- Email: [email protected]
Lipid ratios as predictors of subclinical atherosclerosis
Abstracts / Atherosclerosis 235 (2014) e192–e301
Results:
e289
M. Moria, H. Moria, Y. Yamoria a
Institute World Health Development, Mukogawa Women's University, Nishinomiya, Japan Objectives: To evaluate the sweet intake by FFQ (Food Frequency Questionnaire) in Japanese high school girl students and the relation of the intakes with trans fatty acids (TFA) in blood and the risk factors by health survey.
Ă
Conclusion: cobas b 101 provides rapid, accurate and highly precise measurements of lipid profile and HbA1c. Slight biases in some settings were unimportant for clinically reliable use of cobas b 101 at the point of patient care. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0988. LIPID TARGET ACHIEVEMENT AMONG PATIENTS ACCORDING TO ESC/ EAS AND ACC/AHA GUIDELINES IN A LIPID CLINIC
Methods: We implemented food education and health examination in 2007-2011 for 345 girl students aged 12-18 by analyzing fasting blood samples from 267 girl students and by examining their heights, weights, body fat ratios and FFQ data of food intakes. We analyzed blood TFA and compared the difference of risk factors between two groups in whom TFA were detectable (+) or not (-). Results: The intake rate of the sweets of girl students was 4 times higher than a standard value. TFA were detected in the blood of 203 girl students (76.0%) in whom HDL-C were all over 40mg/dl and LDL-C were over 140mg/dl in 12(4.6%) and atherogenic indices (LDL-C / HDL-C ratios) were over the standard (>2.0) in 35 (12.8%). LDL-C, LDL-C/HDL-C ratios and triglycerides were significantly higher and HDL-C were significantly lower in the (+) group than the (-) group.
H. Milionisa, F. Barkasa, E. Liberopoulosa, M. Kostapanosa, E. Klourasa, M. Elisafa a
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece Objectives: There is a paucity of data regarding attainment of goals of lipidlowering treatment according to current European (ESC/EAS) and recently published American (ACC/AHA) guidelines. The aim of this study was to assess achievement of lipid-lowering treatment goals set by recent guidelines in an outpatient University Hospital Lipid Clinic. Methods: This was an observational study of patients aged 18 years, and a follow-up of for 3 years. The proportions of patients achieving LDL-C targets according to current ESC/EAS guidelines were recorded, along with the percentages of appropriate lipid-lowering treatment proposed by recent ACC/AHA guidelines. Results: One thousand eligible patients were finally enrolled. Of those, 48% were considered 'very high', 41% 'high' and 11% 'moderate' cardiovascular risk according to ESC/EAS guidelines. LDL-C targets were achieved in 25%, 52% and 57% of patients, respectively. According to the American guidelines, 21% of patients were diagnosed with atherosclerotic cardiovascular disease (ASCVD). Almost half of those patients with age 75 years were receiving 'high'-intensity statin therapy, while 32% and 61% of older than 75 years were on 'high' and 'moderate'intensity statin, respectively. Of patients without ASCVD and a baseline LDL-C 190 mg/dL (n¼268), 46% were treated with 'high'-intensity statin. Of patients with type 2 diabetes and age 40-75 years (n¼73), 59% had a SCORE 2.5% (which corresponds to a 10-year risk of ASCVD 7.5%).Of those, 25% were on 'high'-intensity statin. Finally, 17% and 71% of patients with SCORE 2.5 not classified as above (n¼175), were receiving 'high'- and 'moderate'-intensity statin, respectively. Conclusion: In the setting of a specialized lipid clinic, 25% of patients at 'very high' and almost 50% of those at 'high' and 'moderate' risk achieve therapeutic goals according to the European guidelines. On the other hand, the proportions patients receiving 'appropriate-intensity' statin therapy according to ACC/AHA guidelines are relatively high in all patient groups. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0842. THE RISK FACTORS OF TRANS FATTY ACIDS IN JAPANESE SCHOOL GIRLS
Ă
Conclusion: The sweet intakes are very high and TFA from the sweets are presently one of the risk factors of arthrosclerosis in Japanese school girls who may develop atherosclerosis in the future. Therefore, food education is needed for school girls in Japan. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-1128. LIPID RATIOS AS PREDICTORS OF SUBCLINICAL ATHEROSCLEROSIS S. Novoa, F. Macaionea, F.P. Guarneria, E. Corradoa, S. Evolaa, G. Novoa a
Division of Cardiology, University of Palermo, Palermo, Italy
Objectives: Our study aimed to appraise the role of lipid ratios (Non-highdensity lipoprotein cholesterol [non-HDL-C]/HDL-C ratio, low-density lipoprotein cholesterol [LDL-C]/HDL-C ratio and triglycerides [TG]/HDL-C ratio) as predictors of subclinical carotid atherosclerosis (intima-media thickness [IMT] >0,9 mm and < 1,5 mm or atherosclerotic carotid plaque [IMT >1,5 mm]). Methods: 418 asymptomatic subjects were enrolled. All subjects underwent a carotid ultrasound examination. Two groups were individualized in the study population according to the presence/absence of subclinical carotid atherosclerosis: subjects with subclinical carotid atherosclerosis (n. 208) [cases] vs subjects without subclinical carotid atherosclerosis (n. 210) [controls]. The non-HDL-C/HDL-C ratio, LDL-C/HDL-C ratio and TG/HDL-C ratio were evaluated in these groups. Results: The two groups were significant different (p< 0,0001 respectively). The Pearson correlation test showed that the non-HDL-C/HDL-C ratio and the TG/HDL-C ratio were positively interrelated (r: 0,6249; P 4 and >3,8 respectively. The area under the receiver operating characteristic (aROC) curves were 0.828 for non-HDL-C/HDL-C ratio and 0.869 for the TG/ HDL-C ratio (P ¼ 0,051). Conclusion: This study showed that non-HDL-C/HDL-C ratio and the TG/ HDL-C ratio were significant predictors of subclinical carotid atherosclerosis after adjustment for conventional risk factors.
Results:
e289
M. Moria, H. Moria, Y. Yamoria a
Institute World Health Development, Mukogawa Women's University, Nishinomiya, Japan Objectives: To evaluate the sweet intake by FFQ (Food Frequency Questionnaire) in Japanese high school girl students and the relation of the intakes with trans fatty acids (TFA) in blood and the risk factors by health survey.
Ă
Conclusion: cobas b 101 provides rapid, accurate and highly precise measurements of lipid profile and HbA1c. Slight biases in some settings were unimportant for clinically reliable use of cobas b 101 at the point of patient care. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0988. LIPID TARGET ACHIEVEMENT AMONG PATIENTS ACCORDING TO ESC/ EAS AND ACC/AHA GUIDELINES IN A LIPID CLINIC
Methods: We implemented food education and health examination in 2007-2011 for 345 girl students aged 12-18 by analyzing fasting blood samples from 267 girl students and by examining their heights, weights, body fat ratios and FFQ data of food intakes. We analyzed blood TFA and compared the difference of risk factors between two groups in whom TFA were detectable (+) or not (-). Results: The intake rate of the sweets of girl students was 4 times higher than a standard value. TFA were detected in the blood of 203 girl students (76.0%) in whom HDL-C were all over 40mg/dl and LDL-C were over 140mg/dl in 12(4.6%) and atherogenic indices (LDL-C / HDL-C ratios) were over the standard (>2.0) in 35 (12.8%). LDL-C, LDL-C/HDL-C ratios and triglycerides were significantly higher and HDL-C were significantly lower in the (+) group than the (-) group.
H. Milionisa, F. Barkasa, E. Liberopoulosa, M. Kostapanosa, E. Klourasa, M. Elisafa a
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece Objectives: There is a paucity of data regarding attainment of goals of lipidlowering treatment according to current European (ESC/EAS) and recently published American (ACC/AHA) guidelines. The aim of this study was to assess achievement of lipid-lowering treatment goals set by recent guidelines in an outpatient University Hospital Lipid Clinic. Methods: This was an observational study of patients aged 18 years, and a follow-up of for 3 years. The proportions of patients achieving LDL-C targets according to current ESC/EAS guidelines were recorded, along with the percentages of appropriate lipid-lowering treatment proposed by recent ACC/AHA guidelines. Results: One thousand eligible patients were finally enrolled. Of those, 48% were considered 'very high', 41% 'high' and 11% 'moderate' cardiovascular risk according to ESC/EAS guidelines. LDL-C targets were achieved in 25%, 52% and 57% of patients, respectively. According to the American guidelines, 21% of patients were diagnosed with atherosclerotic cardiovascular disease (ASCVD). Almost half of those patients with age 75 years were receiving 'high'-intensity statin therapy, while 32% and 61% of older than 75 years were on 'high' and 'moderate'intensity statin, respectively. Of patients without ASCVD and a baseline LDL-C 190 mg/dL (n¼268), 46% were treated with 'high'-intensity statin. Of patients with type 2 diabetes and age 40-75 years (n¼73), 59% had a SCORE 2.5% (which corresponds to a 10-year risk of ASCVD 7.5%).Of those, 25% were on 'high'-intensity statin. Finally, 17% and 71% of patients with SCORE 2.5 not classified as above (n¼175), were receiving 'high'- and 'moderate'-intensity statin, respectively. Conclusion: In the setting of a specialized lipid clinic, 25% of patients at 'very high' and almost 50% of those at 'high' and 'moderate' risk achieve therapeutic goals according to the European guidelines. On the other hand, the proportions patients receiving 'appropriate-intensity' statin therapy according to ACC/AHA guidelines are relatively high in all patient groups. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-0842. THE RISK FACTORS OF TRANS FATTY ACIDS IN JAPANESE SCHOOL GIRLS
Ă
Conclusion: The sweet intakes are very high and TFA from the sweets are presently one of the risk factors of arthrosclerosis in Japanese school girls who may develop atherosclerosis in the future. Therefore, food education is needed for school girls in Japan. 71 - Risk factors, epidemiology, prevention and treatment of cardiovascular diseases: Miscellaneous EAS-1128. LIPID RATIOS AS PREDICTORS OF SUBCLINICAL ATHEROSCLEROSIS S. Novoa, F. Macaionea, F.P. Guarneria, E. Corradoa, S. Evolaa, G. Novoa a
Division of Cardiology, University of Palermo, Palermo, Italy
Objectives: Our study aimed to appraise the role of lipid ratios (Non-highdensity lipoprotein cholesterol [non-HDL-C]/HDL-C ratio, low-density lipoprotein cholesterol [LDL-C]/HDL-C ratio and triglycerides [TG]/HDL-C ratio) as predictors of subclinical carotid atherosclerosis (intima-media thickness [IMT] >0,9 mm and < 1,5 mm or atherosclerotic carotid plaque [IMT >1,5 mm]). Methods: 418 asymptomatic subjects were enrolled. All subjects underwent a carotid ultrasound examination. Two groups were individualized in the study population according to the presence/absence of subclinical carotid atherosclerosis: subjects with subclinical carotid atherosclerosis (n. 208) [cases] vs subjects without subclinical carotid atherosclerosis (n. 210) [controls]. The non-HDL-C/HDL-C ratio, LDL-C/HDL-C ratio and TG/HDL-C ratio were evaluated in these groups. Results: The two groups were significant different (p< 0,0001 respectively). The Pearson correlation test showed that the non-HDL-C/HDL-C ratio and the TG/HDL-C ratio were positively interrelated (r: 0,6249; P 4 and >3,8 respectively. The area under the receiver operating characteristic (aROC) curves were 0.828 for non-HDL-C/HDL-C ratio and 0.869 for the TG/ HDL-C ratio (P ¼ 0,051). Conclusion: This study showed that non-HDL-C/HDL-C ratio and the TG/ HDL-C ratio were significant predictors of subclinical carotid atherosclerosis after adjustment for conventional risk factors.