Lipids

Bibliography of the current world literature This bibliography is drawn from the journals listed opposite and is selected from a comprehensive bibliography that is compiled by structural biologists and is available on diskette. The bibliography is based on literature entered into our database between 1 st April 1993 and 31 st March 1994 (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue. • Papers considered by the reviewers to be of special interest. oo Papers Considered by the reviewers to be of outstanding interest. The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

Contents Lipids

Biophysical measurements of membrane proteins

655

Lipid organization and modelling

639

Transporters

657

General composition of lipids

642

Miscellaneous

658

Lipoproteins, receptors, binding and anchors

643

Lipid-acting enzymes

645

Engineering and design

Miscellaneous

646

Study of enzyme catalytic mechanisms

660

Protein engineering for enzyme specificity and structure determination

663

Membrane proteins Prostaglandin synthase

647

Antibody engineering

666

Light signal transduction

647 649

Methods for mutagenesis, modification and synthesisof proteins and self-replicating molecules

667

Electron transport proteins Channels and junctions

651

Ribozyme and RNA engineering

668

Membrane-bound receptors

653

De novo

Solid state NMR studies

655

Biosensors

design and stabilization of proteins

669 671

Lipids Lipid organization and modelling Related review: Molecular dynamics and Monte Carlo simulations of lipid bilayers (pp 486--492) Abrams FS, London E: Extension of the Parallax Analysis of Membrane Penetration Depth to the Polar Region of Model Membranes - use of Fluorescence Quenching by a Spin-Label Attached to the Plnospholipid Polar Headgroop. Biochemistry 1993, 32:10826-10831. Ahl PL: Why is the Purple Membrane a 2-Dimensional Crystal. Biophys J 1993, 65:563-564. Ahlstrrn P, Berendson HJC: Molecular Dynamics Study • of Lecithin Monolayers. J Phys Chem 1993, 97:1369 I-13702. [31]. Alam TM: Molecular Dynamics in Lipid Bilayers Anisotropic Diffusion in Ann Odd Restoring Potential (Vol 64, Pg 1681, 1993). Biophys J 1993, 65:2266. Almeida PFF, Vaz WLC, Thompson TE: Percolation and Diffusion in 3-Componeot Lipid Bilayers Effecl of Cholesterol on an Equimolar Mixture of 2 Phosphatidylcholines. Biophys ] 1993, 64:399-412. Alper HE, Bassotino D, Stouch TR: Computer Simulation of a Phospholipid Mooolayer-Water System: the Influence of Long Range Forces on Water Structure and Dynamics. J Chem Phys 1993, 98:9798-9807. Andree HAM, Willems GM, Hauptmann R, Maurerfogy I, Stuart MCA, Hermens WT, Frederik PM, Reutelingsperger CPM: Aggregation of Phospholipid Vesicles by a Chimeric Protein with the N-Terminus

of Annexin-I and the Core of Annexin-V. Biochemistry 1993, 32:4634-4640. Anlonenko YN, Denisov GA, Pohi P: Weak Acid Transport Across Bilayer Lipid Membrane in the Presence of Buffers - Theoretical and Experimental PH Profiles in the Unstirred Layers. Biophys J 1993, 64:1701-1710. Antunesmadeira MD, Madeira VMC: Effects of DDE on the Fluidity of Model and Native Membranes Implications for the Mechanisms of Toxicity. Biochim Biophys Acta 1993, 1149:86-92. Anzai K, Yoshioka Y, Kirino Y: Novel Radioactive Phospholipid Probes as a Tool for Measurement of Phospholipid Traoslocation Across Biomembranes. Biochim Biophys Acta 1993, 1151:69-75. Balakrishnan AR, Easwaran KRK: Lipid-Amphotericin B-Complex Structure in Solution - a Possible 1stStep in the Aggregation Proces~ in Cell Membranes. Biochemistry 1993, 32:4139-4144. Balcom BJ, Petersen NO: Lateral Diffusion in Model Membranes is Independent of the Size of the Hydrophobic Region of Molecules. Biophys J 1993, 65:630-637. Banuelos S, Arrondo JLR, Canaves JM, FerragutJA, Muga A: The Interaction of Daunamycin with Model Membranes -Effect of the Lipid Physical State and the Lipid Composition. Eur J Biochem 1993, 213:1269-1275. 8assolino-Klimas D, Alper HE, Stouch TR: Solute Diffusion ee in Lipid Bilayer Membranes: an Atomic Level Study by Molecular Dynamics Simulation. Biochemistry 1993, 32:12624-12637. [47]. Beleznay Z, Zachowski A, Devaux PF, Navazo MP, Ott P: ATP-Dependent Aminophospholipid Translocalion

© Current Biology Ltd ISSN 0959-440X

in Erythrocyle Vesicles - Stoichiometry of Transport. Biochemistry 1993, 32:3146-3152. Benfenati E, "Valtorta F, Rossi MC, Onofri F, Sibra 1, Greengard P: Interactions of Synapsin-I with Phospholipids - Possible Role in Synaptic Vesicle Clustering and in the Maintenance of Bilayer Structures. J Cell Biol 1993, 123:1845-1855. Berkowitz WF, Pan DF, Bittman R: A New Approach to Archaebaclerial Lipid Models. Tetrahedron Lett 1993, 34:4297-4300. Bhushan A, Mcnamee MG: Correlation of Phospholipid Structure with Functional Effects on the Nicotinic Acetylcholine Receptor - a Modulatory Role for Phosphatidic Acid. Biophys J 1993, 64:716-723. Birmachu W, Voss JC, Louis CF, Thomas DD: Protein and Lipid Rotational Dynamics in Cardiac and Skeletal Sarcoplasmic Reticulum Detected by EPR and Phosphorescence Anisotropy. Biochemistry 1993, 32:9445-9453. Blasko A, Bunion CA, Cerichelli G, McKenzie DC: A Nuclear Magnetic Resonance study of Ion Exchange in Cationic Micelles~ Snccessesand Failures of Models. J Phys Chem 1993, 97:11324-11331. Boni LT, Minchey SR, Perkins WR, Ahl PL, Slater IL, late MW, Gruner SM, Janoff AS: Curvature Dependent Induction of the Interdigitaled Gel Phase in DPPC Vesicles. Biochim Biophys Acta 1993, 1146:247-257 8ottner M, Winter R: Influence of the Local Anesthetic Tetracaine on the Phase Behavior and the Thermodynamic Properties of Phospholipid Bilayers. Biophys ] 1993, 65:2041-2046. Brandenburg K: Fourier Transform Infrared Spectroscopy Characterization of the Lamellar and Nonlamellar

639

640

Lipids Lipid organization and modelling Structures of Free Lipid-A and Re Lipopolysaccharides from Salmonella-Minnesotaand Escherichia-Coli. Biophys J 1993, 64:1215-1231. Bratt PJ, Kevan L: Electron Spin ResonanceLineShape Analysis of Pi-Doxylstearic Acid Spin Probes in Dihexadecyl Phosphate Vesiclesand Effects of CholesterolAddition. J Phys Chem 1993, 97:7371-7374. Brunen M, Engelhardt H: Asymmetry of Orientation and Voltage Gating of the Acidovorax-Delafieldii Porin Omp34 in Lipid Bilayers. EurJ Biochem 1993, 212:129-135. Burke TG, Mishra AK, Want MC, Wall ME: Lipid Bilayer Partitioning and Stability of Camptothecin Drugs. Biochemistry 1993, 32:5352-5364. Chen JW, Hu LY, Hwang F: Phase Transitions of Acholeplasma-Laldlawii Membranes - the Involvement of Mg2+-ATPasein the C-Transition. FEBSLett ]993, 322:253-256. Chen SY, Vandermeer BW:,Theory Of 2-Photon Induced Fluorescence Anlsotropy Decay in Membranes. BiophysJ 1993, 64:1567-1575. Chemomordik LV, Vogel SS, Sokoloff A, Onaran HO, Leikina EA, Zimmerberg J: Lysolipids Reversibly Inhibit CA-2+-Dependent, GTP-Dependentand PHDependent Fusion of Biological Membranes. FEBSLett 1993,318:71-76. Chia N-C, Mendelsohn'R: CH2 Wagging Modes of Unsaturated Acyl Chains as IR Probesof Conformational Order in Methyl Alkenoates and Phosphollpid Bilayers. J Phys Chem 1992, 96:10543-10547.

Chia NC, Vilcheze C, 8ittman R, Mendelsohn R: Interactions of Cholesterol and Synthetic Sterols with Phnspbatidylcbulines as Deduced from Infrared CH2 Wagging Progression Intensities. J Am Chem Soc 1993, 115: t 2050-12055. Colotto A, Kharakoz DP, Lohner K, Laggner P: Ultrasonic Study of Melittin Effects on Phnspholipid Model Membranes. Biophys J ]993, 65:2360-2367. Corbett JD, Cho MR, Golan DE: Deoxygenation Affects Fluorescence Photubleacblog RecoveryMeasurements of Red Cell Membrane Protein Lateral Mobility. giophysJ 1994, 66:25 30. Custodio JBA, Almeida LM, Madeira VMC: The Anticancer Drug Tamoxifen Induces Changes in the Physical Properties of Model and Native Membranes. Biochim Biophys Acta 1993, 1150:123-129. Custodio JBA, Almeida LM, Madeira VMC: The Active Metabulite Hydroxytamoxifen of the Anticancer Drug Tamoxifen Induces Structural Changes in Membranes. Biochim Biophys Acta 1993, 1153:308-314. Czurylo EA, Zborowski J, Dabrowska R: Interaction of Caldesmon with Phospbolipids. Biochem J 1993, 291:403-408. Damodaran KV, Merz KM Jr: A Comparison of DMPC• and DLPE-BasedLipid Bilayers. Biophys J 1994, 66:1076-1087. [46]. Davidson SMK, Liu YP, RegenSL: The Influence of Cholesterol on Nearest-NeighborRecognition in Saturated Phnspholipid Membranes. J Am Chem Soc 1993, 115:10104-10110. Dearaujo PS, Panek AD: The Interaction of Saccharomyces-cerevisiaeTrehalnsewith Membranes. Biochim Biophys Acta 1993, 1148:303-307. Delong LJ, Blasie }K: Effect of Ca2+ Binding on the Profile Structure of the Sarcoplasmic Reticulum Membrane Using Time-ResolvedX-Ray Diffraction. Biophys J 1993, 64:] 750-1759. Dewolf FA, StaffhorstRWHM, Stairs HP, Onwezen MF, Dekruijff 8: Role of Anionic Phnsphollpids in the Interaction of Doxorubicin and Plasma Membrane Vesicles. Drug Binding and Structural Co~isequencesin Bacterial Systems. Biochemistry 1993, 32:6688-6695. Dey I, Buda C, Wiik T, Halver JE, FarkasT: Molecular and Structural Comp~flion of Pho~holipid Membranes in Livers of Marine and Freshwater Fish in Relation to Temperature. Proc Nat/Acad Sci U S A 1993, 90:749[~7502. Dibble ARG, YeagerMD, Feigenson GW: Partitioning of Gramicidin A' BetweenCoexisting Fluid and Gel Phnspholipid Phases.Biochim Biophys Acta 1993, 1153:155-]62. Dobereiner HG, Kas J, Noppl D, Sprenger I, Sackmann E: Budding and Fissionof Vesicles. Biophys J 1993, 65:1396-1403. Domingo }C, Mora M, DemadariagaMA: Incorporation of N-acylethanolamine Phospbulipids into Egg Phosphatidylcholine Vesicles. Characterization and Permeability Properties of the Binary Systems. Biochim Biophys Acta 1993, 1148:30~316. Downing DT, Dose RW, Abraham W: Interaction Between Sphlngnsine and Cholesteryl Sulfate in Epidermal Lipids. J Lipid Res 1993, 34:563 569. Eguchi 1, TerachiT, Kakinuma K: Direct Closure of a 36-Membered Ring Using the McMurry

Coupling - Synthetic Studies on the Macrncyclic Archaebacterial Membrane Lipids. Tetrahedron Lett 1993, 34:2175-2178. Farge E, Devaux PF: Size-Dependent Response of Liposomes to Phnspholipid Tramanembrane Redislrlbufion: from Shape Change to Induced Tension. J Phys Chem 1993, 97:2958-2961. Fattal DR, Benshaul A: A Molecular Model for LipidProtein Interaction in Membranes - the Role of Hydropbubic Mismatch. Biophys J 1993, 65:1795-1809.

Fischer TM: Bending Stiffnessof Lipid Bilayers. 4. Interpretation of Red Cell Shape Change. Biophys J 1993, 65:687-692. Fischer TM: Bending Stiffnessof Lipid Bilayers. 4. Interpretation of Red Cell Shape Change (Vol 65, Pg 687, 1993). Biophys J 1993, 65:2266. Flach CR, Mendelsohn R: A New Infrared Spectroscopic Marker for Cochleate Phasesin PhnsphatidylserineContaining Model Membranes. Biophys J 1993, 64:1113-1121. Fukada T, Okazaki S, Okada h Molecular Dynamics Study of the Lauryl Alcohol-LaurateModel Bilayer. Biophys J 1993, 64:1344-1353. Garcera MJG, EfferinkMGL, DriessenAJM, Konings WN: Invitro Pore-Formiog Activity of the Lantibiotic Nisin - Role of Protonmotive Force and Lipid Composition. Eur J Biochem 1993, 212:417-422. Gascard P, SauvageM, Sulpice JC, Giraud F: Characterization of Structural and Functional Phnsphoinnsitide Domains in Human Erythrocyte Membranes. Biochemistry 1993, 32:5941 5948. Ge MT, Freed }H: An Electron Spin ResonanceStudy of Interactions BetweenGramicidin-A' and Phosphatidylcholine Bilayers. Biophys J 1993, 65:2106-2123. Geli V, KoorengevelMC, Demel RA, Lazdunski C, Killian JA: Acidic Interaction of the Colicin-A Pore-Forming Domain with Model Membranesof Escherichia.coli Lipids Results in a Large Pertubation of Acyl Chain Order and Stabilization of the Bilayer. Biochemistry 1992, 31:11089 11094. Gonzalezmanas JM, Lakey JH, Pattus F: Interaction of the Collcin-A Pore-FormingDomain with Negatively Charged Phnspholipids. EurJ Biochem 1993, 211:625-633. Goyal PS, Menon SVG, DasannacharyaBA, Rajagopalan V: Role of Van Der Waals Forceson Small Angle Neutron Scattering from Ionic Micellar Solutions. Chem Phys Lett 1993, 211:559-563. Hallelt FR, Marsh J, Nickel BG, Wood JM: Mechanical Properties of Vesicles. 2. A Model for Osmotic Swelling and Lysls. Biophys J 1993, 64:435-442. Hardy BH, Pastor RW: Cooformational Sampling of • Hydrocarbon and Lipid Chains in an Ordering Potential. l Comput Chem 1994, 15:208-226. [82]. Hare BJ, Howard KP, PrestegardJH: Torsion Angle Analysis of Glycollpid Order at Membrane Surfaces. Biophys J 1993, 64:392-398. Heller H, SchaeferM, Schulten K: Molecular Dynamics • Simulation of a Bilayer of 200 Lipids in the Gel and in the Liquid-Crystal Phases. J Phys Chem 1993, 97:8343-8360. [32]. Hincha DK, DevriesAL, Schmitt JM: Cryotoxicity of Antifreeze Proteins and Glycoproteins to Spinach Thylakold Membranes - Comparison with Cryotoxic Sugar Acids. Biochim Biophys Acta 1993, 1146:258 264. Hing AW, SchaeferJ: 2-Dimensional RotationalEcho Double ReSOnanceof Va11-[1-C-13]Gly2[N-15]Ala3-Gramicidin-A in Moltilamellar Dimyrisloylphnsphafidylchollne Dispersions. Biochemistry 1993, 32:7593-7604. Horniak L, Pilon M, Vanthof R, Dekruijff B: The Secondary Structure of the FerredoxinTransit Sequence is Modulated by Its Interaction with Negatively Charged Lipids. FEBSLelt 1993, 334:241-246. Hovius R, Thijssen J, Vanderlinden P, Nicolay K, Dekruijff B: Phospbulipid Asymmetry of the Outer Membrane of Rat Liver Mituchondria - Evidencefor Ihe Presence of Cardiollpin on the Outside of the Outer Membrane. FEBSLett 1993, 330:71-76. Huang C, Wang ZQ, Lin HN, Brumbaugh EE: Calorimetric Studies of Fully Hydrated Phosphafidylcholineswith Highly Asymmetric Acyl Chains. Biochim Biophys Acta 1993, 1145:298-310. Huang JY, FeigensonGW: Monte Carlo Simulation of Lipid Mixtures - Finding PhaseSeparation. Biophys J 1993, 65:1788-1794. Hubner W, Mantsch HH, Paltauf F, Hauser H: Conformation of Pho~hatidyiserine in Bilayers as Studied by Fourier Transform Infrared Spectroscopy. Biochemistry 1994, 33:320-326. Ishihara A, Jacobson K: A Closer Look at How Membrane Proteins Move. Biophys J 1993, 65:1754-1755.

Jin AI, Nossal R: TopologicalMechanisms Involved in the Formation of Clathrin-CoatedVesicles. Biophys ] 1993, 65:1523-1537. Jones AL, Harm AC, Harwood JL, Lloyd D: TemporatureInduced Membrane-Lipid Adaptation in Acanthamoeba-Caslenanii. Biochem ] 1993, 290:273-278. Jones ST, Ahlstrom P, Berendsen HJC, Pickersgitl RW: Molecular Dynamics Simulation of a Phnspholipase° A2 Substrate Complex. Biochim Biophys Acta 1993, 1162:135-142. Keller SL, Bezrukov SM, Gruner SM, Tare MW, Vodyanoy I, ParsegianVA: Probability of Afamethicin Conductance StatesVaries with Nonlamellar Tendency of Bilayer Phospholipids. Biophys J 1993, 65:23-27. Kijima Y, Mayrleitner M, Timerman AP, Satin A, schindler H, FteischerS: A Cardiac Clathrin Assembly Protein Forms a Potassium Channel in Planar Lipid Bilayers. ] Bin! Chem 1993, 268:16253-16258. Klingler JF, McConnell HM: Brownian Motion and Fluid Mechanics of Lipid Monolayer Domains. J Phys Chem 1993, 97:6096. Klotz KH, Winterhaher M, Benz R: Use of Irreversible Electrical Breakdown of Lipid Bilaye~ for the Study of Interaction of Membranes with Surface Active Molecules. Bicchim Biophys Acta 1993, 1147:t6t 164. Kuhn ER, Hurst JK: Mechanism of Vectorial Transmembrane Reduction of Viologens Across Phnsphatidylcholine Bilayer Membranes. J Phys Chem t993, 97:1712-1721. Kumaran V: Spontaneons Formation of Vesicles by Weakly Charged Membrane. ] Chem Phys 1993, 99:5490-5499. Laaksonen L, RosenholmJB: Molecular Dynamics Simolations of the Water/Octanoate Interface in the Presenceof Micelles. Chem Phys Lett 1993, 216:429-434. Lamparski H, Lee YS, Sells TD, Obrien DF: Thermotropic Properties of Model MembranesComposed of Polymerizable Lipids. 1. Ph~phatidylcbulines Containing Terminal Acryloyl, Methacryloyl, and Sorbyl Groups. J Am Chem Soc 1993, 115:8096-8102. Lee YC, TaraschiTF, JanesN: Support for the Shape Concept of Lipid Structure Basedon a Headgruup Volume Approach. Biophys J 1993, 65:1429-1432. Lerebours B, Wehrli E, HauserH: Thermodynamic Stability and Osmotic Sensitivity of Small Unilamellar Phnsphatidylcholine Vesicles. Biochim Biophys Acta 1993, 1152:49-60. Leviee Y, Kolinski A, Skolnick J: A Lattice Dynamics Study • of a Laogmuir Monolayer of Monounsaturated Fatty Acids. J Chem Phys 1993, 98:7581-7587. [74]. Li SS, Wang ZQ, Lin HN, Huang C: Energy-Minimized Slructures and Packing States of a Homologous Series of Mixed-Chain Phnsphatidylcholines - a Molecular Mechanics Study on the Diglyceride Moieties. Biophys J 1993, 65:1415-1428. Liang CX, Fwig CS, Stouch TR, Hagler AT: Ablnitio Studies of Lipid Model Species. 1. Dimethyl Phosphateand Methyl Propyl PhosphateAnions. J Am Chem Soc 1993, 115:1537-1545. Lipowsky R: DO~ll~aln-lnducedBudding of Fluid Membranes. Biophys J 1993, 64:1133-1138. Loh RK, Huestis WH: Human Frythrocyle Membrane Lipid Asymmetry - TransbilayerDistribution of Rapidly Diffusing Phnspbatidylserines. Biochemistry ]993, 32:11722-11726. Loheer K, Degovics G, LaggeerP, Gnamusch E, Paltauf F: Squalene Promotes the Formation of Non-Bilayer Structures in Phnspholipid Model Membranes. Biochirn Biophys Acta 1993, 1152:69 77. Lopezgarcia F, Micol V, Villalain J, GomezfernandezJC: Infrared Spectroscopic Study of the Interaction of Diacylglycerol with Phnsphatidylserine in the Presenceof Calcium. Biochim Biophys Acta 1993, 1169:264-272. Lopezgarcia F, Micol V, Villalain J, Gomezfemandez JC: Interaction of Sphingnsine and Stearylamninewith Phnsphatidylserine as Studied by DSC and NMR. Biochim Biophys Acta 1993, 1153:1-8. Luk AS, Kaler EW, Lee SP: Phnspholipase.C.Induced Aggregation and Fnslon of Cholesterol-Lecithin Small Unilamellar Vesicles. Biochemistry 1993, 32:6965-6973. Macquaire F, Baleux F, Huynhdinh 1-, Rouge D, Neumann }M, Sanson A: Proton NMR Confoemational Study of an Annexin-I Fragment - Influence of a Phnspholipidic Micellar Environment. Biochemistry 1993, 32:7244-7254. Marassi FM, Djukic S, Macdonald PM: Influence of Lipid Lateral Distribution on the Surface Charge Response of the Phnsphafidylcholine Headgroupas Detected

Lipids Lipid organization and modelling Using H-2 Nuclear Magnetic Resonance. Biochim Biophys Acta 1993, 1146:219-228. Marassi FM, shivers RR, Macdonald PM: Resolving the Two Monolayers of a Lipid Bilayer in Giant Unilamellar Vesicles Using Deuterium Nuclear Magnetic Resonance. Biochemistry 1993, 32:9936-9943. Markin VS, Hudspeth AJ: To Fuse or not to Fuse? Biophys J 1993, 65:1752-1754. Marrink S-J, Berendsen HJC: Simulation of Water oe TransportThrough a Lipid Membrane. J Phys Chem 1994, 98:41554168. [50]. Marrink S-J, Berkowitz M, Berendsen HJC: Molecular oo Dynamics Simulation of a Membrane/Water Interface: the Ordering of Water and Its Relation to the Hydration Force. Langmuir 1993, 9:3122-3131. [44].

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Morrow MR, Taneva5, Simatos GA, AIIwood LA, Keough KMW: H-2 NMR Studies of the Effect of Pulmonary Surfactant SP-C on the 1,2-Dipalmitoylsn-glycero-3-phosphocholine Headgronp. a Model for TransbilayerPeptides in Surfactant and Biological Membranes. Biochemistry 1993, 32:11338-11344. Moss RA, Li JM, Chang C: Intrabposomaland Interliposomal Effectsof Cholesterol on Pseudoglyceryl Cationic Lipusomes. J Am Chem 5oc 1993, 115:10454-10455. Murakami Y, Hayashida O: Supramolecular Effectsand Molecular Discrimination by Macrncyclic Hosts Embedded in Synthetic Bilayer Membranes. Proc Natl Acad SCi U S A 1993, 90:1140-1145. Murata M, Takahashi S, Shirai Y, Kagiwada S, Hishida R, Ohnishi S: Specificity of Amphiphilic Anionic Peptides for Fusion of Phospholipid Vesicles. Biophys J 1993, 64:724-734. Murata Y, Kuroki Y, Akino T: Role of the C-Terminal Domain of Pulmonary Surfactant Prolein-A in Binding to Alveolar Type-II Cells and Regulation of Phnspholipid Secretion. Biochem J 1993, 291:71 76. Nag K, Keough KMW: EpifluorescenceMicroscopic Sludies of Monolayers Containing Mixtures of Dioleoylphosphatidylcholioesand Dipalmitoylphosphatidylcholines. Biophys J 1993, 65:1019-1026.

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LipidsMiscellaneous Delot E, Bon C: Model for the Interaction of Crotoxin, a Phuspholipase-A(2) Neurotnxin, with Presynaptic Membranes. Biochemistry 1993, 32:10708 10713. Dichek HL, Parrott C, Ronan R, Brunzell JD, Brewer HB, Santamarinafojo S: Functional Characterization of a Chimeric Lipase Genetically Engineered from Human Lipoprotein Lipase and Human Hepatic Lipase. J Lipid Res 1993, 34:1393 1401. Edwards IJ, Goldberg IJ, Parks JS, Xu HZ, Wagner WD: Lipoprolein Lipase Enhances the Interaction of Low Density tipoproteius with Artery-Derived Extracellular Matrix Pruteoglycans. J Lipid Res 1993, 34:1155-1163. Fukuyama Y, Otoshi Y, Miyoshi K, Hasegawa N, Kan Y, Kodama M: Structure of Magnolianin, a Novel Trilignan Possessing Potent 5-Lipoxygenase Inhibitory Activity. Tetrahedron tett 1993, 34:1051-1054. Grit M, Crommelin DJA: The Effect of Surface Charge on the Hydrolysis Kinetics of Partially Hydrogenated Egg Phosphatidylcholine and Egg Phosphatidylglycerol in Aqueous Liposome Dispersions. Biochim Biophys Acta 1993, 1167:49 55. Grochulski P, Li YG, Schrag JD, 8outhillier I-, Smith P, Harrison D, Rubin 8, Cygler M: h~aights into Inteffacial Activation from an Open Structure of Candida-Rugosa Lipase. J Biol Chem 1993, 268:12843 12847. Harrison EH: Enzymes Catalysing the Hydrolysis of Retinyl Eslers. Biochim Biophys Acta 1993, 1170:99-108. Hata A, Ridinger DN, Sutherland S, Emi M, Zhang SH, Myers RL, Ren KS, Cheng T, InDue I, Wilson DE, Iverius PH, Lalouel IM: Binding of Lipoprotein Lipase to Heparin -Identification of 5 Critical Residues in 2 Distinct Segments of the Amino-Terminal Domain. J

Biol Chem 1993, 268:8447 8457. Henderson HE, Ma Y, tiu MS, Clarklewis I, Maeder DL, Kastelein JIP, Brunzell JD, Hayden MR: Structure Function Relationships of Lipoprotein Lipase Mutation Analysis and Mutagenesls of the Loop Region. J Lipid Res 1993, 34:1593 1602. Henly R, Elie CJJ, Buser HP, Ramos G, Moser HE: The Influence of Protecting Groups on Lipase Catalyzed Trausesterifications - Enzymatic Resolution of Racemic Cis-l,3-Cyclopentanediol Derivatives. TPtrahedron Left 1993, 34:2923 2926. lain MK, Maliwal BP: Spectroscopic Properties of the States of Pig Pancreatic Phospholipase-A(2) at Interfaces and Their Possible Molecular Origin. Biochemistry 1993, 32:11838-11846. Jain MK, Rogers J, Hendrickson HS, Berg OG: The Chemical Step is not Rate-Limiting During the Hydrolysis by Phuspholipase-A2 of Mixed Micelles of Phospholipid and Detergent. Biochemistry 1993, 32:8360-8367.

lain MK, Yu BZ, Berg OG: Relationship of tnterfacial Equilibria to Interfacial Activation of PhospholipaseA(2). Biochemistry 1993, 32:11319 11329. Kapus A, Susztak K, Ligeti E: Regulation of the Electrogenic H+ Channel in the Plasma Membrane of Neutrophils - Possible Role of PhnspholipaseA2, Internal and External Protons. Biochem J 1993, 292:445-450. Kozaki K, Gotoda T, Kawamura M, Shimano H, Yazaki Y, Ouchi Y, Orimo H, Yamada N: Mutational Analysis of Human Lipoprotein Lipase by Carboxy~Terminal Truncation. J Lipid Res 1993, 34:1765 1772. Kudo I, Murakami M, Hara S, InDue K: Mammalian NonPancreatic Phuspholipases-A(2). Biochim Biophys Acta 1993, 1170:217-231. Lins L, Piron S, Conrath K, Vanloo B, Brasseur R, Rosseneu M, Baert J, Ruysschaert JM: Enzymatic Hydrolysis of Reconstituted Dimyristoylphosphatidylcholineapo A-I Complexes. Biochim Biophys Acta 1993, 1151:137 142. Lugtigheid RB, Nicolaes GAF, Veldhuizen EJA, Slotboom AJ, Verheij HM, Dehaas GH: Acylation of Porcine Pancreatic Phuspholipase-A2 Influences Penetration and Substrate Head-Group Binding, Depending on the Position of the Acylated Lyslne in the Enzyme Molecule. Eur J Biochem 1993,216:519-525. Martinez C, Nicolas A, Vantilbeurgh H, Egloff MP, Cudrey C, Verger R, Cambillau C: Cutinase, a Lipolytic Enzyme with a Preformed Oxyanion Hole. Biochemistry 1994, 33:83 89. Matsunaga A, Araki K, Moriyama K, Handa K, Arakawa F, Nishi K, Sasaki J, Arakawa K: Detection of a Point Mutation in Cholesteryl Ester Transfer Protein Gene by Polymerase Chain Reaction-Mediated Site-

Directed Mutagenesis. Biochim Biophys Acta 1993, 1166:131-]34. Metier GW, Demacker PNM, Vantol A, Groener JEM, Vanderpalen JGP, Stalenhoef AFH, Vanzutphen LMF, Beynen AC: Plasma Activities of Lecithin Cholesterol Acyltrausferase, Lipid Transfer Proteins and Pust-Heparin Lipases in Inbred Strains of Rabbits Hypo-Respousive or Hyper-Responsive to Dietary Cholesterol. Biochem J 1993, 293:729-734. Nunez L, Amigo L, Rigotti A, Puglielli L, Mingrone G, Greco AV, Nervi F: Cholesterol CrystallizationPromoting Activity of Aminopeptidase-N Isolated from the Vesicular Carrier of Biliary Lip~ds. FEB3 Lett 1993, 329:84-88. Rajasekharan R, Kemp JD: Synthesis of Photoreactive Phosphatidylethanolamine and Its Interaction with Pho~holipase A(2). J Lipid Res 1994, 35:45-51. Ran NM, Sundaram CS: Sensitivity of PhuspholipaseC (Bacillus-cereus) Activity to Lipid Packing in Sonicated Lipid Mixtures. Biochemistry 1993, 32:8547-8552. Reynolds LJ, Hughes LL, Louis AI, Kramer RM, Dennis EA: Metal Ion and Salt Effects on the Phnspholipase-A(2), Lysophuspholipase, and Transacylase Activities of Human Cytosolic Phospholipase-A(2). Biochim Biophys Acta 1993, 1167:272-280. Rugani M, Verger R, Cambillau C: Interfacial Activation of the Lipase-prucolipase Complex by Mixed Micelles Revealed by X-ray Crystallography. Nature 1993, 362:814-819.

Slotte JP,Ostman AL: Oxidation/Isomerization of 5cholesten-3beta-ol And 5-cholesten-3-one to 4-cholesten-3-one in Pure Sterol and Mixed Phospholipid-Containing Monolayers by Cholesterol Oxidase. Biochim Biophys Acta 1993, 1145:243 249. Sohys CE, Bian J, Roberts ME: Polymerizable Phosphatidylcholines - Importance of Phospholipid Motions for Optimum Phnspholipase-A2 and Phospholipnse-C Activity. Biochemistry 1993, 32:9545-9552. Tomita M, Ueda Y, Tamura H, Taguchi R, Ikezawa H: The Role of Acidic Amino-Acid Residues in Catalytic and Adsorptive Sites of Bacillus-cereus Sphingomyellnase. Biochim Biophys Acta 1993, 1203:85 92. Tomoci L, Scheraldi CA, Li XZ, Ide H, Goldberg IJ, Le NA: Abnormal Activation of Lipoprotein Lipase by Non-Equilibrating ApoC.II - Further Evidence for the Presence of Non-Equilibrating Pools of Apolipoproteins C-II and C-Ill in Plasma Lipoproteius. J Lipid Res 1993, 34:1793-1803. Trimble LA, Street IP, Partier H, Tremblay NM, Weech PK, Bemstein MA: N M R Structural Studies of the Tight Complex Between a Trifluoromethyl Ketone Inhibitor and the 85-kDa Human Phnspholipase-A(2), Biochemistry 1993, 32:12560-12565. Uzawa H, Noguchi 1, Nishida Y, Ohrui H, Meguro H: Determination of the Lipase Stereoselectivities Using Circular Dichroism (CD) - Lipases Produce Cbiral Di-O-acylglycerols from Achiral Tri-O-acylglycerots. Biochim Biophys Acta 1993, 1168:253 260. Vandenberg IJM, Denkamp JAEO, Lubin BH, Kuypers EA: Conformational Changes in Oxidized Phospholipids and Their Preferential Hydrolysis by PhnspholipnseA(2) - a Monolayer Study. Biochemistry 1993, 32:4962-4967. Vernet T, Ziomek E, Recktenwald A, Schrag JD, Demontigny C, Tessier DC, Thomas DY, Cygler M: Cloning and Expression of Geotrichum-candidom Lipase-II Gene in Yeast - Probing of the Enzyme Active Site by Site-Directed Mutagenesis. J Biol Chem 1993, 268:26212-26219. Vincent M, Deveer AM, Dehaas GH, Verheij HM, Gallay J: Stereospeciflcity of the Interaction of Porcine Pancreatic Phospholipase-A(2) with Micellar and Mnnomeric Inhibitors. a Time-Resolved Fluorescence Study of the Tryptophan Residue. Eur J Biochem 1993, 215:531-539. Wang CS, Hartsuck JA: Bile Salt-Activated Lipase - a Multiple Function Lipolytic Enzyme. Biochim Biophys Acta 1993, 1166:1 19. Wieder T, Gei[en CC, Reurter W: Antagonism of Phorbol-Ester-Stimulated Phosphatidylcholine Biosynthesis by the Phnspholipid Analogue Hexadecylphnsphocholine. Biochem J 1993, 291:561-567.

Wu SK, Cho WW: Use of Polymerized Mixed kiposomes to Study Interactions of Phospholipase.A(2) with Membranes. Biochemistry 1993, 32:13902-13908.

Yamamoto I, Mazumi 1, Handa T, Miyajima K: Effects of 1,2-Diacylglycerol and Cholesterol on the Hydrolysis Activity of Phuspholipase-D in Egg-Yolk Phosphatidylcholine Bilaye~. Biochim Biophys Acta 1993, 1145:293-297. Yu L, Dennis EA: Effect of Polar Head Groups on the Interactions of Phuspholipase-A2 with Phosphonate Transition-State Analogues. Biochemistry 1993, 32:10185-10192.

Miscellaneous Abel M, Schwarzendrube J, Nuutinen H, Broughan TA, Kawczak P, Williams C, Holzbach RT: Cholesterol Crystallization-Promoters in Human Bile Comparative Potencies of Immunoglobulius, Alpha(1)-Acid Glycoprotein, Phnspholipase-C, and Aminopeptidase-N. J Lipid Res 1993, 34:1141-1148. Amirkhanian JD, Brunt R, Waring AJ, Navar C, Taeusch HW: Full Length Synthetic Surfactant Proteins, SP-B and SP-C, Reduce Surfactant Inactivation by Serum. Biochim Biophys Acta 1993, 1168:315-320. Aubin Y, Prestegard IH: Structure and Dynamics of Sialic Acid at the Surface of a Magnetically Oriented Membrane System. Biochemistry 1993, 32:3422-3428. Bakshi MS, Crisantino R, De List R, Milioto S: Volume and Heat Capacity of Sodium Dodecyl SulfateDodecyldimethylamine Oxide Mixed Micelles. J Phys Chem 1993, 97:6914-6919. Bronshteyn VL, Steponkus PL: Calorimetric Studies of Freeze-Induced Dehydration of Phnspholipids. Biophys J 1993, 65:1853-1865. Casey JR, Reithmeier RAF: Detergent Interaction with Band-3, a Model Polylopic Membrane Protein. Biochemistry 1993, 32:1172-1179. Delfino JM, Schreiber SL, Richards FM: Design, Synthesis, and Properties of a Photoactivatable MembraueSpanning Phospholipidic Probe. J Am Chem Soc ]993, 115:3458 3474. Gershon H, Ghirlando R, Guttman SB, Minsky A: Mode of Formation and Structural Features of D N A Cationic Liposome Complexes used for Traesfection. Biochemistry 1993, 32:7143-7151. liD AS, Castrucci AMD, Hruby VJ, Hadley ME, Krajcarski DT, SzaboAG: Structure-Activity Correlations of Melanotropin Peptides in Model Lipide by Tryptophan Fluorescence Studies. Biochemistry 1993, 32:12264 12272. Lindemuth PM, Bertrand GL: Calorimetric Observations of the Transition of Spherical to Rodlike Micelles with Solubilized Organic Additives. J Phys Chem 1993, 97:7769-7773. Loughrey HC, Ferraretto A, Cannon AM, Acerbis G, Sudati F, Bottiroli G, Masserini M, Soria MR: Characteri~',ion of Biotinylated Liposomes for Invivo Targeting Applications. FEBStett 1993,332:183-188. Marin LML, Laneelle MA, Prome D, Laneelle G, Prome JC, Daffe M: Structure of a Novel Sulfate-Containing Mycubaclerlal Glycolipid. Biochemistry 1992, 31:11106-11111. Matsuoka K, Moroi Y, Saito M: Thermodynamics of Micelle Formation of 1-Dodecanesolfonic Acid. l Phys Chem 1993, 97:13006-13010. Meers P, Mealy T, Pavlotsky N, Tauber Ah Annexin IMediated Vesicular Aggregation - Mechanism and Role in Human Neutropbils (Biochemistry, Vol 31, Pg 6372, 1992). Biochemistry 1993, 32:1390. Tangirala RK, Jerome WG, Jones NL, Small DM, Johnson WJ, Glick JM, Mahlberg FH, Rothblat GH: Formation of Cholesterol Monohydrate Crystals in MacrophageDerived Foam Cells. J Lipid Res 1994, 35:93-104. van Der Sijs DA, Van Eaassen EE, Levine YK: The Interpretation of Fluorescence Anisotropy Decays of Probe Molecules in Membrane Systems. Chem Phys Lett 1993, 216:559-565. Viguera AR, Mencia M, Goni FM: Time-Resolved and Equilibrium Measurements of the Effects of Poly(ethylene Glycol) on Small Unilamellar Phospholipid Vesicles. Biochemistry 1993, 32:370~3713. Yonemoto W, Mcglone ML, Taylor SS: N-Myristylatlo, of the Catalytic Subunit of CAMP-Dependent Protein Kinase Conveys Structural Stability. J Biol Chem 1993, 268:2348 2352.

Membrane proteins Prostaglandin synthase • Light signal transduction

Membrane proteins Prostaglandin synthase Review: (pp 529-535) Boyington JC, Gaffney BJ, Amzel LM: The Three• Dimensional Structure of an Arachidonic Acid 15-Lipoxygenase. Science 1993, 260:1482-1486. [38]. Hohzman MJ, Turk J, Shomick LP: Identification of • a PharmacologicallyDistinct Prostaglandin H Synthase in Cultured Epithelial Cells. J Biol Chem 1992, 267:21438-21445. [13]. Kreusch A, NeubL~serA, S~hihz E,Weckesser I, Schulz GE: • Structureof the Membrane Channel Porin From Rhodopseudomonas Blastlca at 2.0 A Resolution. Protein Science 1994, 3:58-63. [47]. Landoh-Marticorena C, Williams KA, Deber CM, • ReithmelerRAF: Non-Random Distribution of Amino Acids in the TransmembraneSegments of Human Type I Single Span Membrane Proteins. J Mol Bin/1993, 229:602-608. [48]. Meade EA, Smith WL, DeWitt DL: Differential • Inhibition of Prostaglandin Endoperoxide Synthase (Cyclooxygenase)Isozymesby Aspirin and Other Non-steroidal Anti-inflammatory Drugs. J Biol Chem 1993, 268:661e~6614. [12]. Mitchell )A, AkarasereenontP, Thiemermann C, Flower RJ, • VaneJR: Selectivity of Noosteroidal Antiinflammatory Drugs as Inhibitors of Constitutive and Induclble Cyclooxygenase.Proc Nat/Acad Sci USA 1993, 90:11693-11697. [14]. Picot D, Loll PJ, Garavito RM: The X.Ray Crystal Structure of the Membrane Protein Prostaglandin H2Synthase1. Nature 1994, 367:243-249. Popot J: Integral Membrane Protein Structure: • Traosmembraneco-Helicesas Autonomous Folding Domains. Curr Opin Struct Bio11993, 3:532-540. [5]. Ravichandran KG, Boddupalli SS, Hasemann CA, Peterson • JR, DeisenhoferJ: Crystal Structure of Hem@protein Domain of P450BM-3, a Prototype for Microsomal P450's. Science 1993, 261: 731-736. [37]. Ruf HH, Raab-Brill U, Blau C: A Model for the Catalytic • Mechanismof Prostaglandin Endoperoxide Synthase. Biochem SOC Trans 1993, 21:739-744. [23]. Smith WL, Eting TE, Kulmacz RJ, Mamett LJ, TsaiA: Tyrosyl • Radicalsand Their Role in Hydroperoxide-dapendent Activation and Inactivation of Prostaglandin End@peroxideSynthase. Biochemistry 1992, 31:3-7. [25]. Smith WL, Marnett Ll: Prostaglandin Endoperoxide • Synlhases.Metal Ions in Biological Systems Edited by 5igal H, 5igel A. New York: Marcel Dekker, Inc 1994, :163-199. [10]. White SH, Wimley WC: Peptides in Lipid Bylayers: • Structural and Thermodynamic Basisfor Partitioning and Folding. Curr Opin Struct Bio11994, 4:79-86. [45].

Zeng J, Fenna RE: X-ray Crystal Structure of Canine • Myeloperoxidaseat 3 Resolution. J Mol Biol 1992, 226:1 B5-207. [29].

Light signal transduction Related review: Structure and function of the plant light-harvesting complex, LHC-II (pp 519-528) Ahmad I, Giorgi LB, BarberJ, Porter G, Klug DR: Redox Potentials of Cytochrome B-559 in the D1/D2/Cylnchrome-b-559 Reaction Centre of Photosystem-II. Biochim Biophys Acta 1993, 1143:239-242. Allakhverdiev SI, Klimov VV, Carpentier R: Variable Thermal Emissionand Chlorophyll Fluorescencein Photosystem-II Particles. Proc Nat/Acad Sci U 5 A 1994, 91:281-285. Andreasson E, Albertsson PA: Heterogeneity in Photosystem-I - the Larger Antenna of Photosystemlalpha is Due to Functional Connection to a Special Pool of LHCII. Biochim Biophys Acta t993, 1141:175-182. Araga C, Akabori K, SasakiJ, Maeda A, Shiina 1-, Toyoshima Y: Functional Reconstitution of the Primary Quinone Acceptor, QA, in the PhotosystemII Core Complexes. Biochim Biophys Acta 1993, 1142:36~12. Aro EM, Virgin I, Andersson B: Photoinhibition of Photosystem-2 - Inactivation, Protein Damage and Turnover. Biochim Biophys Acta 1993, 1143:113-134. Baciou L, 8ylina EJ, Sebban P: Study of Wild Type and Genetically Modified Reaction Centers from Rhodobacter-capsolatus - Structural Comparison

with Rhndopseudomonas-viridlsand Rhodohactersphaeroides. Biophys J 1993, 65:652~60. Bakou A, Ghanotakis DF: Substitution of Lanthanides at the Calcium Site(s) in Photosystem-II Affects Electron Transport from Tyroslne-Z to P680+. Biochim Biophys Acta 1993, 1141:303-308. Balashov SP, Govindjee R, Kono M, ImashevaE, Lukashev E, EbreyTG, Crouch RK, Menick DR, Feng Y: Effect of the Arginine-82 10 Alanine Mutation in Bacteriorhodop~in on Dark Adaptation, Proton Release,and the Photochemical Cycle, Biochemistry 1993, 32:10331-10343. Bauscher M, Leonhard M, Moss DR, Mantele W: Binding and Interaction of the Primary and the Secondary Electron Accepter Quinones in Bacterial Photosynthesis - an Infrared Spectroelectrnchemical Study of Rhndohacter-sphaeroidesReaction Centers. Biochim Biophys Acta 1993, 1183:59-71. Bellissentfunel MC, Lal J, Bradley KF, Chen SH: Neutron Structure Factorsof Invivo Deuterated Amorphous Protein C-Phycocyanin. Biophys J 1993, 64:1542 1549. Boonstra AF, Visschers RW, Calkoen F, Vangrondelle R, Vanbruggen EFJ, Boekema EJ: Structural Characterization of the B800-850 and B875 LightHarvesting Antenna Complexesfrom RhodobacterSphaeroides by Electron Microscopy. Biochirn Biophys Acta 1993, 1142:181-188. Buchanan SK, Fritzsch G, Ermler U, Michel H: New Crystal Form of the Photosynthetic Reaction Centre from Rhodohacter.Sphaeroidesof Improved Diffraction Quality. J Mol Biol 1993, 230:1311-I 314. Chen Y, Saari ~C, Noy N: Interactions of AII-traos-Retinol and Long-Chain Fatty Acids with Interphotoreceptor Retlnoid-Binding Protein. Biochemistry 1993, 32:11311-11318. Clarke AK, Hurry VM, GustafssonP, Ocluist G: Two Functionally Distinct Forms of the Photosystem-II Reaction.center Protein DI in the Cyanohacterium 5ynechococcus Sp. PCC 7942. Proc Nat/Acad Sci U 5 A 1993, 90:11985 11989. Clarke AK, Soitamo A, Gustafsson P, Oquist G: Rapid Interchange Between Two Distinct Forms of Cyanohacterial Pholosystem-II Reactlon-Center Protein*D1 in Responseto Photoinhiblfion. Proc Nat/ Acad Sci U S A 1993, 90:9973-9977. Davis IH, Heathcote P, Maclachlan DJ, Evans MCW: Modulation Analysis of the Electron Spin Echo Signals of Invivo Oxidised Primary Donor N-14 Chlorophyll Cenlros in Baclerial, P870 and 13960,and Plant Photosystem-I, P700, Reaction Centres. Biochirn Biophys Acta 1993, 1143:183 189. Delasrivas J, Teller A, BarberJ: 2.coupled Beta-Carotene Molecules Protect P680 from Photodamage in Isolated Photosystem-II ReactionCentres. Biochim Biophys gcta 1993, 1142:155-164. Demeter S, Goussias C, Bernat G, Kovacs L, Petrouleas V: Participation of the G = 1 . 9 a n d G = 1 . 8 2 EPR Forms of the Semiqoinone-lron Complex Q(A)(-).Fe2+ of Photosystem-II in the Generation of the Q and C Thermoluminesceoce BandspRespectively.FEBSLett 1993, 336:352-356. Donnelly D, Cogdel[ RI: Predicting the Point at Which Transmembrane Helices Protrude from the Bilayer: a Model of the Antenna Complexesfrom Photosynthetic Bacteria. Prot Eng 1993, 6:629-636. Drachev LA, Dracheva 5V, Kaulen AD: pH Dependence of the Formation of an M-Type Intermediate in the Photucycle of 13-cis-bacteriorhodopsln, FEBSLett 1993, 332:67 70. Drepper F, Carlberg I, Andersson B, Haehnel W: Lateral Diffusion of an Integral Membrane Protein - Monte Carlo Analysis of the Migration of Phosphorylated Light-Harvesting Complex-II in the Thylakoid Membrane. Biochemistry 1993, 32:11915-11922. Durrant JR, HastingsG, Joseph DM, Barber], Porter G, Klug DR: Subpicosecond Equilibration of Excitation Energy in Isolated Photosystem-II Reaction Centers. Proc Natl Acad Sci U S A 1992, 89:11632 11636. Eggers B, VermaasW: Truncation of the D2 Protein in SynechocystisSp. PCC-6803 - a Role of the CTerminal Domain of D2 in Photosystem-II Function and Stability. Biochemistry 1993, 32:1 i 419-11427. Egner U, Hover GA, SaengerW: Modeling and Energy Minimization Studies on the Herbicide Binding Protein (D1) in Photosystem-II of Plants. Biochim Biophys Acta 1993, 1142:106-I14. Fahmy K, Jager F, Beck M, ZvyagaTA, Sakmar TP, Siebert F: Protonation Slates of Membrane-Embedded Carhoxylic Acid Groups in Rhndopsin and Metarhodopsln-II -a Fourier-TransformInfrared Spectroscopy Study of Site-Directed Mutants. Proc Natl Acad 5ci U S A 1993, 90:10206-10210.

Farchaus JW, Wachtveitl J, Mathis P, Oesterheh D: Tyroslne-162 of the Photosynlhetic Reaction Center L-Subunit Playsa Critical Role in the Cytochrornec(2) Mediated Rereduction of the Photooxidized Bacteriochlorophyll Dimer in Rhodohactersphaeroides. 1. Site-Directed Mutagenesisand Initial Characterization. Biochemistry 1993, 32:10885 10893. Fawley MW: Structure of a Prasinoxanthin-Chlorophyll A/b Light-HarvestingComplex of the Green Flagellate Pseudoscourfieldia-marina(Micromonadophyceae). Biochim Biophys Acta 1993, 1183:85-90. Ferrand M, Dianoux AJ, PerryW, Zaccai G: Thermal Motions and Function of Bacteriorhodopsln in Purple Membranes - Effects of Temperatureand Hydration Studied by Neutron Scattering. Proc Nat/ Acad Sci U S A 1993, 90:9668-9672. Finazzi G, Ehrenheim AM, Forti G: Influence of Different Uncouplers on Photosystem-II Photochemistry and Fluorescence. Biochim Biophys Acta 1993, 1142:123-128. Fischbarg J, Cheung M, Czegledy F, Li J, Iserovich P, Kuang KY, Hubbard J, Garner M, RosenOM, Guide DW, Vera )C: Evidencethat Facilitative Glucose Transporters May Fold as Beta-Barrels. Proc Natl Acad Sci U 5 A 1993, 90:11658-11662. Fischer MR, Degroot HJM, RaapJ, Winke[ C, Huff AJ, Lugtenburg J: C-13 Magic Angle Spinning NMR Study of the Light-Induced and TemperatureDependent Changes in Rhodobacter-Sphaeroldes R26 Reaction Centers Enriched In <4'-C-13>Tyroslne. Biochemistry 1992, 31 : 11038-11049. Forti G, EhrenheimAM: The Role of Ascorbic Acid in Photosynthetic Electron Transport. Biochim Biophys Acta 1993, 1183:40~412. Frankel LK, Bricker TM: Interaction of CPa-1 with the Mangauese-Stabilizing Prolein of Photosystem-II -Identification of Domains on CPa-1 Which are Shielded from N-Hydroxysucciolmide Biotinylation by the Manganese.Stabilizing Protein. Biochemistry 1992, 31:11059-11064. Fuchsle G, Bittl R, VanderestA, Lubilz W, Stehlik D: Transient EPR Spectroscopyof the Charge Separated Stale P+Q- in Photosynthetic ReactionCenters . Comparison of Zn-Substituted RhodobacterSphaeroides R-26 and Photosystem-L Biochim Biophys Acta 1993, 1142:23-35. Gale P: Comparison of Bacteriorhndopsin/Phospholipid Interactions in DMPC and DMPG Bilayers - an Electron Spin ResonanceSpectroscopyand Freeze. Fracture Electron Microscopy Study. Biochem Biophys Res Commun 1993, 196:879-884. Geacintov NE: Tracing Charge Separation Events in Photosynthesis * Anomalous Photovoltage Polarity Effects Explained. Biophys J 1993, 65:11-12. Gergely C, Ganea C, Groma G, Yarn G: Study of the Photncycle and Charge Motions of the Bacteriorhndopsin Mutant D96N. Biophys J 1993, 65:2478-2483. Ghosh R, Hoenger A, HardmeyerA, Mihailescu D, • BacofenR, Engel A, RosenbuschJP: Two-Dimensional Crystallization of the Light.Harvesting Complex from Rhodospirillum Rubrum. J Mol Bio11993, 231:501-504. [41]. Gleiter HM, Nugent JHA, Haag E, RengerG: Photolnhibition Affects the Non-Heme Iron Center in Plmtosystem-II. FEBSLett 1992, 313:75-79. Godik Vl, Biankenship RE, CausgroveTP, Woodbury N: Time-ResolvedTryptophan Fluorescencein Photosynthetic Reaction Centersfrom RhodobacterSphaeroides. FEBSLett 1993, 321:229-232, Gong H, Nilsen S, Allen JF: Photoinhibition of Photosynthesis Invivo - Involvement of Multiple Sites in a Photodamage Process Under CO2-Free and O2-Free Conditions. Biochim Biophys Acta 1993, 1142:115-122. Gottstein J, Scherz A, Scheer H: Bacterlochlorophyll Aggregates in Positively Charged Micelles. Biochim Biophys Acta 1993, 1183:413~116. Gruszecki WI, Krupa Z: LHCII, the Major Light-Harvesting Pigment-Protein Complex is a Zeaxanthin Epoxidase. Biochim Biophys Acla 1993, 1144:97-t01. Hacker B, Barquera B, Crofts AR, Gennis RB: Characterization of Mutations in the Cytochrome-b Subunlt of the Bc(1)-Complex of RhodobacterSphaeroides that Affect the Quinone ReductaseSite (Qc). Biochemistry 1993, 32:4403M410. Harem P, Gray KA, Oesterhelt D, Feick R, Scheer H, Zinth W: Subpicosecond Emission Studies of Bacterial Reaction Centers. Biochim Biophys Acta 1993, 1142:99-105. Hanson DK, Tiede DM, Nance SL, Chang CH, Schiffer M: Site-Specificand Compensatory Mutations

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Membrane proteins Miscellaneous Gould GW, Holman GD: The Glucose Traesporter Family - Structure, Function and Tissue-Specific Expression. Biochem J 1993, 295:329-341. Griffin SDJ, Buxton KD, Donaldson IA: The AIpha-DGlucosyl C-2 Hydroxyl is Required for Binding to the H+-Sucrnse Transporter in Phloem. Biochim Biophys Acta 1993, 1152:61-68. July JC, Wickner W: The SecA and SecY Subunits of Translocase are the Nearest Neighbors of a Translncafing Preprolein, Shielding it from Phospholipids. EMBO J 1993, 12:255-264. Jung K, Jung H, Wu )H, Prive GG, Kaback HR: Use of SiteDirected Fluorescence Labeling to study Proximity Relationships in the Lactose Permeaseof Escherichiacoil Biochemistry 1993, 32:12273-12278. Kajiji 5, Talbot F, Grizzuti K, Vandykephillips V, Agresti M, Sara AR, Gros P: Functional Analysis of P-Glycoprotein Mutants Identifies Predicted Tran~membrane Domain-11 as a Putative Drug Binding Site. Biochemistry 1993, 32:41854194. Kampfenkel K, Braun V: Topology of the ExbB Protein in Ihe Cytoplasmic Membrane of E~herichia-Coli. J Biol Chem 1993, 268:6050-6057. Katagiri H, Asano T, Ishihara H, Lin JL, Inukai K, Shanahan MF, Tsukuda K, Kikuchi M, Yazaki Y, Oka Y: Role of Tryptophan-388 of GLUT1 Glucose Transporter in Glucose-Transport Activity and Photoaffinity-Lahelllng with Forskolin. Biochem J 1993, 291:861-867. Kwong FYP, Wu JSR, Shi MM, Fincham HE, Davies A, Henderson PJF,Baldwin SA, Young JD: Enzymic Cleavage as a Probe of the Molecular Structures of Mammalian Equilibrative Nucleoside Transporters. J Biol Chem 1993, 268:22127 22134. Lincke CR, the I, Vangroenigen M, Burst P: The PGlycoprulein Gene Family of Cae~rhal~litis-Elegans - Cloning and Characterization of Genomic and Complementary DNA Sequences. J Mol Biol 1992, 228:701-711. Loo TW, Clarke DM: Functional Consequences of Proline Mutations in the Predicted Transmembrane Domain of P-Glycoprotein. J Biol Chem 1993, 268:3143~ 149. Malik S, Sami M, Watts A: A Role for Band-4.2 in Human Erythrocyte Band-3 Mediated Anion Transport. Biochemistry 1993, 32:10078 10084. May JM, Beechem JM: Monitoring Conformalional Change in the Human Erythrocyte Glucose Carrier - use of a Fluorescenl Probe Attached Io an Exofacial Carrier Sulfhydryl. Biochemistry 1993, 32:2907-2915. Miller C: Cystic Fibrosis - Sickly Channels in Mild Disease. Nature 1993, 362:106. Nakai M, Sugita D, Omata T, Endo T: Sec-Y Protein is Localized in Both the Cytoplasrnic and Thylakoid Membranes in the Cyanobacteriom Synechococcns PCC7942. Biochem Biophys Res Commun 1993, 193:22~234. Pantanowitz S, Bendahan A, Kanner BI: Only One of the Charged Amino Acids Located in the Transmembrane Alpha-Helices of the Gamma-Aminobutyric Acid Transporter (Sublype-A) is Essential for Its Activity. J Biol Chem 1993, 268:3222-3225. Pawagi AB, Wang J, Silverman M, Reithmeier RAF, Deber CM: Transmembrane Aromatic Amino Acid Distribution in P-glycoprotein - a Functional Role in Broad Substrate Specificity. J Mol Biol 1994, 235:554-564. Pourcher T, Zani ML, Leblanc G: Mulagenesis of Acidic Residues in Putative Membrane-Spanning Segments of the Melibiose Permease of Eschericbia-Coli. 1. Effect on Na+-Dependent Transport and Binding Properties. J Biol Chem 1993, 268:3209-3215. Ramamoorthy S, Kulanthaivel P, Leibach FH, Mahesh VB, Ganapathy V: Solubllization and Functional Recor~titution of the Human Placental T~riue Transporter. Biochim Biophys Acta 1993, 1145:250-256. Reizer J, Finley K, Kakuda D, Macleod CL, Reizer A, Saier MH: Mammalian Integral Membrane Receptors are Homologous to Facilitators and Antiporters of Yeast, Fungi, and Eubacteria. Protein Sci 1993, 2:20-30. Roberts E: A Pump Pore Model for Transmembrane Transport of Hydrophilic Solutes. Proc Natl Acad Sci U S A 1993, 90:7456-7460. Roepe PD, Wet LY, Cruz J, Carlson D: Lower Electrical Membrane Potential and Altered PH(i) Homeostasis in Multidrug-Resistant (MDR) Cells - Further Characterization of a Series of MDR Cell Lines Expressing Different Levels of P-Glycoprotein.

Biochemistry 1993, 32:11042-11056, Sahintoth M, Kaback HR: Properties of Interacting Aspartic Acid and Lysine Residues in the Lactose Perrnease of Escherichia-coli. Biochemistry 1993, 32:10027-10035. Said HM, Moflammadkhani R: Folate Transport in Intestinal Brush Border Membrane - Involvement of Essential Histidine Residue(s). Biochern J 1993, 290:237-240.

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Miscellaneous Altieri DC, Plescia J, Plow EF: The Slmctural Motif Glycine-190-Valine-202 of the Fibrinogen-gamma Chain Interacts with CD11b/CD18 Inlegrin (alphaMbeta2, Mac-l) and Promotes Leukocyte Adhesion. J Biol Chem 1993, 268:1847 1853. Andersson H, Vonheijne G: Position-Specific Asp-Lys Pairing can Affect Signal Sequence Function and Membrane Protein Topology. J Biol Chem 1993, 268:21389 21393. Benfenati F, Valtorta F, Rossi MC, Onofri F, Sihra I, Greengard P: Interactions of Synapsin-I wilh Phnspholipids - Possible Role in Synaptic Vesicle Clustering and in the Maintenance of Bilayer Structures. J Cell Biol 1993, 123:1845-1855.

Browning MJ, Krausa P, Rowan A, Bicknell DC, Bodmer JG, Bodmer WF: Tissue Typing the HLA-A Locus from Genomic DNA by Sequence-Specific PCR Comparison of HLA Genotype and Surface Expression on Colorectal Tumor Cell Lines. Proc Natl Acad Sci U S A t993, 90:2842-2845. Carraway KL, Carraway KL, Guy PM, Cerione RA, Carvajal ME, Carraway CAC: Integral Membrane Growlh Factors and the Inlramembrane Mechanism for Stimulation: an Hypothesis for Autonomous Tumor Growth. Prot Eng 1993, 6 (Suppl):76. Chattupadhyay A, Rukmini R: Restricted Mobility of the Sole Tryptophan in Membrane-Hound Mellttln. FEBS Lett 1993, 335:341-344. Cheiminskabertilsson M, Allenmark S, Edebo L: Bulyrylcholinesterase Activity Towards Long-Chain Alkanoylcholines. Kinetics and Mechanism. Biochim Biophys Acta 1993, 1202:56-60. Cheung PH, Culic O, Qiu YH, Earley K, Thompson N, Hixson DC, Lin SH: The Cytoplasmic Domain of C-CAM is Required for C-CAM-Mediated Adhesion Function - Studies of a C-CAM Transcript Containing an Unspliced Intron. Biochem J 1993, 295:427435. Citi S: The Molecular Organization of Tight Junctions. J Cell Biol 1993, 121:485489. Couto AS, Delederkmmer RM, Colli W, Alves MJM: The Glycosylphosphalidylinositol Anchor of the Trypom~tigote-Specific Tc-85 Glycoprotein from Trypanosoma-cruzi -Metabolic-Labeling and Structural Studies. Eur J Biochem 1993, 217:597 602. Creuwels LAJM, Demel RA, Vangolde LMG, Benson B~, Haagsman HP: Effect of Acylation on Structure and Function of Surfactant Protein-C at the Air-Liquid Interface. J Biol Chem 1993, 268:26752-26758. Czurylo EA, Zborowski J, Dabrowska R: Interaction of Calde~'non with Phnspholipids. Biochem J 1993, 291:403408. Dibrino M, Parker KC, Shiloach J, Knierman M, Lukszo J, Turner RV, Biddison WE, Coligan JE: Endogenous Peplides Bound to HLA-A3 Possessa Specific Combination of Anchor Residues that Permit Identification of Potential Antigenic Peptides. Proc Nat/Acad Sci U S A 1993, 90:1508-1512. Dube P, Tavares P, Lurz R, Vanheel M: The Portal Protein of Bacteriophage-SPP1 - a DNA Pump with 13-Fold Symmetry. EMBO l 1993, 12:1303-I 309. Edery M, Levi-Meyrueis C, Paly J, Kelly PA, Diiane J: A Limited Cytoplasmic Region of the Prolactin Receptor Proximal to the Transmembrane Domain is Critical for Signal Transduction. Prot Eng 1993, 6(suppl):76. Falk K, Rotzschke O, Grahovac B, Schendel D, Stevanovic S, Gnau V, Jung G, Strominger JL, Rammensee HG: Allele-Specific Peptide Ligand Motifs of HLAC Molecules. Proc Nat/Acad Sci U S A 1993, 90:I 2005-I 2009. Furuse M, Hirase 1, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S: Occlodio - a Novel Integral Membrane Protein Localizing at Tight Junctions. J Cell Biol 1993, 123:1777-1788. Gallina A, Milanesi G: Tram-Membrane Translocation of a Myristylated Protein Amino Terminus. Biochem Biophys Res Commun ] 993, 195:637-642. Gazit E, Shai Y: Structural Characterization, Membrane Interaction, and Specific Assembly Within Phnspbolipid Membranes of Hydrophobic Segments from Bacillus-lhuriogiensis Var. Israelensis Cytolytic Toxin. Biochemistry 1993, 32:12363 12371. Gerardilaffin C, Delquebayer P, Sudaka P, Poiree JC: Oligomerie Structure of lhe Sodium-Depaudenl Phlorizin Binding Protein from Kidney BrushBorder Membranes. Biochim Biophys Acta 1993, 1151:99-104. Gilmore R: Protein Translocation Across the Endoplasmic Reticulom: a Tunnel with Toll Boolhs at Entry and Exit. Cell 1993, 75:589-592. Greenspoon N, Hershkoviz R, Alon R, Varon D, Shenkman B, Marx G, Federman S, Kapustina G, Lider O: Structural Analysis of Integrin Recognition and the Inhibition of Integrin-Mediated Cell Functions by Novel Nonpeptidic Surrogates of the Arg-Gly-Asp Sequence. Biochemistry 1993, 32:1001 1008. Gumbiner BM: Proteins Associated with the Cytoplasmic Surface of Adhesion Molecules. Neuron 1993, 11:551-564. Guo HC, Madden DR, Silver ML, Jardetzky TS, Gorga JC, 5trominger JL, Wiley DC: Comparison of the P2 Specificity Pocket in Three Human Histocompatibility Antigens-HLA-A-Asterisk-6801, HLA-A-Asterisk-0201, and HLA-B-Asterisk-2705. Proc Natl Acad Sci U S A 1993, 90:8053-8057. Hammer J, Valsasnini P, Tolba K, Bolin D, Higelin J, Takacs B, Sinigaglia F: Promiscuous and AlleleSpecific Anchors in HLA-DR-Binding Peptides. Cell 1993, 74:197 204. Harel M, Schalk I, Ehretsabatier L, Bouet F, Goeldner M, Hirlh C, Axelsen PH~ Silman I, Sussman JL: Quaternary Ligand Binding to Aromatic Residues in

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