List of contents, author and subject index volume 16, 1977

List of Contents, Author and Subject Index Volume 16, 1977

Chief Editors

P.B.llradlev -

_----

I

E. Costa

PERGAMON PRESS

OXFORD-NEW YORK-FRANKFUR

NEUROPHARMACOLOGY (formerly

International

Journal

of Neuropharmacology)

Chief Editors

P. B. BRADLEY, Department Birmingham

of Pharmacology Medical B15 215, England

School,

E. COSTA, Laboratory of Preclinical Pharmacology, National Institute of Mental Health, William A. White Building, Saint Elizabeth’s Hospital, Washington, D.C. 20032, U.S.A.

Executive

Editorial

G. K. AGHAJANIAN,New Haven

R. W. BRIMBLECOMBE, Welwyn Garden City A. R. GREEN, Oxford J. HARVEY, Iowa City SUSAN D. IVERSEN.Cambridge

Advisory M. H. APRISON, Indianapolis R. BALDESSARINI, Boston F. E. BLOOM, La Jolla R. J. BOAKES,Birmingham J. R. BOISSIER,Paris S. BUNNEY, New Haven A. CARLSSON, Gijteborg T. N. CHASE, Bethesda G. G. S. COLLINS, London J. CROSSLAND,Nottingham ANNICA DAHLSTR~M, Giiteborg J. DAVIES, London E. F. DOMINO, Ann Arbor W. FELDBERG,London M. GAL, Iowa City S. GARATTINI, Milan E. GIACOBINI,Storrs A. J. HANCE, Davis I. HANIN, Pittsburgh L. L. IVERSEN,Cambridge J. JACOB, Paris

Editorial

Board

D. JACOBOWITZ,Bethesda J. S. KELLY, Cambridge K. F. KILLAM, Davis A. R. KING, Newcastle-upon-Tyne N. KIRSCHNER,Durham I. J. KOPIN, Bethesda R. KUCZENSKI,Nashville R. KUMAR, London R. KUNTZMAN, Nutley L. LEADBEATER,Salisbury V. G. LONGO, Rome R. P. MAICKEL, Indiana P. MANDEL, Strasbourg E. MARLEY, London H. MCILWAIN, London K. E. MOORE, East Lansing N. H. NEFF, Washington S. H. NGAI, New York A. PLETSCHER,Basle P. H. REDFERN,Bath T. W. ROBBINS,Cambridge R. H. ROTH, New Haven

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CONTENTS NUMBER 1

Editorial Announcement I. K. M. MORTON, C. J. STAGG and R. A. WEBSTER: Perfusion of the central canal and subarachnoid space of the cat and rabbit spinal cord in ho. G. GIANUTSOS and H. LAL: Modification of apomorphine induced aggression by changing central chollnerglc activity in rats D. T. WONG, B. B. MOLLOY and F. P. BYMASTER: Blockade of monoamine uptake by I-amino-4-phcn!lhic!slir[2,2,2]octane (EXP 561) in rat brain and heart A. D. SHERMAN, W. C. HSIAO and E. M. GAL: Cerebral metabolism of [3H]-p-chlorc+amphetaminc G. ZSILLA, G. RACAGNI, D. L. CHENEY and E. COSTA: Constant rate infusion of deuterated phosphor!lzh,,llnc to measure the effects of morphine on acetylcholine turnover rate in specific nuclei of rat brain. G. C. DE TRUJILLO, A. SCOTTI DE CAROLIS and V. G. LONGO: Influence of diazepam, L-DOPA and dop.~nunc on the cerebellar and spinal electrical patterns induced by harmine in the rabbit MONA ELIAS~~N and B. J. MEYERSON: The effects of lysergic acid diethylamide on copulator! hch.~\l~,ur 111 the female rat K. B. J. FRANKLIN and L. J. HERBERG: Amphetamine induces anorexia even after inhibition <),I‘I~~~.I~,-L~I,.I~II~~ synthesis B. E. LEONARD: Drug-induced changes in brain tyrosine hydroxylase activity in viva K. B. J. FRANKLIN and L. J. HERBERG: Noncontingent displacement of catechol-amines h! ilitr;l\cIItrIcIII;lr t!ramine: biphasic dose-response effects on self-situmulation S. B. ROSS and ANNA L. RENYI: Inhibition of the neuronal uptake of 5-hydroxytryptaminc and noradrcnalinc in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N.N-dimethyl-3-(3-pyridyl) allylomincs and their secondary analogues. F. C. COLPAERT. J. E. NIEMEGEERS. J. J. M. D. KUYPS and P. A. J. JANSS~N: Narcotic cut and narcotic state: differential involvement of brain 5-hydroxytryptamine Preliminary Note F. J. GOLDSTEIN. E. T. VERNOT and H. K. STRAHLENWRF: Potentiation of catecholnmine inhibition of ganglionic transmission by A9-tetrahydrocannabinol Announcement

I‘< _.

: I

;-Ii 47

53

57 65

71 73

NUMBER 2 C. L. FAINGOLD: Convulsant-induced enhancement of non-primary sensory evoked responses in reticular formation pathways J. N. SHARMA: Microiontophoretic application of some monoamines and their antagonists to cortical neurones oftherat. L. BONKOWSKI and W. F. DRYDEN: Effects of iontophoretically applied neurotransmitters on mouse brain neurones in culture. B. J. KEY and V. H. MEHTA: Changes in electrocortical activity induced by the perfusion of S-hydroxytryptamine into the nucleus of the solitary tract T. L. YAKSH. J. C. YEUNG and T. A. RUDY: Medial thalamic lesions in the rat: effects on the nociceptive threshold and morphine antinociception T. OKA and E. H~~oYA: The different effect of humoral modulators on the morphine and central nervous system stimulant-induced hyperactivity of rats. ‘. Z. AMIT. DEBORAH E. LEVITAN. Z. W. BROWN and F. R~CAN: Possible involvcmcnt of central factors in the mediation of conditioned taste aversion MARGIT D~)DA. L. GYORGY and MARIA Zs. KOLTAI: Central cholinergic interactions in somato-vegetative reflexes L. S. VAN ORDEN III, J. P. BURKE, JAN A. REDICK. K. E. RYBARCZYK. DIANNA E. VAN ORDEN, HARRlET A. BAKER and B. K. HARTMAN: Immunocytochemical evidence for particulate localization of phenylethanolamine-N-methyltransferase in adrenal medulla. R. HAMMERS, P. CLARENBACH. T. LINDL and H. CRAMI:R: Uptake and metabolism of cyclic AMP in rabbit choroid plexus in citro Preliminary Notes C. L. FAINGOLD and D. M. CASPARY: Changes in reticular formation unit response patterns associated with pentylenetetrazol-induced enhancement of sensory evoked responses. G. BIGGIo, D. DELLA BELLA, V. FRIGENI and A. GUIWTTI: Potentiation of morphine analgesia by musciio; J. L. MEEK, H.-Y. T. YANG and E. COSTA: Enkephalin catabolism i/l ritro and irt rice Erratum. . . . . .

73 83 89 99 107 115 121 125

129 135

143 149 151 155

NUMBER 3 M. REZEK. V. HAVLITEK. K. R. HUGHES and H. FRIESEN: Behaviourai by the administration of small and large doses of somatostatin Y. ISHIDA: Intralaminar thalamic responses to somatic and fastigial ade by strychnine in cats 111

and motor excitation and inhibition induced into the amygdala. stimulation: cortical inhibition and its block-

I57 163

K. ONODERA and A. TAKEUCHI: Inhibitory

effect of streptomycin and related antibiotics on the glutamic receptor of the crayfish neuromuscular junction JOY DAVID. C. L. KAUL and R. S. GREWAL: EPFect of intracaudate drug injections on the striatal syndrome in reserpinized cats W. R. KLEMM, L. R. DREYFUS. E. FORN~:Y and M. A. MAYFIELD: Morphine-induced regional and dose-response differences in multiple-unit activity in rabbits S. K. PURL. L. VOLICER and H. LAL: Effect of apomorphine on dopamine turnover and adenosine 3’. 5’-monophosphate content in striatum of morphine-dependent rats. L. FINCH and P. E. HICKS: Involvement of hypothalamic histamine-receptors in the central cardiovascular actions of histamine. P. ZANDBERG and W. DE JoN(;: a-methylnoradrenaline-induced hypotension in the nucleus tractus solitarii. of the rat: a localization study Preliminary Note B. S. R. SASTRY and J. W. PHILLIS: Evidence that clonidine can activate histamine H,-receptors in rat cerebral cortex...................................

NKMBEK

I71 179 191 205 21 I 219

223

4

T. L. YAKSH and H. 1. YAMAMURA: Depression by morphine of the resting and evoked release of [“HI-acetylcholine from the cat caudate nucleus in ko BRENDA K. COLASANTI: Involvement of brain biogenic amine; in the electroencephalographic and behavioural effects of morphine in post-addict rats B. P. MUKHERJEE, P. T. BAILEY and S. N. PRADHAN: Correlation of lithium effects on motor activity with its brain concentrations in rats D. BIEGER. S. A. GILES and C. H. HOCKMAN: Dopaminergic influences on swallowing Y. MATSU~ and T. DEGUCHI: Cataleptic action of nitrazepam and brain dopamine function in mice T. TSUCHIYA: Effects of l,4-benzodiazepines with a long side chain in position I on the evoked potentials recorded in the limbic system and hypothalamus J. E. ZABIK, R. M. LEVINE, J. H. SPAULDING and R. P. MAICKEL: Interactions of tricyclic antidepressant drugs with deprivation-induced fluid consumption by rats. MARTA WEINSTOCK. CARMELLA WEISS and S. GITTFR: Blockade of 5-hydroxytryptamine receptors in the central nervous system by p-adrenoceptor antagonists. 1. HANBAUER, W. LOVENBERG and E. COSTA: Induction of tyrosine 3-monooxygenase in carotid body of rats exposed to hypoxic conditions J. C. LAMANNA, B. W. YOC’NTS, JR. and M. ROSENTHAL: The cerebral oxidative metabolic response to acute ethanol administration in rats and cats PUSHPA V. THADANI, T. A. SLOTKIN and S. M. STHANBERG: Effects of late prenatal or early postnatal ethanol exposure on ornithine decarboxylase activity in brain heart of developing rats SANDRA L. MORZORATI and C. D. BARNES: Sensitivity of components of the central and vestibular complex to pentobarbital Preliminary Notes M. VELASCO, F. VELASCO, C. CEPEDA and A. M. DE ANDA: Effect of diazepam on pyramidal tract and electromyographic multiple unit activities of cats with chronic epileptogenic foci H.-Y YANG, J. S. HONG and E. COSTA: Regional distribution of leu and met enkephalin in rat brain. Announcement Instructions for the Preparation of Preliminary Notes

221 235 241 245 253 259 267 273 277 283 289 295

299 303

NUMBER 5 A. D. SHERMAN and E. M. GAL: Cerebral metabolism of intraventricular C3H]fenfluramine N. PGSCHLOVA, K. MASEK and M. KRSIAK: Amphetamine-like effects of 5.6-dihydroxy tryptamine on social behaviour in the mouse R. E. DILL and E. COSTA: Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus R. L. PATRICK and J. D. BARCHAS: Potentiation by cocaine of the stimulus-induced increase in dopamine synthesis in rat brain striatal synaptosomes P. N. C. ELLIOT, P. JENNER, G. HUIZING, C. D. MARSDEN and R. MILLER: Substituted benzamides as cerebral dopamine antagonists in rodents G. BARTHOLINI and H. STADLER: Evidence for an intrastriatal GABA-ergic influence on dopamine neurones ofthecat. A. J. AZZARO and D. J. SMITH: The inhibitory action of ketamine HCI on [3H]5-hydroxytryptamine accumulation by rat brain synaptosomal-rich fractions: comparison with [3H]catecholamines and [3H]y-aminobutyric acid uptake A. CONSTANTI: A quantitative study of the y-aminobutyric acid (GABA) dose/conductance relationship at the lobster inhibitory neuromuscular junction A. CONSTANTI: Comparison of dose/conductance curves for GABA and some structurally related compounds at the lobster inhibitory neuromuscular junction C. H. NORRIS, T. H. CAWTHON and R. C. CARROLL: Kanamycin priming for audiogenic seizures in mice Preliminary Note Y. OKADA, Y. TUCHIYA, M. YAGYU, S. KOZAWA and K. KARIYA: Synthesis of bradykinin fragments and their effect on pentobarbital sleeping time in mouse

309 317 323 327 333 343

349 357 361 375

381

NUMBER 6 P. G. GUYENI:T, F. JAVOY. C. EUVKARI~ and J. GLOWINSKI: The effect of drugs on the choline and acetylcholine content of the rat striatum following two methods of sacrifice G. CLARKE and D. W. STRAUGHAN: Evaluation of the selectivity of antagonists of glutamate and acetylcholine applied microiontophoretically onto cortical neurones K. LOWRY. M. E. AB~~D, M. DREXLER and L. G. ABO~D: Antagonism by cholinergic drugs of behavioural effects in cats of an anticholinergic psychotomimetic drug and enhancement by nicotine G. J. ALEXANDER and LENORE M. KOPELOFF: p-Chlorophenylalanine-mediated decrease in susceptibility to audiogenie seizures in inbred mice A. S. BLOOM, E. E. QUINTON and L. A. CARR: Effects of cycloheximide, diethyldithiocarbamate and D-amphetamine on protein and catecholamine biosynthesis in mouse brain ANNA WIRZ-JUSTICE and M. LICHTSTEINER: Differential effect of thyrotrophin releasing hormones on monoamineoxidase activity in the median eminence of male and pro-oestrus female rats M. F. PIERCEY and R. P. HOLLISTER: Morphine fails to block the discharges evoked by intra-arterial bradykinin in dorsal horn neurones of spinal cats M. J. AN~ONACCIO and JEANNE HALLEY: Clonidine hypotension: lack of effect of bilateral lesions of the nucleus solitary tract in anaesthetized cats G. C. PALMER, D. J. JONES, M. A. MEDINA and W. B. STAVINOHA: Influence of injected psychoactive drugs on cvclic AMP levels in mouse brain and lung following microwave irradiation Preliminary Notes M. A. WEDGWOCID and J. H. WOLSTENCROFT: Effects of spermine and spermidine on single brain stem neurones V. K. BHARGAVA and C. M. MCKEAN: Role of 5-hvdroxvtryptamine in the modulation of acoustic brainstem . ._. (far-field) potentials J. S. HONG. H.-Y. T. YANG and E. C~STA: On the location of methionin enkephalin neurons in rat striatum

3x5 391 399 405 41

I

419 425 431 435 445 447 451

NUMBtR 718 C. J. WILSON, JANICE M. JURASKA and P. M. GROVES: Alteration of the neuronal response to amphetamine in the neostriatum by pretreatment with a centrally acting anticholinergic. W. E. HOFFMAN. M. I. PHILLIPS, P. G. SCHMID, J. FALCON and J. F. WEET: Anti-diuretic hormone release and the pressor response to central angiotensin II and cholinergic stimulation. C. LAU, MARIA BAR~OLOM~ and T. A. SLOTKIN: Development of central peripheral catccholaminergic systems in rats addicted perinatally to methadone D. M. COWARD, N. S. DOCGETT and J. E. THOMAS: Central transmitter involvement in LON-954-induced tremorogenesis. J. Buus LASSEN and R. F. SQUIRES: Inhibition of both MAO-A and MAO-B required for the production of hypermotility in mice with the 5-HT uptake inhibitors chlorimipramine and femoxetine. C. A. MARSDEN and G. CURZON: Effects of p-chlorophenylalanine and a-methyltryptophan on behaviour and brain 5-hydroxyindoles R. W. FULLER and K. W. PERRY: Further studies on the effects of N-cyclopropyl-p-chloroamphetamine in rat .brain .., . . . . J. S. BEALE, R. P. WHITE and SHANG-PO HUANG: EEG and blood pressure effects of TRH in rabbits J. N. WEAKLY and W. R. PROCTOR: Barbiturate-induced changes in transmitter release independent of terminal spike configuration in the fog neuromuscular junction. A. DRAY, L. J. FOWLER. N. R. OAKLEY, M. A. SIMMONDSand T. TANNER: Regulation of nigro-striatal dopaminergic neurotransmission in the rat P. B. BRADLEY and G. J. BRAMWELL: Stereospecific actions of morphine on single neurones in the brain stem of the rat ..y Proceedings of the British Association for Psychopharmacology 18-20 July, 1976. Churchill College, Cambridge: Abstracts of Commumcations Preliminary Notes L. GRANDISON and A. GUIDOT-~I: Stimulation of food intake by muscimol and beta endorphin L. M. ORENSANZ Murjoz, F. V. DEFEUDIS and J. L. FANDO: High-affinity binding of ‘H-glycine and 14C-[&a\anine to synaptosomal-mitochondrial fractions of rat CNS regions; effects of strychnine. JANE MELLANBY and D. G. GRAHAME-SMITH: The effect of intracerebral injection of cycloheximide on brain protein synthesis and on the hyperactivity syndrome produced by a monoamine oxidase inhibitor and tryptophan . . . . . . . . . . . . . . . . . . ., H. RIGTER. H. GREVEN and H. VAN RIEZEN: Failure of naloxone to prevent reduction of amnesia by enkephalins

455 463 473 479 485 489 495 499 507 511 519 527 533 537

541 545

NUMBER 9 S. J. PEROUTKA, D. C. U’PRICHARD, D. A. GREENBERG and S. H. SNYDER: Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brain J. D. DEUPREE: Characterization of a norepinephrine binding site in bovine hypothalamus W. E. HOFFMAN. M. 1. PHILLIPS and P. SCHMID: The role of catecholamines in central antidiuretic and pressor mechanisms C. M. LEE, P. C. L. WONG and S. H. H. CHAN: The involvement of dopaminergic neurotransmission in the inhibitory effect of morphine on caudate neurone activities . : N. DAFNY and T. F. BURKS: 5-HT and morphine interaction. effects on sensory input in caudate nucleus and substantia nigra

549 557 563 571 577

M. SEGAL: Morphine

and enkephalin

interactions

with putative

H. TAKEUCHI, M. MATSUMOTO and A. SAKAI: Etrects of biologically able giant

neurones

H. SHINOZAKI and M.

neurotransmitters active peptides

giant snail (Acharinufulica in potassium permeability ., R. C. ELLIOTT: Centrally active drugs

in rat hippocampus on the excitability

581 of identifi-

Fhssac).

of an African ISHIDA: Increase

caused

593 by methamphetamine

in crayfish

opener

muscle...... MARGARET CL~J~LEY and and the sympathetic nervous system of rabbits and cats G. G. BUTERBAUGH and EUYTH~ D. LONDON: The relationship between magnitude of electroshock stimulation and the effects of digitoxigenin. pentylenetetrazol and brain monoamine reduction on electroshock convulsive thresholds. L. H. LAZARUS, M. R. BROWN and MARILYN H. PE’RRIN: Distribution, localization and characteristics of neurotensin binding sites in the rat brain Preliminary Notes R. L. DORRIS and R. E. DILL: Inhibition of catechol-0-methyltransferase by N-butyl gallate. 1.H. ULUS. E. MEYER JR. R. J. W~RTMAN and L. D. LYTLE: Trans-synaptic induction of adrenal tyrosine hydroxyiase following amphetamine treatment in the rat.

603 609

617 625 631 635

NLIMRER10 D. G. HATTAN and H. H. WOI t: Etfects of intrahypothalamic 6-hydroxydopamine on central thermoregulatorq rcsponscs to ( + )- and (~ )-norepinephrine and dopamine. L. S. SKLAR and Z. AMIT: Manipulations of catecholamine systems block the conditioned taste aversion induced by self-administered drugs Y. NIMITKITPAISAN. S. Bose, R. KUMAR and S. N. PRAIIHAN: Effects of L-DOPA on self-stimulation and brain biogenic amines in rats shake behaviour in the rat: a possible quantitative model of central P. BI:DARD and C. J. PYCOXK: “Wet-dog” 5-hydroxytryptamine activity K. J. COLLARD and M. H. T. ROHI RTS: Effects of lithium on the elevation of forebrain 5-hydroxyindoles by tryptophan S. H. NGAI. A. L1.v~. A. D. FIXK. .I. C. YANC; and S. SPECTOR: Central nervous system toxicity of hyperbaric oxygen elects of light. norepinephrine depletion and beta-adrenergic blockade T. F. BURKS and N. DAFNY: Naloxone and morphine effects on sensory-evoked responses M. C. WALLENSTEIN and L. Z. BITO: Prostaglandin El-induced alterations in visually-evoked response and production of epileptiform activity J. A. RI~~IRO and F. PERW-GOM~S: Acetylcholine release in cerebrospinal fluid by ouabain 0. KADLICOVA. K. MA&:K and P. P~TKOVITK?: A possible site of action of bacterial peptidoglycan in the CNS Preliminary Notes R. WEINSHILROI:M and F. RA~MONI): Variations in cathechol-0-methyltransferase activity in inbred strains of rats... . . . . G. G. BUTERRAI:(;H: A role for central serotonergic systems in the pattern and intensity of the convulsive response of rats to electroshock R. J. BOAKES. 1. L. MARTIN and P. R. MITCHELL: Burst firing of cerebellar Purkinje neurones induced by benzodiazepines. N. J. DUN. K. KAIIIARA and A. G. KARCZMAR: Direct postsynaptic membrane effect of dibutyryl cyclic GMP on mammalian sympathetic neurons NL‘MRf:K

639 649 657 663 671 675 681 687 695 699

703 707 711 715

11

R. M. JULIAN and G. W. FOWLI R: A comparative study of the efficacy of newer antiepileptic drugs on experlmentally-induced febrile convulsions. ANN G. HAYES. I. B. GAR.~SID~:and D. W. STRA~GHAN: Effect of four convulsants on the time course of presynaptic inhibition and its relation to seizure actlbity MARYLOUISE ARY. P. L~MAX and B. Cox: Apomorphine hypothermia in the rat: central sites and mechanisms A. PYGRNILX, H. LAHTI and R. HISSA: Thermoregulatory changes induced by intrahypothalamic injections of cholinomimetic substances in the pigeon. Q. J. PITTMAN. W. L. VEALE and K. E. COOPER: Absence of fever following intrahypothalamic injections of prostaglandins in sheep. L. R. STERANKA. R. J. BARRFrT and ELAINE SANDERS-BUSH: Facilitation of Sidman avoidance performance by p-chloroamphetamine: role of biogenic amines L. R. STERANKA, ELAINE SANDERS-BUSH and R. J. BARRETT: Tolerance to p-chloroamphetamine’s effects on Sidman avoidance performance and catecholamine metabolism. M. E. TRULSON~ C. A. Ross and B. L. JACOBS: Lack of tolerance to the depression of raphe unit activity by lysergic acid diethylamide J. J. BUC~AFUS~O and H. E. BREZENOFF: Mechanisms involved in the cardiovascular response to intracerebroventricular injection of noradrenaline and phentolamine S. AMIR: Brain and liver aldehyde dehydrogenase: relations to ethanol consumption in Wistar rats D. P. CARDlNALt: Effects of pentoxifylline and theophylline on neurotransmitter uptake and release by SynaptOsome-rich homogenates of the rat hypothalamus. Preliminary Notes L. VOLICER, S. K. PLJRI and P. CHOMA: Cyclic GMP and GABA levels in rat striatum and cerebellum during morphine withdrawal: effect of apomorphine KRISTIN R. CARLSON: Supersensitivity to apomorphine and stress two years after chronic methadone treatment

719 125 731 737 743 751 761 771 775 781 785

791 795

vii NUMBER 12

C. LAU, J. BARTOLOMI!, F. J. S~I~)LERand T. A. SLOTKIN:Critical periods for effects of prenatal reserpine adminis. tration on development of rat brain and adrenal medulla C. DE MONTIGNYand G. K. AGHAJANIAN:Preferential action of 5:mkthoxytryptamme’ and 5-methoxydimethyltryptamine on presynaptic serotonin receptors: A comparative iontophoretic study with LSD and serotonin M. VELASCO,F. VELASCO,X. ALMANZA,J. MuEioz and A. OLVERA: Effect of dextroamphetamine on somatic evoked potential components in man with special reference to task relevance and selective attention . F. J. WHITE, D. M. KUHN and J. B. APPEL: Discriminative stimulus properties of quipazine . . F. BERGMANN and V. PASTERNAK:Influence of drugs, affecting cholinergic transmission on flash nystagmus . . J. 2. NOWAK, A. PILC, U. LEBRECHTand C. MASLIGSKI:Does histamine interact with choline@ neurones in its cataleptogenic action in the rat? . . . H. TAKEUCHI,1. YOKOIand M. KURONO:Structure-activity relationships of P-hydroxyglutamic acid and its relatives on the excitability of an identifiable giant neurone of African giant snail (Achatina filica Fhssac) J. A. FUENTES,J. GARZON and J. DEL RIO: Potentiation of morphine analgesia in mice after inhibition of brain type B monoamine oxidase . . _ . , . . . . . . . . . . . . . . . . R. P. MA~CKEL,MONIQUEC. BRAUDE and J. E. ZABIK: The effects of various narcotic agonists and an&agonists on deprivation-induced fluid consumption . . . . C. CHINN, A. E. LUND and G. K. W. YIM: The central actions of lidocaine and a pesticide, chlordimeform Preliminary Notes M. AVOLI,M. DEODATI,F. EUSEBI,M. WARDO and P. F. A. BARRA: ~lectr#ncephalo~aphic changes induced by some inhibitors of prostaglandin synthetase in the rat. . . . . . . BARBARAP. FULTONand P. N. R. USHERWOOD:Presynaptic acetylcholine action at the locust neuromuscular junction . . . , . . . . . . . C. J. STAGG:Modification of the time-course of DMPEA toxicity in the mouse by centrally acting drugs . . Announ~ment . . . , . . ‘ . . . . . . . .

799 811 819 827 833 841 849 857 863 867

873 877 881

SUBJECT

INDEX

TO VOLUME

16

A Acetaldehyde on cytochrome a, a3, 283 on nicotinamide adenine dinucleotide-reduced form, 283 Acetylcholine cellular responses, antagonism by morphine, 587 effect of bicuculline in caudate nucleus, 343 in cerebrospinal fluid, release by ouabain. 695 measurement of morphine effect on turnover rate. 25 microiontophoretic application on mouse brain neurones. 89 perfusion into spinal cord. effect on neuronal activity, I plus physostigmine, lowered body temperature after hypothalamic injection. 731 presynaptic action in locust neuromuscular junction, 877 striatal concentration following different methods of sacrifice. effect of drugs. 385 [sH]-Acetylcholine depression of resting and evoked release from caudate nucleus by morphine, 227 Acetylcholine antagonists evaluation of selectivity. microiontophoretic application, 391 3-Acetylpyridine on tyrosine 3-monooxygenase activity in carotid body after exposure by hypoxic conditions. 277 ACh SW Acetylcholine Acidic amino acids cellular responses, potentiation by leucine-enkephalin. 587 Acoustic brainstem potentials role of 5-hydroxytryptophan modulation, 447 5’ Adenosine monophosphate inhibition of cyclic adenosine 3’5’monophosphate uptake into choroid plexus. 135 Adenylate cyclase dopamine stimulated activity. effect of substituted benzamines, 333 Adrenal catecholamines effect of reserpine in developing rats, 799 Adrenal dopamine P-hydroxylase effect of reserpine in developing rats. 799 Adrenal medulla localization of phenylethanolamine-N-methyltransferase, 129 Adrenaline cardiovascular responses to bilateral stereotaxic injection into posterior hypothalamus. 21 I Adrenaline-induced ganglionic inhibition effect of A9-tetrahydrocannabinol. 71 Aggression apomorphine-induced. modification by changes central cholinergic activity, 7 Akinesia effect of substituted benzamines on apomorphine-induced reversal, 333 [‘4C]-fi-Alanine high affinity binding to synaptosomal-mitochondrial fractions effect of strychnine. 537 Albino rabbits activation of flash nystagmus by local application of eserine. 833 Aldehyde dehydrogenase activity in brain and liver, correlation with ethanol consumption, 781 l-~-Allyloxyethyl-5-(O-8uorophenyl)-7-chloro-l,3-dihydro-2H-l,4-benzodiazepin-2-onc on evoked potentials recorded in limbic system and hypothalamus. 259 Alpha adrenergic receptor binding sites interactions with neuroleptic drugs, 549 Amantadine intracaudate injection. reduction of reserpine-induced extrapyramidal symptoms. 179 Amino acids, acidic see Acidic amino acids y-Amino-/I-hydroxybutyric acid log-dose/conductance curves, comparison with r-aminobutyric acid at lobster inhibitory neuromuscular I-Amino-4-phenylbicyclo(2.2.2)octane blockade of monoamine uptake, 11 y-Aminobutyric acid action of ketamine on synaptosomal high affinity transport, 349 cellular responses, lack of antagonism by morphine, 587 dose/conductance relationships at lobster muscle. 357 effect of antibiotics. 171 ix

junction,

367

x

effect of apomorphine on brain concentrations during morphine withdrawal, 791 effect of ethanolamine-0-sulphate on activity and concentration in substantia nigra, 51 l log-dose/conductance curves comparison with related compounds, 367 microiontophoretic application on mouse brain neurones. 89 on dopamine neurones, 343 p-Aminohippuric acid on cyclic adenosine 3’5’monophosphate in choroid plexus, I35 5-Aminomethylsoxazole action on morphine analgesia. 149 stimulation of food intake. 533 &Aminovaleric acid log-dose/conductance. comparison with y-aminobutyric acid at lobster inhibitory neuromuscular junction. Amitriptyline on brain and lung levels of cyclic adenosine 3’5’monophosphate. following microwave irradiation, 435 reduction of deprivation-induced fluid consumption. 267 Amnesia reduction by enkephalin. effect of naloxone. 545 Amodiaquine potentiation of histamine-induced catalepsy, 841 Amphetamine induction of anorexia. lack of antagonism by bis(4-methyl-l-homopiperazinylthiocarbonyl)disulphide, 45 neuronal responses in neostriatum. effect of methscopolamine. 455 effect of scopolamine. 455 on brain and lung levels of cyclic adenosine 3’5’monophosphate following microwave irradiation, 435 on ethanolamine-0-sulphate pretreated rats, 51 I on 5-hydroxytrypotophan-induced ‘wet dog’ shake response, 663 pretreatment. prevention of post-histamine catalepsy, 841 d-Amphetamine no transfer to quipazine cue. 877 on brain tyrosine hydroxylase activity. 47 on memory, 41 I on protein and catecholamine synthesis. 41 I on somatic evoked potential with reference to task relevance and selective attention. 819 on striatal concentrations of acetylcholine after different methods of sacrifice. 385 choline after different methods of sacrifice, 385 transsynaptic induction of adrenal tyrosine hydroxylase. 635 (+)-Amphetamine enhanced oropharyngeal twitch activity. 245 intracaudate injection, reduction of reserpine-induced extrapyramidal symptoms. 179 reduction of N-carbamoyl-2(2,6-dichlorophenyl)acetamidine hydrochloride-induced tremor. 499 Amphetamines reward enhancement. 529 Amygdaloid electrical activity effect of raphe mediated changes of chlordimeform, 867 of lidocaine. 867 Analgesia morphine elicited, effect of naltrexone injection into nucleus accumbens, 323 potentiation after inhibition of brain type B monoamine oxidase. 857 potentiation by 5-aminomethylsoxazole, 149 Angiotensin I, II. III on molluscan giant neurones, 593 Angiotensin II antidiuretic hormone release, 463, 563 increase of blood pressure. 463. 563 Anorexia induction by amphetamine. effect of caffeine, 767 lack of antagonism by bis(4-methyl-I-homopiperazinylthiocarbonyl) disulphide. 45 Anoxia inhibition of cyclic adenosine 3’5’monophosphate uptake into choroid plexus. I35 Antidiuretic hormone release effect of angiotensin II, 463. 563 effect of carbachol. 463 Antiepileptic drugs on experimentally-induced febrile convulsions, 719 Apomorphine antagonism of reserpine-induced rigidity, 179 enhanced oropharyngeal twitch activity, 245 induction of aggression, modification by changed central cholinergic activity. 7

367

XI

induction of hypothermia, central sites and mechanisms, 731 intracaudate injections, reversal of reserpine-induced extrapyramidal symptoms. I79 no transfer to quipazine cue. 877 on brain catecholamines. effect of y-aminobutyric acid during morphine withdrawal, 791 effect of cyclic guanosine 3’5’monophosphate during morphine withdrawal. 791 on brain tyrosine hydroxylase activity, 47 on cyclic adenosine 3’5’monophosphate in striatum of morphine dependent rats, 205 on dopamine turnover in striatum of morphine dependent rats, 205 on ethanolamine-O-sulphate pretreated rats. 51 I on Shydroxytryptophan-induced ‘wet dog’ shake response. 663 pretreatment of post hystamine-catalepsy, 841 reduction of N-carbamoy1-2(2,6-dichlorophenyl)acetamidine-hydrochloride-induced tremor, 479 supersensitivity of striatal dopamine system after chronic methadone treatment, 795 Arecoline antagonism of behavioural effects of N-methyl 4-piperidylisopentynyl phenyl glycolate. 399 DD-Arg-Vasotocin see Deamino-dicarba-Arg-vasotocin DD-Arg-Vassopressin WC Deamino-dicarba-Arg-vassopressin Arousal responses effect of Shydroxytryptamine on duration, 99 effect of lysergic acid diethylamide on duration. 99 Aspartate cellular responses, antagonism by leucine-enkephalin, 587 antagonism by morphine. 587 Asprin intraventricular administration. epileptic activity, 873 evoked excitatory electroencephalogram pattern, 873 Atropine augmentation of central nervous system stimulant-induced increased locomotor activity, I 15 inhibition of morphine-induced increased locomotor activity, 115 intracaudate injection, reduction of reserpine-induced extrapyramidal symptoms, I79 on histamine-induced cardiovascular changes, 21 I on pilocarpine-blockade of apomorphine-induced aggression, 7 on striatal concentrations of acetylcholine after different methods of sacrifice, 385 of choline after different methods of sacrifice, 385 prevention of carbamylcholine-induced hypothermia. 737 reduction of flash nystagmus, 833 selectivity as glutamate antagonist, 39 I Atropine methyl nitrate on histamine-induced catalepsy. 841 Audiogenic seizures p-chlorophenylalanine-mediated decrease in susceptibility, 405 kanamycin priming in mice, 375 Auditory evoked response convulsant-induced enhancement. 73

Bacterial peptidoglycan possible site of action in central nervous system, 699 Barbiturates changes in transmitter release in neuromuscular junction, 507 lack of action on terminal spikes in neuromuscular junction. 507 Behavioural effects cholinergic drug antagonism of N-methyl Cpiperidyl isopentylphenyl glycolate effect, 399 effect of somatostatin administration into amygdala, 157 role on noradrenergic bundle in control, 528 involvement of brain biogenic amines in morphine effect in post addict rats. 235 Bemegride on presynaptic inhibition in cuneate nucleus, 725 Benapryzine selectivity as glutamate antagonist, 391 I,4 Benzodiazepines on evoked potentials recorded in limbic system and hypothalamus, 259 Benztropine on dopamine uptake in synaptosomes, 327 on veratridine-induced dopamine synthesis in synaptosomes, 327 Benzyl-penicillin inhibition of cyclic adenosine 3’5’monophosphate into choroid plexus, 135

xii Bicuculline blockade of p-endorphin-induced eating, 533 enhanced dopamine release in caudate nucleus, 343 inhibition of S-aminomethylsoxazole stimulated food intake, 533 on presynaptic inhibition in cuneate nucleus, 725 release in caudate nucleus, 343 Bilateral lesions of nucleus of solit’ary tract, lack of effect on clonidine hypotension, 431 on Shydroxytryptophan-induced “wet dog” shake response, 663 Binding neuroleptic drug interactions with noradrenaline alpha receptor binding sites, 549 Bis(Cmethyl-l-homopiperazinylthiocarbonyl) disulphide delayed onset of hyperbaric oxygen-induced seizures, 675 on anorexic effect of methamphetamine, 45 on nitrazepam impairment of righting reflex, 253 Blindness effect of hyperbaric oxygen-induced seizures, 675 Blood pressure bimodal, dose related changes after intracerbroventricular injection of noradrenaline. 775 dose dependent pressor response to chlordimeform, 867 dose dependent pressor response to lidocaine, 867 dose dependent rise after bilateral stereotaxic injection of histamine into hypothalamus. 211 effect of thyrotrophin releasing hormone, 499 fall after intracerebroventricular phentolamine, 775 a-methylnoradrenaline-induced decrease in nucleus tractus solitarii, 219 response to angiotensin II, 463 response to carbachol, 463 role of catecholamine in rise after angiotensin II, 563 Body temperature depressed rate of rise during febrile convulsions, 719 Body weight effect of methadone, 473 effect of pre- and post-natal ethanol exposure, 289 effect of reserpine on pre-natal development, 799 Bradykinin electrically evoked-discharges of dorsal horn neurones. effect of morphine. 425 on molluscan giant neurones. 593 on pentobarbital sleeping time. 381 Bradykinin fragments on pentobarbital sleeping time. 381 synthesis, 381 Brain weight effect of methadone, 473 effect of reserpine on prenatal development, 799 Brainstem neurones effect of spermidine, 445 effect of spermine, 445 p-Bromomethyl amphetamine on brain tyrosine hydroxylase activity, 47 (Et3-(4Bromophenyl)-N.N-dimethyl-3-(3-pyridyl) allylamines inhibition of neuronal uptake of 5-hydroxytryptamine. 57 of noradrenaline, 57 (Zt3-(4-Bromophenyl-N,N-dimethyl-3-(3-pyridyl) allylamines inhibition of neuronal uptake of 5-hydroxytryptamine. 57 of noradrenahne. 57 N-Butyl gallate inhibition of catechol-0-methyltransferase, 631 C Caerulein on giant molluscan neurones. 593 Caffeine effects, use of event-related slow potentials as study method. 531 induction of increased locomotor activity, effect of humoral modulators. 115 on brain and lung levels of cyclic adenosine 3’5’monophosphate following microwave Carbachol biphasic effect on flash nystamus, 833 cardiovascular responses to bilateral stereotaxic injection into posterior hypothalamus, on antidiuretic hormone release, 463, 563 on blood pressure increase after angiotensin II. 563

irradiation.

211

435

XIII

N-Carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride induction of tremor, 479 Carbamazepine lack of effect of febrile contractions, 719 Carbamylcholine dose dependent hypothermia after intrahypothalamic injection, 731 Carbidopa plus 6-hydroxydihydroxyphenylalanine, delayed onset of hyperbaric oxygen-induced Carotid body induction of tyrosine 3-monooxygenase elicited by hypoxia, 277 Catalepsy after nitrazepam and drugs influencing monoamine systems, 253 effects of substituted benzamides, 333 induction by histamine, 841 morphine elicited, effect of naltrexone injection into nucleus accumbens, 323 Catechol competition with noradrenaline for binding, 557 Catechol-0-methyltransferase inhibition by N-butyl gallate, 631 variations in activity in inbred strains of rats, 703 Catecholamine synthesis effect of d-amphetamine, 411 effect of cycloheximide, 411 effect of diethyldithiocarbamate, 411 Catecholamine turnover effect of p-chloroamphetamine. 761 Catecholaminergic system development in rats perinatally addicted to methadone, 473 effect of reserpine on prenatal development in brain and adrenal medulla, 799 Catecholamines in adrenal gland. effect of methadone, 473 involvement in antidiuretic mechanism, 563 involvement in mediation of conditioned taste aversion, 649 Caudate nucleus depression of [3H]-acetylcholine resting and evoked release by morphine, 227 effect of 5-hydroxytryptamine and morphine interactions on sensory input, 577 effect of morphine on neuronal activity, involvement of dopaminergic transmission, Central canal perfusion, 1 Central vestibular complex sensitivity of components to pentobarbital, 295 Central transmitters involvement in N-carbamoyl-2(2,6-dichlorophenyl)acetamide-induced tremor, 479 Cerebellar Purkinje neurones burst firing induced by benzodiazepines, 711 Cerebral cortex clonidine activation of histamine HZ-receptors, 223 effect of ethanol, 283 Cimetidine on histamine-induced catalepsy, 841 Cinanserin on discriminative stimulus properties of fentanyl, 65 of saline, 65 Pretreatment. blockade of morphine-induced changes in substantia nigra, 577 Circling apomorphine-induced, reduction by substituted benzamides in unilateral nigrostriatal Circling. ipsilateral induced by substituted benzamides in apomorphine-treated rats, 333 Chlordiazepoxide induction of burst firing of cerebellar Purkinje neurones, 711 on brain tyrosine hydroxylase activity, 47 on spontaneous sympathetic activity in preganglionic superior cervical nerve, 609 Chlordimeform central actions, 867 Chlorgyline lack of effect on morphine analgesia, 857 Chlorimipramine production of hypermotility, after chlorgyline plus r_-deprynyl, 485 p-Chloroamphetamine blockade of neurotoxicity by l-amino-4_phenylbicyclo[2,2,2]octane, 11 cerebral metabolism, 17 chronic administration on rate of disappearance from brain, 761

seizures,

675

571

lesioned

mice, 333

facilitation of Sidman avoidance performance, 751 on brain tyrosine hydroxylasc activity. 47. 751 tolcrancc to effect on Sidman avoidance performance. I’-Chloromcrcuriphenylsulfonic acid inhibition of ~nk~ph~llin catabolism. I 51 /Khloronorephodrine effect of iprindole. 17

741

et&t of 3-(p-triRuoromethylphenoxy)-N-methyl-3-phenylpropyl amine on synthesis, I7 N-2-[O-Chlorophenoxy)ethyI-cypro-propylamine on morphine analgesia. X57 p-Chlorophenylalanine lowering of electroshock convulsive thresholds by modification of effects of d~gitoxigenin. 617 of effects of pcntylenetetrazol. 617 medi~ltion of decreased susceptibility to audiogenic seizures, 405 on bchaviour. 4X9 on hehavioural responses in morphine addiction and withdrawal, 235 on brain 5-hydroxyindoles. 489 on hrain tyrosinc hydroxylase activity. 47 on discrimin~~tiv~ stimulus properties of fentanyl. 65 of saline. 65 on clcctroencephalogram in morphine addiction and withdrawal, 235 on electroshock convulsive thresholds. 617 on nitratepam impairment of righting reflex. 253 on response of non-extensor rats to maximal electroshock stimulation, 707 prctrcatment. enhanced effect of lysergic acid diethyiamid~ on lordosis, 37 on effect of r-methyltryptophan on behaviour, 489 on effect of ~-methyltryptophan on brain S-hydroxyindoles, 489 on protryptiline reduction of deprivation-induced fluid consumption, 267 reversal of morphine-induced changes in caudate nucleus, 577 ~hloropyr~lmin~ antagonism of histamine-induced catalepsy. X41 Chlorpfomarinc competition with noradrenaline for binding. 5.57 on brain and lung levels of cyclic adenosine 3’5’monophosphate microwave irradiation, 435 on brain tyrosine hydroxylase activity. 47 on hypothal~imically evoked potentials. 609 on spontaneous sympathetic activity in preganglionic superior cervical nerve. 609 on thyrotrophin releasing hormone effects on blood pressure, 499 on thyrotrophin releasing hormone effects on electroencephalogram, 499 potentiation of nitrazepam impairment of righting reflex, 253 Chlorpromazine sulfoxide on hrain and iung levels of cyclic adenosine 3’5’monophosphate following microwave irradiation. Choline striatal concentrations following different methods of sacrifice. effect of drugs. 385 Choline acetyltransferase increase in activity in adrenals after D-amphetamine plus iprindole. 635 Cholinergic activity on apomorphin~-induced aggression. 7 Choroid plexus uptake and metabolism of cyclic adenosine 3’5’monophosphate. 135 Clebopride as cerebral dopamine antagonist in rats. 333 Clonazepdm lack of effect on febrile convulsions. 719 Clonidine activiation of histamine Hz-receptors in cerebral cortex, 223 induction of hypotension. lack of effect of bilateral lesions to solitary tract. 431 int~~dudate. antagonism of reserpine-induced eye changes, 179 reduction of N-carbamoyl-2(2,&dichlorophenyl)acetamidine hydrochloride-induced tremor, 479 reduction of discharge rate of cerebral cortical neurones, 223 Clorgyline plus t.-deprenyl followed by chlorimipramine. production of hypermotility. 485 plus L-deprenyl followed by femoxetine. prod~iction of ~y~rmotility. 485 Clozapine on brain tyrosine hydroxylase activity. 47 Cocaine induction of increased locomotor activity, effect of humoral modulators, 115 on dopamine uptake in synaptosomes. 327 on long term exposure to veratridine. 327 on tyrosine uptake in synaptosomes. 327

435

xv

on veratridine-induced dopamine synthesis st~muiation in synaptosomes. 327 on veratridine-induced inhibition of tyrosine accumulation in synaptosomes, 327 Conditioned taste aversion cannabis-induced mediation by central mechanisms. 121 involvement of catecholamines in mediation, 649 A9-tetrahydr~annabinoi-induced, 121 Conductance increase at lobster inhibitory neuromuscular junction in presence of y-aminobutyric acid, 357, 367 Copulatory behaviour effect of lysergic acid diethylamide in female rats. 37 Cortical inhibition of intralaminar thalamic responses to fastigial stimulation, 163 to somatic stimulation, 163 microiontophoretic application of dopamine. 83 5-hydroxytryptophan, 83 noradenaline, 83 Curarization on thyrotrophin releasing hormone effects on blood pressure. 499 on electroencephalogram, 499 Cyclazocine on deprivation-induced fluid consumption. 863 Cyclic adenosine 3’5’monophosphate effect of apomorphine on striatum content in morphine dependent rats, 205 effect of psychoactive drugs on brain and lung levels after microwave irradiation, 435 reduction in dopamine stimulated production by clebopride, 333 uptake and metabolism in rabbit choroid plexus, 135 Cyclic AMP see Cyclic adenosine 3’5’monophosphate Cyclic GMP SW Cyclic guanosine 3’5’monophosphate Cyclic Guanosine 3’5‘monophosphate effect of apomorphine of brain concentrations during morphine withdrawal, 791 inhibition of cyclic adenosine 3’5’monophosphate uptake into choroid plexus. 135 Cyclohcximide. intracerebral injection. effect on monoamine oxidase inhibitor plus tryptophan, 541 on memory, 411 on protein and catecholamine synthesis, 411 on tyrosine 3-monooxygenase activity in carotid body after exposure to hypoxic conditions, Cyclopentolate reduction of flash nystagmus, 833 ~-Cyclopropyi-~chloroamphetamine effect in brain. 495 Cyproheptadine blockade of quipazine discrimination, 877 on discriminative properties of fentanyl. 65 of sahne. 65 Cytochrome n. aa effect of acetaldehyde. 283 effect of chlorpromazine. 283 effect of ethanol. 283 effect of phenobarbital. 283

D Deamino-dicarba-Arg-vasotocin on giant molluscan neurones, 593 Deamino-dicarba-Arg-vassopressin on grant moltuscan neurones, 593 Deamino-di~rba-oxito~n on giant molluscan neurones, 593 Debenzylated product as cerebral dopamine antagonist in rodents, 333 Decapitation on striatal acetylcholine concentration determination, 385 on striataf choline concentration determination. 385 Denervation effect on sensitivity of hypothalamic hypothermic receptors to dopamine. 639 to f +) and f -) noradrenaline. 639

277

XVi

L-Dcprenyl plus chlorgyline followed by chlorimipramine. production of hypermotility. 485 plus chlorgyline followed by femoxetine. production of hy~ermotility. 485 potenti~~tion of morphine analgesia. 857 Desipramine competition with noradrenaline for hinding. 557 reduction of depri~tion induced Ruid consl~mption. 267 Desychronization asprin-induced. attenuation by prostaglandin E,. 873 Dexamphetaminc SW r&Amphetamine Dexetimide on apomorphine-induced aggression. 7 on pilocarpine-blockade of apomorphine-induced aggression. 7 Dextro~Im~het~iminc SW ~-Amphetamillc Dcxtrophan stereospecific actions on single brainstem neurones, 519 Diazcpam blockade of effects of chlordim~form. 867 of lidocaine, 867 hlockadc of harmine-induced spinal seizures. 31 effects. use of event related slow potentials as study method. 531 lack of influence on harmine-induced cerebeltar spiking, 31 on hrain tyrosine hydroxylase activity. 47 on electromyographic multiple units activities of cats with chronic epileptogenic foci, 299 on evoked potential recorded in hypothalamlis. 259 in limbic system. 259 on pyramidal tract of cats with chronic epileptogenic foci. 299 on spontaneous sympathetic activity in preganglionic superior cervical nerve. 609 Dibutyryl cyclic adenosine 3’5’monophosphate on neurotransmittcr uptake and release by synaptosome-rich homogenates, 785 Dibutyryl cyclic guanosine 3’5’monophosphate direct post synaptic membrane effect on mammalian sympathetic neurones. 715 ~ichloroisopr~~terenol competition with noradrenaline for binding, 557 Diethyidjthiocarbamatc on memory. 411 on protcin and catecholamine synthesis. 411 Dipitoxigenin on electroshock convufsant thresholds. 617 on response or non-extensor rats to maximal electroshock stimulation, 707 DIGT SW Digitoxigenin Dihydroxyphenylacetic acid effect of stibstitutcd benzamides on striatal and mesoiimbic ievels. 333 I.-Dihydroxyphenylalaninc antagonism of harmine tremor, 31 enhanced oropharangeal twitch activity. 245 failure to modify harmine-induced eiectroencephaio~~am changes. 31 intracaudate injection. reduction of reserpine-induced ~xtrapyramidal symptoms. 179 on brain hiogenic annne concentrations. 657 on self-stimolatiocl behaviour. 657 plus Ro4-4602. on striatal levels of acetylcholine after different methods of sacrifice. 385 on striatal levels of choline after different methods of sacrifice. 385 plus L-r-hydrazino-r-methyl-(3.4-dihydroxyphenyl)-proprionic acid monohydrate on ~-metbyi-~-tyrosine induced potentiation of nitrazepam catalepsy. 253 on rescrpine-induced potentiation of nitrazepam catalepsy. 253 S,h-Dihydroxytryptamine on amphet~~mine-like effect of social behaviour. 3 17 on brain catecholamines. 317 on brain Shydroxytryptamine. 3 I ‘I Dimethoxymethylamphetamine on brain tyrosine hydroxylase activity, 47 [3H]-2-(2‘~-Dimctboxy) phenoxyethy~mine methyl ben~odioxan. 549 3’7’-Dimethyl-(5oxo-hexyl) xanthine on uptake of neurotransmitters by synaptosome rich homogenates. 785 ~~,~‘-Dimethyl-phenobarbital on febrile convulsions. 719 Diphenhydramine antagonism of histamine-induced catalepsy. 841 Dipropylacetic acid phenobarbital like effects on febrile contractions, 719

xvi! Discrimina&ive stimulus properties of 2 piperazinyl quinoline. 827 DMMP we N,N’-dimethyl-phenobarbital L-DOPA SW L-Dihydroxyphenylalanine Dopamine action of ketamine on synaptosomal high affinity transport.

349 blockade of harmine tremors, 31 brain concentrations after S,6-dihydroxytryptamine, 317 brain concentrations in untreated post-addict rats after morphine challenge. 235 concentrations in ipsilateral striatum after ethanolamine-O-sulphate pretreatment. 51 I decrease in uptake after preincubation of synaptosome-rich homogenates with 3.7 dimethyl-l(5-oxo-hexyl)-xanthine, 785 with theophylline, 785 depletion after reserpine, effect on potentiation of nitrazepam-catalepsy, 253 dose related hypothermia, effect of 6hydroxydopamine. 639 effect of apomorphine on turnover in striatum of morphine dependent rats. 205 effect of dibutyryl cyclic adenosine 3’5’monophosphate on release by synaptosome-rich homogenates, 785 on uptake by synaptosome-rich homogenates, 785 effect of L-dihydroxyphenylalanine on brain concentrations, 657 enhanced oropharyngeal twitch activity. 245 enhanced release in caudate nucleus after bicuculline, 343 after picrotoxin, 343 failure to modify harmine-induced electroencephalogram changes. 31 intracaudate injection. reduction of reserpine-induced extrapyramidal symptoms. 179 on antidiuretic hormone release, 563 microiontophoretic application to cortical neurones, 83 microiontophoretic application to mouse brain neurones. 89 pressor responses, 563 reduction of N-carbamoyl-2(2,6-dichlorophenyl)acetamide-induced tremor, 479 reduced utilization in ~-methyl-p-tyrosine pretreated post addict rats, after morphine f:hallenge, [‘HI-Dopamine formation from [3H]-tyrosine, effect of p-chloroamphetamine, 761 Dopamine antagonists ability of substituted benzamines to act in rodents. 333 Dopamine conversion index effect of p-chloroamphetamine, 751 Dopamine excitatory responses microiontophoretic application of methysergide, 83 microiontophoretic application of phentolamine, 83 Dopamine ~-hydroxylase in adrenal gland, effect of methadone, 473 Dopamine-induced ganglionic inhibition effect of A9-tetrahydrocannabinol, 7I Dopamine neurones influence of ~-aminobutyric acid, 343 Dopamine receptors role in apomorphine-hypothermic effect, 731 Dopamine synthesis potentiation by cocaine of veratridine-induced stimulation in synaptosomes, 327 veratridine-induced stimulation, effect of benztropine in synaptosomes, 327 Dopamine turnover acute effects of substituted benzamides in striatal and mesolimbic areas, 333 Dopamine uptake in synaptosomes, effect of benztropine. 327 effect of cocaine, 327 Dopaminergic system impairment. facilitation of cataleptic action of nitrazepam, 253 regulation of nigro-striatal pathway, 511 Dopaminergic transmission involvement in morphine inhibition on caudate neurone activity. 571 Dorsal hippocampus infusion of A9-tetrahydrocannabinol, induction of conditioned taste aversion, I21 Dorsal horn neurones failure of morphine to block bradykinin-evoked electrical discharges, 425 Dorsal noradrenergic bundles role in behavioural control, 528 Doxepin reduction of deprivation-induced fluid consumption, 267 Drug discrimination effect of 5-hydroxytryptamine agonists, 65

235

,..

XVIII

effect of S-hydroxytryptamine Drug trials effect on patients, 532

antagonists,

65

E ECOG see Electrocorticogram EDTA see Ethyline diamine tetra acetic acid EEG see Electroencephalogram EKG see Electrocorticogram Electrical activity. amygdaloid SW Amygdaloid electrical activity Electrical stimulation of substantia nigra, on spontaneous activity of caudate neurones, 571 Electrocorticogram after 5-hydroxytryptamine perfusion in nucleus of solitary tract, 99 after lysergic acid diethylamide perfusion into nucleus of solitary tract, 99 effect of prostaglandin E,, 687 evaluation of amphetamine on general alertness, 819 Electrocencephalogram effect of somatostatin administration into amygdala, 157 effect of thyrotrophin releasing hormone. 499 evaluation of amphetamine in general alertness, 819 involvement of brain biogenic amines in morphine effect in post-addict rats. 235 morphine-induced decrease of theta rhythm, 191 sequential changes after pentylenetetrazol. 73 sequential changes after strychnine, 73 Electromyogram abolition of reserpine-induced rigidity by apomorphine, 179 Electromyographic multiple unit activities effect of diazepam in cats with chronic epileptogenic foci, 299 Electron microscopy localization of particulate phenylethanolamine-N-methyltransferase. 129 Electroshock convulsive thresholds effect of brain monoamine reduction, 617 effect of digitoxigenin, 617 effect of pentyletetrazol, 617 Electroshock stimulation role of 5-hydroxytryptaminergic systems in convulsive response. 707 Eledoisin-related peptide on molluscan giant neurones, 593 Elerobarbital see NJ’-dimethoxymethyl-phenobarbital EMG see Electromyogram /?-Endorphin stimulation of food intake. 533 Endorphins blockade by naloxone, 681 Enkephalins see also leucine-enkephalin methionine-enkephalin Enkephalins catabolism, 15 1 reduction of amnesia, effect of naloxone. 545 EOS see Ethanolamine-0-sulphate Epilepsy effect of diazepam on pyramidal tract, 299 on electroencephalographic unit activity, 299 Epileptiform activity production by prostaglandin E,, 687 Epinephrine see Adrenaline Erythro-b-hydroxy-D-glutamic acid lack of effect on periodically oscillating neurone excitability of mollusca giant neurone. 849 Erythro-j%hydroxy-L-glutamic acid inhibitory effect on periodically oscillating neurone excitability of mollusca giant neurone. 849 Erythro-tricholonic acid inhibitory effect on periodically oscillating neurone excitability of mollusca giant neurone. 849 Eserine biphasic effect on flash nystagmus, 833 Ethanol cerebral oxidative metabolic response to acute administration, 283 correlation between intake and dehydrogenase activity, in brain, 781 in liver, 781

xix intraperiton~ai administration of conditioned taste aversion, 121 pre and post natal exposure, on body weight, 289 on ornithine decarboxylase activity, 289 on tissue weight, 289 production of conditioned taste aversion, effect of catechol amines, 649 Ethanol-O-sulphate effect of y-aminobutyric acid activity and concentrations in substantia nigra. 511 Ethyline diamine tetra acetic acid inhibition of enkephalin metabolism, 151 Event-related slow potentials for study of effects of centrally ading drugs, 531 Evoked potentials effects of 1,Cbenzodiazepines recorded in hypothalamus, 259 recorded in limbic system, 259 in preganglionic superior cervical nerve after hypothalamic stimulation, 609 Evoked responses convulsant-induced enhancement, 73 Evoked sympathetic cell potentials in spinal cord, response to hypothalamic stimulation, 609 Excitability testing effect of convulsant drugs on depolarization of primary aRerent terminals. 725 Excitatory effects after microiontophoretic application to single brain stem neurones, of spermidine. 445 of spermine, 445 Excitatory postsynaptic potential depression by streptomycin, 171 EXP 561 see I-Amino_Cphenylbicyclo[2,2.]octane Extrapyramidal symptoms effect of intracaudate drug injection in reserpine pretreated rats. 179 F Fastigial stimulation intralaminar thalamic responses, 163 Febrile convulsions effect of antiepileptic drugs, 719 effect of N,N’-dimethoxymethyl-phenylbarbital, 719 Febrile convulsive temperature threshold elevation by N,N~-dimethyl-phenobarbital, 719 Femoxetine production of hypermotility, after clorgyline plus t_-deprenyl pretreatment, 485 Fenfluramine time course of cerebral metabolism after intravenous injection, 309 Fever absence, following injection of prostaglandins in sheep, 743 Firing rate effect of morphine on spontaneously active brain stem neurones. 519 FLA 57 on conditioned taste aversion, 649 FLA 63 see Bis(4-methyl-l-homopiperazynylthiocarbonyl)disulphide Flash nystagmus influence of drugs, 833 Flash rates broadening of effective range by eserine, 833 Fluid consumption deprivation-induced, effect of narcotic agonists, 863 effect of narcotic antagonists. 863 effect of t~cycIic-antidepressants, 267 Fluotoxetine on effects of N-cyclopropyl-p-chloroamphetamine in brain, 495 Fluphenazine lack of effect on quipazine discrimination, 877 Flurazepam induction of burst firing of cerebellar Purkinje neurones, 711 Food intake effect of p-chlorophenylalanine, 489 effect of %-methyltryptophan, 489 stimulation by j?-endorphin, 533 stimulation by 5-aminomethyisoxazoIe, 533

xx

G Ganglionic transmission potentiation by A’-tetrahydrocannabinnol of catecholamine inhibition. 71 Glutamate cellular responses, antagonism by icucine-~nkephalin. 587 cellular responses, antagonism by morphine. 587 decrease in uptake after preincubation of synaptosome-rich homogenates with 3,7-dimethyl-l(5-oxo-hexyl)-xanthine, 785 with theophylline, 785 depolarization action, depression by methamphetami~e. 603 effect of dibutyryl cyclic adenosine 3’S’-monophosphate on release by synaptosome-rich homogenates, 785 on uptake by synaptosome-rich homogenates. 785 microiontophoretic application on mouse brain neurones, 89 Glutamate antagonists evaluation of selectivity, microiontophoretic application, 391 Glutamate potential depression by streptomycin, 17 I Glutamate receptor inhibitory effect of streptomycin at crayfish neuromuscular junction. 171 Glutamic acid diethyl ester unreliable as glutamate antagonist. 391 Glycine microiontophoretic application on mouse brain neurones. 89 release from enkephalin. 151 [3H]-Glycine high affinity binding to synaptosomal-mitochondrial fractions. effect of strychnine, 537 Guanidoacetic acid log-dose/conductance curves, comparison with y-aminobutyric acid at lobster inhibitory

neuromuscular

H HA-966 SW I hydroxy-3-aminopyrrolid-2-one Habituation of startle reaction effect of lysergic acid diethylamide. 37 Haloperidol effect of pretreatment on morphine effect on caudate neurones. 571 lack of effect on quipazine discrimination. 877 on antidiuretic hormone release after angiotensin II, 563 on blood pressure after angiotensin II. 563 on brain tyrosine hydroxylase activity, 47 on spontaneous sympathetic activity in preganglionic superior cervical nerve. 609 on striatal concentrations of actylcholine following different methods of sacrifice. 385 of choline following different methods of sacrifice, 385 potentiation of aitrazepam impairment of righting reflex. 253 [3H]-Haloperidol labelling of dopamine receptor sites 549 Hermine on cerebellar and spinal electrical activity, 31 Head twitch Shydroxytryptophan-induced, effect of fl-adrenoceptor antagonists. 273 Heart rate dose related rise after bilateral stereotaxic injection of histamine into hypothalamus, 71 I effect of intracerebroventricular administration of noradrenaline. 775 effect of (-) ~-methylnoradrenaline in nucleus tract soiitarii. 219 Heroin intravenous administration. physiological and psychological responses, 529 “High affinity” binding of [i4C]-fi-alanine to synaptosomal-mitochondrial fractions, etfect of strychnine. 537 of [3H]-glycine to synaptosomal-mitochondrial fractions, effect of strychnine, 537 Histamine and catalepsy. 841 bilateral stereotaxic injection into hypothalamus. dose related rise in blood pressure. 21 I dose related rise in heart rate. 211 increase in cyclic adenosine 3’5’monophosphate concentrations in choroid plexus. 135 lack of effect on amphetamine-induced stereotypy, 841 apomorphine-induced stereotypy, 841 microiontophoretic application to mouse brain neurones, 89 reduction of discharge rate of cerebral neurones, 223

junction.

367

XXI

Histamine receptors hypothalamic, involvement in central cardiovascular actions of histamine. 2i I Histamine H2 receptors activation by clonidine cerebral cortex, 223 Home cage behaviour effect of p-ChIorophenylanine, 489 effect of a-methyltryptamine, 489 effect of a-methyltryptophan. 489 Homovanillic acid ipsilateral striatal concentrations. after ethanolamine-0-sulphate, 511 mesolimbic concentrations, effect of substituted benzatnides, 333 striatal concentrations, effect of substituted benzamides. 333 Hot plate test effect of medial thalamic lesions, 107 5-HT SW SHydroxytryptamine 5-HTP srr 5-Hydroxytryptophan Humoral modulators on central nervous system stimulant-induced hyperactivity, 115 on morphine-induced hyperactivity, 115 L-r-Hydrazino-z-methyI-8(3,4-dihydroxyphenyl)proprionic acid monophosphate plus L-dihydroxyphenylalanine on ~-methyl-p-tyrosine-induced potentiation of nitrazepam catalepsy, 253 on reserpine-induced potentiation of nitrazepam, 253 I-Hydroxy-3-aminopyrrolid-2-one selectivity as glutamate antagonist. 391 p-Hydroxyamphetamine on brain and lung levels of cyclic adenosine 3’S’monophosphate. following microwave irradiation, 435 4-Hydroxydihydroxyphenylalanine plus carbidopa. delayed onset of hyperbaric oxygen-induced seizures, 675 6-Hydroxydopamine blockade of neurotoxicity by I-amino-4-phenylbicyclo[2.2,2]octane, 1I on antidiuretic hormone release after angiotensin II, 563 on blood pressure increase after. angiotensin Ii, 563 on central thermoregulatory responses to dopamine, 639 to (+) and (-) noradrenaline, 639 /GHydroxyglutamic acid structure-activity relationship on excitability of molluscan giant neurone, 849 S-Hydroxyindoleacetic acid brain concentrations of p-chlorophenylalanine, 489 of r-methyl tryptophan, 489 increase by lithium of tryptophan-pr~u~d increases in concentrations. 671 SHydroxytryptamine blockade of uptake by I-amino-4-phenylbicyclo[2,2,2]octane. II brain concentrations effect of p-chlorophenylalanine. 489 effect of L-dihydroxyphenylalanine, 657 effect of Wdihydroxytryptamine. 317 effect of Shydroxytryptamine. 663 effect of x-methyltyrptophan. 489 in mice susceptible to audiogenic seizure after p-chlorophenyfalanine, 405 cardio~~Isctllar responses after bilateral stereotaxic injection into posterior hypothalamus. 21 I cellular responses. lack of antagonism by morphine. 587 competition with noradrenaline for bindlng. 557 decrease in turnover after I-amino-4-phenylbicyclo[2,2,2]octane. II decrease in uptake after preincubation of synaptosome-rich homogenates with 3.7-d~methyl-i(5-oxo-hexyl).xanthinc. 785 with thcophyllinc. 785 efiect of dihutyryl cyclic adenosine 3’5’monophosphate on release by synaptosome-rich homogenates. 785 on uptake by synaptosomc-rich homogenates. 785 effect of lithium on effects of tryptophan. 671 elevated brain concentrations in untreated post addict rats after morphine challcngc. 235 inhibition of neuronel uptake by ~E)-3-(4-bromophenyl)-N.IV-dimethyl-3(3-pyridyl)allylamines. 57 by (Z)-3-(4-bromophcnyl)-N.N-dimethyl-3(3-pyridyl)allylamines. 57 inhibition of uptake by chlorjmipramin~. 485 by femoxetine. 485 interaction with morphine. on sensory input in caudate nucleus and substantia nigra. 577 involvement in narcotic cue, 65 lack of effect on reserpine-induced extrapyramidal and eye signs, 179 lowered brain levels after ~-cyciopropy~-p-chior~mphe~mine. 495

xxii

microiontophoretic application to cortical neurones. 83 to mouse brain neurones. 89 to pre- and post-synaptic neurones. 81 I on duration of arousal responses. 99 perfusion into nucleus of solitary tract. changes in spontaneous clectrocortical activity. 99 role in modulation of acoustic brainstem potentials. 447 spinal concentrations. after systemic 5-hydroxytryptamine administration. 663 “wet dog” shake behaviour as quantitative model for activity. 663 [‘HI-5-Hydroxytryptamine effect of ketamine on synaptosomal accumulation and catabolism, 349 on synaptosomal high affinity transport. 349 5-Hydroxytryptamine inhibitory response effect of microiontophoretic application of methysergide. 83 S-Hydroxytryptamine receptors blockade in central nervous system by /I-adrenergic antagonists. 273 5-Hydroxytryptaminergic system role in convulsive response to electroshock. 707 5-Hydroxytryptophan induction of “wet dog” shake behaviour. 663 Hyperactivity central nervous system stimulant-induced. effect of humoral modulators. I15 effect of intracerebral injection of cycloheximide after monoamine oxidase inhibitor plus tryptophan. morphine-induced. effect of humoral modulators. I I5 Hyperbaric oxygen toxicity to central nervous system, 675 Hypermotility after selective inhibition of monoamine oxidase and 5-hydroxytryptamine uptake. 485 Hypertension on molluscan giant neurones. 593 Hyperthermia. abolition in curarized animals. 499 Hypotension affinity of neuroleptic drugs to r-receptor and dopaminq receptor binding sites, index of propensity. clonidine-induced. lack of effect of bilateral lesions to solitary tract, 431 r-methyladrenaline-induced in nucleus tractus solitarii. 219 Hypothalamic histamine receptors involvement in central cardiovascular action of histamine. 21 I Hypothalamic hypothermic receptors effect of denervation. effect on sensitivity to dopamine. 639 to (+) and (-) noradrenaline. 639 Hypothalamic synaptosomes effect of methylxanthines on neurotransmitter uptake and release. 783 Hypothalamus characterization of noradrenaline binding site. 557 dose-dependent hyperthermic response to apomorphine. 731 Hypothermia effect of 6-hydroxydopamine on dose-related responses to dopamine. 639 (+) and (-) noradrenaline. 639 induced by apomorphine. central sites and mechanisms. 731 Hypoxia induction of tyrosine-3-monooxygenase after exposure. 277 on ~0,. pCOz and pH in arterial blood. 277

ID 495-37 SW I-~-Allyloxyethyl)_5-(O-Ruorophenyl)-7-chloro-~.3-dihydro-2H-~.4 ID 622 sw I-(p-methyl-sulfonylethyl)5-(O-fl~~orophenyl~7-chloro-l.3-dihydro-2H-l.4 lbotechnic acid inhibitory effect on periodically oscillating neurone excitability of mollusca lmipramine on brain tyrosine hydroxylase activity. 47 reduction of deprivation-induced fluid consumption. 267 Input resistance of crayfish opener muscle. effect of methamphetamine. 603 Intralaminar neurones blockade of inhibitory influence of cerebral cortex by strychnine. I63 lntralaminar thalamic responses to fastigial stimulation. 163 to somatic stimulation. 163

benzodiazepin-2-one benzodiazepin-2-one giant

neurone.

849

541

549

XXI,,

Iontophoresis SW Microiontophoresis Iprindole increase in cerebral levels of fcnfluramine. 309 on brain tyrosine hydroxylase activity. 47 on synthesis of p-chloronorephedrine. I7 Iso-trichlomic acid inhibitory effect of periodically oscillating ncuronc Isoprenaline cardiovascular responses after bilateral stereotaxic Isoproterenol competition with noradrenalinc for binding. 557 Isopropamide on pilocarpine-blockade of apomorphone induced

excitability injection

aggression.

of mollusca into posterior

giant

neuronc.

hypothalamus.

7

J Junction potentials effect of methampetamine

in crayfish

opener

muscle.

603 K

Kainic acid on methionine-enkephalin content of various areas of brain. 451 Kanamycin on neuromuscular junction of crayfish. 171 primmg for audiogenic seizures. 375 Ketamine effect of synaptosomal accumulation and catabolism of [3H]-4-hydroxytryptaminc. on synaptosomal high affinity transport of p-aminobutyric acid, 349 of dopamine. 349 of [‘HI-5-Hydroxytryptamine. 349 of noradrenaline. 349

349

L Leptasol on presynaptic inhibition in cuneate nucleus. 725 Lesions. bilateral SW Bilateral lesions Leucine release from enkephalin. I51 Leucine-enkephalin antagonism of cellular responses. to aspartate. 587 to glutamate. 587 potentiation of cellular responses to acidic amino acid. 587 regional distribution in rat brain. 303 Levallorphan on deprivation-induced fluid consumption. 863 Levorphanol stereospecific actions on single brainstem neurones. 519 Lidocaine central actions. 867 Light effect on hyperbaric oxygen-induced seizures. 675 Lilly 51641 SW N-2-(@chlorophenoxy)ethyl-cypropylamine Lilly1 10140 SW 3-(p-trifluoromethylphenoxy)N-methyl-3-phenylpropylaminc Lithium correlation of effects on motor activity with brain concentrations. 241 intracellular levels in patients receiving lithium carbonate. 527 on elevation of forebrain 5-hydroxyindoles by tryptophan. 671 production of conditioned taste aversion. effect of catecholamines, 649 Litter size effect of reserpine. 799 Liver-cell growth factor on giant molluscan neurones. 593 Local anaesthetic action of centrally active drugs on preganglionic cervical nerve. 609 Locomotor activity effect of lysergic acid diethylamide. 37 increase after central nervous system stimulants. effect of humoral modulators. morphine-induced increase. effect of humoral modulators. 115 LON-954 see N-carbamyl-2-(2,6-dichlorophenyl)acetamidine hydrochloride

I I5

X49 21 I

XX,”

Lordosis effect of lysergic acid diethylamide. 37 Luteinizing-hormone-releasing hormone. on molluscan giant ncurones. 593 Lys-bradykinin on molluscan giant ncurones. 593 Lysergic acid dicthylamide depression of raphL: unit activity. 771 microiontophorctic application on pre- and post-synaptic neurones. XI 1 on hrain and lung levels of cyclic adenosine 3’5’monophosphatc following microwave irradiation. on copulatory bchaviour in female rats. 37 on habituation of startlc response. 37 on locomotor activity. 37 on vocalization hehaviour. 37 perfusion into solitary tract. changes in spontaneous electrocortical activity. 99 potency for producing “wet dog” shake behaviour. 663 transfer to qtliparinc cut. X27 I,-Lysergic acid diethylamide on duration of arousal responses. 99

435

M Maternal weight gain effect of rcscrpine. 799 Medial thalamic lesions on antinociceptive action of morphine. 107 on nociceptive threshold. 107 Melnnocyte-stimulating-release inhibiting factor on giant molluscan ncuroncs. 593 Membrane conductance ;-aminohutyric acid-evoked changes in lohstcr muscle fihres. 357 Membrane potential of crayfish opcncr muscle. effect of methamphetamine. 603 Memory effect of r/-amphetamine. 41 I effect of cycloheximidc. 41 I effect of diethyldithiocarhamate Mepcridone on deprivation-induced fluid consumption. 862 Mephcnesin effect of perfusion on neuronal activity. I Mrprohamatc on spontaneous sympathetic activlt!, m prcganglionic cervical nerve. 609 Mrpyramine antagonism of histamine induced catalepsy. 841 Mrsencephalic rctlcular formation convulsant-induced enhancement of non-primary sensory evoked potentials. 73 Met-lys-bradykinin on molluscan giant neurones. 593 Methadone chrome treatment. supersensitivit) to apomorphine and stress. 795 on deprivation-induced fluid consumption. X63 prenatal addiction on development of catrcholamincrgic system. 473 Mcthamphetaminc anorexic effect in rats pretreated with bis(4-methyl-I-homopiperarlnyl-thiocarhonyl) disulphidc. 45 increase in potassium permeability in crayfish opener muscle. 603 induction of locomotor activity. effect of humoral modulators. I I5 Methionine-enkephalin regional distribution in rat hrain. 303. 451 Mcthiothepin blockade of quipazine discrimination. 877 5-mcthoxydlmethyltyrptamine effect of intravenous administration on frequency of firing rate of prc- and post-synaptic neurones. effect of microiontophoretic application on pre- and post-synaptic nrurones. 8 I I potency for producing “wet dog” shake hehaviour. 663 5-Methoxytryptaminc effect of microiontophoretic application on pre- and post-synaptic neurones. 81 I Methscopalaminc inhibition of morphine-induced increased locomotor activity. II5 on neuronal response to amphetamine in neostriatum, 455 2-Methyl histamine rise in blood pressure after bilateral stereotaxic injection into posterior hypothalamus. 21 I rise in heart rate after bilateral stereotaxic

injection

into posterior

hypothalamus.

21 I

XI

I

XX”

4-Methyl histamine rise in blood pressure after bilateral stereotaxic injection into posterior hypothalamus. 21 1 rise in heart rate after bilateral stereotaxic injection into posterior hypothalamus. 21 I N-Methyl-4-piperidyl isopentynylphenyl glycolate behavioural effects, antagonism by cholinergic drugs. 399 I-(/~-ethyl-sulfonylethyl)-5-(O-fl~~orophenyl-7-chloro-7-l.3-dihydro ZH-I.4 benrodiazepin-2-one on evoked potentials recorded in limbic system and hypothalamus. 259 r-Methyl-p-tyrosinc inhibition of central nervous system stimulant-induced hyperactivity. 115 inhibition of morphine-induced hyperactivity. I I5 lack of effect on response of non-extensor rats to electroshock treatment. 707 modification of effects of digitoxigenin to lower electroschock convulsive thresholds. 617 of pcntylenctetrazol to lower electroshock convulsive thresholds, 617 on behavioural responses in morphine addiction and withdrawal. 235 on brain and lung levels of cyclic adenosine 3’5’-monophosphate after microwave irradiation, on brain tyrosine hydroxylase activity. 47 on conditioned taste aversion. 649 on electroencephalogram in morphine addiction and withdrawal. 235 on electroshock convulsant thresholds. 617 on striatal concentrations of acetylcholine following different methods of sacrifice. 385 of choline following different methods of sacrifice. 385 potcntiation of N-carbamoyl-2-(2.6-dichlorophenyl)acetamidine hydrochloride-induced tremor, potentiation of nitrazepam impairment of righting reflex. 253 prctrcatmcnt. on effect of lysergic acid diethylamide on lordosis. 37 on protriptyline reduction of deprivation-induced fluid consumption. 267 Methylatropine inhibition of morphine-induced increased locomotor activity. 1 I5 inhibition of morphine-induced increased locomotor activity. 1I5 N-Methylatropinium nitrate reduction of flash nystamus. 833 (-) z-Methylnoradrenalinc induction of hypotension in nucleus tractus solitarii. 219 Methylphenidate reward enhancement. 529 r-Methyltryptaminc on home-cage behaviour. 489 on motor activity. 489 r-Methyltryptophan on behaviour. 489 on brain hydroxyindoles. 489 Mcthysergide blockade of quipazine discrimination. 877 microiontophoretic application on dopamine excitatory responses. 83 on 5-hydroxytryptamine-induced inhibitory responses. 83 on noradrenaline excitatory responses. 83 on discriminative stimulus properties of saline or fentanyl. 65 on 5-hydroxytryptamine-induced sleep. 273 stomach contractlons. on 5-hydroxytryptophan-induced head twitch. 273 on pinna reflex, 273 Metiamidc antagonism of depressant effect of clonidine. 223 of histamine. 223 lack of effect on depressant effect of noradrenaline. 223 on histamine-induced catalepsy. 841 Metoclopramide as cerebral dopamine antagonist in rodents. 333 Microiontophoresis application of monoamines and antagonists to cortical neurones. 83 application of neurotransmitters to mouse brain neurones. 89 evaluation of sensitivity of glutamate and acetylcholine antagonists. 391 Microwave irradiation influence of psychoactive drugs on brain and lung levels of cyclic adenosine 3’5’monophosphate. striatal acetvlcholine concentration determination. 185 striatal chol&e concentration determination. 385 Miosis reserpinc-induced. effect of intracaudatc drug injection. I79

435

479

435

MK-4X6 \C’CI.-2-hydra/ino-7-methyl-/I-(3.4 dihydroxyphcnyl) propionic acid monohydrate Monoamine oxidasc activity clTccl ol’ thyrotrophin rclcasing horminc. 41 I Monoamine oxidasc inhihition by chkqylinc and I.-dcprcnyl with 5-hydroxytl-yptaminc blockade. production of hypcrmotility. 4X5 13~ !V-cvclop~-opqI-/‘-chloroamphct~~m~nc. 495 Monoam~nc oxidasc inhibitors and food. 577 pIti\ tr~l~tophan. on ctTcct of intraccrchral cyclohcximidc. 541 Monoamlnc oxidase type B inhlhition. Ipotcntiatlon. 01‘ niorphinc nnnlgcsia. X57 Monoamincs hlochadc or uptake hy I-am~no-4-phcnyIhicycl~[~.~.~]octnnc. II Morphine antinociccptivc action. cfTcct of medial thalamic Icsions. 107 hraiu concsntrations after mono;tminc oxldasc inhihitors. X57 depression of rating and cvokcd rclcasc of [3H]-acctylcholinc from caudate nucleus. 227 failure to block hradykinin-evoked discharges in dorsal horn ncuroncs. 425 induction of dose-rcsponsc diffcrcnccs in multiple-unit activity. I91 induction of regional diffcrcnccs on multiple-unit activity. I91 inhibitory cllicl on caudatc ncuronc activities. involvement 0r ncurotransmlssion. 571 interaction with 5-hydroxqtryptaminc. on sensory input in caudnte nt&us and suhstantia nigra. 577 Intra~~critoneal administr;ition. induction of conditioned taste aversion. 121 mca\ul-cmcnt of cti’cct on acctylcholinc turnover rate. 25 microiontoplic~~-ctic application. cffcct on cellular responses to ncurotransmittcrs. 587 on dol~~ltllinc-ind~~cc~i fluid consumption. X62 on scnsot-y-cvokcd rcsponscs. 6x1 production or conditioned taste aversion. clTcct of catccholamines. 649 production ol incrcascd locomotor activity. effect of humoral modulators. I I5 rcvcrsal of efTccts on sensor)-evoked rssponses hy naloxonc. 6x1 stcrcospccilic actions on single hrainstcm ncuroncs. 519 Mot-phinc addiction involvcmcnt of brain hlogcnic amincs in hchavioural cffccts or morphine in post-addict rats. 235 in clcctl-oenccphalogr~~pllic cffccts of morphine-addict rats. 235 Morphine analgesia clTcct Or medial thalnmic Icsions. 107 potcntiation aftcl- inhibition of brain type B monoamine oxidnsc. X57 potcntiation hq 5-aminomcthqlsoxal-olc. 149 Morphine dcpsndcncc 011 ctl’cct of apomorphlnc on adcnosinc 3’5’monophosphatc in striatum. 205 on dopaminc turnover in striatum. 205 Morphine withdrawal ctlcct of apomorphinc on brain concentrations of ;,-amtnohutyric acid. 791 of cyclic gunnosinc Z’S’monophosphatc. 791 Motor activity correlation of efccts of lithmm with brain concentrations. 241 cffcct of /+chlorophcn) lalanine. 4X9 clTcct of Y-mcthyltryptaminc. 4X9 cfcct of r-mcthqltryptophan. 4X9 Motor control etTcct of somatostatin administration into amygdala. 157 Multiple-unit activity dose-response ditlcrenccs to morphine. I91 cfTect of diazcpam in cats with chronic cpileptogenic l&i. 299 index of opiate effect. I91 regional responses to morphine. I91 Muscimol .SW S-nminomethylsoxarolc N NA SW Noradrcnalinc NADH .SW Nicotinamidc adenine dinucleotide-reduced form Nalorphine on levorphanol produced depression. 519 on morphine produced depression. 519 Naloxonc cellular responses to morphine lack of antagonism. 5X7 on levorphanol produced depression. 519 on morphine-induced changes in amplitude of evoked responses. 577 on morphine produced depression. 519

xxvii on reduction of amnesia hy enkephalins. 545 on sensory evoked rcsponscs. 681 reversal of morphine effect on evoked rclcasc of [3H]acetylcholinc from caudatc nucleus. 227 on sensory evoked rcsponscs. 681 Naltrcxone antagonism of morphine action of acetylcholine turnover rate. 25 blockade of /I-cndorphin-induced eating. 533 blockade of noradrenalinc-induced eating. 533 effect of intracranial bilateral in.iection into nucleus accumhens on morphine analgesia. 323 on morphine catalepsy. 323 on deprivation-induced fluid consumption. 863 Narcotic cue involvement of brain 5-hydroxytryptaminc. 65 NS SW Noradrenalinc Ncmhutal on spontaneous sympathetic activity in preganglionic superior cervical nerve, 609 Neomycin on neuromuscular junction of crayfish, 171 Neuroleptic drugs competition with [JH]-2-([2’6’dimethoxy]phenoxyethylamino) methyl benzdioxan for z-adrenergic receptor binding [3H]-Haloperidol for dopamine receptor binding sites. 549 Neuromuscular junction y-aminobutyric acid dose/conductance relationship in lobster. 357 barb~tLirate-indtlced changes in transmitter release. 507 comparison of dose,conductance curves for y-aminobutyric acid and rebated compounds. 367 presynaptic acetylcholine action in locust. 877 Neuronal activity after spinal cord perfusion with drugs, 1 Neuronal firing rate in caudate putamen following amphetamine. effect of methscopolamine 455 effect of scopolamine. 455 Neurotensin binding sites. distriblltion. localization and characteristics. 625 on molluscan giant neurones. 593 Neurotoxicity of p-chloroamphetamine. blockade by I-amino-4-phenylbicyclo[2.2.2]octane. II of 6-hydroxydopamine. blockade by I-amino-4-phenylbicyclo[2,2,2]octane. 1I NeLlrotr~lnsmitters microiontophoretic application on mouse brain neurones. 89 Nicotinamide adenine dinucleotidc-reduced form changes in redox level after ethanol. 283 effect of acetaldehyde, 283 Nicotine efiects. use of event-related slow potentials as study method. 531 slightly enhanced behavioural effects of N-methyl-Cpiperidyl isopentynylphenyl glycolate. 399 Nictitating membrane relaxation reserpine induced, effect of intracaudate drug injection. 179 Nigrostriatal pathway regulation of dopaminergic neurotransmission in rat. 511 Nitrazepam cataleptic action. 253 effects. use of event-related slow potentials as study method. 531 induction of burst firing of cerehellar Purkinje neurones, 711 Nocimptive threshold effect of medial thalamic lesions, 107 Noradrenaline action of ketamine on synaptosomal high affinity transport. 349 blockade of uptake by f-amino-~phenylhicycio~2.2.2Joctane. 1f brain concentrations after L-dihydroxyphenylalanine, 657 after 5.6-dihydroxytryptamine. 317 in mice susceptible to audiogenic seizures after p-chlorophenylalanine. 405 in untreated post-addict rats after morphine test dose, 235 cardiovascular responses to bilateral stereotaxic injection into posterior hypothalamus. 211 cellular responses. antagonism by morphine. 587 dose related. bimodal changes in blood pressure after intracerehroventricular injection, 775, dose-related hypothermia. effect of 6-hydroxydopamine. 639 effect of ~-cyclopropyi-p-chloroamphetamine on brain levels. 495 effect of depletion on hyperbaric oxygen-induced seizures. 675

sites. 549

c&t of dihutyryl cyclic adcnosine 3’5’monophosphate on release by synaptosome rich homogenates. 785 on uptake by synaptosome-rich homogenates. 785 inhibition of neuronal uptake by (Et3-(4 bromophenyl~N.N-dimethyl-3-(3-pyridyl)allylamines. 57 by (Zt3-(4 bromophenyl)_N.N-dimethyl-3-(3-pyridyl) allylamines. 57 lack of metabolism during binding assay. 557 lack of oxidation. 557 microiontophoretic application to cortical ncurones. X3 to mouse .hram ncurones. 89 reduction of N-carbamoyl-2.6-dichlorophenyl)acetamidinc hydrochloride-induced reduction of discharge rate of cerebral cortical neurones. 223 stimulation of food intake. 533 uptake. decrease after preincubation with 3.7-dimethyl-l(5-oxo-hcxyl)xanthine. 785 with theophyllinc. 785 [“HI-Noradrcnalinc formation from [‘HI-tyrosine. effect of p-chloroamphctamine. 761 Noradrenaline conversion index elTcct of p-chloroamphctaminc. 751 Noradrenaline excitatory responses. microiontophoretic application of methysergide. 83 of phentolaminc. 83 Noradrenaline binding site characterization in bovine hypothalamus. 557 Noradrenaline-induced-ganglionic inhibition ctTcct of A9-tctrahydrocannabinol. 71 Noradrenergic bundles. dorsal ,SW Dorsal noradrenergic bundles Norcpinephrinc .SW Noradrenalinc Nortryptaline reduction of deprivation-induced fluid consumption. 267 Nucleus accumbens blockade by naltrexonc injection of morphine analgesia. 323 of morphine catalepsy. 323 Nucleus tractus solitarii -x-mcthylnoradrcnaline-induced decrease of blood pressure. 219

tremor.

0 Opener muscle increases potassium permcahility. effect of methamphetamine. 603 Opiate effect multiple unit activity as index. 191 Opium alkaloids on deprivation-induced consumption. 863 Org GB94 on brain tyrosine hydroxylase activity. 47 Ornithine decarhoxylase activity in brain and heart after pre and post natal ethanol exposure. 289 measurement of activity after reserpine in developing rats. 799 Oropharyngeal twitch activity comparison with swallowing elicited by electrical stimulation. 245 OTA SW Orophanyngeal twitch activity Ouahain inhibition of cyclic adcnosinc 3’5’monophosphate uptake into choroid plexus. release of acetylcholine in cerhrospinal fluid. 695 Oxotremorinc depression of pressor responses. 125 induction of sustained contraction of nictitating membrane. 125 on striatal concentrations of acetylcholine. after different methods of sacrifice. 385 of choline. after diRerent methods of sacrifice. 385 Oxprenolol blockade of 5-hydroxytryptamine receptors in central nervous system. 273 on 5-hydroxytryptamine-induced sleep, 273 on 5-hydroxytryptamine-induced stomach contractions. 273 on 5-hydroxytryptophan-induced head twitch, 273 on pinna reflex. 273 DD Oxytocin .SCCDeamino-dicnrha-oxytocin

135

479

XXIX

P

effect of 3-(p-trifluoromethylphenoxy)N-methyl-3-phenylpropyl amine on synthesis. 17 Papaverine on brain and lung levels of cyclic adenosine 3’5’monophosphate following microwave irradiation. Paracetamol intraventricular administration. epileptic activity. 873 evoked excitatory electroencephalogram pattern. 873 Pargyline on brain and lung levels of cyclic adenosine 3’5’monophosphate following microwave iradiation. potentiation of morphine analgesia. 875 PC.02 effect of hypoxic conditions in arterial blood. 277 PEA SW 2-Phenylethylamine Pentarocine on deprivation-induced fluid consumption, 863 Pentetrazol potentiation of convulsant properties by N-carbamyl-2(2.6-dichlorophenyI)acetamide. 479 Pentobarbital on thyrotrophin releasing hormone effects on blood pressure. 499 on electroencephalogram. 499 sensittvity of components of central vestibular complex. 295 Pentobarbital sleeping time effect of bradykinin and its fragments. 381 Pentoxifyline SW 3.7-dimethyl-l(5-oxo-hexyl) xanthine Pentylenetetrazol enhanced sensory evoked responses, changes in reticular formation response patterns. 143 induction on seizures, effect on evoked responses. 73 lack of effect on response on non-extensor rats to electroshock, 707 on electroshock convulsant thresholds, 617 Peptidoglycan. bacterial SW Bacterial peptidoglycan Peptides effect on molluscan giant neurones. 593 Perfusion of spinal cord, I Periodically oscillating neurones effect of biologically active peptides in African giant snail. 593 study of /?-hydroxyglutamic acid and analogues. 849 PH effect of hypoxic conditions in arterial blood. 277 O-Phenanthroline inhibition of enkephalin metabolism. I51 Phenobarbital changes in transmitter release in neuromuscular junction. 507 Phenobarbitone sodium on brain tyrosine hydroxylase activity. 47 Phenoprophen intraventricular administration. epileptic activity, 873 evoked excitatory electroencephalogram pattern, 873 Phenoxybenzamine on brain tyrosine hydroxylase activity. 47 Phentolamine blockade of noradrenaline-induced eating. 533 competition with noradrenaline for binding, 557 intraventricular administration. abolition of hypotensive response to low dose noradrenaline, 775 fall in arterial pressure, 775 on noradrenaline decrease in heart rate. 775 intravenous administration, abolition of pressor response to-high dose noradrenaline. on antidiuretic hormone release after angiotensin II. 563 on blood pressure increase after angiotensin II. 563 on histamine-induced cardiovascular changes. 211 microiontophoretic application. on dopamine excitatory responses, 83 on noradrenaline excitatory responses. 83 Phenyl-methyl-sulfonyl fluoride lack of inhibition of enkephalin catabolism, 151 Phenylephrine competition with noradrenaline for binding, 557

775

435

435

xxx

etfect of ~hydroxydop~tmine, on antidiuretic hormone release. 563 on pressor rcsponscs. 563 Phenylethanolamine-N-methyltransfcrase localization in adrenal medulla. 129 particulate form, I29 2-Phenylethylamine potentiation of morphine analgesia. 857 Phosphodiesterase inhibition of activity by thcophylhne. incrcascd intracellular cyclic adenosine 3’5’monophosphate. Phosphoryicholine constant rate infusion. measurement of morphine effect on acetylcholine turnover. 25 Physalaemin on molluscan giant ncurones. 593 Physostigmine ant~~gonism of bch~~vio~l~~l effect of A’-methyl 4-pipcridyl isopentyryl-phenylglycolate. 399 depression of pressor reflexes. I25 enhanced reflex contractions of nictitating membrane. I25 on reserpine-induced extrapyramidal and eye signs. I79 Pictrotoxin enhanced dopaminc release in caudate nucleus. 343 on presynaptic inhibition in cuneatc nucleus. 725 Pigeon cffcct of cholinomimetics on body tempcraturc. 737 Pilocarpine on apomorphinc-ind~lced aggression. 7 Pimozide antagonism of apomorphine-induced hypothermia. 731 on conditioned taste aversion. 649 pretreatment. effect on morphine etTect on caudate neurones. 571 Pindolol on S-hydroxytrypt~minc induced. sleep. 273 stomach contractions. 273 on S-hydroxytryptophan-induced head twitch. 273 on pinns retlex. 273 Pinna reflex etTcct of /Cadrenoceptor antagonists. 273 Piperoxan on histamine-induced cardiovascular changes, 21 I 2-Piperazinyl quinolinc discriminative stimulus properties. 827 potency for producing “wet dog” shake behaviour. 663 2-Piperazinyl quinoline cue antagonism by Shydroxytryptamine antagonism. 877 Pipradol reward enhancement. 529 Piribedil on brain tyrosine hydroxylase activity. 47 Pizotifen on discriminative stimulus properties of saline or fentanyl. 65 PO? effect of hypoxic conditions in arterial blood. 277 PON SW Periodically oscillating neurone Potassium increase in permeability caused by methamphetamine in crayfish opener muscle. Practolol on brain tyrosine hydroxylase activity. 47 Prarepam on evoked notentials recorded in limbic svstem and hvnothalamus. 259 ,* Preganglionic’cervical nerve action of tranquilizing agents on spontaneous sympathetic activity. 609 Pressor responses depression by oxotremorine, I25 depression by physostigmine, 125 effect of angiotensin II. 463 Presynaptic inhibition effect of convulsant drugs on time course. 725 Primary afferent depolarization effect of convulsant drugs. 725 Probenecid inhibition of cyclic adenosine 3~S’monophosphate in choroid plexus. I35

603

135

xxx,

Procaine selectivity as glutamate antagonist. Propioceptive transmission &et of amphetamine. X19

391

blockade of ~-~ydr~x~tryptamine receptors in centrat nervous y&cm. 233 comRe~~t~on with noradrenaiine for bindinE. 577 on drain tyrosinc hydroxylase activity. 47 on Shydroxytryptamine induced, sleep. 273 stomach contractions. 273 on j-hydroxytryptophan-induced head twitch. 273 on hyperbaric oxygen-induced seirures. 675 on puma reflex. 273 Prostaglandin E, attenuation of asprin-induced desynchro~iz~ltion. 873 increase in cyclic adenosino 3~Smonoph~sphate levels in choroid plexus. 135 induction of alterations in visually evoked response. 687 int~hypoth~l~mic injection. absence of fever. 743 on ~lectr~ortico~~m. 687 production of cpilcptiform activity. 687 Prosta~landin E, inttahypothalamic in,jection. absence of fever, 743 Prostaglandin synthetase inhibition by. asp&. 873 paracrtamol. x73 ~h~noprophen. 873 Protein concentration on C3H]( -)noradrenaline hinding. 557 Protein synthesis effect of ~~-arnph~tarn~l~e. 41 I effect of cycioheximide. 411 cfkct of diethyldithiocar~mate. 411 effect of cerebral in_jection of cylcohex~mid~ on monoamine oxidasc inhibitor plus tryptophan, Protryptytine reduction af depr~~~atioR-~ndueed fluid co~s~irnptjon. 267 Ptosis rescrpine-induced. effect of intracaudate drug injection. 179 PTZ SW Pentyletctrazol Pyribenzamine on rescrpine-induced extrapyram~da~ and eye signs. I79 Pyrogenic readion depression by destruction of raphe nuclei and pararaphcai structures. 699

541

Q Quipazine SW 2-piperazinyl quinoline Quisqualic acid inhibitory effect on per~odi~lty osciftating

nettrone excitability

of mot&can

giant neuronrs.

849

R Raphc unit activity dcprcssion by lysergic acid diethylamidc. 771 Reserpinc modification of di~jtox~genin decreased electroshock convulsive thresholds. 617 rnod~~~at~on of pentylenetetra~~l decreased electroshock convulsive thresholds, 617 on brain and lung levels of cyclic adenosine 3’5’monophosphate following microwave irradiation. 435 on brain tyrosine hydroxylase activity. 47 on electroshock convulsive thresholds. 617 on extrapyramidal and eye signs. 179 on rat brain and adrenal medulla on prenatal development, 799 on response of nanbextensor rats to maximal electroshock stimulation. 707 on striatai concentratjons af acetykholine. after different methods of sacrifice. 385 af choline. after different methods of sacrifice, 385 potentiation of N-carbamoyl-2(2.6-dichlorophenyI)acetamidine hydrochloride-induced tremor. 479 potentiation of nitrazepam impairment of righting reflex. 253 pretreatment. duplication of reduced striatal dopaminergic activity. 179 Respiration frequencies evaluation of amphetamine on generai alertness. 819

xxxii Reticular formation unit response patterns associated with convulsant-induced enhancement Reward enhancement by psychomotor stimulant drugs. Rigidity reserpine-induced. antagonism by

pentylenctctraLol of responses. 73

enhanced sensory

evoked responses.

143

529 apomorphine.

179

s Scopolamine antagonism of oxotremorinc effect on pressor reflexes. 12.5 antagonism of physostigmine effect on pressor reflexes. I25 augmentation of central nervous system stimulant-induced increased locomotor activit). It5 augmentation of morphine-induced hyperactivity. I I5 blockade of thryrotrophin releasing hormone effect on clectroenccphalogram. 499 on histamine-induced catalepsy. 841 pretreatment. prevention of post-histamine catalepsy. 841 ( -) Scopolamine on neuronal response to amphetnminc in ncostriatum. 455 Sedation aflinity of neuroleptic drugs. to alpha rcccptor binding sitcs. Index of propensity. 549 to dopaminc receptor binding sites. index of propensity. 549 Sci7urc activity elTcct of convulsants in relation to presynaptic Inhibition. 725 induced by chlordimeform. blockade by raphe stimulation. 867 induction by cxposurc to hyperbaric oxygen. 675 kanamycin priming in mice. 375 Seizures. audiogenic .YCQAudiogcnic sci/urcs Sclectivc attention and somatic evoked potential. effect of D-amphetamine. Xl9 Self stimulation behaviour offcct of amphetamine. 53 effect of L-dihydroxyphenylalaninc. 657 effect of tyraminc. 53 Sensory evoked responses pcnt>lcnetetrazol-enhanced. changes in reticular formation untt rcsponscs. I42 SEP SW Somatic evoked potentials Serotonin sre 5-Hydroxytryptamine Shock titration test effect of medial thulamic Icsions. 107 Sidman avoidance pcrformancc facilitation by IT-chloroamphetamine. role of biogcnic amincs. 75 I tolerance to elTccts of p-chloroamphetamine. 761 Sinus nerve terminals participation m induction of tqrosine-3-mono-oxqgenase elicited by hypoxia. 777 Sinus nerve transection on tyrosinc 3-monooxqgenase activity in carotid hod). after cxposurc to hgpoxic conditions. Sleep S-hydroxytryptamine-induced. effect of /Gadrenoceptor antagonists. 273 Sleep-waking cycle effect of somatostatin admmistration into amygdaln. I57 Social behavlour cfTcct of 5.6-dihydroxytryptaminc. 317 Sodium free medium. inhibition of cyclic adcnosmc 3’5’monophosphate uptake into choroid plexus. I35 Solitary tract hilatcral lesions to nucleus. lack of effect of clonidine hypotcnsion. 43 I Somatic evoked potential elect of tl-Amphetamme. X I9 Somatic stimulation intralnminar thalamic response. I63 Somato-vegetative reflexes central cholinergic interactions. 125 Somatostatin administration into amygdala on behaviour. I57 on electroencephalogram. I57 on motor control. I57 on sleeping-waking cycle. 157 on giant molluscan. ncurones. 597

277

XXIII

Iontophorcsis WC Microiontophoresis lprindole increase in cerebral levels of fenfluramine. 309 on brain tyrosine hydroxylase activity. 47 on synthesis of p-chloronorephedrine. I7 Iso-trichlomic acid inhibitory effect of periodically oscillating ncuronc Isoprenaline cardiovascular responses after bilateral stereotaxic lsoproterenol competition with noradrenalinc for binding. 557 lsopropamide on pilocarpine-blockade of apomorphone induced

excitability injection

aggression.

of mollusca into posterior

giant

ncurone.

hypothalamus.

7

J Junction potentials effect of methampetamine

in crayfish

opener

muscle.

603 K

Kainic acid on methionine-enkephalin content of various areas of brain. 451 Kanamycin on neuromuscular junction of crayfish. 171 primmg for audiogenic seizures. 375 Ketamine effect of synaptosomal accumulation and catabolism of [‘HI-Shydroxytryptaminc. on synaptosomal high affinity transport of 1;-aminobutyric acid. 349 of dopamine, 349 of [3H]-5-Hydroxytryptamine. 349 of noradrenaline. 349

349

L Leptasol on presynaptic inhibition in cuneate nucleus. 725 Lesions. bilateral SLJPBilateral lesions Leucine release from enkephalin. I51 Leucine-enkephalin antagonism of cellular responses. to aspartate. 587 to glutamate. 587 potentiation of cellular responses to acidic amino acid, 587 regional distribution in rat brain. 303 Levallorphan on deprivation-induced fluid consumption. 863 Levorphanol stereospecific actions on single brainstem neurones. 519 Lidocaine central actions. 867 Light effect on hyperbaric oxygen-induced seizures, 675 Lilly 51641 SW N-2-(O-chlorophenoxy)ethyl-cypropylamine Lilly1 10140 SW 3-(p-triffuoromethylphenoxy)N-methyl-3-phenylpropy~amine Lithium correlation of effects on motor activity with brain concentrations. 241 intracellular levels in patients receiving lithium carbonate. 527 on elevation of forebrain 5-hydroxyindoles by tryptophan. 671 production of conditioned taste aversion. effect of catecholamines, 649 Litter size effect of reserpine. 799 Liver-cell growth factor on giant molluscan neurones. 593 Local anaesthetic action of centrally active drugs on preganglionic cervical nerve. 609 Locomotor activity effect of lysergic acid diethylamide. 37 increase after central nervous system stimulants. effect of humoral modulators. morphine-induced increase. effect of humoral modulators. 115 LON-954 SW N-carbamyl-2-(2.6dichlorophenyl)acetamidine hydrochloride

I15

849 21 I

XXXIV

Tctrahydroammoacridinc antagonism of behevioural n”-Tetrahydrocannahinol

clfects on N-methyl-4-pipcrtdyl

isopentynylphenyl

glycolatc.

3YY

infusion into dorsal hippocampus. induction of conditioned taste aversion. 121 intrapcritoneal administration. induction of conditioned taste aversion. I 21 potcntiation of catcchoiamine inhibition of synaptic transmission, 71 production of conditiollcd tast‘x _ aversion. effect of catechol~~mines. 64Y Tctrodotoxin on ouahain rclcase of acetylcholine in cerebrospinal fluid. 695 Thalamic responses to mescnccph~~lic reticular stimuli. convttlsant-indticcd reduction. 73 A“-THC SW A”-Tctrahydrocannahinol Thcophyllinc inhibition of phospt~~)dicstcr~~s~ activity, on uptake of putative nc~lrotr~insmittcrs Thcrmorcgulatton

increased intr~~cellul~~r cyclic adenosine ~‘S’monophosph~itc. by> synaptosomc-rich homogenates. 785

changes induced by intrahypothalamic cholinomimctic drugs. 731 effect of ~lpomorphinc. 131 cffcct of intrahypothalamic B-hydroxydopaminc on responses. to dopaminc. 639 to (i) and (~ ) noradrcnalinc. 639 Theta rhythm morph&-induced decrcascd incidence. 191 Thrco-/j-hydroxy-t>-glutamic acid lack of c&t OR periodically oscillating neurone excitability of mollusca giant neurones. 849 Thrco-li-hydroxy-r-glutamic acid inhibitory eiTect on periodically oscillating ncurone excitability of mollusca giant neurones. 849 Threo-tricholomic acid inhibitory cffcct on periodically oscillating neuronc excitability of mollusca giant ncuroncs. 849 Thyrotro~hii~ releasing hormone on blood pressure. 499 on electroencephnlogram. 499 on giant mollusca neurones. 593 on monooxidasc activity in median eminence of male and pre-ocstrus female rats. 419 Tigan as cerchral dopaminc antagonist in rodents. 333 Tissue weight cffcct of prc and post natal ethanol exposure. XY Tolerance lack of. depression of raphc unit activity by lysergic acid diethylamide. 771 IO hypothermic ctfects of ~ipomorphinc. 73 I Tonically autoactive ncurones erect of biologically actiyc pcptides in African Giant snail. 593 Tranquillircrs and s~mp~lthetic nervous system. 6OY Transmitter rclcasc harbitur~~tc-induced in neuromuscular junction. SO7 Tremor N-cnrhun~o~I-~(2.6-dichlorophcnyl)acetamide-induced. central transmitter involvement. 479 Trcmorinc lack of effect on rescrpme-induced extra pyramidal and cyc signs. I79 Trifluopctwinc on spontaneous sympathetic activity- in pr~~~ngiionjc superior cervical nerve. 609 3-(/~-Trifl~toromcthylphenoxy)-N-methyl-3-phenylpropylamine increase in cerebral concentrations of fenfluramine. 309 on formation of ~)-chloro~im~het~lminc metaholites. I7 Tryptamine on discriminative stimulus properties of saline or fcntanyl. 65 Try ptophan elevation of forchrain S-hydroxyindoics. effect of lithium. 671 on discriminattvc stimulus properties of saline or fentanyl, 65 plus carbidopa. potency for producing ‘wet dog’ shake behaviour. 663 plus monoamine oxidase inhibitor. hyperactivity syndrome. effect of cycloheximidc. 541 pretreatment. morpl~jne-indllced changes in substnntia nigra. 577 Tryptophan hydroxylasc lowcrcd brain concentrations after ,Y-cyclopropyl-/I-chloroamphetamine. 495 Tubocuraninc lack of etfect on c;~rhamyIcholinc-indilcrd ilypcrth~rrnj~~. 737 Tuftsin on giant niollusca ncuroncs. 593 Tyraminc colnpctitiol~ with nor~idrcn~llinc for binding. 557 concentrations in food and drink. 527

I 35

XXX”

on self stimulation. 53 release from enkephalin. 151 vcratridine-induced inhibition

of accumulation

in synaptosomes.

effect of cocaine. 327

[3H]-Tyrosinc effect of /I-chloroamphetamine on conversion to [3H]-noradrenaline Tyrosine hydroxylasc drug-induced changes in activity in brain. 47 effect of p-chloroamphetaminc on activity iu rim 761 effect of rescrpine in developing rats. 799 in adrenal gland. effect of methadone. 473 increased activity. after /I-chloroamphetaminc iu ~+to. 751 in adrenals. after tl-amphctaminc plus iprindolc. 635 Tyrosine 3-monooxygcnase induction in carotid body elicited by hypoxia. 277 Tyrosinc uptake in synaptosomes. cffcct of cocaine. 327

Vasoprcssin role in angiotensin produced pressor cffcct. 463 Veratridinc in synaptosomes. cffcct of cocaine. 327 Vestihular complex sensitivity of components to pcntoharhital. 295 Visual evoked rcsponscr convulsant-induced cnhancemcnt. 73 induction of alterations by prostaglandin E,. 687 Vocalization effect of lysergic aad dieth>lamidc. 37

W WB-4104 .sw 2-[2’6’-dimcthoxy]phcnoxycthylaminc WDS sw ‘Wet dog’ shake hchaviour ‘Wet dog’ shake hchaviour quantitative model of central 5-hydroxytryptaminc

methyl

honrodioxan

activity. 663

X Xenopsin on mollusca

giant ncuroncs.

593

and [3H]-dopamine.

761

AUTHOR

Abgood, L. G. Abgood, M. E. Aghajanian, G. H. Alexander, G. J. Almanza, X. Amir, S. Amit, Z. Anda, A. M. de see De Anda, A. M. Antonaccio, M. J. Appel, J. B. Ary, M. Avoli, M. Azzako, A. J.

399 399 811 405 819 781 121,649

Bailey, P. T. Baker, H. A. Barchas, J. D. Barnes, C. D. Barra, P. F. A. Barrett, R. J. Barthohni, G. Bartolome, J. Bartolome, M. Beale, J. S. Bedard, P. Bergman, F. Bhargava. V. K. Bieger, D. Biggio. G. Bito, L. Z. Bloom, A. S. Boakes. R. J. Bonkowski, L. Bose. S. Bradley, P. B. Brown, M. R. Brown. Z. W. Bramwell, G. J. Braude, M. C. Brezenotf, H. E. Buccafusca, J. J. Burke, J. P. Burks, T. F. Buterbaugh, G. G. Bymaster. F. P.

241 129 327 295 873 751, 761 343 799 473 499 663 833 447 245 149 687 411 711 89 657 519 625 121 519 863 775 775 129 577. 681 617, 707 11

Cardinali, D. P. Carlson, K. R. Cart-, L. A. Carroll, R.C. Caspary, D. M. Cawthon, T. H. Cepeda, C. Chan, S. H. H. Cheney, D. L. Chinn, C. Choma, P. Clarenbach, P.

431 827 731 873 349

785 795 411 375 143 375 299 571 25 867 791 135

INDEX

TO VOLUME

Clarke, G. Clubtey, M. Colasanti, B. K. Collard, K. J. Colpaert, F. C. Constanti, A. Cooper, K. E. Costa, E. Coward, D. M. Cox, B. Cramer. H. Curzon, G. Dafny, N. David, J. De Anda, A. M. De Jong, W. De Montigny, C. De Trujillo, G. C. Defeudis. F. V. Deguchi, T. Del Rio, J. Della Beha. D. Deodarti, M. Deupree, J. D. Dill, R. E. Dada, M. Doggett. N. S. Dorris, R. L. Dray, A. Drexler, M. Dreyfus, L. R. Dryden W. F. Dun, N. J. Eliasson, M. Elliot, P. N. C. Elliott, R. C. Eusebi, F. Euvrard, C.

391 609 235 671 65 357, 367 743 25, 151, 277 303, 323, 451 479 731 135 489 577, 681 179 299 219 811 31 537 253 857 149 873 557 63, 323 125 479 631 511 399 191 89 71.5 31 333 609 873 385

Faingold, C. L. Falcon, J. Fando, J. L. Finch, L. Finck. A. D. Forney, E. Fowler, G. W. Fowler, L. J. Franklin, K. B. J. Friesen, H. Frigeni, v. Fuentes, J. A. Fuller, R. W. Fulton, B. P.

73, 143 463 537 211 675 191 719 511 45, 53 157 149 857 495 877

Gal, E. M. Gartside, I. B.

17, 309 725 -xxvii

16

Garzon. J. Gianutos. G. Gitter, S. Giles, S. A. Gtowinski, J. Goldstein. F. J. Grahame-Smith, D. G. Grandison, L. Greenberg, D. A. Greven, H. Grewal, R. S. Groves, P. M. Guidotti, A. Guyenet, P. C. Gyorgy. L.

857 7 273 245 385 71 541 533 549 545 179 455 149, 533 385 125

Halley, J. Hammers, R. Hanbauer, I. Hartman, B. K. Hattan, D. G. Havlicek, V. Hayes, A. G. Herberg, L. J. Hicks, P. E. Hissa, R. Hockman, C. H. Hoffman, W. E. Hollister. R. P. Hong, J. S. Hosoya, E. Hsiao, W. C. Huang, S.-P. Hughes, K. R. Huizing, G.

431 135 277 129 639 1.57 725 45, 53 211 737 245 463, 563 425 303, 451 I15 17 499 157 333

fshida, M. Ishida. Y.

603 163

Jacobs, B. L. 771 Janssen, P. A. J. 65 Javoy, F. 385 Jenner, P. 333 Jones, D. J. 435 Jong, W. de see De Jong, W. Julien, R. M. 719 Juraska, J. M. 455 KadlecovB, 0. Kaibara, K. Karczmar, A. G. Kariya, K. Kaul, C. L. Key, B. J. Klemm, W. R. Koltrai, M. Z. Kopeloff, L. M. Kozawa. S. KrSiak, M.

699 71s 715 381 179 99 191 12s 405 381 317

XXXVlll

Kuhn, D. M. Kumar, R. Kurono, M. Kuyps, J. J. M. D.

827 657 849 65

Lahti, H. Lal, H. Lamanna, J. C. Lassen, J. B. Lau, C. Lazarus, L. H. Lebrecht, U. Lee, C. M. Leonard, B. E. Levine, R. M. Levitan, D. E. Levy, A. Lichtsteiner, M. Lindl, T. Lomax, P. London. E. D. Longo. V. G. Lovenberg, W. Lowy. K. Lund. A. E. Lytle, L. D.

731 I, 205 283 485 473, 799 625 841 571 47 267 121 675 419 135 731 617 31 277 399 867 635

McKean, C. M. Maikel. R. P. Marsden C. A. Marsden, C. D. Martin, I. L. MaSek, K. Maslinski. C. Matsui. Y. Matsumoto, M. Mayfield, M. A. Medina, M. A. Meek. J. L. Mehta. V. H. Mellanby. J. Meyer. E. Jr Meyerson. B. J. Miller. R. Mitchell. P. R. Molloy. B. B. Montigny. C. de see De Montigny. Morton. I. K. M. Morzorati. S. L. Mukherjee. B. P. Mmioz. J. Muiioz. L. M. 0.

477 267, 863 489 333 711 317. 699 841 253 593 191 435 151 99 541 635 37 333 711 II C. 29; 241 819 537

Niemegeers. J. E. Ngai. S. H. Nimitkitpaisan. Y. Norris, C. H. Nowak, J. Z.

65 675 657 315 841

Oakley, N. R. Oka, T.

511 115

Okada, Y. Olvera, A. Onodera. K.

381 819 171

Palmer, G. C. Pasternak, V. Patrick, R. L. Peres-Gomes, F. Peroutka, S. J. Perrin. M. H. Perry. K. W. Petrovicky. P. Phillips, M. I. Phillis. J. W. Picardo, M. Piercy, M. F. Pile, A. Pittman, Q. J. Poschlova, N. Pradhan, S. N. Proctor. W. R. Puri, S. K. Pycock. C. L. Pyiirnila. A. Quinton.

435 833 327 695 549 625 495 699 463, 563 223 873 425 841 743 317 241. 657 507 205. 791 663 731

E. E.

411

Racagni, G. Raymond, F. Redick, J. A. Renyi, A. L. Rezek, M. Ribeird, J. A. Rigter. H. Rio, J. Del see Del Rio. J. Roberts, M. H. T. Rogan. F. Rosenthal, M. Ross. C. A. Ross. S. B. Rudy, T. A. Rybarczyk. K. E. Sakai. A. Sanders-Bush. E. Sastry. B. S. R. Schanberg. S. M. Schmid, P. Scotti de Carolis. A Segal, M. Seidler, F. J. Sharma. J. N. Sherman. A. D. Shinozaki. H. Simmonds. M. A. Sklar. L. S. Slotkin. T. A. Smith. D. J. Snyder. S. H. Spaulding, J. H. Spector, S. Squires, R. F.

25 703 129 57 157 695 545 671 121 283 771 57 107 129

593 751. 761 223 289 463. 563 31 587 799 83 17. 309 603 511 649 289. 473. 799 349 549 267 675 485

Stadler, H. Stagg, C. J. Steranka, L. R. Strahlendorf, H. K Straughan, D. W. Stavinoha. W. B.

343 1,881 751. 761 71 391. 725 435

Takeuchi, A. Takeuchi, H. Tanner, T. Thadani. P. V. Thomas, J. E. Trujillo. G. C. de see De Trujillo. G. Trulson, M. E. Tsuchiya, T. Tuchiya. Y.

171 593, 849 511 289 479

UPrichard. Ulus. I. H. Usherwood.

D. C.

771 259 381

P. N. R.

549 635 X77

Van Orden. D. E. Van Orden. L. S. 111 Van Reizen, H. Veale. W. L. Velasco. F. Velasco. M. Vernot, E. T. Volicer, L.

129 129 545 743 299,819 299,819 71 205. 791

Wallenstein. M. C Weakly, J. N. Webster, R. A. Wedgwood. M. A Wee< J. F. Weinshilboum, R. Weinstock. M. Weiss. C. White. F. J. White. R. P. Wilson. C. J. Wirz-Justice. A. Wolf, H. H. Wolstencroft. J. H Wong. D. T. Wong. P. C. L. Wurtman. R. J. Yaksh. T. L. Yagyu. M. Yamamura. H. I. Yang. H.-Y. T. Yang. J. C. Yeung. J. C. Yim. G. K. W. Yokoi. I. Younts. B. W. Jr Zabil. J. E. Zandberg, P Zsilla. G.

687 507

1 445 463 703 273 273 827 499 455 419 639 445 II 571 635 107. 227 3x1 227 151. 303. 451 675 107 876 849 2x3 267, X63 219 25

AIMS AND SCOPE publishes papers concerned with original studies of the actions of drugs and biologically active substances on the central and peripheral nervous systems in animals and man. The principal aim of the Journal is to further our understanding of the mechanisms of action of drugs on the nervous system as well as to facilitate communications between the different scientific disciplines, and between basic science and clinical investigation. Neuropharmacology is aninterdisciplinarysubjectand thejournal welcomes articles in the following fields providing they are primarily concerned with elucidating mechanisms of drug action on the nervous system: I. Molecular pharmacology. 2. Electrophysiological pharmacology, 3. Cytochemical neuropharmacology, 4. Behavioural pharmacology or psychopharmacology. Papers which bridge one or more of these disciplines will be especially encouraged. Manuscripts may be submitted as (a) full length papers or (b) Preliminary Notes, which should need a minimum of editing inorder to facilitate rapid publication(seeInformationforContributors). Review articles, announcements and special supplements dealing with symposia or international conferences of special interest to neuropharmacology, may also be published from time to time. Neuropharmacology

INFORMATION

FOR CONTRIBUTORS

In view of the interdisciplinary nature of the Journal and to avoid misunderstandings, contributors are urged to define in which context indefinite words are used, e.g. stress, adapt, etc. Additionally it would be helpful if the use of terms peculiar to a particular discipline were avoided whenever possible. Neither the Editors nor the Publishers accept responsibility for the views or statements expressed by authors in original papers, or Preliminary Notes. This Journal should be cited in lists of reference as Neuropharmacology. MANUSCRIPTS All manuscripts submitted for publication and all scientific correspondence as well as news and general information should be sent to one of the two Chief Editors: P. B. BRADLEY, Birmingham (for Europe, Middle East, Africa and Australasia) or E. COSTA, Washington (for North and South America, India and Far East). Manuscripts should be typewritten on one side of the paper, double spaced with wide margins and submitted in duplicate (one original and one carbon copy or photocopy).

Manuscripts

must

proof alterations-except be minimal.

be carefully printer’s

checked and

errors-should

submitted in exfenso or as Premust contain original research which has not been published and which is not being considered for publication elsewhere. Papers accepted by Neuropharmacology may not be reprinted in any language without the consent of the Editors. Original papers in extenso should be concise. They should include: a Summary, a brief Introduction, Methods, Results, Discussion, Acknowledgements (if any) and References. A short title (maximum 40 characters) should be provided and, for the purpose of future indexing, key words of the paper should be given. The title of the paper, the author’s name and surname and the name and address of the institute, hospital, etc. where the work was carried out should be indicated at the top of the paper. Summaries. The summary (not exceeding 200 words) should be submitted on a separate sheet in duplicate. The summary will appear at the beginning of the article. References should be placed at the end of the paper, in alphabetical order and arranged as follows: author’s name and initials, year, title of the article, title of the journal (abbreviated according to the rules adopted in the fourth edition of the World List of Scientific Periodicals (Butterworths, London), volume, inclusive page numbers. e.g. Holzbauer, M. and Vogt, M. (1959). Denression bv reseroine of the noradre’naline cc¢&ion in hypothalamus of cat. J. Neurochem. 1: 8-12. References to books should include the author’s name and initials, year, title of book, volume, edition, page numbers, publisher and place of publication. The article

liminary Nofes

e.g. Dow,

E. and Moruzzi, G. (1958). The

Physiology Cerebellum,

and Pafhology of the 1st edn, pp. 66-120.

University of Minnesota Press, Minneapolis. Where relevant, the title of a paper within a book and the editor(s) of the book should be given. e.g. Abood, L. G. (1968). The psychotomimetic glycolate esters. In: Drugs Aflecting the Cenfral Nervous System (Burger, A., Ed.), Vol. 2, pp. 127-167. Dekker. New York. References should be quoted in the text by giving the author’s name, followed by the year of publication in parentheses. For more thantwo authors, all names are given when first cited, but when subsequently referred to, the name of the first author is given followed by the words “era/.“as for example-First citation: Corrodiner. Fuxe and HGkfelt (1966) but subsequently, Corrodiner et

al. (1966).

The references should be submitted on a separate sheet of paper. Footnotes, as distinct from literature references, are best avoided. Illustrations and diagrams should be kept to a minimum. They should be submitted in duplicate and each should be marked lightly on the back with the number and author’s name. Photographs should be on glossy paper, preferably not less than 7 x 5 inches in size, and submitted unmounted. Originals of diagrams and graphs may be sent but will not be returned to the author. Illustrat;ons with white traces on a black background should be avoided. Captions accompanying illustrations snould be typewritten on separate sheets. Tables and figures should be constructed so as to be intelligible without reference to the text. each table and column being provided with a hdading where necessary. The same information should not be reproduced in both tables and figures. Nomenclature. The generic or chemical name of drugs should be used. Trade or registered names may be referred to once at the beginning of the paper. Abbreviations or code numbers should be avoided except where absolutely necessary. Units. The SI symbols for units should be used (see Units, Symbols and Abbreviations (1972) The Royal Society of Medicine, London). For example, the amount of a substance should be given in moles and concentrations be expressed as molar. Notes or Preliminary Papers on original research or technical investigations should have not more than 1000 words, 2 figures, 1 table and 10 references. A brief Summary (maximum 100 words) should precede the note. Letters to the Editors. Queries, correspondence and all other editorial commumcations including information about forthcoming meetings may be sent to the Editors. Proofs. Two sets of page proofs will be supplied, one of which may be retained by the author. Authors are requested to correct their proofs and return them within 3 days of receipt to Professor Bradley. Reprints can be supplied at a reasonable price if application is made on the order form sent out with the proofs.