subject index

INTERNATIONAL

JOURNAL

OF

RABMTION ONCOLOGY BIOCOGY~PHYiSICS VOLUME

18. NUMBER

I

JANUARY

TABLE

1990

OF CONTENTS

Editor’s Note P. Robin

??DEDICATION Brigit H. P. van der Werf Messing F. Ellis and P. Levendag

??SPECIAL

3

FEATURES

Squamous Cell Carcinoma of the Sopraglottic Larynx Without Clinically Detectable Problem of Local Relapse and Influence of Overall Treatment Time C. J. M. Hoekstra, P. C. Levendag and W. L. J. van Putten

Lymph Node Metastases:

I3

Late Radiation Damage in Prostate Cancer Patients Treated by High Dose External Radiotherapy in Relation to Rectal Dose W. G. J. M. Smit, P. A. Helle, W. L. J. van Putten. A. J. Wijnmaalen, J. J. Seldenrath and B. H. P. van der Werf-Messing Dose-Effect

Relation of Interstitial

A. C. C. Ruifrok, P. C. Levendag,

Low-Dose

Rate Radiation (Ir-192)

R. F. Lakeman,

in an Animal Tumor Model

31

I.-K. K. Deurloo and A. G. Visser

Development of Blood Vessel-Related Radiation Damage in the Frimbria of the Central Nervous H. S. Reinhold, W. Calve, J. W. Hopewell and A. P. van den Berg Performance

of Prototype

Flouroscopic

A. G. Visser. H. Huirenga.

Radiotherapy

System

Localized

Unresectable

Imaging System

43

Pancreatic

with a Fiber

51

Cancer

59

M. J. M. van Mierlo and W. L. J. van Putten

The Role of Radiotherapy in the Treatment of Bile Duct Carcinoma B. Veeze-Kuijpers. J. H. Meerwaldt, J. S. Lam&is, M. van Blankenstein, Film Dosimetry

37

V. G. M. Althof and B. N. Swanenburg

Measurement of Tumor pH During Microwave Induced Experimental and Clinical Hyperthermia Optic pH Measurement System S. A. van de Merwe, A. P. van den Berg, J. van der Zee and H. S. Reinhold

A. D. Treurniet-Donker.

of Clinical Electron

23

W. L. J. van Putten and 0. T. Terpstra

63

Beams

L. J. van Battum and H. Huizenga

69

A Ring Capacitor Applicator in Hyperthermia: Energy Distributions in a Fat-Muscle Layered Model for Different Ring Electrode Configurations G. C. van Rhoon, M. J. Sowinski, P. M. van den Berg, A. G. Visserand H. S. Reinhold

77

??ORIGINAL The Prognostic

CONTRIBUTIONS Significance

of Late Local Recurrence

J. M. Kurtz, J.-M. Spitalier. R. Amalric,

H. Brandone,

Effect of Postoperative Radiotherapy on Changes Lang Carcinoma N. C. Choi, D. J. Kanarek and H. C. Grill0

After Breast-Conserving

Y. Ayme. J. Jacquemier,

in Pulmonary

Therapy

D. Hans and C. Bressac

Function in Patients

With Stage

87

II and IIIA

Dose Fractionation and Regeneration in Radiotherapy for Cancer of the Oral Cavity and Oropharynx. Normal Tissue Responses: Acute and Late Effects B. Maciejewski. H. R. Withers, J. M. G. Taylor and A. Hliniak

95 Part 2.

IO1

Carcinoma of the Larynx

in In-Situ

The Role of Radiotherapy

113

P. M. MacLeod and F. Daniel Radiation Therapy for Early Glottic Cancer (TlNOMO):

Field T. Teshima, Aerobic

II. Prospective

Randomized

Study Concerning Radiation 119

M. Chatani and T. lnoue by SR 4233 In Yirro and In Viva

Radiosensitization

E. M. &man.

125

M. J. Lemmon and J. M. Brown

Between In Vitro Radiosensitivity and In Vim Radioresponse of In Vitro Radiosensitivity and Endogenous Cellular Glutathione

Comparison Parameters

of Mutine Levels

Tumor Cell Lines I: 133

R. G. Btistow, P. A. Hardy and R. P. Hill Thermal

Sensitivity

and Thermal

Tolerance

of Human B-Lineage

Acute Lymphoblastic

Leukemia

(ALL) Cells 147

W. S. Min. C. W. Song and F. M. Uckun

0 PHASE I/II STUDIES Retrospective uation

Analysis

of Hypetthetmia

J. U&on. A. K. Mutthy.

0 ONCOLOGY

for Use in the Palliative Treatment

S. G. Taylor IV. F. R. Hendrickson

Eval-

and L. H. Lanzl

I55

INTELLIGENCE

Normal Tissue Reactions and Complications Rates Adjusted for Censoring

T. E. Schultheiss,

of Cancer: A Multi-Modality

Following

High-Energy

Neutron

Beam Therapy

II: Complication

L. Cohen and J. Mansell

I65

??BRIEF COMMUNICATIONS Influence of Radiation Therapy on the Lung-Tissue and Associated Symptoms S. Rotstein. I. Lax and G. Svane

in Breast Cancer Patients:

Can Simulation Measurements be Used Patients Treated for Breast Cancer?

the Irradiated

CT-Assessed

Density

Changes

I73

to Predict

Lung Volume

in the Tangential

Fields

in

B. A. Bornstein, C. W. Cheng, L. M. Rhodes, H. Rashid. P. C. Stomper. R. L. Siddon and J. R. Harris Irradiation

of Prosthetically

J. Halpern.

M. D. McNeese, S. S. Ktoll and N. Ellerbtoek

Spontaneous

Pneumothorax

Augmented

in Patients

Breasts: A Retrospective

Irradiated

Study on Toxicity

and Cosmetic

Results

I89

for Hodgkin’s

Disease

and Other Malignant

Lymphomas

R. D. Pezner, D. A. Horak, H. 0. Sayegh and J. A. Lipsett Interstitial

‘%

Flexible

Catheter

Radiofrequency

0 TECHNICAL

INNOVATIONS

193

Hypetthetmia

Pelvic Carcinomas D. R. Gofiinet. S. D. Ptionas. D. S. Kapp. T. V. Samulski. J. M. Mariscal and M. A. Bagshaw

Treatments

of Head and Neck and Recurrent

P. Fessenden.

G. M. Hahn, A. W. Lohtbach. 199

AND NOTES

Comparison of Different Radiation Types and Irradiation Geometries in Stereotactic M. H. Phillips, K. A. Ftankel. J. T. Lyman, J. I. Fabrikant and R. P. Levy Digital Tumor Fluotoscopy

(DTF)-A

181

New Direct Imaging System in the Therapy

Radiosurger> 21 I Planning for Brain Tumors

M. Herbst and M. Frijdet

221

Spiral Microstrip Hypetthermia Applicators: Technical Design and Clinical Performance T. V. Samulski, P. Fessenden, E. R. Lee, D. S. Kapp, E. Tanabe and A. McEuen

233

Interstitial

Iridium 192 for Cutaneous

J. M. Crook, J. J. Mareton,

Carcinoma

G. Matinello.

of the External

Nose

M. Raynal. J. Huart, S. Leung, J. P. LeBoutgeois

and B. Pietquin

243

Pitfalls in the Use of High Energy X Rays to Treat Tumors in the Lung 249

K. E. Ekstrand and W. H. Barnes

??COMPUTER Testing

APPLICATIONS

a 3-D Radiation Therapy

J. Jacky and C. P. White

Planning Program 253

??EDITORIAL Snpraglottic

Laryngeal

Carcinoma

A. R. Harwood

263

??CORRESPONDENCE Postoperative

Irradiation

for Squamous

Cell Carcinoma

of the Head and Neck

B. Vikram

267

Response to Dr. Vikram J. T. Parsons. W. M. Mendenhall Chemotherapy

and R. J. Amdur

and Brain Tumors:

261

A Reply to Levitt

G. E. Laramore 0

268

MEETINGS

VOLUME

271

18. NUMBER 2

FEBRUARY

TABLE

1990

OF CONTENTS

Editor’s Note

273

P. Rubin 0

ORIGINAL

CONTRIBUTIONS

Thoracic Irradiation in Hodgkin’s Disease: N. J. Tarbell. L. Thompson and P. Mauch The Role of Limited Surgery

Disease

Control and Long-Term

Complications

275

With Irradiation

in Primary Treatment

of Doctal In Situ Breast Cancer

283

A. T. Stotter. M. McNeese, M. J. Oswald. F. C. Ames and M. M. Romsdahl Metastatic

Carcinoma

in the Cervical Lymph Nodes From an Occult Primary: A Conservative

Approach

to the

Role of Radiotherapy

R. G. T. Glynne-Jones.

A. K. Anand, T. E. Young and R. J. Berry

289

Management of Local Residual Primary Lesion of Nasopharyngeal Carcinoma: II. Results of Prospective domized Trial on Booster Dose Y. Jie-hua. X. Guo-zhen. H. Yu-hua. L. Su-yan. L. Yu-zhong, Q. De-xing. W. Xue-lin and G. Xian-zhi Endometrial

Adenocarcinoma,

Adjovant

J. H. Meerwaldt, C. J. M. Hoekstra. Postoperative Vaginal Irradiation Stage I B. G. Sorbe and A.-C. Smeds Bowel Complications

H. Mameghan.

Radiotherapy

Tailored

to Prognostic

Rate Afterloading

and P. C. M. Kope~

Technique

in Endometrial

299

Carcinoma

305

After Radiotherapy

R. Fisher, J. Mameghan.

for Carcinoma

of the Prostate:

The Volume Effect

W. H. Watt and A. Tynan

315

Superiority of Post-Radiotherapy Adjuvant Chemotherapy With CCNU, Over BCNU for Anaplastic Gliomas: NCOG 6G6l Final Report

V. A. Levin, P. Silver. J. Hannigan,

295

Factors

W. L. J. van Putten. A. J. S. Tjokrowardojo With High Dose

Ran-

Procarbazine,

and Vincristine

(PCV)

W. M. Wara. P. H. Gutin, R. L. Davis and C. B. Wilson

Glutathione Depletion and Cytotoxicity of Buthionine Sulphoximine C. C. Ling. R. S. L. Wong and R. D. Basas

and SR2508

321

in Rodent and Human Cells

325

Comparison Between In Vitro Radiosensitivity and In P’ivo Radioresponse in Morine Tumor Cell Lines II: In Vivo Radioresponse Following Fractionated Treatment and In Vitro/fn Viva Correlations

R. G. Bristow and R. P. Hill

331

Tissue Distribution of ‘%Z- and 3H-Labelled L. M. Cobb. J. Nolan and S. Butler Effect of Recombinant Irradiation

Human Granulocyte

Misonidazole

in the Tumor-Bearing

Mouse

347 Colony-Stimulating

M. Fushiki, K. Ono. K. Sasai, Y. Shibamoto.

Factor on Granulocytopenia

K. Tsutsui. T. Nishidai, M. Takahashi

in Mice Induced by

and M. Abe

353

Fraction Size-Dependent Y. Abe and M. Urano

Acute Skin Reaction of Mice After Multiple Twice-A-Day

Doses 359

Radiation Response of Xenografts of a Human Squamous Cell Carcinoma and a Glioblastoma A Progress Report H. D. Suit. A. Zietman, K. Tomkinson. J. Ramsay. L. Gerweck and R. Sedlacek Trimodality Therapy (Drug/Hyperthermia/Radiation) T. S. Herman. B. A. Teicher and S. A. Holden

??PHASE

Multiforme: 365

With BCNU or Mitomycin C 375

I/II STUDIES

Interstitial Thermoradiotherapy: Thermal Dosimetry and Clinical Results D. S. Shimm. J. M. Kittelson, J. R. O&on. S. A. Aristirahal. I.. C. Barlow and T. C. Cetas

3x3

Final Report of the Phase I Trial of the Hypoxic Cell Radiosensitizer SR 2508 (Etanidazole) Radiation Therapy Oncology Group 83-ll3 C. N. Coleman. T. H. Wasserman. R. C. Unasun. J. Halsey. L. Nell, S. Hancock and T. L. Phillips

3x9

??BRIEF

COMMUNICATIONS

Patterns of Second Recurrence of Malignant V. Massey and K. E. Wallner

Astrocytomas 395

CNS Tumor Induction by Radiotherapy: A Report of Four New Cases and Estimate of Dose Required L. W. Gavin, G. V. Dalrymple. E. L. McGuire. A. W. Maners and J. R. Broadwater

399

The Results of Radiotherapy for Orbital Pseudotumor R. Lanciano, B. Fowhle. R. C. Sergott, S. Atlas, P. J. Savino. T. M. Bosley and J. Rubenstein

407

Salivary Gland Tumors of the Oral Cavity L. Tran. J. Sidrys. A. Sadeghi. N. Ellerhroek, D. Hanson and R. G. Parker

413

Radiobiological Advantages of an Immediate Interstitial Boost Dose in Conservative Treatment of Breast Cancer E. C. Krishnan. L. Krishnan. E. P. Cytaki. C. D. Woolf, M. M. Henry. F. Lin and W. R. Jewel1

419

0

TECHNICAL

INNOVATIONS

AND NOTES

An Inverse Problem in Radiation Therapy N. H. Barth

425

The Verification of an Inverse Problem in Radiation Therapy H. M. Kooy and N. H. Barth

433

Radiation Qualities of X-Ray Beams in Cooperative M. Tatcher and A. S. Glicksman

441

Clinical Trials

A CT-Based Computerized Treatment Planning System for 1-125 Stereotactic Brain Implants K. Weaver, V. Smith, J. D. Lewis, B. Lulu, C. M. Barnett, S. A. Leibel, P. Gutin, D. Larson and T. Phillips

445

Influence of Hip Prostheses on High Energy Photon Dose Distributions C. H. Sibata, H. C. Mota, P. D. Higgins, D. Gaisser. J. P. Saxton and K. H. Shin

455

Radiation Dose Perturbation in the Presence of Permanent Vascular-Access F. R. Bagne. H. W. Merrick III, N. Samsami and R. R. Dobelhower Jr.

463

Injection Ports

Shielding Requirements On-Site Loading and Acceptance Testing of the Leksell Gamma Knife A. H. Maitz, L. D. Lunsford. A. Wu, G. Lindner and J. C. Flickinger

0 SPECIAL

469

FEATURE

Present Status on Treatment L. Ding-jiu

of Esophageal

Cancer in China 477

0 EDITORIALS Dilemmas and Decisions S. H. Levitt and C. K. K. Lee

485

The Inverse Problem M. Goitein

489

??CORRESPONDENCE Response to Dilemmas and Decisions N. J. Tarbell and P. Much

493

??MEETINGS

495

??ONCOLIT

VOLUME

Al

18, NUMBER

3

MARCH

TABLE

OF CONTENTS

Editor’s Note P. Rubin 0

1990

497

ORIGINAL

CONTRIBUTIONS

CT Simulator: A New 3-D Planning and Simulating System for Radiotherapy: Part 1. Description of System T. Nishidai, Y. Nagata, M. Takahashi, M. Abe, N. Yamaoka. H. Ishihara. Y. Kubo. H. Ohta and C. Karusa

499

CT Simulator: A New 3-D Planning and Simulating System for Radiotherapy: Part 2. Clinical Application Y. Nagata, T. Nishidai. M. Abe, M. Takahashi. K. Okajima, N. Yamaoka. H. Ishihara, Y. Kubo, H. Ohta and C. Karusa

505

Dose-Response for Local Control With Hyperfractionated Radiation Therapy in Advanced Carcinomas Upper Aerodigestive Tracts: Preliminary Report of Radiation Therapy Oncology Group Protocol 83-13

J. D. Cox, T. F. Pajak. V. A. Marcial, G. E. Hanks, M. Mohiuddin,

of the

K. K. Fu, R. W. Byhardt and P. Rubin

515

Accelerated Fractionation Radiation Therapy for Liver Metastases: Selection of an Optimal Patient Population for the Evaluation of Late Hepatic Injury in RTOG Studies S. A. Leibel. C. Guse. S. E. Order, F. R. Hendrickson, R. U. Komaki, C. H. Chang, L. W. Brady, T. H.

Wasserman. Radiation

523

K. J. Russell. S. 0. Asbell, T. L. Phillips, A. H. Russell and T. F. Pajak

Therapy

of Invasive

A. Arakawa, T. Yasunaga. Fibromatoses:

Thymoma

Y. Saitoh, H. Uozumi, C. Takada, Y. Baba, K. Yoshizumi

From Postsurgical

Surveillance

R. Miralbell, H. D. Suit, H. J. Mankin. Pineal Region Germinomas

in Childhood

D. Jenkin, M. Berry, H. Chan, S. Weitrman Effect of Normobaric

to Combined

L. R. Zuckerberg, Treatment

M. Greenberg,

Surgery and Radiation

and M. Takahashi

Therapy 535

M. A. Stracher and A. E. Rosenberg

Considerations

B. Hendrick,

H. Hoffman,

R. Humphreys,

M. Sonley and 541

Oxygen on Tumor Radiosensitivity:

Fractionated

Studies

A. Rojas, U. Carl and K. Reghebi

547

Tumor Necrosis Factor as an Adjunct to Fractionated 1. Nishiguchi, V. Willingham and L. Milas Heterogeneity

in Tumor Microvascular

Response

Radiotherapy

in the Treatment

555

T. Secomb and J. F. Gross

The Response of Two Human Tumor Xenografts to Fractionated Irradiation. Growth Delay, Tumor Control, and In Vitro Cell Survival Assays

H. D. Suit, K. N. Tomkinson,

of Murine Tumors

to Radiation

M. W. Dewhirst, R. Oliver, C. Y. Tso, C. Gustafson,

A. L. Zietman,

The Derivation

559 of a/j3 Ratios From

H. D. Thames and R. S. Sedlacek

Computerized Tomography Versus Perfusion Lung Scanning in Canine Radiation Lung Injury 1. H. Ahmed, J. W. Logus, E. El-Khatib, J. J. Battista, H. Ferri, B. C. Lentle, G. C. W. Man and S. F. P. Man Radiosensitization

529

of Two Murine Fihrosarcomas

569

577

With 6-Thioguanine

J. H. Kim, A. A. Alfieri, S. H. Kim and S. S. Hong

583

Pathophysiological Changes After Local Heating of Rat Liver M. Uda, J. L. Osborn, C. K. K. Lee, R. E. Nakhleh and C. W. Song

587

Thermal

Enhancement

H. B. Stone

of Radiation-Induced

Leg Contracture

595

0 BRIEF COMMUNICATIONS Local Hyperthermia and Radiation Therapy in the Retreatment of Superficially Disease 1. A. Petersen and D. S. Kapp

Located Recurrences in Hodgkin’s 603

Prevention of Hypothyroidism Related to Mantle Irradiation for Hodgkin’s Disease: Preparative V. A. Mar&&Vega, S. E. Order, G. Lastner. P. D. Cole, N. LaFrance and M. O’Neill

Phantom Study

Tolerance of the Liver to the Effects of Yttrium-90 Radiation B. N. Gray. M. A. Burton. D. Kelleher, P. Klemp and L. Matz Twice-Daily Anesthesia in Infants Receiving Hyperfradionsted L. Menache. P. J. Eifel. D. L. Kennamer and J. A. Belli

613

619 Irradiation 625

The Results of Radiotherapy of Cancer of the Middle Ear S. Korreniowski and J. Pszon

631

Carotid Thrombosis Following Neck Irradiation G. K. Call. P. F. Bray. W. R. K. Smoker. S. S. Buys and J. K. Hayes

635

??TECHNICAL

INNOVATIONS

AND NOTES

A Digital Fluoroscopic Imaging Device for Radiotherapy P. Munro. J. A. Rawlinson and A. Fenster Computation of Digitally Reconstructed Radiographs G. W. Sherouse. K. Novins and E. L. Chaney

Localization 641

for Use in Radiotherapy

Treatment

Design 651

Development of Total-Skin Electron Therapy at Two Energies R. S. Cox. R. J. Heck, P. Fessenden. C. J. Karzmark and D. C. Rust Analysis of Movement of lntrathoracic Neoplasms Using Ultrafast Computerized C. S. Ross, D. H. Hussey. E. C. Pennington. W. Stanford and J. F. Doornbos

0 COMPUTER

659 Tomography

APPLICATIONS

An Interactive Treatment Planning System for Ophthalmic Plaque Radiotherapy M. A. Astrahan, G. Luxton. G. Jozsef, T. D. Kampp, P. E. Liggett, M. D. Sapozink and Z. Petrovich

??SPECIAL

671

679

FEATURES

The “Recall Effect” in Radiotherapy: Is Subeffective, Reparable Damage Involved? H. Kitani, T. Kosaka. T. Fujihara. K. Lindquist and M. M. Elkind

689

Regulation, Coverage, and Reimbursement W. T. McGivney and W. R. Hendee

697

of Medical Technologies

??EDITORIALS Evaluation of New Radiation Oncology Technology A. R. Smith

701

On the Definition of Local Control J. T. Parsons. P. J. McCarty, P. V. Rao. W. M. Mendenhall

and R. R. Million

Are Cancer Researchers Speaking the Same Language? T. F. Pajak and C. E. Guse 0

707

CORRESPONDENCE

Response to Goitein A. M. Cormack Preoperative Irradiation in Endometrial M. F. Schray and G. D. Malkasian

709 Carcinoma:

A Reassessment? 709

Rebuttal J. M. Vaeth Low Dose, Continuous Infusion 5-Fluorouracil Plus Radiotherapy T. A. Rich. L. Hughes, J. A. Ajani and W. Brock 0

705

MEETINGS

709 for Anal Cancer 710 711

VOLUME

18, NUMBER 4

APRIL 1990

TABLE OF CONTENTS

??DEDICA TION Inaugural

Address:

The Past is the Prologue for the Future

P. Rubin

715

??SPECIAL

FEATURES

The Treatment and Long-Term Prognosis 1950-1981 H. J. G. Bloom. J. Glees and J. Bell Long-Term

Psychological

L. Jannoun

and H. J. G. Bloom

of Children

Intracranial

Tumors:

A Study

of 610 Cases,

723

Effects in Children Treated for Intracranial

Tumors

747

The Role of Radiotherapy in the Management Experience With 186 Patients

J. Glaholm,

With

of Intracranial

Meningiomas:

The Royal Marsden

Hospital

H. J. G. Bloom and J. H. Crow

Medulloblastoma

in Adults:

755

A Review of 47 Patients

Treated

Between

1952 and 1981

763

H. J. G. Bloom and E. M. Bessell Pineal and CNS Germ Cell Tumors:

D. P. Dearnaley,

Royal Marsden

R. P. A’Hern, S. Whittaker

Low Grade Glioma

of the Cerebral

Hospital

Experience

1962-1987

773

and H. J. G. Bloom

Hemispheres

in Adults:

A Retrospective

Analysis

of 88 Cases

783

A. C. Whitton and H. J. G. Bloom Management of Primary Cerebral Lymphoma With Initial Chemotherapy: With Patients Treated With Radiotherapy Alone

M. Brada, D. Dearnaley,

Preliminary

Results and Comparison

787

A. Horwich and H. J. G. Bloom

Radiotherapy for High Grade Gliomas G. E. Sheline

793

Key Problems in the Management of Children With Brain Tumors G. J. D’Angio, L. B. Rorke, R. Packer, L. Sutton and R. Zimmerman

805

Studies on High Grade Cerebral N. M. Bleehen

81 I

??ORIGINAL Childhood

Gliomas

CONTRIBUTIONS

Cerebellar

Astrocytomas:

Is There a Role for Postoperative

Irradiation?

D. M. Garcia, J. E. Marks, H. R. Latifi and A. B. Kliefoth Radiation

Therapy

for Head and Neck Cancers

815

in the Elderly

A. Lusinchi, J. Bourhis, P. Wibault, A. M. Le Ridant and F. Eschwege Locally Advanced

J. Halpern,

Breast Cancer Treated

With Neutron

819

Beams:

M. H. Maor, D. H. Hussey, G. C. Henkelmann,

Long-Term Follow-Up in 28 Patients V. Sampiere and M. D. McNeese

825

The Role of Kilovoltage Irradiation in the Treatment of Keloids J. F. Doornbos, T. J. Stoffel, A. C. Hass, D. H. Hussey, A. P. Vigliotti, B-C. Wen, M. K. Zahra and V. Sundeen The Prevalence

and Severity

of Late Effects in Normal

L. Poulakos. J. H. Elwell, J. W. Osborne, R. W. Summers

Rat Duodenum

L. F. Urdaneta,

Following

M. Hauer-Jensen,

lntraoperative

Irradiation

A. P. Vigliotti. D. H. Hussey and 841

The Role of the H-ras Oncogene in Radiation Resistance and Metastasis W. G. McKenna, M. C. Weiss, V. J. Bakanauskas, H. Sandier, M. L. Kelsten, J. Biaglow. S. W. Tuttle, B. Endlich. C. C. Ling and R. J. Muschel The Use of Postoperative Irradiation for the Prevention of Heterotopic Biologic Fixation (Porous Coated) Prosthesis: An Animal Model

A. Konski. C. Weiss, R. Rosier, C. Poulter, V. Pelligrini, P. Anthony, M. Henzler and P. Rubin

833

Bone After Total Hip Replacement

C. McCollister

849

With

Evarts, M. Richardson, 861

Fractionation Sensitivity and Immunological Status in Radiation Treated Murine Sarcomas R. Miralbell, A. Zietman, P. Okunieff, H. D. Thames and H. D. Suit

867

Enhancement of Radiation Damage in Cellular DNA Following Unifilar Substitution A. J. Fornace Jr., P. P. Dobson and T. J. Kinsella

873

With Iododeoxyuridine

Radiobiology of the Rhabdomyosarcoma RIH of the Rat: Influence of the Size of Irradiation Response, Tumor Bed Effect, and Neovascularization Kinetics F. Wiirschmidt. H.-P. Beck-Bornholdt and H. Vogler

Field on Tumor 879

Radiotherapy of the Rhabdomyosarcoma RlH of the Rat: Postoperative Radiotherapy U. M. Carl, H.-P. Beck-Bornholdt. M. Baumann. J. Lorenzen and H. Vogler

883

Large Scale Optimization of Beam Weights Under Dose-Volume Restrictions M. Langer, R. Brown. M. Uric J. Leong. M. Stracher and J. Shapiro

887

Evaluation and Optimization of the Electromagnetic M. F. Iskander. A. M. Tumeh and C. M. Furse

Performance

of Interstitial

Antennas for Hyperthermia 895

Changes in Human Skin Blood Flow by Hyperthermia C. W. Song. L. M. Chelstrom and D. J. Haumschild

??PHASE i/Ii CLINICAL

903

TRIALS

Adjunctive Therapy (Whole Body Hyperthermia Versus Lonidamine) to Total Body Irradiation for the Treatment of Favorable B-Cell Neoplasms: A Report of Two Pilot Clinical Trials and Laboratory Investigations H. I. Robins. W. 1. Longo. R. A. Steeves, J. D. Cohen. C. L. Schmitt, A. J. Neville, S. O’Keefc, R. Lagoni and C. Riggs

0 BRIEF

909

COMMUNICATIONS

Persisting Cyclical Uterine Bleeding in Patients Treated With Radical Radiation placement for Carcinoma of the Cervix M. J. McKay. C. A. Bull, C. R. Houghton and A. 0. Langlands

Therapy

and Hormonal

Re921

Radiation Therapy for Gliomas of the Optic Nerve and Chiasm J. J. Kovalic. P. W. Grigsby. M. J. Shepard, B. B. Fineberg and P. R. Thomas

927

Effects of pH on Heat Sensitization of Mammalian X. Li, Z. Wang, G. L. Chu and W. C. Dewey

933

0

TECHNICAL

INNOVATIONS

Cells With Procaine Hydrochloride

AND NOTES

Treatment Planning for Protocol-Based Radiation Therapy P. Hahn. S. Shalev. D. Viggars and P. Therrien

937

Physics of Gamma Knife Approach on Convergent Beams in Stereotactic Radiosurgery A. Wu. G. Lindner, A. H. Maitz, A. M. Kalend. 1. D. Lunsford, J. C. Flickinger and W. D. Bloomer

941

Treatment Planning of Template-Guided Stereotaxic B. A. Lulu, W. Lutz, B. Stea and T. C. Cetas

951

Brain Implants

An Interactive System for Point Dose Optimization G. Starkschall, G. C. Henkelmann and K. K. Ang

957

Dosimetric Analysis in Brachytherapy of Carcinoma of the Cervix 1. Krishnan, E. P. Cytacki. C. D. Wolf. E. K. Reddy, L. S. Gemer, P. G. S. Giri, S. R. Smalley and R. G. Evans

965

0

EDITORIAL

Management of Childhood Cerebellar Astrocytoma D. A. Larson. W. M. Wara and M. S. B. Edwards

971

??CORRESPONDENCE Volume Effects R. J. Yaes

975

Response to Letter by Dr. Yaes G. J. Kutcher, C. Burman and J. Lyman

975

??MEETINGS

977

0 ONCOLIT

Al

VOLUME

18, NUMBER

MAY

5

TABLE Editor’s

OF CONTENTS

Note

P. Rubin 0

1990

979

ASTRO

SPECIAL

Presidential S. E. Order

Address:

FEATURES

Systemic

Radiotherapy-The

New Frontier

981

Radiation-Induced R. G. Parker

Cancer as a Factor in Clinical

0

CONTRIBUTIONS

Making

(The 1989 ASTRO

Gold Medal Address)

993

ORIGINAL

Aneurysm,

Decision

Arachnoiditis

and Intrathecal

AU (Gold)

D. M. Pence, T. H. Kim and S. H. Levitt Enteric Morbidity

of Postoperative

1001

Pelvic External

Beam and Brachytherapy

for Uterine Cancer

R. A. Potish and K. E. Dusenbery

1005

Analysis of Preoperative Intracavitary Stage I Endometrial Carcinoma

Cesium

Application

W. T. Sause, D. B. Fuller, W. G. Smith, G. H. Johnson. Reduction

of Spinal Metastases

1. D. Kaplan,

After Preemptive

Versus

Postoperative

External

Beam

Radiation

in

H. P. Plenk and R. B. Menlove

Irradiation

in Prostatic

101 I

Cancer 1019

R. Valdagni, R. S. Cox and M. A. Bagshaw

A Randomized

Study of the Efficacy of Adjuvant

J. R. Torrisi, A. Dritschilo,

Local Graft Irradiation

Following

Renal Transplantation

K. W. Hatter, B. Helfiich, C. D. Berg, G. Whitfield, D. Stablein and M. Alijani

Monoclonal Antibody 17-1A Treatment A Comparison of ‘3’I-Labeled Growth of LS174T Human Colon Carcinoma Xenografts

to External

D. J. Buchsbaum, R. K. Ten Haken, D. B. Heidorn, Guilbault, Z. Steplewski and A. S. Lichter

A. A. Glatfelter,

T. S. Lawrence,

Beam

Irradiation

V. H. Terry. D. M. 1033

Chemosensitization of the Nitrosoureas by 2-Nitroimidazoles cokinetic and Structure-Activity Considerations

in the Subcutaneous

9L Tumor

Model:

Pharma-

104 3

K.-H. Wang, C. A. Wallen and K. T. Wheeler An Animal

Model of Prophylactic

M. Mildenberger, Evaluation

of Cell Subpopulations

Combined

Modality

M. L. Patchen,

Irradiation:

Histologic

Effects at Acute, Early and Delayed

Stages

T. G. Beach, E. G. McGeer and C. M. Ludgate

P. C. Keng, J. Allalunis-Turner

Radiation

Cranial Isolated

From Human

105

Tumor Xenografts

by Centrifugal

Elutriation

and D. W. Siemann

Radioprotection:

106

The Use of Glucan and Selenium

With WR-2721

T. J. MacVittie and J. F. Weiss

Effect in Mouse

R. Gorodetsky,

1069

Skin: Dose Fractionation

and Wound Healing

X. Mou, D. R. Fisher, J. M. G. Taylor and H. R. Withers

Gamma-Irradiation

Response of Cocultivated

IO27

on the

1077

Bone Marrow Stromal Cell Lines of Differing

Intrinsic

Radiosen-

sitivity

M. A. Santucci, T. J. FitzGerald, and J. S. Greenberger

K. Harigaya,

B. Woda, M. A. Sakakeeny,

P. Anklesaria,

K. Kase, C. A. Holland 1083

Fractionation Effects and Repair Kinetics in Rat Kidney E. van Rongen, W. C. Kuijpers and H. T. Madhuizen Physiologic

Consequences

of Local Heart Irradiation

B. J. Geist, S. Lauk, M. Bornhausen Combination

of Radiation

Therapy

1093

in Rats

and K.-R. Trott and Intracranial

1107 Bleomycin

in the 9L Rat Brain Tumor Model

B. F. Kimler, D. F. Martin, R. G. Evans, R. A. Morantz and T. S. Vats Tumor Control

in Long-Term

Survivors

Following

Superficial

R. J. Myerson, C. A. Perez, B. Emami, W. Straubc.

??PHASE I/II CLINICAL Treatment of Advanced rouracil Infusion

M. Rotman,

Transitional

H. Aziz, M. Porrazzo,

Randomized Trial Comparing A Preliminary Report

1115

Hyperthermia

R. R. Kuske, L. Leybovich and D. Von Gerichten

1123

TRIALS Cell Carcinoma

of the Bladder

With Irradiation

K. N. Choi, M. Silverstein, J. Rosenthal.

Single Dose Versus

A. Konski, V. Pellegrini, C. Poulter, J. DeVanny,

Fractionated

Irradiation

and Concomitant

G. Laungani for Prevention

5-Fluo-

and R. Macchia of Heterotopic

1131

Bone:

R. Rosier, C. McCollister Evarts, M. Henzler and P. Rubin

1139

Intraoperative Radiation Therapy Combined With External Irradiation in Nonresectable Non-Small-Cell Cancer: Preliminary Report F. M. Juettner, K. Arian-Schad, G. Porsch, H. Leitner, J. Smolle, F. Ebner, A. Hack1 and G. Friehs

Lung

Abnormal Clinical Pharmacokinetics of the Developmental Radiosensitizers Pimonidazole (Ro 03-8799) and Etanidazole (SR 2508) T. S. Maughan, H. F. V. Newman, N. M. Bleehen. R. Ward and P. Workman 0

BRIEF

143

I51

COMMUNICATIONS

Combined Modality Therapy of Extrahepatic Biliary System Cancer B. D. Minsky, M. F. Wesson, J. G. Armstrong, N. Kemeny, B. Reichman,

J. Botet and D. Nori

Radiotherapeutic Considerations in the Treatment of Hemangioblastomas of the Central Nervous System S. R. Smalley, P. J. Schomberg, J. D. Earle, E. R. Laws Jr.. B. W. Scheithauer and J. R. O’Fallon

??TECHNICAL

INNOVATIONS

1157 1165

AND NOTES

First Clinical Experience With a Newly Developed Electronic Portal Imaging Device H. Meertens, M. van Herk. J. Bijhold and H. Bartelink

I173

Gapping Fields on Sloping Surfaces R. Keys and P. W. Grigsby

1183

Dose Calculation and Measurements for a CT Compatible Version of the Fletcher Applicator K. J. Weeks and J. C. Dennett

1191

Measurement of Dose Rate From Exposure-Calibrated “s1 Seeds G. Luxton. M. A. Astrahan. D. 0. Findley and 2. Petrovich

1199

A Thin I-125 Seed Eye Plaque to Treat Intraocular Tumors Using an Acrylic Insert to Precisely Position the Sources C. Karolis, R. B. Frost and F. A. Billson

1209

Shielding Considerations for an Operating Room Based lntraoperative Electron Radiotherapy Unit M. D. Mills, P. R. Almond, A. L. Boyer, T. G. Ochran, W. Mad&an. T. A. Rich and E. B. Dally

215

Design of Metallic Electron Beam Cones for an lntraoperative Therapy Linear Accelerator K. R. Hogstrom, A. L. Boyer, A. S. Shiu, T. G. Ochran, S. M. Kirsner, F. Krispel and T. Rich

223

A Technique for Delivery of Total Body Irradiation for Bone Marrow Transplantation in Adults and Adolescents J. C. Breneman, H. R. Elson, R. Little, M. Lamba, A. E. Foster and B. S. Aron

1233

Selection of Techniques for Orthovoltage Radiation Therapy E. C. McCullough

I 137

The Source-Skin Distance Measuring Bridge: A Method to Avoid Radiation Teleangiectasia Interstitial Therapy for Breast Cancer E. Van Limbergen, E. Briot and M. Drijkoningen 0

SPECIAL

in the Skin After 1239

FEATURES

Training in Academic Radiation Oncology in the U.S.: A Report to the Inter Society Council for Radiation Oncology R. G. Parker

1245

RTOG Quality Assurance Guidelines for Clinical Trials Using Hyperthermia M. W. Dewhirst, T. L. Phillips, T. V. Samulski, P. Stauffer, P. Shrivastava. B. Paliwal, T. Pajak, M. Gillim, M. Sapozink, R. Myerson, F. M. Waterman, S. A. Sapareto, P. Carry, T. C. Cetas. D. B. Leeper, P. Fessenden. D. Kapp, J. R. Oleson and B. Emami

I249

??ONCOLOGY

INTELLIGENCE

Radiobiological Aspects of Low Dose Rates in Radioimmunotherapy J. F. Fowler

1261

??EDITORIAL Stage 1 Endometrial Carcinoma: The Importance of Pathologic Review in Retrospective Analyses P. J. Eifel and M. Hendrickson

1271

??CORRESPONDENCE Effect of Dose Rate on Local Control and Necrosis in the Reirradiation of Faucial Arch Squamous Cell Carcinomas With Interstitial Iridium 192 J. J. Mazeron and J. M. Crook

1275

Surgery Versus Brachytherapy Complications J. G. Wierzbicki, P. Patel, R. J. Yaes and Y. Maruyama

1275

Response to Mazeron and Wierzbicki J. Fontanesi

1277

0

MEETINGS

1279

VOLUME

18, NUMBER 6

JUNE 1990

TABLE

OF CONTENTS

Editor’s Note P. Rubin

0

1281

ORIGINAL

CONTRIBUTIONS

Cellular Radiosensitivity of Primary Head and Neck Squamous Cell Carcinomas W. A. Brock, F. L. Baker, J. L. Wike, S. L. Sivon and L. J. Peters

and Local Tumor Control

I283

Primary Radiotherapy in the Treatment of Stage I and II Oral Tongue Cancers: Importance of the Proportion of Therapy Delivered With Interstitial Therapy C. D. Wendt, L. J. Peters, L. Del&s, K. K. Ang, W. H. Morrison, M. H. Maor, K. T. Robbins. R. M. Byers.

L. S. Carlson and M. J. Oswald Is Interstitial

Implantation

I287

Essential

for Successful

R. L. Foote, J. T. Parsons, W. M. Mendenhall. Iridium-192

Curietherapy

J. J. Mazeron, L. Grimard. Bourgeois and B. Pierquin Primary Radiotherapy 1963 to 1985

L. V. Johansen,

Radiotherapeutic

for TI and T2 Epidermoid

M. Raynal. E. Haddad,

of Base of Tongue Carcinoma?

1293

Carcinomas

of the Floor of Mouth

P. Piedbois. M. Martin, G. Marinello.

R. C. Nair, J. P. Le I299

of TI Squamous

J. Overgaard,

Treatment

R. R. Million, N. J. Cassisi and S. P. Stringer

Cell Carcinoma

M. Hjelm-Hansen

of the Larynx: Analysis

of 478 Patients Treated

From

I307

and C. C. Gadeberg

Relation Between Responses to Induction Chemotherapy and Subsequent centric Squamous Cell Carcinomas of the Head and Neck X. Panis, P. Coninx, T. D. Nguyen and M. Legros Carcinoma of the Major Salivary Glands Treated by Surgery or Surgery C. A. North, D.-J. Lee, S. Piantadosi. M. Zahurak and M. E. Johns

Radiotherapy

in Advanced

or Multi1315

Plus Postoperative

Radiotherapy

1319

The Risk of Second Cancer (SC) in Padents Treated for Testicular Seminoma A. Hellbardt, R.-O. Mirimanoff, M. Obradovic. B. Mermillod and J.-P. Paunier

1327

The Radiation Therapy of Early Stage Cutaneous T-Cell Lymphoma B. Micaily, C. Moser, E. C. Vonderheid, C. Koprowski, D. Lightfoot,

1333

Correlations Between In Vivo “P NMR Spectroscopy Survival After Radiotherapy

K. K. Fu. M. F. Wendland, Radiotherapy

Measurements,

A. Markoe and L. Brady Tumor Size, Hypoxic

Fraction and Cell

1341

S. B. Iyer, K. N. Lam, H. Engeseth and T. L. James

Prior to Cortical Allograft

Limb Sparing

in Dogs With Osteosarcoma:

A Dose Response

Assay

D. E. Thrall, S. J. Withrow, B. E. Powers, R. C. Straw. R. L. Page, G. L. Heidner, D. C. Richardson, K. W. Bissonnette, C. W. Betls, D. J. DeYoung, R. H. Wrigley, D. A. Sim, S. L. Richter, S. M. LaRue and E. L. Gillette

I35 I

Interaction Between Flavone Acetic Acid (LM-975, NSC 349512) and Radiation in Glasgow’s Osteogenic In Vivo W. De Neve, J. Evelhoch, C. Everett, N. Simpson, M.-C. Bisscry, T. Corbett and F. Valeriote

1359

Targeting

of Human Glioma Xenografts

In Viva Utilizing Radiolabeled Antibodies S. E. Order, P. M. Wanek, J. K. Poggenburg

J. A. Williams, B. W. Wessels, M. D. Wharam,

Enhanced IUdR Radiosensitization by “‘Am Photons R. Nath, P. Bongiorni, P. 1. Rossi and S. Rockwell 16,16-Dimethyl Prostaglandin E2 and/or Syngeneic After Supra-Lethal Total Body Irradiation L. B. Berk. K. D. Patrene and S. S. Boggs The Dependence posure

T. S. Lawrence, Long-Term

of Halogenated

Pyrimidine

M. A. Davis, J. Maybaum,

Recovery

and Reirradiation

F. A. Stewart. Y. Oussoren and A. Luts

Relative to **6Ra and ‘*‘I Photons

and J. L. Klein

1367

at 0.72 Gy/hr

1377 Bone Marrow

Incorporation

Transplantation

of Mouse

Increase

Mouse

Survival 1387

and Radiosensitization

P. L. Stetson and W. D. Ensminger

Tolerance

Sarcoma

on the Duration of Drug Ex-

I393

Bladder

1399

The Relative Biological Effectiveness of Photon Radiation From Encapsulated Human Origin: 1. Normal Diploid Fibroblasts M. J. Marchese. P. E. Goldhagen. M. Zaider. D. J. Brenner and E. J. Hall

Iodine-125, Assessed in Cells of 1407

Combination Therapy of Pions and SPG (Sonifilan, Schizophyllan), A Biological Response Modifier for Mouse Tumor Systems Y. Ogawa, G. B. Goodman, D. J. Chaplin. W. Grulkey and G. K. Y. Lam

1415

Boron Neutron Capture Enhancement of “*Cf Brachytherapy J. L. Beach. C. B. Schroy. M. Ashtari, M. R. Harris and Y. Maruyama

1421

Relationship of Changes in pH and Energy Status to Hypoxic Cell Fraction and Hyperthermia J. A. Koutcher. D. Barnett, A. B. Kornblith. D. Cowburn, T. J. Brady and L. E. Gerweck 0

Sensitivity 1429

BRIEF COMMUNICATIONS

The Reduction of Radiation Damage to the Spinal Cord by Post-Irradiation S. Hornsey. R. Myers and T. Jenkinson Intermediate Dose Rate Remote Afterloading Brachytherapy B. Speiser and L. Spratling

for lntraluminal

INNOVATIONS

of Vasoactive Drugs 1437

Control of Bronchogenic Carcinoma 1443

Endobronchial Radiation Therapy (EBRT) in the Management M. Roach III. E. M. Leidholdt Jr.. B. S. Tatera and J. Joseph

??TECHNICAL

Administration

of Lung Cancer 1449

AND NOTES

Portal Dose Images 1: Quantitative Treatment Plan Verification J. W. Wong. E. D. Slessinger. R. E. Hermes, C. J. Offutt, T. Roy and M. W. Vannier

1455

Portal Dose Images II: Patient Dose Estimation X. Ying, L. Y. Geer and J. W. Wong

1465

On-Line Radiotherapy Imaging With an Array of Fiber-Optic Image Reducers J. W. Wang. W. R. Binns. A. Y. Cheng, L. Y. Geer. J. W. Epstein, J. Klarmann Full Integration of the Beam’s Eye View Concept Into Computerized D. L. McShan. B. A. Fraass and A. S. Lichter

Treatment

and J. A. Purdy

1477

Planning 1485

Treatment Planning for Gamma Knife Radiosurgery With Multiple lsocenters J. C. Flickinger. L. D. Lunsford. A. Wu, A. H. Maitr and A. M. Kalend

1495

Design of an Afterloading Vaginal Applicator C. A. Perez. E. Slessinger and P. W. Grigsby

I503

Applicator for Use of Cesium-I37 Miniaturized P. P. Kumar. R. R. Good and G. F. McCaul The Effect of Applicator R. A. Polish

(MIRALVA)

Tube Sources in the Treatment

of Uterine Cervix Cancer I509

Geometry on Dose Specification

in Cervical Cancer 1513

Physical Aspects of External Beam Radiotherapy for the Treatment M. Soubra. P. B. Dunscombe, D. 1. Hodson and G. Wong

of Malignant

Pleural Mesothelioma 1521

??EDITORIALS How Essential is Interstitial C. C. Wang

Radiation Therapy to Curability

of Head and Neck Cancer? 1529

Unnecessary Irradiation of the Normal Larynx W. M. Mendenhall, J. T. Parsons and R. R. Milhon

0

1531

CORRESPONDENCE

Reply to Dr. Wang’s Editorial C. D. Wendt

1535

Keeping the Arytenoid Dose Low C. C. Wang

1535

Critique of “Stereotactic Radiosurgery for Intracranial Accelerator” M. Wollin, A. Kuruvilla. A. R. Kagan and A. Olch Response to Wollin ef al. J. S. Loeffler and E. Alexander

111

Arteriovenous

Malformations

Using a Standard

Linear 1535

1536

AUTHOR INDEX Volume 18, 1990 Abe, M., 353,499, 505 Abe, Y., 359 A’Hem, RX, 773 Ahmed, I.H., 577 Ajani, J.A., 710 Alexander III, E., 1535 Altieri, A.A., 583 Alijani, M., 1027 Allahmis-lamer, J., 1061 Almond, P.R., 1215 Althof, V.G.M., 43 Amalric, R., 87 Amdur, R.J., 267 Ames, EC., 283 Anand, A.K., 289 Ang, K.K., 957, 1287 Anklesaria, P, 1083 Anthony, P., 861 Arakawa, A., 529 Aria&Chad, K., 1143 Aristizabal, S.A., 383 Armstrong, J.G., 1157 Aron, B.S., 1233 Asbell, SO., 523 Ashtari, M., 1421 Astrahan, M.A., 679, 1199 Atlas, S., 4067 Ayme, Y., 87 Aziz, H., 1131 Baba, Y., 529 Bagne, F.R., 463 Bagshaw, M.A.. 199, 1019 Bakanauskas, V.J., 849 Baker, FL., 1283 Barlow, L.C., 383 Barnes, W.H., 249 Bamett, CM., 445 Bamett, D., 1429 Bartelink, H., 1173 Barth, N.H., 425, 433 Basas, R.D., 325 Battista, J.J., 577 Baumann, M., 883 Beach, J.L., 1421 Beach, T.G., 1051 Beck-Bomholdt, H.-P., 879, 883 Bell, J., 723 Belli, J.A., 625 Berg, C.D., 1027 Berk, L.B., 1387 Berry, M., 541 Berry, R.J., 289 Bessell, E.M., 763 Betts, C.W., 1351 B&low, J., 849 Bijhold, J., 1173 Billson, EA., 1209 Binns, W.R., 1477 Bissery, M.-C., 1359 Bissonnette, K.W., 1351 Bleehen, NM., 811, 1151

Bloom, H.J.G., 723, 747, 755, 763, 773, 783, 787 Bloomer, W.D., 941 Boggs, S.S., 1387 Bongiomi, P., 1377 Bomhausen, M., 1107 Bomstein, B.A., 181 Bosley, T.M., 407 Botet, J., 1157 Bourhis, J., 819 Boyer, A.L., 1215, 1223 Brada, M., 787 Brady, L.W., 523, 1333 Brady, T.J., 1429 Brandone, H., 87 Bray, PF., 635 Breneman, J.C., 1233 Brenner, D.J., 1407 Bressac, C., 87 Briot, E., 1239 Bristow, R.G., 133, 331 Broadwater, J.R., 399 Brock, W., 710, 1283 Brown, J.M., 125 Brown, R., 887 Buchsbaum, D.J., 1033 Bull, CA., 921 Burman, C., 975 Burton, M.A., 619 Butler, S., 347 Buys, S.S., 635 Byers, R.M., 1287 Byhardt, R.W., 515 Call, G.K., 635 calve, w., 37 Carl, u., 547 Carl, U.M., 883 Carlson, L.S., 1287 Cassisi, N.J., 1293 Cavin, L.W., 399 Cetas, T.C., 383, 951, 1249 Chan, H., 541 Chaney, E.L., 651 Chang, C.H., 523 Chaplin, D.J., 1415 Chatani, M., 119 Chelstrom, L.M., 903 Cheng, A.Y., 1477 Cheng, C.W., 181 Choi, K.N., 1131 Choi, N.C., 95 Chu, G.L., 933 Cobb, L.M., 347 Cohen, J.D., 909 Cohen, L., 165 Cole, P.D., 613 Coleman, C.N., 389 Coninx, P., 1315 Corbett, T., 1359 Cormack, A.M., 709 Cony, P., 1249

Cowbum, D., 1429 Cox, J.D., 515 Cox, R.S.. 659, 1019 Crook, J.M., 243, 1275 Crow, J.H., 755 Cytacki, E.P., 419, %5 D’Angio, G.J., 805 Dally, E.B., 1215 Dahymple, G.V., 399 Daniel, F., 113 Davis, M.A., 1393 Davis, R.L., 321 De Neve, W., 1359 De-xing, Q., 295 DeVanny, J., 1139 DeYoung, D.J., 1351 Deamaley, D.P., 773,787 Delclos, L., 1287 Dennett, J.C., 1191 Deurloo, I.-K.K., 31 Dewey, W.C., 933 Dewhirst, M.W., 559, 1249 Ding-jiu, L., 477 Dobelbower Jr., R.R., 463 Dobson, PP., 873 Doombos, J.F., 671, 833 Drijkoningen, M., 1239 Dritschilo, A., 1027 Dunscombe, P.B., 1521 Dusenbery, K.E., 1005 Earle, J.D., 1165 Ebner, E, 1143 Edwards, M.S.B., 971 Eifel, P.J., 625, 1271 Ekstrand, K.E., 249 El-Khatib, E., 577 Elkind, M.M., 689 Ellerbroek, N., 189,413 Ellis, F., 3 Elson, H.R., 1233 Elwell, J.H., 841 Emami, B., 1123, 1249 Endlich, B., 849 Engeseth, H., 1341 Ensminger, W.D., 1393 Epstein, J.W., 1477 Eschwege, E, 819 Evans, R.G., %5, 1115 Evelhoch, J., 1359 Everett, C., 1359 Fabrikant, J.I., 211 Fenster, A., 641 Ferri. H., 577 Fessenden, P., 199, 233, 659, 1249 Findley, D.O., 1199 Fineberg, B.B., 927 Fisher, D.R., 1077 Fisher, R., 315 FitzGerald, T.J., 1083

Flickinger, J.C., 469,941, Fontanesi, J., 1277 Foote, R.L., 1293 Fomace Jr., A. J., 873 Foster, A.E., 1233 Fowble, B., 407 Fowler, J.F., 1261 Frankel, K.A., 211 Friehs, G., 1143 Froder, M., 22 1 Frost, R.B., 1209 Fu, K.K., 515, 1341 Fujihara, T., 689 Fuller, D.B., 1011 Fume, CM., 895 Fushiki, M., 353

1495

Gadeberg, C.C., 1307 Gaisser, D., 455 Garcia, D.M., 815 Geer, L.Y., 1465, 1477 Geist, B.J., 1107 Gemer, L.S., %5 Gerweck, L., 365, 1429 Gillette, E.L., 1351 Gillim, M., 1249 Giri, P.G.S., %5 Glaholm, J., 755 Glatfelter, A.A., 1033 Glees, J., 723 Glicksman, AS., 441 Glynne-Jones, R.G.T., 289 Goffinet, D.R., 199 Goitein, M., 489 Goldhagen, PE., 1407 Good, R.R., 1509 Goodman, G.B., 1415 Gorodetsky, R., 1077 Gray, B.N., 619 Greenberg, M., 541 Greenberger, J.S., 1083 Grigsby, P.W., 927, 1183, 1503 GriJlo, H.C., 95 Grimard, L., 1299 Gross, J.F., 559 Grulkey, W., 1415 Guilbault, D.M., 1033 Guo-ahen, X., 295 Guse, C., 523, 707 Gustafson, C., 559 Gutin, P.H., 321, 445 Hackl, A., 1143 Haddad, E., 1299 Hahn, G.M., 199 Hahn, P., 937 HaJl, E.J., 1407 Halpem, J., 189, 825 Halsey, J., 389 Hancock, S., 389 Hanks, G.E., 515 Hannigan, J., 321

Hans, D., 87 Hanson, D., 413 Hardy, P.A., 133 Harigaya, K., 1083 Harris, J.R., 181 Harris, M.R., 1421 Hatter, K.W., 1027 Harwood, A.R., 263 Hass, AC., 833 Hauer-Jensen, M., 841 Haumschild, D.J., 903 Hayes, J.K., 635 Heck, R.J., 659 Heidner, G.L., 1351 Heidom, D.B., 1033 Helfrich, B., 1027 Hellbardt, A., 1327 Helle, P.A., 23 Hendee, W.R., 697 Hendrick, B., 541 Hendrickson, F.R., 155, 523 Hendrickson, M., 1271 Henkelmann, G.C., 825,957 Henry, M.M., 419 Henzler, M., 861, 1139 Herbst, M., 221 Herman, T.S., 475 Hermes, R.E., 1455 Higgins, P.D., 455 Hill, R.P., 133, 331 Hjelm-Hansen, M., 1307 Hliniak, A., 101 Hodson, D.I., 1521 Hoekstra, C.J.M., 13, 299 Hoffman, H., 541 Hogstrom, K.R., 1223 Holden, S.A., 375 Holland, C.A., 1083 Hong, S.S., 583 Hopewell, J. W., 37 Horak, D.A., 193 Homsey, S., 1437 Horwich, A., 787 Houghton, C.R., 921 Huart, J., 243 Hughes, L., 710 Huizenga, H., 43, 69 Humphreys, R., 541 Hussey, D.H., 671,825, 833, 841 Inoue, T., 119 Ishihara, H., 499, 505 Iskander, M.F., 895 Iyer, S.B., 1341 Jacky, J., 253 Jacquemier, J., 87 James, T.L., 1341 Jannoun, L., 747 Jenkin, D., 541 Jenkinson, T., 1437 Jewell, W.R., 419 Jie-bua, Y., 295 Johansen, L.V., 1307 Johns, M.E., 1319 Johnson, G.H., 1011 Joseph, J., 1449

Jozsef, G., 679 Juettner, EM., 1143 Kagan, A.R., 1535 Kalend, A.M., 941, 1495 Kampp, T.D., 679 Kanarek, D.J., 95 Kaplan, I.D., 1019 Kapp, D.S., 199,603, 1249 Kapp, KS., 233 Karolis, C., 1209 Karzmark, C.J., 659 Kase, K., 1083 Kazusa, C., 499, 505 Kelleher, D., 619 Kelsten, M.L., 849 Kemeny, N., 1157 Keng, P.C., 1061 Kennamer, D.L., 625 Keys, R., 1183 Kim, J.H., 583 Kim, S.H., 583 Kim, T.H., 1001 Kimler, B.F., 1115 Kinsella, T.J., 873 Kirsner, S.M., 1223 Kitani, H., 689 Kittelson, J.M., 383 Klarmann, J., 1477 Klein, J.L., 1367 Klemp, P., 619 Kliefoth, A.B., 815 Komaki, R.U., 523 Konski, A., 861, 1139 Kooy, H.M., 433 Koper, P.C.M., 299 Koprowski, C., 1333 Komblith, A.B., 1429 Korzeniowski, S., 631 Kosaka, T., 689 Koutcher, J.A., 1429 Kovalic, J.J., 927 Krishnan, E.C., 419 Krishnan, L., 419, %5 Krispel, E , 1223 Kroll, S.S., 189 Kubo, Y., 499, 505 Kuijpers, W.C., 1093 Kumar, P.P., 1509 Kurtz, J.M., 87 KuNvilla, A., 1535 Kuske, R.R., 1123 Kutcher, G.J., 975 LaFrance, N., 613 Lagoni, R., 909 Lakeman, R.F., 31 Lam, K.N., 1341 Lam, G.Y.K., 1415 Lamba, M., 1233 Lameris, J.S., 63 Lanciano, R., 407 Langer, M., 887 Langlands, A.O., 921 Lanzl, L.H., 155 Laramore, G.E., 268 Larson, D., 445,971

La Rue, S.M., 1351 Lastner, G., 613 Latift, H.R., 815 Lauk, S., 1107 Laungani, G., 1131 Lawrence, T.S., 1033, 1393 Laws Jr., E.R., 1165 Lax, I., 173 Le Bourgeois, J.P., 243, 1299 Lee, C.K.K., 485, 577 Lee, D.-J., 1319 Lee, E.R., 233 Leeper, D.B., 1249 Legros, M., 1315 Leibel, S.A., 445, 523 Leidholdt Jr., E.M., 1449 Leitner, H., 1143 Lemmon, M.J., 125 Lentle, B.C., 577 Leong, J., 887 Le Ridant, A.M., 819 Leung, S., 243 Levendag, P.C., 3, 13, 31 Levin, V.A., 321 Levitt, S.H., 485, 1001 Levy, R.P., 211 Lewis, J.D., 445 Leybovich, L., 1123 Li, X., 933 Lichter, A.S., 1033, 1485 Liggett, P.E., 679 Lightfoot, D., 1333 Lin, F., 419 Lindner, G., 469, 941 Lindquist, K., 689 Ling, C.C., 325, 849 Lips&t, J.A., 193 Little, R., 1233 Loeffler, J.S., 1535 Logus, J.W., 577 Lohrbach, A.W., 199 Longo, W.L., 909 Lorenzen, J., 883 Ludgate, C.M., 1051 Lulu, B., 445, 951 Lunsford, L.D., 469, 941, 1495 Lusinchi, A., 819 Luts, A., 1399 Lutz, w., 951 Luxton, G., 679, 1199 Lyman, J.T., 211,975 MacLeod, P.M., 113 MacVittie, T.J., 1069 Macchia, R., 1131 Maciejewski, B., 101 Madhuizen, H.T., 1093 Madigan, W., 1215 Maitz, A.H., 469,941, 1495 Malkasian, G.D., 709 Mameghan, H., 315 Mameghan, J., 315 Man, G.C.W., 577 Man, S.F.P., 577 Maners, A.W., 399 Mankin, H.J., 535 Mansell, J., 165

Maor, M.H., 825, 1287 Marchese, M.J., 1407 Marchial, V.A., 515 Marcial-Vega, VA., 613 Marinello, G., 243, 1299 Mar&al, J.M., 199 Markoe, A., 1333 Marks, J.E., 815 Martin, D.F., 1115 Martin, M., 1299 Maruyama, Y., 1276, 1421 Massey, V., 395 Matz, L., 619 Mauch, P., 275, 493 Mat&an, T.S., 1151 Maybaum, J., 1393 Mazeron, J.J., 243, 1275, 1299 McCarty, P.J., 705 McCault, G.F., 1509 McCollister Evarts, C., 861, 1139 McCullough, E.C., 1237 McEuen, A., 233 McGeer, E.G., 1051 McGivney, W.T., 697 McGuire, E.L., 399 McKay, M.J., 921 McKenna, W.G., 849 McNeese, M.D., 189, 283, 825 McShan, D.L., 1485 Meertens, H., 1173 Meerwaldt, J.H., 63, 299 Menache, L., 625 Mendenhall, W.M., 267,705, 1293, 1531 Menlove, R.B., 1011 Mermillod, B., 1327 Merrick III, H.W., 463 Micaily, B., 1333 Milas, L., 555 Mildenberger, M., 1051 Million, R.R., 705, 1293, 1531 Mills, M.D., 1215 Min. W.S., 147 Minsky, B.D., 1157 Miralbell, R., 535, 867 Mirimanoff, R.-O., 1327 Mohiuddin, M., 515 Morantz, R.A., 1115 Morrison, W.H., 1287 Moser, C., 1333 Mota, H.C., 455 Mou, X., 1077 Munro, P., 641 Murthy, A.K., 155 Muschel, R.J., 849 Myers, R., 1437 Myerson, R.J., 1123, 1249 Nagata, Y., 499, 505 Nan, R.C., 1299 Nakhleh, R.E., 587 Nath, R., 1377 Neville, A.J., 909 Newman, H.F.V., 1151 Nguyen, T.D., 1315 Nisbidai, T., 353,499, 505 Nishiguchi, I., 555

Nolan, J., 347 Noll, L., 389 Nori, D., 1157 North, C.A., 1319 Novins, K., 651 Obradovic, M., 1327 O&ran, T.G., 1215, 1223 O’Fallon, J.R., 1165 Offutt, C.J., 1455 Ogawa, Y., 1415 Ohta, H., 499, 505 Okajima, K., 505 O’Keefe, S., 909 Okunieff, P., 867 Olch, A., 1535 Oleson, J.R., 383, 1249 Oliver, R., 559 O’NeilI, M., 613 Ono, K., 353 Order, S.E., 523, 613,981, Osbom, J.L., 587 Osborne, J.W., 841 Oswald, M.J., 283, 1287 Oussoren, Y., 1399 Overgaard, J., 1307

1367

Packer, R., 805 Page, R.L., 1351 Pajak, T.F., 515, 523, 707, 1249 PaliwaI, B., 1249 Panis, x., 1315 Parker, R.G., 413,993, 1245 Parsons, J.T., 267, 705, 1293, 1531 Patchen, M.L., 1069 Patel, I?, 1276 Patrene, K.D., 1387 Paunier, J.-P., 1327 Pellegrini, V., 1139 PeUigrini, V., 861 Pence, D.M., 1001 Pennington, E.C., 671 Perez, CA., 1123, 1503 Peters, L.J., 1283, 1287 Petersen, LA., 603 Petrovich, Z., 679, 1199 Pezner, R.D., 193 Phillips, T.L., 389, 445, 523, 1249 Phillips, M.H., 211 Piantadosi, S., 1319 Piedbois, P., 1299 Pierquin, B., 243, 1299 Plenk, H.P., 1011 Poggenburg, J.K., 1367 Porrazzo, M., 1131 Porsch, G., 1143 Potish, R.A., 1005, 1513 Poulakos, L., 841 Poulter, C., 861, 1139 Powers, B.E., 1351 Prionas, S.D., 199 Pszon, J., 631 Purdy, J.A., 1477 Ramsay, J., 365 Rao, P.V., 705 Rashid, H., 181

Rawlinson, J.A., 641 Raynal, M., 243, 1299 Reddy, E.K., %5 Regbebi, K., 547 Reichman, B., 1157 Reinhold, H.S., 37, 51,77 Rhodes, L.M., 181 Rich, T.A., 710, 1215, 1223 Richardson, D.C., 1351 Richardson, M., 861 Richter, S.L., 1351 Riggs, c., 909 Roach III, M., 1449 Robbins, K.T., 1287 Robins, H.I., 909 Rockwell, S., 1377 Rojas, A., 547 Romsdahl, M.M., 283 Rorke, L.B., 805 Rosenberg, A.E., 535 Rosenthal, J., 1131 Rosier, R., 861, 1139 Ross, C.S., 671 Rossi, PI., 1377 Rotman, M., 1131 Rotstein, S., 173 Roy, T., 1455 Rubenstein, J., 407 Rubin, P., 1, 273, 497, 515, 715, 861, 979, 1139, 1281 Ruifrok, A.C.C., 31 Russell, A.H., 523 Russell, K.J., 523 Rust, D.C., 659 Sadeghi, A., 413 Saitoh, Y., 529 Sakakeeny, M.A., 1083 Sampiere, V., 825 Samsami, N., 463 Samulski, T.V., 199, 233, 1249 Sandier, H., 849 Santucci, M.A., 1083 Sapareto, S.A., 1249 Sapozink, M.D., 679, 1249 Sasai, K., 353 Sause, W.T., 1011 Savino, P.J., 407 Saxton, J.P., 455 Sayegh, H.O., 193 Scheithauer, B.W., 1165 Schmitt, C.L., 909 Schomberg, P.J., 1165 S&ray, M.F., 709 Schroy, C.B., 1421 Schultheiss, T.E., 165 Secomb, T., 559 Sedlacek, R., 365, 569 Seldenrath, J.J., 23 Sergott, R.C., 407 Shalev. S., 937 Shapiro, J., 887 Sheline, G.E., 793 Shepard, M.J., 927 Sherouse, G.W., 651 Shibamoto, Y., 353 Shimm, D.S., 383

Thames, H.D., 569, 867 Therrien, P., 937 Thomas, P.R., 927 Thompson, L., 275 Thrall, D.E., 1351 Tjokrowardojo, A.J.S., 299 Tomkinson, K., 365, 569 Torrisi, J.R., 1027 llan, L., 413 Beumiet-Danker, A.D., 59 titt, K.-R., 1107 Tso, C.Y., 559 Tsutsui, K., 353 ‘Ihmeh, A.M., 895 ‘Ibttle, S.W., 849 Tynan, A., 315

Shin, K.H., 455 Shiu, A.S., 1223 Shrivastava, P., 1249 Sibata, C.H., 455 Siddon, R.L., 181 Sidrys, J., 413 Siemann, D.W. 1061 Silver, P., 321 Silverstein, M., 1131 Sim, D.A., 1351 Simpson, N., 1359 Sivon, S.L., 1283 Slessinger, E.D., 1455, 1503 Smalley, S.R., 965, 1165 Smeds, A.-C., 305 Smit, W.G.J.M., 23 Smith, V., 445 Smith, A.R., 701 Smith, W.G., 1011 Smoker, W.R.K., 635 Smolle, J., 1143 Song, C.W., 147, 587, 903 Sonley, M., 541 Sorbe, B.G., 305 Soubra, M., 1521 Sowinski, M.J., 77 Speiser, B., 1443 Spitalier, J.-M., 87 Spratling, L., 1443 Stablein, D., 1027 Stanford, W., 671 Starkschall, G., 957 Stauffer, P., 1249 Stea, B., 951 Steeves, R.A., 909 Steplewski, Z., 1033 Stetson, P.L., 1393 Stewart, EA., 1399 Stoffel, T.J., 833 Stomper, P.C., 181 Stone, H.B., 595 Stotter, A.T., 283 Stracher, M.A., 535, 887 Straube, W., 1123 Straw, R.C., 1351 Stringer, S.P., 1293 Su-yan, L., 295 Suit, H.D., 365, 535,569, 867 Summers, R.W., 841 Sundeen, V., 833 Sutton, L., 805 Svane, G., 173 Swanenburg, B.N., 43

Vaeth, J.M., 709 Valdagni, R., 1019 Valeriote, E, 1359 van Battum, L.J., 69 van Blankenstein, M., 63 van de Merwe, S.A., 51 van den Berg, A.P., 37, 51 van den Berg, P.M., 77 van der We&Messing, B.H.P., 23 van der Zee, J., 5 1 van Herk, M., 1173 Van Limberben, E., 1239 van Miedo, M.J.M., 59 Vannier, M. W., 1455 van Putten, W.L.J., 13, 23, 59, 63, 299 van Rhoon, G.C., 77 van Rongen, E., 1093 Vats, T.S., 1115 Veeze-Kuijpers, B., 63 Viggars, D., 937 Vigliotti, A.P., 833, 841 Vikram, B., 267 Visser, A.G., 31,43,77 Vogler, H., 879, 883 Von Gerichten, D., 1123 Vonderheid, E.C., 1333

‘Ihkada, C., 529 nkahashi, M., 353,499, 505, 529 Tknabe, E., 233 Tarbell, N.J., 275, 493 ‘Iktcher, M., 441 Tktera, B.S., 1449 ‘lhylor IV, S.G., 155 ‘Ikylor, J.M.G., 101, 1077 Teicher, B.A., 375 Ten Haken, R.K., 1033 Terpstra, O.T., 63 Tery, V.H., 1033 Teshima, T., 119

Wallen, C.A., 1043 Wallner, K.E., 395 Wanek, P.M., 1367 Wang, C.C., 1529 Wang, Z., 933 Wara, W.M., 321, 971 Ward, R., 1151 Wasserman, T.H., 389, 523 Waterman, EM., 1249 Watt, W.H., 315 Weaver, K., 445 Weeks, K.J., 1191 Weiss, C., 861

Uckun, EM., 147 Uda, M., 587 Uozumi, H., 529 Urano, M., 359 Urbon, J., 155 Urdaneta, L.F., 841 Uric, M., 887 Urtasun, R.C., 389

Weiss, J.F., 1069

Wibault, P., 819

Wong, K.-H.,

1043

Weiss, M.C., 849

Wierzbicki, J.G., 1276

Wong, R.S.L.,

325

Weitzman, S., 541

Wijnmaalen, A.J., 23

Woolf, C.D., 419

Wen, B.-C., 833

Wike, J.L., 1283

Workman, P., 1151

Yu-hua, H., 295

Wendland, M.F., 1341

Williams, J.A., 1367

Wrigley, R.H., 1351

Yu-zhong, L., 295

Wendt, C.D., 1287

Wiilingham, V., 555

Wu, A., 469, 941, 1495

Wessels, B.W., 1367

Wilson, C.B., 321

Wurschmidt, F., 879

Ying, X., 1465 Yoshizumi, K., 529 Young, T.E., 289

Wesson, M.F., 1157

Withers, H.R., 101, 1077

Wharam, M.D., 1367

Withrow, S.J., 1351

Xian-zhi, G., 295

Zahurak, M., 1319

Wheeler, K.T., 1043

Woda, B., 1083

Xue-Iin, W., 295

Zaider, M., 14307

White, C.P., 253

Wolf, C.D., 965

Whitfield, G., 1027

Wollin, M., 1535

Yaes, R.J., 975, 1276

Zietman, A., 365,569,

Whittaker, S., 773

Wang, G., 1521

Yamaoka, N., 499, 505

Zimmerman, R., 805

Whitton, A.C., 783

Wong, J.W., 1455, 1465, 1477

Yasunaga, T., 529

Zuckerberg, L.R., 535

Zahra, M.K., 833

Zeman, E.M., 125 867

KEYWORD SUBJECT INDEX Volume 18. 1990 A

Access 697 Acute lymphoblastic leukemia 147 Adenoid cystic carcinoma 413 Adjuvant Chemotherapy 723 Radiotherapy 299 Adults 763 Aerobic radiosensitization 125 Afterloading Applicator 1503 Technique 305 Age effects 747 Allograft 135 1 Irradiation 1027 Alpha/beta 1093 Ratio 359 Americium-241 1377 Anesthesia 625 Aneurysm 1001 Antibody(ies) 981, 1033 Iodine-131 monoclonal 1033 Labelled 126 1 Radiolabeled 1033 Applicator(s) 233 Afterloading 1503 Cervical 1191, 1509 Intracavitary 1503 Ring 77 Vaginal 1503 Assay(s) Clonogenic 147 Predictive 133, 331, 1283 Astrocytoma(s) 395, 723,811 Cerebellar 815, 971 Low grade 783 Auger electrons 1377 Availability 697 AVM 211 B

Base of tongue neoplasms 1293 BCNU 321, 375 Beam(s) Electron 69, 1521 Perturbation 455 Quality 441 Beam’s eye view 1485 Bile duct Cancer 1157 lbmor 63 Biological response modifiers (BRM) 353 Bladder Cancer 1131 Mouse 1399 Bleomycin 1115 Blood Brain barrier 1437 Vessels 37 Blood flow 1437 Liver 587 Bone Metastases 1019 Prevention of heterotopic 1139

Bone marrow 353 Stroma 1083 Transplant 1233 Transplantation 1387 Booster dose 295 Boron neutron capture therapy 1421 Bowel complications 315 Brachytherapy 63, 419, %5, 1157, 1199, 1293, 1377, 1407, 1421, 1449, 1513 Calculations 1191 CT treatment planning 445 Endobronchial 1443 Gynecological 1503 Interstitial 199 Brain Gliomas 783 Implant 445 Prophylactic irradiation 1051 Stem gliomas 723 Brain tumor211,221, 1115, 1421 Research 805 Breast Augmentation 189 Cancer 173, 283,419, 825 Conservative treatment 1239 Cosmesis 189 Irradiation 189 Neoplasms 181 Radiotherapy 87 Recurrent cancer 87 Breast-conservation 87 Therapy 283 BRM (biological response modifier) 1415 Bromodeoxyuridine 1393 Bronchogenic carcinoma 1443 C

Calcium channels 1437 Calculation(s) Brachytherapy 1191 Dose 425 Monte Carlo 1407 Three-dimensional dose 1455 Cancer(s) Bile duct 1157 Bladder 113 1 Breast 173, 283,419, 825 Cervical 1513 Cervix 1509 Childhood 805 Colon 1033 Colorectal 199 Early glottic 119 Endometrial299, 1055, 1011 Esophageal 477 Glottic 1307 Head and neck 13, 199, 819 Lung 1051, 1143, 1443 Middle ear 631 Nasal skin 243 Oral cavity 101 Pancreatic 59 Prostate 315 Prostatic 1019 Recurrent breast 87 Second 1327

A25

Supraglottic 1307 Therapy 1033 Capacitive heating 587 System 77 Carbogen 547 Carcinoma(s) Adenoid cystic 413 Bronchogenic 1443 Cervical 965 Colorectal523 Ductal in-situ 283 Endometrial305 In-situ 113

Laryngeal 1307 Major salivary glands 13 19 Nasopharyngeal295 Perfusion lung 577 Prostate 23 Resected Stage II and IIIA lung 95 Second primary 1307 Squamous cell 365, 1283, 1315 Supraglottic 263 Cardiac complication 275 Cardiovascular function 1107 Carotid occlusion 635 Cauda equina syndrome 1001 CCNU 321 Cell Cycle 1061 Hypoxic sensitizers 389 Subpopulations 1061 Cell survival 1341 Curves 125 Tlimor 33 1 Centrifugal elutriation 1061 Cerebellar astrocytoma(s) 815, 971 Cervical applicator(s) 1191, 1509 Cervical cancer 15 13 Cervical carcinoma 965 Cervical metastases 289 Cervix cancer 1509 Cf-252 1421 Charged particles 211 Chemo-radiation 113 1 Chemosensitization 1043 Chemotherapy 155, 321, 477, 763, 773, 787, 811, 921 Adjuvant 723 Continuous infusion 5-FU 113 1 Induction 1315 Childhood intracranial tumors 723 Children 625 Choroidal melanoma 679, 1209 Chronic lymphocytic leukemia 909 Cine CT 671 Clinical Application 505 Trial 295 Clinically negative neck 13 Clonogenic assay 147 CNS 37, 1437 Neoplasms 399 Cobalt-60 305,941 Cognitive development 747 Colon cancer 1033 Colorectal Cancer 199 Carcinoma 523

Combined modality Care 805 Treatment 59 Combined photon 1521 Complete response 1333 Complication(s) 23, 101, 165 Bowel 315 Cardiac 275 Lung 173 Radiotherapy 1001 Computed Radiographs 65 1 Tomography 18 1 Computer 253 Aided treatment design 65 1 Assisted radiation treatment planning 887 Computerized Dosimetry 1513 Treatment planning 1485 Computerized tomography (CT) 577 Cine 67 1 Simulator 499, 505 Ultrafast 671 Conservative breast treatment 1239 Continuous infusion chemotherapy 5-FU 113 1 Coverage 697 Craniopharyngiomas 723 Craniospinal irradiation 1001 CRE 305 CT-guided implants 95 1 C3h mice 867 CT treatment planning 23 Brachytherapy 445 Cutaneous T-cell lymphoma 1333 Cytotoxicity 325 D

Damage DNA 1359 Late radiation 1399 Sublethal 689 Davo1463 Delay Growth 879, 883 Net growth 879 Demyelination 37 Desmoid tumor 535 Digitally reconstructed radiographs 65 1 Disease Hodgkin’s 193, 275, 603, 613, 1183 Radiation-induced heart 1107 Radiotherapy of benign 883 DNA damage 1359 Dog 1351 Dose 723 Booster 295 Calculation 425, 489 Comparison 211 Constant 1199 Distribution 45 Effect relationship 23 Fractionation 101, 1077 Inhomogeneity 249 Rate effect 1083 Remembered 689 Response 31 Specification 15 13 Thermal 155 Uniformity 463 Volume histograms 937 Dosimetry 419,941,965, 1033, 1199, 1407, 1495

Computerized 1513 Electron 1223 Film 69 Intracavitary 1191 Radiation 679 Drug interactions 1069 Ductal carcinoma in-situ 283 Duodenum 84 1 E

Early Glottic cancer 199 Responses 595 Effect(s) Age 747 Dose rate 1083 Late 1107 Late radiation 1077 Memory 689 Postoperative radiotherapy on pulmonary function 95 Radiation 463, 1051 Recall 689 ‘lbmor bed 879 Volume 101,315 Elderly 819 Electron(s) 463, 957, 1215 Auger 1377 Beams 69, 1521 Cones 1223 Dosimetry 1223 Therapy 659 Endobronchial Brachytherapy 1443 Irradiation 1449 Endometrial Cancer 299, 1005, 1011 Carcinoma 305 Endometrium 921 Energy status 1429 Enteric morbidity 1005 Ependymomas 723 Equipment 1237 Era Megavoltage 723 Orthovoltage 723 Esophageal cancer 477 Etanidazole 389, 1151 Exercise testing in rats 1107 External beam irradiation 1033, 1143 Eye Plaques 1209 Radiotherapy 1209 F

FDA approval 697 Femoral hip prosthesis 455 Fiber optic 5 1 Fibromatoses 535 Field(s) Gapping 1183 Mantle 1183 Radiation factor 119 Film(s) Dosimetry 69 Portal 651 Simulation 651 Flavone acetic acid 1359 Flexible RF electrodes 199 Floor of mouth neoplasms 1299

A26

Flow Laser Doppler 903 Skin blood 903 Fluorescent screens 641 Fluoroscopic imaging systems 641 Fraction Hypoxic 1341 Size 359 Fractionated irradiation 1093 Fractionation 515, 547, 569, 867, 883 Dose 1077 Multiple 359 Function Cardiovascular 1107 Pulmonary 1107 Functional capacity 723 G Gamma knife 469, 1495 Gapping fields 1183 Germinoma 773 Pineal 54 1 Glioblastoma multiforme 321, 365 Glioma(s) 321, 395 Brain 783 Brain stem 723 High grade 793 Human 1367 Optic 723 Optic nerve 927 Glottic cancer 1307 Glucan 1069 Glutathione levels 133 Granulocyte colony-stimulating factor (G-CSF) 353 Granulocytopenia 353 Growth delay 33 1, 879, 883 GSH denletion 325 Gynecological brachytherapy 1503 H

Halogenated pyrimidine 1393 Head and neck 1315 Cancer(s) 13, 199,819 Health care technology 697 Heat Sensitivity 1429 Sensitization 933 Heating Capacitive 587 Radiofrequency 77 Hemangioblastoma 1165 Hematopoiesis 1387 Hemopoiesis 1069 Hemorrhage and radiotherapy 1001 Hepatic enzyme concentration 587 Hepatitis 619 Radiation 523 Heterogeneity 559 High LET (linear energy transfer) radiation 1415 High dose rate 305 High grade gliomas 793 High-energy X ray(s) 463 Therapy 249 Hodgkin’s disease 193, 275, 603, 613, 1183 H-ras oncogenes 849 Human 1283 Glioma 1367 Skin 903

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1901 s’o”‘U

Intrathoracic 671 Oropharyngeal 1293 Neovascularization kinetics Net growth delay 879 Neuropathy 389 Neutron(s) 165 Beam irradiation 825 Nitrosoureas 1043 Normal tissue(s) 347,595 Damage 353

879

0

On-line Portal imaging 64 1, 1477 Radiotherapy imaging 1465 Ophthalmic irradiation 1199 Optic Gliomas 723 Nerve glioma 927 Optimization 433, 489, 887, 957, 965 Oral cavity 413 Cancer 101 Oral tongue 1287 Orbital pseudotumor 407 Oropharyngeal neoplasms 1293 Orthovohage X rays 1237 Era 723 Osteomyelitis 165 Osteosarcoma 1351 Oxygen 547

Pelvic external radiation and brachytherapy 1005 Radiotherapy 1319 Pourous coated implant 861 Predictive assays 133, 331, 1283 Predictors of tumor response 101 Premarket approval application (PMAA) 697 Premarket no&cation (510K) 697 Prevention of heterotopic bone 1139 Primary Cerebral lymphoma 787 Culture 1283 Unknown 289 Procaine hydrochloride 993 Procarbazine 321 Prognostic factors 299, 523, 763, 811 Proliferation 126 1 During irradiation 359 Prophylactic brain irradiation 1051 Prospective randomized study 119 Prostaglandin(s) 1387 Prostate cancer 315 Prostatic cancer 1019 Protocols 937 Psychological Outcome 747 Sequelae 723 Pulmonary Function 1107 Tolerance to postoperative radiotherapy 95

Q

P

Quality assurance 253, 1173, 1249 Quality of survival 763

Palliative therapy 1449 Pancreatic cancer 59 Parotidectomy 1319 Pathological changes in liver 587 Patient Dose estimation 1465 Set-up 43 Set-up verification 1173 PCV 321 Pediatric Brain tumor(s) 747, 805,815,971 ‘Ibmors 927 Perfusion lung carcinoma 577 Pharmacokinetics 389, 1043, 1151 pH measurement 5 1 Ihmor 5 1 Photon(s) 211, 433, 463 Combined 1521 Pimonidazole 115 1 Pineal Germinoma 541 Tumors 773 Pion 1415 Planning Therapy 2 11 Treatment 253, 425. 433, 489. 937,951,957, 671, 1521 Plaque 679 Pneumothorax 193 Point A 1513 Portal Film(s) 641, 651 Image 1455 Imaging 1173 Post irradiation drugs 1437 Postoperative Irradiation 833

R

Radiation 31, 155, 375, 399,477, 595, 619,635, 921, 1359 Computer assisted treatment planning 887 Dosimetry 679 Effect(s) 463, 1051 Field factor 119 Hepatitis 523 High LET (linear energy transfer) 1415 Induced heart disease 1107 Inhibition of heterotopic bone 861 Injury 353, 577,841 Intracavitary 1011 Leakage 1215 Necrosis 1437 Oncology residents 1245 Pneumonitis 275 Reaction(s) 165, 305 Resistance 849 Risk 399 Total skin electron beam 1333 Toxicity 773 Treatment 541 Radiation therapy 113, 193, 399,407,441, 515, 523, 529, 583, 815, 819, 887,927, 971, 1011, 1115,1157, 1165, 1173,1293, 1327 Intraoperative 1143 Low-dose 603 Radical surgery 413 Radiobiological advantages 419 Radiobiology 867 Radiofrequency heating 77 Radiographs Computed 65 1 Digitally reconstructed 65 1

A28

Radioimmunotherapy 1033, 1261, 1367 Radiolabeled antibodies 1033 Radioprotection 1069 Radiosensitivity 1083 Intrinsic 133,331 Radiosensitization 873, 1377 Aerobic 125 Radiosensitizer 389, 547, 811, 1151, 1393 Radiosurgery 941, 1495 Stereotactic 211, 469 Radioteleangiectasia 1239 Radiotherapy 63, 101, 173, 181, 211, 243, 263, 283, 289, 295, 631, 671, 755, 763, 773, 783, 787, 793, 811, 1027, 1077, 1237, 1299, 1307, 1315, 1341, 1351, 1415, 1521 Adjuvant 299 Benign disease 833 Breast 87 Complications 1001 Eye 1209 Hemorrhage 1001 Imaging 43 Interstitial 1287 Intraoperative 1215, 1223 Postoperative 1319 Pulmonary tolerance to postoperative 95 Split-course 13 Treatment planning 181, 455, 505 Treatment verification 1477 Radium-226 1377 Rat 841 Brain tumor model 1115 Liver 587 Reaction Radiation 165, 305 Skin 359 Recall effect 689 Recurrence 395 Recurrent breast cancer 87 Reimbursement 697 Reirradiation 1399 Relative biological effectiveness (RBE) 1407 Remembered dose 689 Renal transplantation 1027 Reoxygenation 559 Repair 689, 1359 Kinetics 1093 Reperfusion injury 1437 Response 1143 Research Brain tumor 805 Training 1245 Resected Stage II and IIIA lung carcinoma 95 Residual primary lesion 295 Response(s) Complete 1333 Early 595 Late 595 Treatment 1315 Ring applicator 77 RlH rhabdomyosarcoma 883 RTOG 515

S

Salvage surgery 87 Sarcoma(s) KHT 1415 Murine 867 SCCVII tumor 1415 SC 9L tumor 1043

Second Cancer 1327 Primary carcinoma 1307 Selenium 1069 Seminoma 1327 Sensitivity Heat 1429 Thermal 147 Shielding 469 Simulation 1485 Films 651 6-thioguanine 583 Size Fraction 359 Irradiation field 879 Skin Blood flow 903 Human 903 Reactions 359 Total 659 Small-colony formation 689 Soft X rays 1407 Software testing 253 Source installation 469 SPG (sonifilan) 1415 Split-course radiotherapy 13 Squamous cell carcinoma 365, 1283, 1315 SR 4233 125 SR2508 325, 389 Stereotactic Frame 941 Radiosurgery 2 11, 469 Stereotaxic implants 951 Stereotaxy 445 Steroid treatment 407 Sublethal damage 689 Superficial 155 Hyperthermia 1123 Supraglottic Cancer 1307 Carcinoma 263 Supraglottis 13 Suprasellar tumors 773 Surgery 13,477 Radical 413 Salvage 87 Survival 63,723 Cell 1341 2.0 Gy 1283 Syndrome Cauda equina 1001 Von-Hippel Lindau 1165 Systemic treatment 981 T

Targetted therapy 1261 Teratoma 773 Theray 1033 Boron neutron capture 1421 Breast-conservation 283 Cancer 1033 Electron 659 High energy x-ray 249 Imaging 641 Palliative 1443

Planning 211 Radiation 113, 193, 399,407,441,515, 523, 529, 583,815, 819,887, 927,971, 1011, 1115, 1157, 1165, 1173, 1293, 1327 Targetted 1261 Trimodality 375 Thermal Dose 155 Enhancement 595 Sensitivity 147 Thermoluminescent dosimetry 1367 Thermometry 603, 1249 Thermotolerance 147 31-P-nuclear magnetic resonance 1429 Three-dimensional (3-D) 253, 1485 Dose calculations 1455 Treatment planning system 499 Thrombosis 635 Thymoma 529 Thyroid dysfunction 275 Time-dose fractionation scheme 1165 Tissue(s) Injury 37 Normal 347,595 Normal damage 353 TNF 555 Tolerance 63, 101, 165, 921 Total body irradiation 529, 909, 1233, 1387 Total hip arthroplasty 1139 Total skin 659 Electron beam radiation 1333 Tract Upper digestive 515 Upper respiratory 515 Transplantation Bone marrow 1387 Renal 1027 Treatment Combined modality 59 Computed aided design 651 Radiation 541 Response 1315 Steroid 407 Systemic 981 Uncertainties 1465 Treatment planning 253, 425, 433, 489, 671, 937, 951, 957, 1521 CT 23 Radiotherapy 181, 455, 505 Computer assisted radiation 887 Computerized 1485 Treatment verification 43, 1465 Radiotherapy 1477 Trimodality therapy 375 ‘Ihmor-induction 399 Thmor(s) 547 Bed effect 879 Bile duct 63 Biology 867 Brain211, 1115, 1421 Cell survival 33 1 Childhood intracranial 723 Desmoid 535 Human 1061 Hypoxia 1429 Intraocular 1209

A29

Irradiation 555 Localization 1367 Mouse 125 Murine 583 Pediatric 927 Pediatric brain 747, 805, 815, 971 pH 51 Pineal 773 Response predictors 101 SCCVII 1415 SC 9L 1043 Size 1341 Subpopulations 375 Suprasellar 773 T.V. cameras 641 2nitroimidazoles 389, 1043 U

Ultrafast computerized tomography Unifilar substitution 873 Unknown primaty 289 Upper Digestive tract 515 Respiratory tract 515 V

Vaginal Applicator 1503 Bleeding 921 Irradiation 305 Shortening 305 Vascular access 463 Verification 1485 Patient set-up 1173 Radiotherapy treatment 1477 Treatment 1455 Volume effect 101, 315 Von-Hippel Lindau syndrome 1165 W

Whole Body hyperthermia 909 Lung irradiation 275 Wound healing 1077 WR-2721 1069 X

X rays 441 High-energy 463 High-energy therapy Orthovoltage 1237 Soft 1407 Xenografts 365, 1061 Human tumor 569 Y

Yttrium-90

619

249

671