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Liver cell carcinoma
440
Book Reviews
oxidation and reduction, electron and proton transfer; membrane structure and storage of free energy; metalloproteins; the quinone connection; photosynthesis; light and redox linked H+ translocation, pumps, cycles and stoichiometry; transduction of electrochemical ion gradients to ATP synthesis; active transport; answers to problems; physical, chemical and biochemical constants. The text is well written and provided with many diagrams and illustrations. It will help many students increase their understanding of bioenergetics. Journal of Chromatography. Vol. 506Edited by R. W. GIESE, J. K. HAKEN., K. MACEK and L. R. SNYDER. 708 pp. 1990. Elsevier, Amsterdam. In the 32 years of its existence the Journal of Chromatography has published more than 30,000 papers on 250,000 pages and has expanded from 1 volume a year to 37 volumes a year. Volume 500 in addition to the normal papers has a chapter by Michael Lederer presenting his Journal of Chromatography Family Picture Album with 172 photographs of chromatographers over the years. Plant Polyphenols; Vegetable HASLAM. 230~~. 1989. Cambridge
Tannins Revisited-E. University Press, $70.
The plant phenols account for the astringent taste of many plant products such as tea and wine, and are used in tanning leather. They are classified into two main groups: the proanthocyanidins and the polyesters based on gallic and/or hexahydroxydiphenic acid and their derivatives. They can form complexes with proteins and polysaccharides. This volume surveys their chemistry, origins, and application. Percutaneous Absorption; Mechanisms, Methodology and Drug Delivery. Second edition-Edited by R. L. BRONAUGH and H. L. MAIBACH. 664 pp. 1989. Humana Press, Clifton, NJ. $125 (USA and Canada). Elsewhere $150. Drugs given via the skin have many advantages; the total dose given can be smaller than that given by the other methods; the drugs can be given continuously at a finite rate; it has a high patient acceptability; the method of application of a common drug can be patented. The new edition of this book brings the information up to date and in the 37 chapters considers the fundamental problems of drug absorption via the skin and the methods that are being used to obtain reliable delivery of drugs. Psychoactive Drugs; Tolerance and Sensitizatio*Edited by A. J. GOUDIE and M. W. EMMETT-OGLESBY. 600 pp. 1989. Humana Press, Clifton, NJ. $79.80 (USA). Elsewhere $89.50. The main chapters in this book are; tolerance and sensitization-an overview; instrumental learning in behavioural tolerance to drugs; pharmacological conditioning and drug effects; behavioural and pharmacological history as a determinant of tolerance and sensitization; tolerance to drug discriminative stimuli; mechanisms in drug tolerance and sensitization; dopamine receptor changes during chronic drug administration; sensitization to action of antidepressant drugs; adaptation in neuronal calcium channels as a common basis for physical dependence on central depressant drugs; definitions and explanations; pharmacological overview. The main problem dealt with in this book is that psychoactive drugs are often given to patients over periods of years and the patient’s reaction to the drug changes. It links the behavioural, clinical and molecular pharmacology research evidence.
Liver Cell Carcinoma-Edited by P. BANNASCH, D. KEPPLER and G. WEBER.525 DV. 1989. Kluwer, Dordrecht. Holland. D.Fl 289; $121.50. _Three main risk factors for liver cancer are hepatitis B virus (HBV), aflatoxins and alcohol abuse. It is estimated that the lag between infection with HBV and the appearance of hepatocellular carcinoma takes 30-50 years. Animal models of HBV are now available in the hepadna virus induced liver carcinoma, and virus associated hepatomas in woodchuck, ground squirrel and ducks. Chemicals such as aflatoxins, alcohol, steroids (including contraceptives), and nitrosamines, can induce hepatomas. This volume discusses all these points together with the phenotypic changes and altered gene expression in the hepatomas, improved diagnosis, and the treatment of liver carcinomas. Primary prevention of liver cancer by vaccination against HBV is strongly supported. New Drugs in Oncology-Edited FIEBIG. 302 pp. 1989. Karger,
by W. QUEISSERand H. H. Basel. S.Fr. 79: $52.75.
This volume contains a series of papers on the use of different drugs to treat cancers. These include 5-fluorouracil, 5 aza-2-deoxycytidine. cabergoline, droloxifene, zindoxifene, 4-hydroxy-androstenedione, anthracylines (pirarubicin, idarubicin epirubicin), nitrosoureas, metal complexes, ether lipids, immune modulators, and interferons. Basic and Clinical Concepts of Lung Cancer-Edited by H. H. HANSEN. 368 pp. 1989. Kluwer, Dordrecht, Holland. D.Fl 305; $125. Lung cancer is the second most frequent cancer (after stomach cancer which is the first) with 660,500 new cases a year in the world. There is a major increase in the developing world mainly due to an increase in smoking, with a corresponding decrease in smoking and lung cancer in the USA. This volume deals with different aspects of lung cancer; diagnosis, immunohistochemistry, oncogenes, autocrine growth factors, tumor endocrine markers, interferons, prognosis in adenocarcinoma, surgical adjuvant therapy, high dose chemotherapy, bone marrow transplantation, CNS therapy, later complications, psychosocial aspects. Ivermectin and Averme&+-Edited pp. 1989. Springer, Berlin. DM
by W. C. Campbell. 132.
363
Fermentation of the actinomycete Sfrepfomyces uuermirilis produces a series of avermectins [A’s]. The A’s are a range of 16 membered macrocylic lactones. They have no antibacterial or antifungal properties. The milibemycins are structurally related but lack the Cl3 disaccharide substituent. A’s are powerful antihelmintics that can be injected or given orally to sheep, cattle, pigs, dogs, cats, and man with very low toxicity to the host but a powerful action on the nematode worm parasites. A’s bind to the GABA receptors of the parasites and affects their chloride channels. At the concentrations used A does not significantly cross the mammalian blood-brain barrier and so does not affect the mammalian CNS GABA receptors. A’s can also be used as pesticides against insects and insect larvae. A’s do not persist or accumulate in the soil and rapidly photolyze in water. This volume summarises the information on A’s chemical structures, production, mode of action, toxicity, pharmacokinetics, metabolism, and use. The A’s will soon be a billion dollar industry. Antimicrobial Chemotherapy. 2nd edition-Edited D. Greenwood. 372 pp. 1989. Oxford University Oxford. $45; Paper $24.95.
by Press,
The first edition of this book appeared in 1983. The 1980’s have seen the development of the fluoroquinolines and novel
Book Reviews
oxidation and reduction, electron and proton transfer; membrane structure and storage of free energy; metalloproteins; the quinone connection; photosynthesis; light and redox linked H+ translocation, pumps, cycles and stoichiometry; transduction of electrochemical ion gradients to ATP synthesis; active transport; answers to problems; physical, chemical and biochemical constants. The text is well written and provided with many diagrams and illustrations. It will help many students increase their understanding of bioenergetics. Journal of Chromatography. Vol. 506Edited by R. W. GIESE, J. K. HAKEN., K. MACEK and L. R. SNYDER. 708 pp. 1990. Elsevier, Amsterdam. In the 32 years of its existence the Journal of Chromatography has published more than 30,000 papers on 250,000 pages and has expanded from 1 volume a year to 37 volumes a year. Volume 500 in addition to the normal papers has a chapter by Michael Lederer presenting his Journal of Chromatography Family Picture Album with 172 photographs of chromatographers over the years. Plant Polyphenols; Vegetable HASLAM. 230~~. 1989. Cambridge
Tannins Revisited-E. University Press, $70.
The plant phenols account for the astringent taste of many plant products such as tea and wine, and are used in tanning leather. They are classified into two main groups: the proanthocyanidins and the polyesters based on gallic and/or hexahydroxydiphenic acid and their derivatives. They can form complexes with proteins and polysaccharides. This volume surveys their chemistry, origins, and application. Percutaneous Absorption; Mechanisms, Methodology and Drug Delivery. Second edition-Edited by R. L. BRONAUGH and H. L. MAIBACH. 664 pp. 1989. Humana Press, Clifton, NJ. $125 (USA and Canada). Elsewhere $150. Drugs given via the skin have many advantages; the total dose given can be smaller than that given by the other methods; the drugs can be given continuously at a finite rate; it has a high patient acceptability; the method of application of a common drug can be patented. The new edition of this book brings the information up to date and in the 37 chapters considers the fundamental problems of drug absorption via the skin and the methods that are being used to obtain reliable delivery of drugs. Psychoactive Drugs; Tolerance and Sensitizatio*Edited by A. J. GOUDIE and M. W. EMMETT-OGLESBY. 600 pp. 1989. Humana Press, Clifton, NJ. $79.80 (USA). Elsewhere $89.50. The main chapters in this book are; tolerance and sensitization-an overview; instrumental learning in behavioural tolerance to drugs; pharmacological conditioning and drug effects; behavioural and pharmacological history as a determinant of tolerance and sensitization; tolerance to drug discriminative stimuli; mechanisms in drug tolerance and sensitization; dopamine receptor changes during chronic drug administration; sensitization to action of antidepressant drugs; adaptation in neuronal calcium channels as a common basis for physical dependence on central depressant drugs; definitions and explanations; pharmacological overview. The main problem dealt with in this book is that psychoactive drugs are often given to patients over periods of years and the patient’s reaction to the drug changes. It links the behavioural, clinical and molecular pharmacology research evidence.
Liver Cell Carcinoma-Edited by P. BANNASCH, D. KEPPLER and G. WEBER.525 DV. 1989. Kluwer, Dordrecht. Holland. D.Fl 289; $121.50. _Three main risk factors for liver cancer are hepatitis B virus (HBV), aflatoxins and alcohol abuse. It is estimated that the lag between infection with HBV and the appearance of hepatocellular carcinoma takes 30-50 years. Animal models of HBV are now available in the hepadna virus induced liver carcinoma, and virus associated hepatomas in woodchuck, ground squirrel and ducks. Chemicals such as aflatoxins, alcohol, steroids (including contraceptives), and nitrosamines, can induce hepatomas. This volume discusses all these points together with the phenotypic changes and altered gene expression in the hepatomas, improved diagnosis, and the treatment of liver carcinomas. Primary prevention of liver cancer by vaccination against HBV is strongly supported. New Drugs in Oncology-Edited FIEBIG. 302 pp. 1989. Karger,
by W. QUEISSERand H. H. Basel. S.Fr. 79: $52.75.
This volume contains a series of papers on the use of different drugs to treat cancers. These include 5-fluorouracil, 5 aza-2-deoxycytidine. cabergoline, droloxifene, zindoxifene, 4-hydroxy-androstenedione, anthracylines (pirarubicin, idarubicin epirubicin), nitrosoureas, metal complexes, ether lipids, immune modulators, and interferons. Basic and Clinical Concepts of Lung Cancer-Edited by H. H. HANSEN. 368 pp. 1989. Kluwer, Dordrecht, Holland. D.Fl 305; $125. Lung cancer is the second most frequent cancer (after stomach cancer which is the first) with 660,500 new cases a year in the world. There is a major increase in the developing world mainly due to an increase in smoking, with a corresponding decrease in smoking and lung cancer in the USA. This volume deals with different aspects of lung cancer; diagnosis, immunohistochemistry, oncogenes, autocrine growth factors, tumor endocrine markers, interferons, prognosis in adenocarcinoma, surgical adjuvant therapy, high dose chemotherapy, bone marrow transplantation, CNS therapy, later complications, psychosocial aspects. Ivermectin and Averme&+-Edited pp. 1989. Springer, Berlin. DM
by W. C. Campbell. 132.
363
Fermentation of the actinomycete Sfrepfomyces uuermirilis produces a series of avermectins [A’s]. The A’s are a range of 16 membered macrocylic lactones. They have no antibacterial or antifungal properties. The milibemycins are structurally related but lack the Cl3 disaccharide substituent. A’s are powerful antihelmintics that can be injected or given orally to sheep, cattle, pigs, dogs, cats, and man with very low toxicity to the host but a powerful action on the nematode worm parasites. A’s bind to the GABA receptors of the parasites and affects their chloride channels. At the concentrations used A does not significantly cross the mammalian blood-brain barrier and so does not affect the mammalian CNS GABA receptors. A’s can also be used as pesticides against insects and insect larvae. A’s do not persist or accumulate in the soil and rapidly photolyze in water. This volume summarises the information on A’s chemical structures, production, mode of action, toxicity, pharmacokinetics, metabolism, and use. The A’s will soon be a billion dollar industry. Antimicrobial Chemotherapy. 2nd edition-Edited D. Greenwood. 372 pp. 1989. Oxford University Oxford. $45; Paper $24.95.
by Press,
The first edition of this book appeared in 1983. The 1980’s have seen the development of the fluoroquinolines and novel