List of Compounds Chromatographed

550

List of Compounds Chromatographed Acebutolol 134, 148 Acenocoumarol 35 7-Acetanudomtrazepam 463, 475 Acetammophen 85, 89, 91, 433, 438 Acetate 115, 116 Acetates 109 Acetylcholme 116 N-Acetylprocamamide 15, 20 N-Acetylretmyl amine 483, 498 Acetylsahcylic acid 89, 90 a,-Acid glycoprotem 16, 36, 62, 70 Acltretm 484, 488, 493, 494, 499-503 Aclacmomycin A 259 4’-(9-Acrldinylamino)methanesulfon-m-aml~~de 262 Acrolem 243, 245 Acyclovn 297, 299, 303, 304, 324, 326, 327, 329, 330, 340,341 Acyclow, metabohtes 341 1-Acyl-lysophosphatichc acid 111 Adenme 325, 329 Adenosine 323,303, 329 Adenosine trlphosphate 117 Adeptolon 373, 396 Adeptolon, metabohtes 396 Adlmolol 134 Admazolam 466, 467 ADP 110, 329, 331, 332 p-Adrenergic blockmg agents 13 1-l 80 Adnamycin 255 Adnamycinone 260 Adnblastma 255, 258 Alamne ammotransferase 22 Albumin 242 Alcohol 15 Alcohols 7 ‘Alcophosphamlde 244 Aldophosphamlde 244 Aldosterone 22 Alexan, see Cytarabme Ahmemazme 374, 391, 396 Ahmemazme, metabohtes 382, 391, 396 Alkanolamme antlhlstammes 372, 401 Alkylamme antihistammes 372, 401 5-Allyl-5-cyclopentylbarblturic acid 434 Alprazolam 466, 467, 476 Alprenolol 16, 134, 141-144, 148, 160, 164 Alprenolol, metabohtes 143 Amantldme 297, 300, 348-350, 355-358, 363 Amazolon, see Amantldme Ametrantone 261 Amlkacm 540

Ammes 7 Ammo acids 71, 113 Ammoanthraqumones 261, 262 Ammobenzophenone 460 Ammoglycosldes 512, 533-541 7-Aminomtrazepam 463, 475 2-Ammo-5-mtrobenzophenone 475 7-Ammotnflupromazme 68 Amlodarone 18, 19 Amltrlptylme 16, 18, 37, 38, 511 Amlodlpme 184-187, 192, 193 Ammonia 113 Amoxic&n 534 AMP 110, 329, 331 Amplcllhn 521, 522, 534 Amphgen 297, 350, 362, 363 Amsacnne 262,263 Analgesics 402 Antazohne 373, 382, 396 Antazohne, metabohtes 396 Anthracychne aglycones 260 Anthracyclme glycosides 259 Anthracychnes 260 Anthraqumone glycosides 255-261 Antiarrhythmlcs 402, 511 Antibiotics 509-548 Anticancer drugs 235-294 Antichohnergics 39 Antlconvulsants 33, 511 Antidepressants 18, 32, 33. 402, 511 AntiepileptIc drugs 32, 421-457 AntiepIleptIc drugs, metabohtes 424441 Antimetabohtes 266274 Antmeoplastlc drugs 511 Antiparkmsomans 402 Antltumour antibiotics 253-266 Antitumour drugs 113 Ant]-ulcer agents 407-420 Antwlral agents 295-368 Anxiolytlcs 459 Aqua[l,l-b~s(ammomethyl)cyclohexane]sulpl platinum(H) 251 Ara-A 331, 337, 338 Ara-ADP 331, 332, 338 Ara-AMP 338 Ara-ATP 332, 338 9-p-D-Arabmofuranosylhypoxanthme 337 9-b-D-Arabmofuranosyluracll 337 Arabmosldes 295368 Arabltm, see Cytarabine Ara-C 331, 336, 338, see also Cytarabine Ara-CDP 338

551

Ara-CMP 338 Ara-CTP 331, 338 Aracytrdme, see Cytarabme Aracytme, see Cytarabme Ara-Hx 337-339 Ara-U 331, 335, 336, 338, 339 Arrldone 297, 300, 350, 351, 354, 355, 363 Arotmoid free acid 492 Arotmoids 484 Aspartate ammotransferase 22 Aspirin 68 Atenolol 134, 139, 143, 148, 153-156, 164 Atenolol, metabohtes I43 ATP 110, 329, 331, 332 Atria1 natrmrebc peptrde 22 Azatadine 373, 384, 391, 396 Azatadme, metabolites 396 Azathroprme 273 Azelastme 373, 384 Azelastme, metabohtes 384 3’-Azrdo-3’-deoxythymrdme 21 Azlocilhn 521, 522, 535 Aztreonam 523, 528, 533, 539 Bamrpme 373, 396 Bamrpme, metabohtes 396 Barbiturates 70 Befunolol 134 Bemdrpme 184-186, 191 Benzodtazepme 460 Benzodrazepmes 39, 402, 423, 430432, 459. Benzodrazepmes, metabolites 43 1, 467-47 1 Benzqumamide 373, 396 Benzqumamrde, metabohtes 396 Benzylthrouracrl 61 Betaxolol 134, 140, 148, 151, 156, 164, 167 Bevantolol 134, 140, 148 Bile acids 242 Bihrubin 63 Biogenic ammes 22 Btoxine, see Moroxydme Btsantrene 261 Brs(2-chloroethyl)amme 247 1,3-Brs(2-chloroethyl)-1-mtrosurea 249 Brsmonodrgitoxosrdes 218 Brsoprolol 134, 148, 154, 164, 166 Bleomycm 265 Bleomycm A, 264, 265 Bleomycm A, 264, 265 Bleomycm A, BT 265 Bleomycm A, 264, 265 Bleomycm B, 264 Bleomycm B, 265 Bleomycm B, 264, 265 Bleomycm B, 265 Bleomycm CHP 265 Bleomycm DM-A, 265 Bleomycm PEPP 265

Bleomycm(s) 263-266 P-Blockers 39, 70, 131-180, 402 Bone-scanning drphosphonates 112 Bopmdolol 134, 148, 158, 164 Bomaprolol 134 Bovme serum albumin 69971, 73 Bromazepam 461,466,467 2-Bromopropronate 115 5-Bromouractl 270 Bromovinyldeoxyurrdme 297, 305, 306, 326, 328, 330 5-(2-Bromovmyl)-2’-deoxyurtdme 300, 363 Bromovinyldeoxyurrdme, metabohtes 346, 347 Bromphemramme 373, 391, 396 Bromphemramme, metabohtes 396 Bucmdolol 135, 147, 148 Buchzme 374, 391, 396 Buchzme, metabohtes 396 Bufuralol 135 Bumtrolol 135, 164 Bunolol 135 Burpanolol 135, 164 Busulfan 2433245 Butobarbttone 434 Butofilol 135 Butyrophenones 68, 402 Caffeine 433, 438, 440 Calcium channel blockers 18 l-2 13 Calmoduhn 68 Camazepam 46 1, 466, 467 Carazolol 135, 141, 148, 161, 164 Carbamazepme 20, 21, 36, 85, 89, 93, 94, 427,428, 433-443 Carbamazepme-trans-diol 437, 439 Carbamazepme-10,l 1-dtol 428, 433 Carbamazepme-10,l I-epoxrde 427, 428, 434-437, 439, 440,442, 443 Carbazepme, metabohtes 427, 428, 450 Carbapenem rmrpenem 533 Carbemctllin 535 Carbenoxolone sodium 408 Carbmoxamme 373, 391, 396 Carbmoxamme, metabohtes 396 Carbohydrates 116 Carboplatmum 251 Carbovn 297, 299, 306, 328, 342 Carboxyacyclovu 341 Carboxyhc acids 7, 66, 109, 116 1-Carboxy-4-oxoretmoic acid 483 Carboxyphosphamrde 244, 247 Cardiac glycosrdes 215234 Carmmomycm 209, 256, 257 Carmmomycmol 257 Carte0101 135 Carumonam 533 Carvedrlol 148, 160, 164 Catecholammes 22. 24

552

CDP 331 CdR 331 Cefaclor 536 Cefadroxrl 521, 536 Cefamandole 536 Cefaprrm 536 Cefazohn 536 Cefixkme 538 Cefmenoxime 89, 90, 521, 523, 537 Cefoperazone 52 1, 522, 537 Cefotaxime 516, 521-523, 532, 537 Cefottam 89, 537 Cefoxttm 537 Cefpiramrde 521, 523, 538 Cefpirome 521 Cefpodoxrme 521, 522 Cefradin 536 Cefroxadm 537 Cefsoludm 523, 528, 537 Ceftazrdrme 521-523, 538 Ceftizoxrme 537 Ceftrtaxone 516, 522. 523, 528, 538 Cefuroxrme 536 Celiprolol 135, 164, 167 Cephalaxm 536 Cephalosporms 513, 516, 532, 533, 53&538 Cephalotm 536 Cerubtdine 255, 258 Cetamolol 135 Chlorambuctl 240-242 Chloramphemcol 19, 23, 40, 85, 89, 91, 93, 95, 96. 438, 514, 541, 545 Chlorbenzoxamine 373, 396 Chlorbenzoxamine, metabohtes 396 Chlorcychzme 374, 396 5-Chloro-2’-deoxyundine 271 Chloroacetaldehyde 244 4-Chlorobupranolol 164 Chlorocychzme, metabohtes 396 Chlorodesmethyldtazepam 466, 468 Chlordtazepoxrde 460, 461, 463, 466, 467 N-2-Chloroethylaznidme 244 I-(2-Chloroethyl)-3-cyclohexyl-1-mtrosurea 249 I-(2-Chloroethyl-3-(4-trans-methylcyclohexyl)-lmtrosurea 249 3-(2-Chloroethyl)-1,3-oxazohdm-2-one 244 Chloropyramme 373, 382, 396 Chloropyramme, metabohtes 396 Chloroqume 35 Chlorothen 373, 391 5-Chlorouracrl 270, 271 Chlorphen(n)amme 373, 384, 391, 396 Chlorphen(rr)amme, metabohtes 384, 391, 396 Chlorphenoxamme 373, 382, 391, 396, 397 Chlorphenoxamme, metabohtes 397 Chlorpromazine 20, 23 Chlorpromazme N-oxide 23

Chlorpromazme sulfoxrde 23 Chohne 116 c+Chymotrypsm 70 Crlastatm 533, 539 Crmetrdme 374-376, 388, 407409,412 Crmetrdme sulfoxrde 408 Cmnarrzme 182, 205, 207-209, 374, 384, 391, 397 Cmnarrzme, metabohtes 397 Cmolazepam 464 Crprofloxacm 521, 524, 533, 543 Crsplatm 113, 263 Ctsplatm, metabohtes 114 Clavulamc acid 527, 528, 532, 533, 539 Clemastme 373, 391, 397 Clemastme, metabohtes 397 Clemrzole 373, 397 Clemrzole, metabohtes 397 Chmazolam 466, 468 Clobazam 431, 444-447, 463,465, 466, 475 Clofibrrc acrd 69 Clonazepam 22,431,432,443,461,463,466,468 Clorazepate 46 1. 466 Clorazeptc acid 463 Clotrazepam 466, 468 Cloxacrlhn 521, 522, 535 Cloxazolam 466 CMP 331 Cocame 85. 86 Codeme 7, 85, 86, 88, 89 Colchtnne 62 Corns01 22 Creatmine 21 CTP 331 Cyclmes 5 13 Cychzme 374, 392. 397 Cyclizme, metdbohtes 397 N-Cyclopentyldesrsopropylpropranolol 157 Cyclophosphamrde 240, 245-247 Cyclosporm 38 Cyproheptadme 373, 384, 392, 397 Cyproheptadme, metabohtes 384, 397 Cysteme 23 Cytarabme 297. 299, 307-311, 323, 332, 335-339, 363 Cytrdme 303, 323 Cytrdme monophosphate-N-acetylneurammtc actd 104 Cytrdme monophosphate-N-acetylneurammtc actd synthetase 103 Cytrdme tnphosphate 117 Cytochrome P450 22 Cytosar, see Cytarabme Cytosme 325. 329 Cytosme arabmose 271 Cytosme arabmose trlphosphate 271 Cytosme arabmoside 271, 272 Daunorubtcm 2555257. 259-261

553

dCDP 331 dCMP 331 dCTP 33 1 Debrrsoqume 35 Decanoate 69 Dechlorobupranolol 164 N-Dechloroethylcyclophosphamrde 244 Defsulodm 40 Delorazepam 466 4-Demethoxydaunorubtcm 261 4-Demethoxydaunorubrcmol 261 Demethylbleomycm A, 264 13.Demethyiretmorc acid 483, 495, 497 Demetmdene 373 Demoxepam 463, 467,468 Dendrtd, see Idoxuridme Denztmof 444,447,&S N-Deoxydemoxepam 468 4’.Deoxydoxorubtcm 256 7-Deoxydoxorubtcmolone 260 5’.Deoxy-5-Auorourrdme 270 Dephenhydramme 373 Deptropme 385 Desacetylcefotaxrme 521, 523, 532, 537 Desacetyldtlttazem 198, 199 Desacetylmettpranol 160 Desacetylmettpranolol 149 Desacetylvmblastme 276 Desalkylflurazepam 472 Descarboxyloflazepate 469, 475 Desctclovn 297, 299, 3 14 N-Desethylamtodarone 18, 19 Desrpramme 16, 18, 38, 511 Desmethylchlordtazepoxrde 463 N-Desmethylclobazam 431, 463, 475 N-Desmethyldtazepam 431,467,469,471,474,475 Desmethylmephenytoin 434, 440 N-Desmethylmethsuxtmrde 432, 434-436, 439, 442 N-Desmethyltamoxtfen 28 1 Dextromethorphan 19 1,3-Dtacyl-1,3-dtethylurea 250 2,4-Dtammo-N-lo-methylpterotc aad 267, 268 Drammme(l,l-cyclobutanedtacarboxylato)plattnum 251 cu-Dtammmedichloroplatmum 251-253. 263 Diazepam 6264, 82, 92, 93, 431, 461463, 465, 466, 469, 470, 473, 474 Dtazepam, metabohtes 92, 93, see also Oxazepam. Tamazepam, Nordrazepam Dtbekacme 540 2’,3’-Dtdehydro-2’,3’-deoxythymtdme 297, 315, 328 2’,3’-Didehydro-3’-deoxythymldlne 299, 363 2’,3’-Dtdeoxyadenosme 297, 299, 311, 3 12, 326, 327, 342, 344, 345 2’,3’-Drdeoxyadenosme, metabohtes 343

2’,3’-Drdeoxycytrdme 21, 297, 299, 263, 312, 313, 335, 342, 344 2’,3’-Dtdeoxycytrdme, metabohtes 343 2’3.Drdeoxymosine 263, 297, 299, 313, 314, 326, 3422345 2’,3’-Drdeoxynucleosides 296, 3422345 2’,3’-Drdeoxyurtdme 343, 344 Drdesethylflurazepam 472 Drfloxacm 52 1, 543 Dtflumsal 23, 24 Dtgttoxrgenm 222-225 Dtgttoxigemn btsdtgrtoxostde 222, 224, 229 Dtgttoxtgenm monodtgrtoxostde 222, 224, 229 Dtgrtoxm 216-219, 222-224, 226, 229, 232 Dtgttoxm, metabohtes 225 Dtgoxtgenm 218, 221, 222, 224, 226, 230, 231 Dtgoxtgenm btsdtgttoxtstde 218, 221, ‘ZZI, 224, Z%7231 Drgoxrgenm monodtgttoxostde 218, 221, 222, 224, 227-23 I Dtgoxm 14, 28, 33, 38, 216224, 226232 Dtgoxm, hydrolyses products 231 Dtgoxm, metabohtes 223 10.1 I-Dthydrocarbamazepme 43@36,440 Dthydrodrgrtoxm 2 17 20R-Dthydrodtgoxigenm 224, 229, 230 Drhydrodrgoxm 217, 218,220, 222,224, 228-233 20R-Drhydrodrgoxm 230 Dihydrodugoxm, hydrolyses products 231 Dthydroergotamme 19 5,6-Dthydro-5-fluorouracrl 271 Drhydrolevobunolol 159 Dthydropyrtdmes 182, 185, 187, 193, 195, 210 frans-lO,ll-Drhydroxy-10,l l-drhydrocarbamazepme 434436 1,4-Duodobutane 245 Ddevalol 148, 166 Ddtrazem 19, 89. 94, 182, 197-202, 210 Dtmethadtone 432 Dtmethylbupranolol 164 Dtmetmdene 397 Dtmetmdene, metabohtes 397 Drmetotrazme 374, 397 Dtmetottazme, metabohtes 397 2,3-Dmorthromboxane B, 19 Dtphenhydramme 38, 382, 392,397 Drphenhydramme, metabohtes 392, 397 Dtphenylpyrahne 373, 397 Dtphenylpyralme, metabohtes 397 Drpotassmm chlorazepate 466, 469 Dtsopyramtde 35, 36 Dodecanoate 69 Doxtfluorourrdme 270 Doxorubtcm 21, 255, 511 Doxorubrcmol256, 258 Doxorubrcmolone 260 Doxorubtcinone 260

554

Doxycychne 545 Doxylamme 373, 385, 392, 397 Doxylamme, metabolites 385, 392, 397 Drug-protein binding 51-77 dTDP 331 d’ITP 331 dUMP 331 Edrophonium 18 Emaml, see Iodoxuridme Enoxacm 543 Envtroxrme 297, 300, 351, 359, 360, 363 4’-Epidoxorubicm 256, 257, 259 5,6-Epoxyretmoic acid 483, 495, 497 5,6-Epoxyretmoyl fl-glucuromde 483 Erpalfa, see Cytarabme Erythromycm 544 Esmolol 136, 142, 148, 157 Ethodom 438 Ethosuximtde 433437,439, 440,442,443 4-Ethoxyphenylretmamrde 483, 498 Ethylenedtamme antihtstammes 372, 401 Ethylenedtammmemalonatoplatmum(II) 251 Ethylloflazepate 466, 469 Ethylretmamtde 483, 494, 495, 497 Ethyl retmoate 483 5-Ethyl-5+tolyl)barbtturtc acid 434, 439, 440 Etmttdme 374, 376, 388, 409, 415 Etodroxizme 374, 397 Etodroxrzme, metabolites 397 Etopostde 276, 277 Etretmate 483485, 493, 494, 500-503 Exaprolol 136 Falmtolol 136, 148 Famotidme 375, 376, 389, 409, 412, 413 Fatty acids 69 Felbamate 444, 449 Felodipine 184189, 192, 194, 195 Flavodilol 164 Fleroxacm 524, 543 Flestolol 148 Flordipme 184186, 192, 193 Flumequme 542 Flumolol 136, 148 Flunarizme 182, 205, 207-210, 374, 392,444,451, 452 Flumtrazepam 431, 461,465,466,469 5-Fluorocytosme 270 5-Fluoro-2’-deoxycytidme 270 5-Fluoro-2’-deoxyundine 271 5-Fluoro-2’-deoxy-5’-urtdme monophosphate 268 2’-Fluoro-5-iodoaracytosme 297, 300, 303, 315, 345, 363 2’-Fluoro-5-iodoaracytosme, metabohtes 323, 346, 347 Fluoropyrtmtdines 268-27 1 5-Fluorouractl 23, 268, 271, 345, 511 5-Fluoroundme 271

5-Fluoroundme diphosphate glucose 270 Flupenttxol 38 Fluphenazme 37, 68 Flurazepam 461,463,466.469,472 Fluzmamtde 444, 448 Foscarnet 300, 351, 360-363 Foscarnet sodmm 298 Ftorafur 270 Furosemide 20, 61, 62, 65, 89, 93 Gabapentm 444, 445 Ganctclovtr 298, 299, 315, 316, 326, 329, 341 GDP 33 I Gentamrcm 28, 540 Gitoxm 225 Glucose Glucuromc 7

555

4.Hydroxy-N-desmethyltamoxlfen 280 lo-Hydroxylo,11 -dlhydrocarbamazepme 434 erlythro-9-(2-Hydroxy-3-nonyl)hypoxanthme I9 2-Hydroxy-4-oxoretmolc acid 483 3-Hydroxy-4-oxoretmolc acid 483 Hydroxyethylflurazepam 472 4-Hydroxyethylretmamlde 483, 498 7-Hydroxymethotrexate 266268 9-Hydroxymethyl-IO-carbamoylacndane 434 Hydroxymethylcimetldine 408 I-Hydroxymethyl-4-hydroxymidazolam 473 I-Hydroxymethylmrdazolam 473 Hydroxymetoprolol 149 4-Hydroxymldazolam 473 p-Hydroxyphenobarbltal429, 430, 434-436 2-Hydroxyphenylretmamlde 483 4-Hydroxyphenylretmamlde 495, 497, 498 p-Hydroxyphenytom 434 Hydroxyprolme 105 4-Hydroxypropranolol 142 4-Hydroxyretmolc acid 483 4-Hydroxytamoxifen 28 I Hydroxyurea 273 Hydroxyzme 374, 385, 392 Hydroxyzme, metabohtes 397 Hypnotics 459, 511 Hypoxanthine 343-345 Ibuprofen 20, 35 Icotldme 375, 376, 388 Idarublcm 256, 259, 261 Idexur, see Idoxundme Idoxundme 298, 300, 316, 317, 323, 326, 345. 363 Idulea, see Idoxundme Idu Oculos, see Idoxuridme Idunclm, see Idoxundine Ifosfamide 240, 247, 248 Imidazole antlblotlcs 546 2-(4-1mldazolyl)ethylamme 371 Imlpenem 528,539 Imlpramine 16, 23, 38, 511 Irmpramme N-oxide 23 Indacrmone 35 Indenolol 136, 160 Inorganic phosphate 22 Inosltol phosphates 11 I Inosttol phosphohplds 111 Insulin 15 Interleukm-2 238 5-Iodo-2’-deoxycytidme 298, 300, 317, 345, 363 SIodo-2’-deoxyuridme 345 Iretm, see Cytarabme Isomand 546 Isoprenahne 133 Isopropylbupranolol 164 Isothipendyl 374, 398 Isotlupendyl, metabolites 398 Isotretmom 483, 484

Isradlpme 184-186, 192, 194 Kanamycm 540 Kerecld, see Idoxuridme Ketamme 35 Ketazolam 461, 463, 466 4-Ketocyclophospharmde 244-247 4-Ketoifosfamlde 248 6-Ketoprostuglandin F,= 19 Ketotlfen 373, 398 Ketotlfen, metabohtes 398 Labetalol 136, 143, 148, 158, 164, 166 D-Lactam antlbiotlcs 512, 520, 521, 529, 531-533, 539, see also Pen&lms, Cephalosponns p-Lactamase mhlbltors 527 Lamotngme 444, 449 Latamoxef 538 Laxatwes 402 Leukotnene B, 38 Levamlsole 268 Levobunolol 142, 149, 159 Levomoprolol 144, 149, 151 Lldocame 15, 16, 36, 61, 511 Lmcosamldes 5 14 Lipids 18, 116 Loflazepate 469, 415 Loprazolam 466 Loratamde 371, 373, 385 Loratadme, metabolites 385 Lorazepam 431,461,465,466,468, 470 Lormetazepam 46 I, 463, 466, 470 Lysophosphatidlc acids 112 Macrohdes 514, 541 Mamdlpme 184-187, 191 Mantadan, see Amantlclme Mantadix, see Amantldme Mebhydrohne 373, 385, 398 Mebhydroline, metdbolites 398 Meclllmam 535 Mecloxamme 373, 398 Mecloxamme, metabohtes 398 Meclozme 374, 385, 393, 398 Meclozme, metabohtes 398 Medazepam 461,466, 470, 474,476 Medraxolol 149, 160 Medrylamme 373, 398 Medrylamme, metabohtes 398 Mefenamlc acid 70 Melphalan 241-243 Menogarol257 Mephenytom 434-436, 440 Mepmdolol 136, 143, 149 Mepyramme 373, 382, 385, 393, 398 Mepyramine, metabohtes 385, 398 Meqmtazme 374, 398 Mequitazme, metabohtes 398 Meradan, see Rlmantldme 6-Mercaptopurme 273, 274, 511

556

Mercapturic acid 7 Mesondazme 37, 38 Metaclazeparn 466 Methapyrrlene 373, 386 Methapyrtlene, metabohtes 386 Methotrexate 17, 21, 89, 90, 92, 239, 266268. ,511 Methotrexate polyglutamate 268 4-Methoxyphenylretmamide 483, 498 Methsuxtmtde 432-436, 442 2-Methylammo-5-chloro-benzophenone 476 2-Methylcarbamazepme 428 Methylclonazepam 431 5-Methylcytosine 270 N-Methyl-2’-deoxyadenosme 345 /I-Methyldtgoxm 224, 228 p-Methylphenobarbital 434436 5-Methyl-5-phenylhydamom 432 pMethylphenytom 434436 p-Methylprimtdone 434-436 Methylpropylsuccunmtde 439 Methyl retmoate 491 Methylsuxtmide 434436 6-Methyluracil 271 Mettpranolol 136, 149 Metoprolol 136, 1422145, 149151. 154, 157, 164, 167, 169, 171 Metoprolol, metabolites 142. 143 Metromdazole 40, 525, 546 Mezlocilhn 521-523, 535 Mtdantan, see Amantidme Midazolam 431, 465, 466, 470, 473 Midazolam, metabohtes 473 Mitomycm A 254 Mitomycm B 254 Mitomycm C 253, 254 Mttomycms 253-255 Mttosane 254 Mttosene 254 Mitoxantrone 261, 262 Monobactam aztreonam 533 Monodesethylflurazepam 472 Monodtgitoxostdes 218 Moprolol 136 Moroxydme 298, 300, 351, 352, 358, 359. 363 Morphme 7, 85, 86, 88, 89 Motretnude 483, 493 Muscannic receptor antagonists 411, 417419 Muscaruuc receptor blocker, M, 408 Mydantane, see Amantidme Myosm 68 Nadolol 137, 149, 150, 159, 164 Nafimidone 444,447 Nahdtxic acid 542 Naltiazem 197-202 Naphthoxylactic acid 141 Naproxen 37 Nebwolol 149

Neomycm 540 Netilmtcm 540 Neurammtc acid 103 Neuroleptics 402 Neuropeptides 22 Nicardipme 184-186, 191, 194, 195 Nifedipme 182. 184187. 190, 193-195 Nifenalol 137 Nilvadtpme 184-186, 191 Nimodipme 184-186, 191, 196 Nimorazole 40 Ntrvanol434 Ntsoldrpme 184186, 191, 196 Nitrazepam 431,461. 463,466,470, 475 Nitrendipme 184, 185, 188, 191, 193, 194, 196 Nitrogen mustard 242, 243 Nitrogen mustards, see also Melphalan, Chlor, buctl Nttroglycerme 15 Nttrophenylpyndine 186 Nttrosophenylpyndme 186 Nitrosureas 2499251 Nizatidme 375. 376, 388. 389, 407-420 Nizatidme, metabohtes 409; 415 Nordiazepdm 92, 93, 463, 466, 469, 475 Nortloxacm 521, 542, 543 Nortriptyhne 16, 18, 38 Norverapamil204 Novobiocm 540 Nucleostdes 111 Nucleotides 109-l 11 Octanoate 69 Oestradtol 69 Ofloxacm 521, 543 Omeprazole 65, 66, 411, 416 Omeprazole, metabohtes 411, 416 Oncovm 275 Ophthalmidme, see Idoxuridme Opioids 402 Orphenadrme 373, 393, 398 Orphenadrme, metabolites 398 Ovomucotd 70. 71 Oxactllin 535 Oxatomide 374, 398 Oxatomide drug, metabohtes 398 Oxazaphosphonne 248 Oxazaphosphormes 240, 244-248 Oxazepam 92,93,431,461,4631166, 4688471 Oxazolam 461. 466 Oxazolodmedione 432 Oxcarbazepme 434, 440, 444, 450,45 1 Oxcarbazepme. metabohtes 450 4-0x0-1 6-hydroxyretmoic acid 483 Oxomemazme 374,399 Oxomemazme. metabolites 399 2-Oxoquazepam 47 1 4-Oxoretmoic acid 483. 493499

557

4-Oxoretmoyl /Cglucuromde 483 Oxprenolol 137, 143, 144, 149, 165, 171 Oxprenolol, metabohtes 143 Pamatolol 137 Paraquat 15 Pefloxacm 521, 542 Penbutolol 137, 149, 165 Penicillin 522 Penicillin G 521, 534 Pemcillins 513, 531, 532, 534, 535 1,5-Pentanediol dimethylsulphonate 245 Pentazocme 35 Perphenazme 68 Phenacemlde 432, 434-436 Phenacetylurea 432 Pheneturlde 35 Phemndamine 373, 399 Phemndamme, metabohtes 399 Phemramme 373, 393, 399 Phemramme, metabohtes 399 Phenobarbital 17, 28, 36, 85, 89, 91-93, 429, 430, 433-441, 443, 511 Phenobarbital-N-glucoslde 430 Phenobarbital, metabohtes 429, 430 Phenols 7 Phenothlazme 68 Phenothlazme antihlstammes 372, 401 Phenothiazmes 68 Phenylacetlc mustard 241 Phenylbutazone 62, 65, 67, 70, 72 Phenylethylmalonannde 434, 439, 440 Phenyltoloxamme 373, 399 Phenyltoloxamme, metabohtes 399 Phenytom 17, 28, 36, 82, 89, 93,428,429,433-$43, 511 Phenytom, metabohtes 428, 429 Phleomycm 265 Phleomycm E 265 Phleomycm G 265 Phosphates 109 l,l,l’-Phosphmotluoylkldlne trasaznldme 248, 249 Phosphohpids 109 Phosphorarmde mustard 244, 245, 247 Pinazepam 466, 471 Pmdolol 137, 139, 142, 143, 149, 155, 162, 165 Pmdolol, metabohtes 143 Pipemldic acid 542 P~peracillm 521-523, 526, 535 Piperazme antihlstammes 372, 401 Piperazme derivatives 205-209 Pirenzepme 408, 411 Plasma proteins 51-77 Platinum compounds 251-253 Podophyllotoxm derivatives 276-278 Polymers 109 Polysulphonated naphthylurea 278 Porfiromycm 254

Potassium 22 Practolol 137 Prazepam 461, 463, 466, 471 Predmsolone 59 Prenylamme 209 Prmudone 433-446, 511 Pntstmamycm 544 Priridllol 137, 142, 149 Procamanude 15, 20, 21, 23, 28, 89, 93, 157, 511 Progabide 433445 Prolactin 22 Prohne 105, 106 Promethazme 374, 382, 386, 393, 399 Promethazme, metabolites 399 Pronethand 137, 472 Propofol21 Propranolol 15. 16, 35, 62, 88, 89, 93, 96, 137, 139, 140, 143, 144, 146, 149, 150, 155, 156, 160, 163, 165-167, 169-172, 511 Propranolol, metabohtes 141-143 2-n-Propyl-2-pentenoic acid 425 Prostaglandm E, 408 Prostaglandm I, 408 Proteins 18, 123 Proton pump mhibltors 411, 416 PTH-ammo acids 107 Purme antinietabolites 273-275 Pyridostigmme 18 Pynlamme, see Mepyramme Pyrophosphate 111 Pyrrobutamme 373, 399 Pyrrobutamine, metabohtes 399 Quazepam 466, 471 Qumidme 16, 29, 8S89, 93, 146, 511 Qumme 88, 89 Qumolones 513, 520, 523, 525, 541-543 Radioactive compounds 101-129 Radlopharmaceutlcals 112 Ramtldme 375, 376, 383, 387, 389, 408-414 Ramtldme, metabohtes 410 Ravenast 375, 393, 395 HZ-Receptor antagonists 407420 Remoxipride 107 Retinal 482, 495 Retinal acetylhydrazone 483, 498 Retmaldehyde 482 Retmolc acids 484. 491, 493499, 502, 505 Retmolds 37, 481-508 Retmol 495 Retmotaurme 483, 502 Retmoyl fi-glucuromde 483, 495, 497, 505 Retmyl acetate 495 Retmyl esters 482, 490 Retmyl hnoleate 495 Retmyl oleate 495 Retmyl palmltate 495 Retrowr, see Zldovudme

558

Rrbavtrin 296, 298, 299, 317, 318, 3388340, 363 Rrbavtrm-5’-DP 338 Rtbavtrn--5’-MP 338 Rrbavtrtn-5’-TP 338 Rrbonucleottdes 109 Rrboxanude 296,298,299, 318,330,333-336,339, 340 Rtmanttdme 298, 300, 352, 353, 355-358, 363 Rtmantrdme, diastereomers 357 Roxatidme 375, 376, 389, 394, 395, 400, 402, 411, 412,417419 Roxatrdme, metabohtes 389, 394, 400 Roxtthromycm 525, 528 Salbutamol 35 Sahcylates 29 Sahcyhc acid 69, 70 Sedatwes 5 11 Sotalol 35, 138, 143, 149, 159, 165, 166 Spmach coupling factor 62 Spuoplatm 251 Steroids 69, 116 Stiripentol 444, 449 Stoxtl, see Idoxundme Sugars 109 Sulbactam 533, 539 Sulfamethoxazole 541, 545 Sulfonamtdes 7, 8 Sulforidaztne 37 Sulphamethrzole 70 Sulphonamrde 61 Sulphonylureas 70 Suramm 238,239, 278,279 Symmetrel, see Amanttdine Talmolol 138 Tamoxtfen 280, 281 Tazobactam 526528 Tetcoplanm 524, 526, 528, 529, 544 Telenzepme 418, 419 Temafloxactn 521, 524 Temarotene 483, 485, 504 Temazepam 92, 93, 460, 461, 463, 464, 466, 469, 471 Temelastme 373, 386 Temposrde 276, 277 Terfenadme 371, 373, 382, 399, 401 Terfenadme, metabohtes 399 Tertalolol 138, 149 Tertatolol, metabohtes 15 1 Testosterone 118 Tetracycline 525, 526, 528, 545 Tetracyclines 541 I-(Tetrahydro-2-furanyl)-5-tluorouractl 270 Tetrahydrourtdme 272 Tetramtsole 35 Tetrazepam 466 Tetrmom 484 Thenyldramme 374, 386, 393

Thenyldtamme, metabohtes 386 Theophylhne 21, 29, 32, 33, 89, 438, 51 Threthylperanne 374, 393, 399 Threthylperazme, metabolttes 399 6-Thtoguanme 273, 274 Thropurmes 273-275 Thromboxane B, 19 Thymtdme 303, 323 Thymrdme tnphosphate 117 Thymme 329 Trcarctlhn 522, 535 Ttenoxolol 149, 166 Ttmolol 138, 149, 150, 160 Tundazole 546 Tobanum 138 Tobramycm 540 Tocaimde 35 Tolamolol 138 Tohprolol 138, 165 Tolpropamtne 373, 399 Tolpropamine, metabohtes 399 Tolylbarbrturrc acid 434 Tosulfloxacm 521, 524 Trace elements 18 Tramlast 373, 386 Tnazolam 431, 463, 465, 466, 471 1,2,4-Trtazole-3-carboxamtde 338 Tnazolobenzodrazepmes 464 Trtchloroethanol 7 Trtethylenephosphoramtde 248 5-Tnfluoromethyl-2’-deoxycyttdine 270 Trrflupromazme 374, 393, 399 Tnflupromazme, metabohtes 399 Tnmethadrone 432 Tnmethoprtm 541, 545 Trrpelenamme 374, 386, 393, 399 Trtpelenamtne, metabohtes 386, 399 Trtproltdme 373, 386, 393 Trtprohdme, metabohtes 386 Trts(butoxyethyl)phosphate 16 Tropolone methyl ester 61 Tryptophan 62, 66, 69 L-Tryptophan 65 Tubultn 61, 62 Tyrosme 327 Udrctl, see Cytarabme UDP 33 1 UdR 331 UMP 33 1 Uractl 329 Urea 113 Unc actd 343-345 Undme 303, 323 UTP 331 Valproate 424427, 432437,440-443 Valproate, metabohtes 4255427 Valprotc acid 18, 36, 38

559

Valpromtde 444, 445 Vancomycm 521, 524, 544 Vasopressm 22 Verapamtl35, 201-206, 210 Vtdarabme 298, 299, 318-320, 339, 363 Vrgabatrm 444, 445 Vmblastme 263, 275, 276 Vmca alkaloids 275-276, 511 Vmcrrstme 275 Vmdesme 275 y-Vmyl-GABA, see Vtgabatrm Vna-A, see Vidarabme Vtramrd, see Rtbavtrm Vtrazole, see Rtbavtrm Vtroml, see Moroxydme

323, 325, 332, 337-

Vnusmm, see Moroxydme Vtrustat, see Moroxydme Vitamin A 482, 491, see also Retinotds Vitamins 18 Warfarm 35, 36, 60-63, 65, 69, 70 Xamoterol 138 Xanthme 343, 344 Xrbenolol 138 YM-09538 138 Zrdovtdme 298, 299, 301, 302, 32@322, 335, 342, 344, 363 Zidovudme, metabohtes 343, 344 Zmvtroxrme 360 Zomsamrde 434436, 439, 440, 444, 448 Zowrax 297