- Email: [email protected]
Lobelin in asphyxia of the newborn
REVIEWS
AiVD
451
ABSTRACTS
It can readily be seen from the above that even though the outlook for the premature is not a rosy one, results are sufficiently good to justify the care and time expended. The most essential thing is maintenance of body temperature, which Breast milk is escan be better provided by hot water bottles than incubators. sential, at least for the first few weeks, and co’d-liver oil and phosphorus is given in small doses from t,he second month as a prophylactic against the widely prevT. C. HI~PELIII~N. alent rickets. Miktiicz-Radecki: Intraeardial Injection of Adrenalin and Subcutaneolus Injection of Lobelin in the Treatznent of Pallid Asphyxia in the New Born. Zentralblatt fiir Gynakologie, 1922, xxxix, 1574. The child was undoubtedly affected by scopolamine, morphia, and ether administered to the eclamptic mother during the course of four hours and resuscitated after forty-five minutes by means of the above-mentioned two drugs. The writer refers to the history of adrenalin injection for the reestablishment of cardiac activity, and suggests the ventricle as .the ideal spot for the injection. The introduction of the needle alone has a marked influence on the heart. The object is to stimulate not only the heart but the respiratory center as well, and in search for a drug to act in this respect in conjunction with adrenalin, the author suggests lobelin, the alkaloid of Lobelia inflata. The injection ‘of one to three mg. subcutaneously has remarkable results. Where the heart action is satisfactory, subcutaneous injection of the lobelin will suffice, when the heart action is weak the combination with adrenalin is recommended. The dose of adrenalin used was LI'MXE. 0.5 mg. Rainey, E. H.: Intracardiac Injection of Pituitrin ish Medical Journal, 1924, No. 3304, ‘i-17.
in Asphyxia
Neonatonun.
Brit-
The child was born in a condition of white asphyxia, with the cord only feebly pulsating. The child ma,de no attempt at respiration, and by the time he had been separated and his throat cleared of mucus the pulse ceased. In spite of pulling on the tongue, hot bath, cardiac massage, and artificial respiration by inflation, the heart was not audible. Adrenalin was not at hand, but 0.25 C.C. of pituitrin was injected directly into the heart, and inflation respiration was continued. Within half a minute the heart began to beat and so continued with increasing force. After five minutes’ further forced respiration the child began to make three or four active attempts at. respiration a minute. By the end of an hour he was breathing satisfactorily, and his condition gave no further trouble. FRED L. ADAIR. Miltner: Lobalin in Asphyxia of the Newborn. und Gyrrakologie, 1923, Ixii, 60.
Monatsschrift
fiir
Geburtshiilfe
During the last eight months, the author has employed lobelin hydrochloride to resuscitate newborn children who were profoundly asphyxiated. The drug was used in forty-two cases after attempts had been made to resuscitate these children by other means. Three milligram doses were given subcutaneously under the breast. In only eight cases was it necessary to repeat the injection to secure results. The children usually responded in from one to five minutes and cried in from rive to ten minutes. Eight children could not be revived but autopsies showed this to have been impossible because of the extensive anatomic changes present. The author believes that lobelin is a specific excitor of the respiratory center. J. P. GREENHILL.
AiVD
451
ABSTRACTS
It can readily be seen from the above that even though the outlook for the premature is not a rosy one, results are sufficiently good to justify the care and time expended. The most essential thing is maintenance of body temperature, which Breast milk is escan be better provided by hot water bottles than incubators. sential, at least for the first few weeks, and co’d-liver oil and phosphorus is given in small doses from t,he second month as a prophylactic against the widely prevT. C. HI~PELIII~N. alent rickets. Miktiicz-Radecki: Intraeardial Injection of Adrenalin and Subcutaneolus Injection of Lobelin in the Treatznent of Pallid Asphyxia in the New Born. Zentralblatt fiir Gynakologie, 1922, xxxix, 1574. The child was undoubtedly affected by scopolamine, morphia, and ether administered to the eclamptic mother during the course of four hours and resuscitated after forty-five minutes by means of the above-mentioned two drugs. The writer refers to the history of adrenalin injection for the reestablishment of cardiac activity, and suggests the ventricle as .the ideal spot for the injection. The introduction of the needle alone has a marked influence on the heart. The object is to stimulate not only the heart but the respiratory center as well, and in search for a drug to act in this respect in conjunction with adrenalin, the author suggests lobelin, the alkaloid of Lobelia inflata. The injection ‘of one to three mg. subcutaneously has remarkable results. Where the heart action is satisfactory, subcutaneous injection of the lobelin will suffice, when the heart action is weak the combination with adrenalin is recommended. The dose of adrenalin used was LI'MXE. 0.5 mg. Rainey, E. H.: Intracardiac Injection of Pituitrin ish Medical Journal, 1924, No. 3304, ‘i-17.
in Asphyxia
Neonatonun.
Brit-
The child was born in a condition of white asphyxia, with the cord only feebly pulsating. The child ma,de no attempt at respiration, and by the time he had been separated and his throat cleared of mucus the pulse ceased. In spite of pulling on the tongue, hot bath, cardiac massage, and artificial respiration by inflation, the heart was not audible. Adrenalin was not at hand, but 0.25 C.C. of pituitrin was injected directly into the heart, and inflation respiration was continued. Within half a minute the heart began to beat and so continued with increasing force. After five minutes’ further forced respiration the child began to make three or four active attempts at. respiration a minute. By the end of an hour he was breathing satisfactorily, and his condition gave no further trouble. FRED L. ADAIR. Miltner: Lobalin in Asphyxia of the Newborn. und Gyrrakologie, 1923, Ixii, 60.
Monatsschrift
fiir
Geburtshiilfe
During the last eight months, the author has employed lobelin hydrochloride to resuscitate newborn children who were profoundly asphyxiated. The drug was used in forty-two cases after attempts had been made to resuscitate these children by other means. Three milligram doses were given subcutaneously under the breast. In only eight cases was it necessary to repeat the injection to secure results. The children usually responded in from one to five minutes and cried in from rive to ten minutes. Eight children could not be revived but autopsies showed this to have been impossible because of the extensive anatomic changes present. The author believes that lobelin is a specific excitor of the respiratory center. J. P. GREENHILL.