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Liver transplant for hepatocellular carcinoma in Qatar: an initial experience
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ePoster Abstracts
the treatment options offered, which may include endotherapy and percutaneous transhepatic cholangiography with stenting or a biliary bypass with bile duct resection. The feasibility and lower morbidity of stent placement could potentially obscure the diagnosis of an underlying malignant or pre-malignant process. Methods: We present a presumptively benign biliary stricture that developed following hepaticoenterostomy for a CBD injury. The patient had repeat bouts of cholangitis requiring an endoscopic stent and PTC drain over the course of one year. Revision of the biliary anastomosis was ultimately performed, and pathological review of the stricture revealed low grade epithelial dysplasia. Results: In patients with postoperative strictures and repeat bouts of cholangitis, negotiation of the stricture itself is technically challenging due to the angulation and dense fibrous tissue. This may not suggest a malignancy, but having a low threshold to operate may be better substantiated if the malignant potential is considered in select patients. Conclusion: Although endoscopic therapy of biliary strictures has lower associated morbidity and its availability has increased substantially, definitive surgical intervention has the benefit of resecting imperceptible dysplastic or malignant strictures and may be associated with longer survival.
P149 ARTERIAL SUPPLY TO THE LIVER IN AN UNSELECTED WEST INDIAN POPULATION S. O. Cawich, A. Sinanan, P. Johnson and M. Gosein University of the West Indies, St. Augustine, Trinidad and Tobago Objective: There are many known variations in the arterial supply to the liver. We sought to document the existing variations in an unselected population in the West Indies. This information is invaluable to optimize hepatobiliary services in the West Indies. Methods: Over 18 months, 205 CT scans were evaluated at a hepatobiliary referral centre in Trinidad & Tobago. We described the arterial supply of the liver using the conventional classification proposed by Michels et al. Results: In this West Indian population, 112 persons (54.6%) had conventional Type 1 anatomy. The distribution of variants was similar to those described in medical literature. However, we found a significantly greater incidence of type 2 replaced right hepatic arteries in 30/205 (14.6%) persons (P 0.483 and a significantly lower incidence of Type 6 accessory right hepatic arteries in 5 (2.4%, P Value 0.349) of persons. The incidence of the remaining variations was similar to that in medical literature. Conclusion: Although 54.6% persons in this West Indian population have conventional arterial supply to the liver, the distribution of anatomic variants is quite different to that seen in North American and European centres. We found a higher incidence or replaced right hepatic arteries and a lower incidence of accessory right hepatic arteries. Hepatobiliary surgeons in the West Indies should be cognizant of these differences in order to optimize outcomes.
P150 LIVER TRANSPLANT FOR HEPATOCELLULAR CARCINOMA IN QATAR: AN INITIAL EXPERIENCE K. Ahmed, W. Elmoghazy, A. Elaffandi and H. Khalaf Hamad General Hospital, Doha, Qatar Objective: Liver transplant is the best available option for early unresectable hepatocellular carcinoma (HCC). Liver transplant program in Qatar started by the end of 2011 and has progressed steadily since then, and here we report our initial experience. Methods: From December 2011 till present, 16 patients were transplanted, 8 of whom had HCC diagnosed on magnetic resonance imaging. Milan criteria was used to select the patients. Patients were divided into two groups: HCC versus non-HCC groups. Data were summarized as mean SD. Survival was calculated using KaplaneMeir curves, and SPSS was used for analysis. Results: Over the study period, sixteen patients were transplanted with a mean follow-up of 1.5 1.3 years. Twelve patients had HCV infection. Fifteen patients were males with a mean age of 52.6 7.4 years at time of transplant. The average length of stay in the intensive care was 2.1 0.7 days and for hospital stay was 12.5 3.4 days. There was no significant difference in the study groups regarding age, sex, average post-operative stay in intensive care unit and in the hospital and survival. There were no reported cases of vascular or biliary complications in both groups. One-year and overall patient survivals after liver transplant are 93% and 87%, respectively. No reported cases of HCC recurrence after transplant. One patient was lost from each group. Conclusion: Despite the initial small number, outcome of transplants is excellent in terms of patient survival, surgical complications and HCC recurrence compared to the international figures.
P151 LIVER WEDGE RESECTION IN GALLBLADER CANCER. SURVIVAL AND SURGICAL RESULTS A. Troncoso, H. Losada, H. Herrera, J. Silva, L. Acencio, O. Arias and L. Burgos Universidad de La Frontera, Temuco, Chile Objective: To describe survival and surgical outcomes in terms of postoperative morbidity and mortality of patients undergoing wedge liver resection plus lymphadenectomy between 2008 and 2016. Methods: Case series of patients undergoing liver wedge resection between 2008 and 2016 at Hospital Temuco and Clinica Alemana Temuco. Biodemographic, surgical and clinical outcome variables were recorded. All patients were evaluated with chest-abdominal- pelvis CT for staging and tumor markers in a multidisciplinary meeting. Descriptive statistics were used measures of central tendency and dispersion. Results: Total of 22 patients, 21 females and 1 male. Preoperative T stage (TNM): stage T1a (n = 2, both with compromise of Rokitansky Aschoff sinuses), stage T1b HPB 2017, 19 (S1), S120eS192
ePoster Abstracts
the treatment options offered, which may include endotherapy and percutaneous transhepatic cholangiography with stenting or a biliary bypass with bile duct resection. The feasibility and lower morbidity of stent placement could potentially obscure the diagnosis of an underlying malignant or pre-malignant process. Methods: We present a presumptively benign biliary stricture that developed following hepaticoenterostomy for a CBD injury. The patient had repeat bouts of cholangitis requiring an endoscopic stent and PTC drain over the course of one year. Revision of the biliary anastomosis was ultimately performed, and pathological review of the stricture revealed low grade epithelial dysplasia. Results: In patients with postoperative strictures and repeat bouts of cholangitis, negotiation of the stricture itself is technically challenging due to the angulation and dense fibrous tissue. This may not suggest a malignancy, but having a low threshold to operate may be better substantiated if the malignant potential is considered in select patients. Conclusion: Although endoscopic therapy of biliary strictures has lower associated morbidity and its availability has increased substantially, definitive surgical intervention has the benefit of resecting imperceptible dysplastic or malignant strictures and may be associated with longer survival.
P149 ARTERIAL SUPPLY TO THE LIVER IN AN UNSELECTED WEST INDIAN POPULATION S. O. Cawich, A. Sinanan, P. Johnson and M. Gosein University of the West Indies, St. Augustine, Trinidad and Tobago Objective: There are many known variations in the arterial supply to the liver. We sought to document the existing variations in an unselected population in the West Indies. This information is invaluable to optimize hepatobiliary services in the West Indies. Methods: Over 18 months, 205 CT scans were evaluated at a hepatobiliary referral centre in Trinidad & Tobago. We described the arterial supply of the liver using the conventional classification proposed by Michels et al. Results: In this West Indian population, 112 persons (54.6%) had conventional Type 1 anatomy. The distribution of variants was similar to those described in medical literature. However, we found a significantly greater incidence of type 2 replaced right hepatic arteries in 30/205 (14.6%) persons (P 0.483 and a significantly lower incidence of Type 6 accessory right hepatic arteries in 5 (2.4%, P Value 0.349) of persons. The incidence of the remaining variations was similar to that in medical literature. Conclusion: Although 54.6% persons in this West Indian population have conventional arterial supply to the liver, the distribution of anatomic variants is quite different to that seen in North American and European centres. We found a higher incidence or replaced right hepatic arteries and a lower incidence of accessory right hepatic arteries. Hepatobiliary surgeons in the West Indies should be cognizant of these differences in order to optimize outcomes.
P150 LIVER TRANSPLANT FOR HEPATOCELLULAR CARCINOMA IN QATAR: AN INITIAL EXPERIENCE K. Ahmed, W. Elmoghazy, A. Elaffandi and H. Khalaf Hamad General Hospital, Doha, Qatar Objective: Liver transplant is the best available option for early unresectable hepatocellular carcinoma (HCC). Liver transplant program in Qatar started by the end of 2011 and has progressed steadily since then, and here we report our initial experience. Methods: From December 2011 till present, 16 patients were transplanted, 8 of whom had HCC diagnosed on magnetic resonance imaging. Milan criteria was used to select the patients. Patients were divided into two groups: HCC versus non-HCC groups. Data were summarized as mean SD. Survival was calculated using KaplaneMeir curves, and SPSS was used for analysis. Results: Over the study period, sixteen patients were transplanted with a mean follow-up of 1.5 1.3 years. Twelve patients had HCV infection. Fifteen patients were males with a mean age of 52.6 7.4 years at time of transplant. The average length of stay in the intensive care was 2.1 0.7 days and for hospital stay was 12.5 3.4 days. There was no significant difference in the study groups regarding age, sex, average post-operative stay in intensive care unit and in the hospital and survival. There were no reported cases of vascular or biliary complications in both groups. One-year and overall patient survivals after liver transplant are 93% and 87%, respectively. No reported cases of HCC recurrence after transplant. One patient was lost from each group. Conclusion: Despite the initial small number, outcome of transplants is excellent in terms of patient survival, surgical complications and HCC recurrence compared to the international figures.
P151 LIVER WEDGE RESECTION IN GALLBLADER CANCER. SURVIVAL AND SURGICAL RESULTS A. Troncoso, H. Losada, H. Herrera, J. Silva, L. Acencio, O. Arias and L. Burgos Universidad de La Frontera, Temuco, Chile Objective: To describe survival and surgical outcomes in terms of postoperative morbidity and mortality of patients undergoing wedge liver resection plus lymphadenectomy between 2008 and 2016. Methods: Case series of patients undergoing liver wedge resection between 2008 and 2016 at Hospital Temuco and Clinica Alemana Temuco. Biodemographic, surgical and clinical outcome variables were recorded. All patients were evaluated with chest-abdominal- pelvis CT for staging and tumor markers in a multidisciplinary meeting. Descriptive statistics were used measures of central tendency and dispersion. Results: Total of 22 patients, 21 females and 1 male. Preoperative T stage (TNM): stage T1a (n = 2, both with compromise of Rokitansky Aschoff sinuses), stage T1b HPB 2017, 19 (S1), S120eS192