary Care Unit as result of an episode of coronary disease were prospectively studied. Levels of Total cholesterol (Tchol), HDL cholesterol (HDL), triglycerides (TG) and Lp(a) were analysed after patients had fasted for more than 12 hours. LDL cholesterol (LDL) was calculated using Friedwald's formula, when the TG did not exceed 300 mg/dl. The following cutoff points were established in order to divide patients into 2 groups: Tcho 200 mg/dl; HDL 35 mg/dl; LDL 130 mg/dl;TG 200 mg/dl and Lp(a) 30 mg/dl. In order to determine new coronary events, a mean follow-up of 32 + 13 months was carded out. For statistical analysis the Student t test was employed for the comparison of percentages of independent groups Results: mg/dl CT > 200 CT < 200 LDL > 130 LDL < 130 TG >_ 200 TG < 200
Pts (%)
Events (%)
P
144 (63%) 83 (37%) 141 (72%) 56 (28%) 73 (32%) 154 (68%)
64 (45%) 25 (30%) 59(42%) 14 (25%) 38 (52%) 51 (33%)
<0.05 0.02 0.007
No differences were found according to the cutoff points for HDL and Lp(a). Condnsions: Differences exist in the appearance of coronary events during follow-up of patients with early onset coronary disease according to the levels of Tchol, LDL and TG in the acute phase being the number of events significantly less in patients with Tchol levels less than 200 mg/dl, LDL levels less than 130 mg/dl and TG levels less than 200 mg/dl.
I ThT8:W37 [ Is rehabilitation
in women
beneficial as men?
S. Asgary, N. Sarraf Zadegan, Gh. Naderi, A. Pourshams Abadi, K. Rabiei.
Isfahan Cardiovascular Rsearch Center. Pharmaconosy Department school of pharmazy lsfahan, lran Rationale: Cardiac rehabilitation is an essential component of the long term comprehensive managment of coronary patients. Objective: Determining the effect of rehabilitation on blood lipid profile in men and women. Methods: The study sample was 40 women with the mean age = 54.2 + 8.21 and 100 men with the mean age = 51.8 + 9.58 who were selected randomly from all patients with myocardial infarction referred to the rehabilitation unit in Isfahan cardiovascular research center. Eight-week rehabilitation program was started. Each session included a 20-minute stretching and warming up, a 20-minute conditioning period and a 15-minute cooling down. This program was performed as 3 sessions per week. Serum lipoproteins of all patients were measured before and after, rehabilitation. Results: There was no significant difference between age in the men and women. The obatined results show that rehabiliation can decreased TG, T.chol and LDL-cholesterol and the HDL-cholesterol level to be increased significantly (P < 0.05) in both sexes. Also, it was determined by statistical unparied t-test that there were no significant differences between two sexes regarding the effect of rehabilitation on these factors. Conclusions: As determined that increasing blood lipids is a major risk factor for cardiovascular disease and also rehabilitation improves lipid profiles in both men and women. It means that both men and women benefit from rehabilitation.
Xllth International Symposium on Atherosclerosis, Stockholm, Sweden, June 25-29, 2000
Hypertension Normal coronariography
Tchol/HDL < 5 (39)
TcholCT/HDL > 5 (190)
p
7 (18%) 6 (30%)
77 (40%) 7 (6%)
0.007 <0.005
No differences were found in the prevalence of diabetes or smoking habits in either group. No differences were seen during follow-up in the presence of angina, myocardial infarction, heart failure or need for revascularisation. Conclusions: Our group of patients younger than 50 years old with ischemic heart disease and showing a Tchol/HDL less than or equal to 5, present less prevalence of hypertension and show more frequently absence of significant coronary lesions in comparison with those patients with an altered lipid profile.
ThT5:W37 ] Early-onset single vessel coronary disease A. Batalla I , G.I. Cubero 2, J.J.R. Reguero2 , S. Hevia2, S. Braga2, E. Bustillo 2, E. Merino2, J.C. Sanmartin2, A. Cortina2. Department of Cardiology;
l Hospital de Cabuehes (Gij6n); 2Hospital Central de Asturias (Oviedo), Spain Purpose: To determine common characteristics of patients under 50 years of age with single vessel coronary disease. Methods: Consecutively, 119 male patients before 50 years of age (mean age 42 4- 4 years), who were admitted to our Coronary Care Unit as result of an episode of coronary disease and at least a coronary lesion greater than 70% in the coronariography, were prospectively studied. Smoking habits, arterial hypertension, diabetes and dyslipemia were determined during the acute phase by means of a questionnaire, physical examen and fasting analysis. The follow cutoff points were established: Total cholesterol (Tchol) 200 mg/dl; HDL cholesterol (HDL) 35 mg/dl; LDL cholesterol (LDL) 130 mg/dl; Tryglicerides (TG) 200 mg/dl and Lp(a) 30 mg/dl. In order to determine new coronary events, a mean follow-up of 32 5= 13 months was carried out. For statistical analysis the Chi-Square test with Fisher's test was applied. Results:
Lp(a) > 30 mg/dl
Single vessel disease (49)
Multivessel disease (70)
p
23 (47%)
46 (66%)
<0.05
No differences were found in the prevalence of hypertension, diabetes or smoking habits in either group. No differences were seen according to the cutoff points in Tchol, HDL, LDL and TG. Nor were any difference during follow-up in the presence of angina, myocardial infarction, heart failure, mortality or need for revascularisation. Conclusions: Patients with early onset of coronary disease and single vessel disease present normal Lp(a) levels more frequently than those with multivessel disease. I
ThT6:W371 The relationship of dyslipemia w i t h other coronary risk factors in males with early coronary disease A. Batalla I , G.I. Cubero 2, J.J.R. Reguero 2, S. Braga2, E. Bustillo 2 , S. Hevia2 , E. Merino 2, J.C. Sanmarffn 2, A. Cortina2. Department of Cardiology;
1Hospital de Cabuehes (Gij6n); 2Hospital Central de Asturias (Oviedo), Spain Purpose: To determine a possible association between dyslipemla and other coronary risk factors in early coronary disease. Methods: Consecutively, 229 male patients before 50 years of age (mean age 42 5= 4 years), who were admitted to our Coronary Care Unit as result of an episode of coronary disease were prospectively studied. Smoking habits, arterial hypertension, diabetes and dyslipemia were determined during the acute phase by means of a questionnaire, physical examen and fasting analysis. An attempt was made to determine a possible association between dyslipemia and other risk factors. We considered dyslipemia a Total cholesterol-HDL cholesterol ratio (Tchol/HDL) greater than 5. For statistical analysis the Chi-Square test was applied. Results are presented in the table. No differences were found in relation to smoking habits and diabetes Conclusions: In our study of males with early coronary disease an association was found between dyslipemla and arterial hypertension that the
323
Hypertension
No Hypertension
p
77 (40.5%) 7 (18%)
113 (59.5%) 32 (82%)
0.01
CT/HDL > 5 (n: 190) CT/HDL < 5 (n: 39)
prevalence of arterial hypertension is significantly greater in the group of patients with a Tchol/HDL greater than 5.
ThT7:W37 1 Lipid levels and coronary events A. Batalla I , G.I. Cubero 2, J.J.R. Reguero2, S. Hevia 2, S. Braga 2, E. Bustillo 2 , E. Merino 2, J.C. Sanmartin2 , A. Cortina2 . Dept. of Cardiology; 1Hospital de
Cabue~es (Gijdn ); 2Hospital Central de Asturias (Oviedo), Spain Purpose: To determine whether differences exist in the appearance of coronary events in patients with coronary disease before 50 years of age according to the levels of different lipoprotein fractions. Methods: Consecutively, 227 male patients (pts) before 50 years of age (mean age 42 + 4 years), who were admitted to our Coronary Care Unit as result of an episode of coronary disease were prospectively studied. Levels of Total cholesterol (Tchol), HDL cholesterol (HDL), triglycerides (TG) and Lp(a) were analysed after patients had fasted for more than 12 hours. LDL cholesterol (LDL) was calculated using Friedwald's formula, when the TG did not exceed 300 mg/dl. The following cutoff points were established in order to divide patients into 2 groups: Tcho 200 mg/dl; HDL 35 mg/dl; LDL 130 mg/dl;TG 200 mg/dl and Lp(a) 30 mg/dl. In order to determine new coronary events, a mean follow-up of 32 + 13 months was carded out. For statistical analysis the Student t test was employed for the comparison of percentages of independent groups Results: mg/dl CT > 200 CT < 200 LDL > 130 LDL < 130 TG >_ 200 TG < 200
Pts (%)
Events (%)
P
144 (63%) 83 (37%) 141 (72%) 56 (28%) 73 (32%) 154 (68%)
64 (45%) 25 (30%) 59(42%) 14 (25%) 38 (52%) 51 (33%)
<0.05 0.02 0.007
No differences were found according to the cutoff points for HDL and Lp(a). Condnsions: Differences exist in the appearance of coronary events during follow-up of patients with early onset coronary disease according to the levels of Tchol, LDL and TG in the acute phase being the number of events significantly less in patients with Tchol levels less than 200 mg/dl, LDL levels less than 130 mg/dl and TG levels less than 200 mg/dl.
I ThT8:W37 [ Is rehabilitation
in women
beneficial as men?
S. Asgary, N. Sarraf Zadegan, Gh. Naderi, A. Pourshams Abadi, K. Rabiei.
Isfahan Cardiovascular Rsearch Center. Pharmaconosy Department school of pharmazy lsfahan, lran Rationale: Cardiac rehabilitation is an essential component of the long term comprehensive managment of coronary patients. Objective: Determining the effect of rehabilitation on blood lipid profile in men and women. Methods: The study sample was 40 women with the mean age = 54.2 + 8.21 and 100 men with the mean age = 51.8 + 9.58 who were selected randomly from all patients with myocardial infarction referred to the rehabilitation unit in Isfahan cardiovascular research center. Eight-week rehabilitation program was started. Each session included a 20-minute stretching and warming up, a 20-minute conditioning period and a 15-minute cooling down. This program was performed as 3 sessions per week. Serum lipoproteins of all patients were measured before and after, rehabilitation. Results: There was no significant difference between age in the men and women. The obatined results show that rehabiliation can decreased TG, T.chol and LDL-cholesterol and the HDL-cholesterol level to be increased significantly (P < 0.05) in both sexes. Also, it was determined by statistical unparied t-test that there were no significant differences between two sexes regarding the effect of rehabilitation on these factors. Conclusions: As determined that increasing blood lipids is a major risk factor for cardiovascular disease and also rehabilitation improves lipid profiles in both men and women. It means that both men and women benefit from rehabilitation.
Xllth International Symposium on Atherosclerosis, Stockholm, Sweden, June 25-29, 2000