Liver Diseases in the Hemochromatosis and Iron Overload Screening Study

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2006;4:807

CME Activities Liver Diseases in the Hemochromatosis and Iron Overload Screening Study Adams PC, et al, Authors Test ID No.: 0014

Contact hours: 1.0

Expiration Date: July 31, 2007

Question 1: Iron concentration is elevated in all the following organs in hemochromatosis EXCEPT:

a. b. c. d. e.

Liver Heart Pancreas Joints Testis

Question 2: The following were the findings of the HEIRS (Hemochromatosis and Iron Overload Screening) study EXCEPT:

a. b. c. d.

ALT was elevated in 16% of C282Y homozygotes ALT was elevated in 36% of non-C282Y homozygotes ALT was elevated in 10% of control participants Stage 3 or 4 fibrosis was present in 10%–15% of C282Y homozygotes e. Stage 3 or 4 fibrosis was present in 1% of non-C282Y homozygotes

Question 3: In patients with hemochromatosis, a combination of ferritin ⬎1000 mcg/L, AST ⬎40 units/L, and platelets ⬍200,000 mm3 predicts the presence of cirrhosis in what percentage of cases?

a. b. c. d. e.

20% 40% 60% 80% 100%

Question 4: The following were additional findings of the HEIRS (Hemochromatosis and Iron Overload Screening) study EXCEPT:

a. Approximately 80% of C282Y homozygotes had elevated hepatic iron concentration b. Approximately 80% of non-C282Y homozygotes had elevated hepatic iron concentration c. Non-C282Y homozygotes with elevated iron concentration had a diagnosis of hepatitis B, hepatitis C, or NASH rather than hemochromatosis d. Patients had elevated iron concentrations even without liver disease e. A patient on hemodialysis had the highest hepatic iron concentration