LOCI OF HUMAN HÆMOGLOBIN GENES

LOCI OF HUMAN HÆMOGLOBIN GENES

1422 al. " XBD=2541 XBD=1794 XBD=1873 XBD=1952 XBD=2053 XBD=2110 XBD=2264 XBD=2308 XBD=2458 XHG=1392 XHG=1807 XHG=1886 XHG=1966 XHG=2066 XHG=2124 XHG...
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1422 al.

" XBD=2541 XBD=1794 XBD=1873 XBD=1952 XBD=2053 XBD=2110 XBD=2264 XBD=2308 XBD=2458 XHG=1392 XHG=1807 XHG=1886 XHG=1966 XHG=2066 XHG=2124 XHG=2276 XHG=2364 XHG=2470 YBD=374 YBD=368 YBD=367 YBD=373 YHG=337>serum-cholinesterase, YHG=337>this YHG=347>was YHG=337>done YHG=338>by YHG=337>Goedde YHG=343>et YHG=337>who YHG=337>also, XBD=262 XHG=874 XBD=314 XBD=388 XBD=535 XBD=652 XBD=695 XBD=783 XBD=858 XBD=952 XBD=1027 XBD=1062 XBD=1182 XBD=1327 XHG=142 XHG=278 XHG=330 XHG=404 XHG=550 XHG=668 XHG=711 XHG=800 XHG=967YBD=368 XHG=1043 XHG=1077 XHG=1197 YBD=375 YBD=367 YBD=368 YBD=376 YHG=338>regard YHG=344>to YHG=338>the YHG=337>district YHG=347>nurse YHG=337>is YHG=337>that YHG=337>she YHG=347>now YHG=337>has YHG=346>a YHG=338>much YHG=345>greater

XBD=282 XBD=348 XBD=494 XBD=582 XBD=788 XBD=926 XBD=998 XBD=1112 XBD=1177 XBD=1327 XHG=141 XHG=312 XHG=378 XHG=523 XHG=610 XHG=817 XHG=1028 XHG=1141 XHG=1206 YBD=421 YBD=419 YBD=420 YBD=414 YBD=413 YBD=415 YHG=384>mileage YHG=390>to YHG=393>cover; YHG=383>the YHG=390>argument YHG=382>might YHG=384>be YHG=383>used -they YHG=383>in YHG=384>favour " XBD=2398 XBD=2541XHG=956 XBD=1438 XBD=1466 XBD=1698 XBD=1872 XBD=2084 XBD=2213 XHG=1392 XHG=1449 XHG=1483 XHG=1715 XHG=1893 XHG=2106 XHG=2233 XHG=2418 YBD=422 YBD=421 YBD=420 YBD=414 YHG=384>by YHG=393>a YHG=383>particularly YHG=384>sensitive YHG=384>technique, YHG=383>found YHG=383>that YHG=383>showed " XBD=1331 XBD=182 XBD=218 XBD=408 XBD=554 XBD=615 XBD=730 XBD=870 XBD=964 XBD=1080 XBD=1129 XBD=1268 XHG=892 XHG=142 XHG=199 XHG=239 XHG=430 XHG=576 XHG=633 XHG=985 XHG=1102 XHG=1151 XHG=1290 YBD=460 YBD=465 YBD=466 YBD=459 YBD=459 YBD=459 YBD=460 YHG=430>of YHG=439>a YHG=439>narrower YHG=429>zoning YHG=429>of YHG=436>G.P.s, YHG=435>except YHG=429>that YHG=428>there YHG=429>is YHG=429>choice YHG=430>of XBD=1451XHG=753 XBD=1512 XBD=1579 XBD=1690 XBD=1846 XBD=2004 XHG=1390 XHG=1472 XHG=1522 XHG=1594 XHG=1705 XHG=1860 YBD=467 YHG=430>3% YHG=429>the YHG=430>usual YHG=439>enzyme YHG=429>activity. " XBD=1326 XBD=261 XHG=791 XBD=352 XBD=441 XBD=509 XBD=644 XBD=763 XBD=942 XBD=1178 XBD=1223 XHG=142 XHG=289 XHG=380 XHG=469 XHG=532 XHG=687 XHG=970YBD=505 XHG=1208 XHG=1252 YBD=504 YBD=505 YBD=505 YBD=506 YHG=475>doctor YHG=475>but YHG=481>not YHG=474>of YHG=484>nurse. YHG=474>The YHG=474>midwife YHG=473>attachment YHG=474>I YHG=476>find

Department of Chemical Pathology,

School of Medicine, " XBD=1326 XBD=308 XHG=962 XBD=440 XBD=526 XBD=747 XBD=949 XBD=988 XBD=1182 XBD=1226 XHG=142 XHG=322 XHG=453 XHG=539 XHG=759 XHG=1002YBD=551 XHG=1211 XHG=1240 YBD=557 YBD=559 YBD=558 YBD=558YHG=520>is YBD=551 YBD=552 YHG=521>valuable, YHG=527>except YHG=521>that YHG=520>domiciliary YHG=520>midwifery YHG=519>declining. YHG=521>I YHG=521>have R. HEYWORTH. Leeds, 2. " XBD=1234 XBD=203 XHG=781 XBD=328 XBD=416 XBD=546 XBD=694 XBD=765 XBD=962 XBD=1013 XBD=1086 XHG=142 XHG=218 XHG=344 XHG=431 XHG=562 XHG=711 XHG=978YBD=598 XHG=1029 XHG=1102 YBD=597 YBD=597 YBD=597YHG=567>interested YBD=605 YHG=573>not YHG=566>found YHG=567>that YHG=567>health YHG=567>visitors YHG=577>are YHG=567>in YHG=565>old YHG=566>people. Wharfedale Group of Hospitals, " XBD=1323 XBD=242 XHG=844 XBD=312 XBD=421 XBD=529 XBD=595 XBD=675 XBD=830 XBD=956 XBD=1060 XBD=1114 XHG=187 XHG=254 XHG=324 XHG=434 XHG=541 XHG=608 XHG=687 XHG=968YBD=644 XHG=1072 XHG=1126 YBD=652 YBD=643 YBD=644 YBD=644 YBD=652 YHG=613>To YHG=623>my YHG=613>mind YHG=613>there YHG=623>are YHG=620>two YHG=614>features YHG=613>which YHG=619>must YHG=613>be YHG=614>preserved: The General Hospital, HELEN M. J. FIRTH. " XBD=1324 XBD=192 XHG=873 XBD=280 XBD=578 XBD=842 XBD=919 XBD=1008 XBD=1187 XBD=1256 XHG=142 XHG=223 XHG=311 XHG=608 XHG=950YBD=698 XHG=1039 XHG=1216 XHG=1282 YBD=697 YBD=690 YBD=691 YBD=698 YBD=690 YHG=659>(a) YHG=660>the YHG=659>doctor-patient YHG=660>relationship; YHG=660>(b) YHG=659>the YHG=660>equality YHG=660>of YHG=660>all Otley, Yorks. " XBD=1324 XBD=239 XHG=915 XBD=384 XBD=468 XBD=629 XBD=743 XBD=899 XBD=973 XBD=1124 XBD=1272 XHG=141 XHG=270 XHG=400 XHG=484 XHG=646 XHG=758 XHG=988YBD=738 XHG=1141 XHG=1288 YBD=736 YBD=737 YBD=745 YBD=745 YBD=737 YBD=736 YHG=713>G.P.s. YHG=706>These YHG=712>two YHG=706>features YHG=706>alone YHG=713>prevent YHG=706>the YHG=713>present YHG=706>decline YHG=706>in " XBD=1324 XBD=304 XHG=955 XBD=415 XBD=540 XBD=578 XBD=823 XBD=917 XBD=986 XBD=1099 XBD=1162 XHG=140 XHG=326 XHG=438 XHG=560 XHG=599 XHG=843 XHG=1007 XHG=1120 XHG=1183 YBD=783 YBD=790 YBD=782 YBD=791 YBD=784 YBD=784 YBD=783 YHG=752>numbers YHG=752>from YHG=752>being YHG=762>a YHG=753>catastrophic YHG=762>one. YHG=753>It YHG=759>must YHG=753>be YHG=752>realised " XBD=1324 XBD=213 XHG=827 XBD=244 XBD=459 XBD=513 XBD=655 XBD=814 XBD=854 XBD=1052 XBD=1176 XHG=140 XHG=226 XHG=257 XHG=473 XHG=522 XHG=668 XHG=869YBD=830 XHG=1065 XHG=1189 YBD=828 YBD=829 YBD=836 YBD=837 YBD=838 YBD=830YHG=799>is YBD=829 YHG=798>that YHG=808>a YHG=798>proportion YHG=798>of YHG=799>general YHG=799>practice YHG=799>inevitably YHG=799>minor YHG=798>routine LOCI OF HUMAN HÆMOGLOBIN GENES " XBD=1321 XBD=243 XHG=800 XBD=340 XBD=555 XBD=650 XBD=712 XBD=783 XBD=945 XBD=1000 XBD=1167 XHG=139 XHG=260 XHG=357 XHG=570 XHG=666 XHG=726 XHG=961YBD=877 XHG=1012 XHG=1184 YBD=881 YBD=882 YBD=877 YBD=882 YBD=876 YHG=845>work, YHG=845>kept YHG=845>interesting YHG=846>only YHG=846>by YHG=847>the YHG=845>element YHG=846>of YHG=845>personal YHG=845>service. Shooter " XBD=2532 XBD=1697 XHG=2394 XBD=1782 XBD=2072 XBD=2308 XBD=2379 XHG=1435 YBD=909 XHG=1715 XHG=1960 XHG=2089 XHG=2324 YBD=913 YHG=875>evidence YBD=907 YBD=906 YBD=905 YHG=877>SIR,-Huehns YHG=876>and YHG=876>P YHG=874>summarised YHG=874>the have JOHN GREENWOOD. " XBD=2530 XBD=1442 XHG=2432 XBD=1515 XBD=1621 XBD=1768 XBD=1824 XBD=2015 XBD=2131 XBD=2200 XBD=2271 XBD=2306 XBD=2386 XBD=2417 XHG=1388 YBD=955 XHG=1457 XHG=1532 XHG=1637 XHG=1784 XHG=1836 XHG=2032 XHG=2147 XHG=2215 XHG=2289 XHG=2322 XHG=2402 YBD=961 YHG=922>chains YBD=953 YBD=954 YBD=960 YBD=952 YBD=958 YBD=951 YHG=923>for YHG=923>the YHG=923>close YHG=923>linkage YHG=923>of YHG=923>structural YHG=931>genes YHG=921>for YHG=921>the YHG=922>j3 YHG=921>and YHG=922>8 " XBD=2531 XBD=1428 XHG=2483 XBD=1570 XBD=1827 XBD=1922 XBD=2075 XBD=2171 XBD=2264 XBD=2468 XHG=1387 YBD=1001 XHG=1442 XHG=1588 XHG=1859 XHG=1939 XHG=2092 XHG=2190 XHG=2283 YBD=1000YHG=967>data YBD=1007 YBD=1008 YBD=999 YBD=998 YBD=1006 YHG=968>here YHG=969>of YHG=969>human YHG=968>haemoglobin. YHG=969>We YHG=975>present YHG=968>supporting YHG=969>the " XBD=2531 XBD=1569 XHG=2294 XBD=1781 XBD=1847 XBD=1965 XBD=2101 XBD=2185 XBD=2268 XHG=1387 YBD=1054 XHG=1597 XHG=1807 XHG=1869 XHG=1991 XHG=2144 XHG=2212 YBD=1055 YHG=1015>accompanying YBD=1046 YBD=1047 YBD=1053 YBD=1045 YBD=1044 YHG=1016>presumed YHG=1015>proximity YHG=1015>of YHG=1015>these YHG=1024>genes. YHG=1014>In YHG=1013>the " XBD=2530 XBD=1557 XBD=1632 XBD=1803 XBD=1874 XBD=1925 XBD=1971 XBD=2116 XBD=2366 XBD=2430 XHG=1386 XHG=1574 XHG=1648 XHG=1821 XHG=1891 XHG=1943 XHG=1988 XHG=2131 XHG=2381 XHG=2445 YBD=1101 YBD=1100 YBD=1093 YBD=1099 YBD=1098 YBD=1092 YHG=1062>pedigree, YHG=1062>the YHG=1062>proband YHG=1062>(11, YHG=1062>4) YHG=1062>is YHG=1061>doubly YHG=1060>heterozygous YHG=1060>for YHG=1062>sickle SILENT GENEYBD=1094 FOR SERUM-CHOLINESTERASE " XBD=2529 XBD=1616 XHG=2328 XBD=1709 XBD=1768 XBD=1855 XBD=1893 XBD=2048 XBD=2203 XBD=2311 XHG=1386 YBD=1146 XHG=1636 XHG=1731 XHG=1788 XHG=1874 XHG=1913 XHG=2067 XHG=2236 YBD=1147 YHG=1107>haemoglobin YBD=1140 YBD=1139 YBD=1138 YBD=1137 YHG=1109>haemoglobin YHG=1109>(Hb YHG=1109>S) YHG=1108>and YHG=1119>a YHG=1108>8-chain YHG=1108>variant. YHG=1106>The |>" " XBD=468 XBD=695 XBD=752 XBD=839 XBD=1003 XBD=1111 XBD=1221 XBD=395 XHG=418 XHG=491 XHG=717 XHG=774 XHG=861 XHG=1026 XHG=1134 XHG=1245 XHG=183 YBD=1167 YBD=1166 YBD=1166 YBD=1173 YBD=1166 YHG=1136>six YHG=1136>individuals YHG=1136>in YHG=1135>families YHG=1134>SIR,-Only YHG=1135>have YHG=1136>been YHG=1136>des" XBD=1321 XBD=1581 XBD=1637 XBD=1824 XBD=1855 XBD=1968 XBD=2007 XBD=2168 XBD=2215 XBD=2261 XBD=2332 XBD=2394 XBD=2529 XHG=1386 XHG=1594 XHG=1650 XHG=1838 XHG=1868 XHG=1981 XHG=2021 XHG=2180 XHG=2228 XHG=2275 XHG=2345 XHG=2408 YBD=1193YHG=1136>five YBD=1185 YBD=1183 YBD=1184 YBD=1191 YBD=1186 YHG=1156>containing YHG=1164>an YHG=1155>abnormal YHG=1156>8 YHG=1155>chain YHG=1155>is YHG=1154>referred YHG=1160>to YHG=1162>as YHG=1153>Hb YHG=1154>B2, YHG=1155>because " XBD=321 XBD=427 XBD=511 XBD=779 XBD=859 XBD=993 XBD=1142 XBD=1257 XBD=1326 XHG=137 XHG=349 XHG=456 XHG=538 XHG=807 XHG=886 XHG=1009 XHG=1172 XHG=1285 YBD=1218 YBD=1220 YBD=1213 YBD=1212 YBD=1212 YBD=1220 YBD=1213 YHG=1181>cribed YHG=1181>who YHG=1191>are YHG=1182>homozygotes YHG=1182>for YHG=1182>the YHG=1182>silent YHG=1191>gene 1 &dquo; 5, " XBD=2528 XBD=1426 XHG=2499 XBD=1508 XBD=1712 XBD=1779 XBD=1845 XBD=2150 XBD=2330 XBD=2388 XBD=2476 XHG=1386 YBD=1233 XHG=1450 XHG=1537 XHG=1739 XHG=1803 XHG=1875 XHG=2177 XHG=2355 XHG=2413 YBD=1239 YHG=1181>of YBD=1238 YBD=1231 YBD=1232 YHG=1202>the&dquo; YHG=1201>similarity YHG=1201>of YHG=1202>its YHG=1200>electrophoretic YHG=1199>mobility YHG=1206>to YHG=1200>that YHG=1201>in " XBD=530 XBD=729 XBD=831 XBD=1022 XBD=1139 XBD=1321 XHG=137 XHG=568 XHG=769 XHG=869 XHG=1059 XHG=1178 YBD=1259 YBD=1266 YBD=1260 YBD=1260 YBD=1259 YHG=1228>serum-cholinesterase YHG=1229>(El YHG=1229>We YHG=1228>describe YHG=1228>here YHG=1228>another sEl S). " XBD=2528 XBD=1578 XHG=2472 XBD=1754 XBD=1941 XBD=2001 XBD=2140 XBD=2216 XBD=2279 XBD=2461 XHG=1385 YBD=1279 XHG=1596 XHG=1773 XHG=1961 XHG=2015 XHG=2158 XHG=2233 XHG=2291 YBD=1286 YHG=1248>and YBD=1278 YBD=1277 YBD=1283 YBD=1284 YHG=1248>previously YHG=1248>reported YHG=1248>examples YHG=1247>of YHG=1247>certain YHG=1247>Hb YHG=1247>A2 YHG=1247>variants,lO " XBD=255 XBD=351 XBD=431 XBD=529 XHG=137 XHG=267 XHG=362 XHG=444 YBD=1313 YBD=1305 YBD=1306 YHG=1274>family YHG=1274>with YHG=1281>two YHG=1275>such YHG=1274>individuals. " XBD=755 XBD=1428XHG=541 XBD=1606 XBD=1826 XBD=1877 XBD=2057 XBD=2164 XBD=2310 XBD=2420 XBD=2469 XBD=2527 XHG=1385 XHG=1446 XHG=1623 XHG=1842 XHG=1895 XHG=2088 XHG=2181 XHG=2326 XHG=2434 XHG=2479 YBD=1324 YBD=1332 YBD=1325 YBD=1326 YHG=1294>its YHG=1303>common YHG=1303>occurrence YHG=1294>in YHG=1294>Negroes. YHG=1294>The YHG=1294>genetic YHG=1294>study YHG=1294>of YHG=1294>the XBD=212 XHG=841 XBD=383 XBD=708 XBD=809 XBD=907 XBD=1108 XBD=1178 XBD=1321 XHG=180 XHG=245 XHG=417 XHG=742 XHG=943YBD=1368 XHG=1141 XHG=1214 YBD=1376 YBD=1375 YBD=1368 YBD=1368YHG=1346>was YBD=1375 YHG=1337>A YHG=1337>healthy YHG=1337>twelve-year-old YHG=1337>boy YHG=1336>admitted YHG=1344>to YHG=1337>Ilkley " XBD=2527 XBD=1555 XBD=1613 XBD=1720 XBD=1947 XBD=2004 XBD=2083 XBD=2216 XBD=2386 XBD=2465 XHG=1385 XHG=1573 XHG=1625 XHG=1737 XHG=1965 XHG=2017 XHG=2100 XHG=2232 XHG=2402 XHG=2479 YBD=1379 YBD=1371 YBD=1380 YBD=1372 YBD=1373 YHG=1341>members YHG=1340>of YHG=1341>three YHG=1340>generations YHG=1341>of YHG=1341>this YHG=1340>family YHG=1340>indicates YHG=1341>that YHG=1341>the XBD=348 XHG=842 XBD=520 XBD=587 XBD=748 XBD=801 XBD=828 XBD=937 XBD=1198 XBD=1252 XBD=1321 XHG=138 XHG=361 XHG=534 XHG=601 XHG=761 XHG=810 XHG=951YBD=1415 XHG=1212 XHG=1262 YBD=1422 YBD=1414 YBD=1422 YBD=1415 YBD=1414 YHG=1383>Coronation YHG=1383>Hospital YHG=1383>for YHG=1384>excision YHG=1384>of YHG=1394>a YHG=1384>small YHG=1384>hxmangioma YHG=1384>of YHG=1383>the " XBD=2527 XBD=1525 XBD=1640 XBD=1870 XBD=1944 XBD=2022 XBD=2207 XBD=2267 XBD=2340 XBD=2382 XBD=2461 XHG=1387 XHG=1546 XHG=1661 XHG=1890 XHG=1964 XHG=2043 XHG=2228 XHG=2283 XHG=2362 XHG=2403 XHG=2479 YBD=1426 YBD=1420 YBD=1418 YBD=1419 YHG=1387>f3-chain YHG=1388>locus YHG=1387>responsible YHG=1387>for YHG=1387>the YHG=1388>synthesis YHG=1389>of YHG=1387>Hb YHG=1387>S YHG=1387>and YHG=1388>the XBD=273 XHG=850 XBD=605 XBD=815 XBD=905 XBD=1025 XBD=1129 XBD=1320 XHG=136 XHG=323 XHG=641 XHG=942YBD=1468 XHG=1062 XHG=1165 YBD=1467 YBD=1469 YBD=1468 YBD=1461 YBD=1468 YHG=1436>tongue. YHG=1430>Premedication, YHG=1430>pethidine YHG=1430>(25 YHG=1431>mg.) YHG=1431>and YHG=1431>atropine " XBD=2526 XBD=1523 XBD=1636 XBD=1865 XBD=1937 XBD=2015 XBD=2077 XBD=2152 XBD=2206 XBD=2282 XBD=2383 XHG=1386 XHG=1542 XHG=1657 XHG=1884 XHG=1957 XHG=2036 XHG=2097 XHG=2172 XHG=2225 XHG=2301 XHG=2400 YBD=1464 YBD=1471 YBD=1466 YBD=1465 YBD=1472 YHG=1434>8-chain YHG=1434>locus YHG=1434>responsible YHG=1433>for YHG=1434>Hb YHG=1435>B2 YHG=1444>are YHG=1434>in YHG=1435>the YHG=1442>trans YHG=1434>position " XBD=1317 XBD=207 XBD=325 XBD=414 XBD=536 XBD=850 XBD=910 XBD=1019 XHG=137 XHG=228 XHG=347 XHG=436 XHG=557 XHG=931 XHG=1039 YBD=1515 YBD=1514 YBD=1507 YBD=1515 YHG=1477>(0.6 YHG=1477>mg.), YHG=1486>was YHG=1477>given YHG=1476>intramuscularly YHG=1477>hour YHG=1476>preoperatively. XBD=1420XHG=868 XBD=1497 XBD=1682 XBD=1794 XBD=1981 XBD=2041 XBD=2121 XBD=2255 XBD=2442 XBD=2526 XHG=1385YBD=1508 XHG=1440 XHG=1517 XHG=1716 XHG=1813 XHG=2000 XHG=2055 XHG=2140 XHG=2274 XHG=2458 YBD=1518YHG=1486>an YBD=1511 YBD=1520 YBD=1512 YHG=1480>in YHG=1480>the YHG=1479>proband. YHG=1480>The YHG=1481>members YHG=1480>of YHG=1480>this YHG=1480>family YHG=1480>combined YHG=1480>with XBD=347 XHG=775 XBD=449 XBD=633 XBD=750 XBD=995 XBD=1099 XBD=1219 XBD=1320 XHG=136 XHG=382 XHG=485 XHG=668 XHG=1020 XHG=1134 XHG=1252 YBD=1555 YBD=1554 YBD=1562 YBD=1561 YBD=1562 YBD=1554 YHG=1523>Anaesthesia YHG=1533>was YHG=1523>induced YHG=1523>with YHG=1523>thiopentone YHG=1523>(250 YHG=1524>mg.) YHG=1523>and " XBD=2526 XBD=1481 XBD=1612 XBD=1775 XBD=1848 XBD=2082 XBD=2144 XBD=2298 XBD=2373 XBD=2495 XHG=1384 XHG=1498 XHG=1628 XHG=1793 XHG=1861 XHG=2100 XHG=2156 XHG=2310 XHG=2388 XHG=2504 YBD=1565 YBD=1566 YBD=1559 YBD=1558 YBD=1545 YHG=1527>those YHG=1527>whose YHG=1526>findings YHG=1536>are YHG=1527>summarised YHG=1528>by YHG=1528>Pearson YHG=1527>and YHG=1527>Moore YHG=1527>11 XBD=436 XHG=731 XBD=537 XBD=673 XBD=958 XBD=1320 XHG=138 XHG=481 XHG=579 XHG=1000 YBD=1601 YBD=1608 YBD=1602 YBD=1609 YHG=1570>suxamethonium YHG=1570>(40 YHG=1570>mg.). YHG=1570>Intermittent YHG=1570>positive-pressure " XBD=2526 XBD=1466 XBD=1525 XBD=1713 XBD=1772 XBD=1829 XBD=1990 XBD=2151 XBD=2205 XBD=2331 XBD=2433 XBD=2472 XHG=1384 XHG=1485 XHG=1547 XHG=1732 XHG=1789 XHG=1848 XHG=2008 XHG=2171 XHG=2224 XHG=2349 XHG=2448 XHG=2488 YBD=1604 YBD=1612 YBD=1606 YBD=1605 YHG=1574>total YHG=1575>51 YHG=1573>offspring YHG=1574>of YHG=1575>10 YHG=1574>suitable YHG=1575>matings YHG=1575>in YHG=1574>which YHG=1574>there YHG=1574>is YHG=1583>no XBD=336 XHG=849 XBD=518 XBD=608 XBD=826 XBD=902 XBD=1029 XBD=1126 XBD=1163 XBD=1320 XHG=137 XHG=360 XHG=542 XHG=631 XHG=924YBD=1648 XHG=1051 XHG=1145 XHG=1187 YBD=1649 YBD=1655 YBD=1648 YBD=1648 YHG=1618>ventilation YHG=1617>(i.P.P.v.) YHG=1627>was YHG=1617>performed YHG=1617>for YHG=1617>about YHG=1617>half YHG=1627>a YHG=1618>minute " XBD=1945 XBD=1558 XBD=1722 XBD=1753 XBD=1831 XBD=1860 XHG=1384 XHG=1569 XHG=1736 XHG=1765 XHG=1843 XHG=1871 YBD=1659 YBD=1651 YBD=1652 YHG=1630>crossover YHG=1620>between YHG=1623>(3 YHG=1621>and YHG=1622>8 YHG=1620>loci. XBD=222 XHG=910 XBD=254 XBD=416 XBD=472 XBD=625 XBD=769 XBD=894 XBD=977 XBD=1010 XBD=1110 XBD=1318 XHG=138 XHG=236 XHG=269 XHG=431 XHG=483 XHG=640 XHG=785 XHG=992YBD=1694 XHG=1026 XHG=1125 YBD=1702 YBD=1695 YBD=1700 YBD=1694 YBD=1694 YBD=1700 YHG=1665>with YHG=1674>a YHG=1664>mixture YHG=1664>of YHG=1673>oxygen, YHG=1664>nitrous YHG=1664>oxide, YHG=1664>and YHG=1674>a YHG=1663>little YHG=1664>halothane, " XBD=2525 XBD=1673 XBD=1743 XBD=1833 XBD=1982 XBD=2188 XBD=2298 XBD=2450 XHG=1431 XHG=1707 XHG=1775 XHG=1864 XHG=2014 XHG=2220 XHG=2329 XHG=2478 YBD=1697 YBD=1699 YBD=1705 YBD=1698 YHG=1667>Observations YHG=1667>in YHG=1667>family YHG=1668>described YHG=1668>here YHG=1674>suggest YHG=1667>the " XBD=1318 XBD=206 XBD=300 XBD=371 XBD=564 XBD=642 XBD=776 XBD=847 XBD=922 XBD=991 XBD=1132 XHG=138 XHG=218 XHG=312 XHG=382 XHG=576 XHG=654 XHG=789 XHG=861 XHG=1003 XHG=1144 YBD=1742 YBD=1748 YBD=1741 YBD=1748 YBD=1741 YHG=1711>and YHG=1710>then YHG=1710>the YHG=1710>halothane YHG=1720>was YHG=1711>turned YHG=1711>off, YHG=1711>but YHG=1711>the YHG=1710>patient YHG=1710>remained XBD=1552XHG=934 XBD=1607 XBD=1638 XBD=1805 XBD=1935 XBD=1992 XBD=2133 XBD=2201 XBD=2285 XBD=2337 XBD=2525 XHG=1384 XHG=1568 XHG=1620 XHG=1656 XHG=1821 XHG=1952 XHG=2004 XHG=2148 XHG=2216 XHG=2299 XHG=2348 YBD=1751 YBD=1744 YBD=1745 YBD=1752 YHG=1713>existence YHG=1724>a YHG=1720>separate YHG=1723>means YHG=1715>control YHG=1714>for YHG=1721>rate YHG=1714>of YHG=1713>production " XBD=1317 XBD=270 XHG=881 XBD=366 XBD=521 XBD=617 XBD=838 XBD=957 XBD=1160 XBD=1269 XHG=138 XHG=298 XHG=395 XHG=551 XHG=646 XHG=985YBD=1788 XHG=1189 XHG=1298 YBD=1796 YBD=1787 YBD=1796 YBD=1788YHG=1757>The YBD=1787 YHG=1756>apnoeic YHG=1756>and YHG=1764>i.P.P.v. YHG=1766>was YHG=1757>continued. YHG=1757>operation YHG=1757>took YHG=1757>5 " XBD=1318 XBD=286 XHG=784 XBD=372 XBD=485 XBD=569 XBD=667 XBD=767 XBD=951 XBD=1114 XHG=138 XHG=304 XHG=390 XHG=503 XHG=587 XHG=683 XHG=982YBD=1842 XHG=1132 YBD=1834 YBD=1835 YBD=1842 YBD=1835 YHG=1803>minutes YHG=1803>and YHG=1803>there YHG=1813>was YHG=1813>very YHG=1804>little YHG=1803>bleeding. YHG=1804>Apnoea YHG=1803>continued " XBD=1317 XBD=269 XHG=796 XBD=524 XBD=583 XBD=681 XBD=772 XBD=996 XBD=1078 XBD=1186 XHG=138 XHG=293 XHG=548 XHG=608 XHG=706 XHG=1021 XHG=1103 XHG=1212 YBD=1888 YBD=1881 YBD=1889 YBD=1889 YBD=1881 YHG=1851>despite YHG=1850>nikethamide YHG=1851>(2 YHG=1850>ml.) YHG=1850>and YHG=1850>nalorphine YHG=1851>(10 YHG=1851>mg.) YHG=1851>intra" XBD=1317 XBD=312 XHG=943 XBD=401 XBD=561 XBD=779 XBD=867 XBD=922 XBD=984 XBD=1186 XBD=1257 XHG=137 XHG=333 XHG=421 XHG=582 XHG=799 XHG=887 XHG=1002 XHG=1204 XHG=1274 YBD=1935 YBD=1929 YBD=1928 YBD=1929 YBD=1928 YHG=1897>venously, YHG=1897>and YHG=1897>assisted YHG=1897>respiration YHG=1897>had YHG=1904>to YHG=1898>be YHG=1897>continued YHG=1897>for YHG=1898>90 " XBD=1315 XBD=295 XHG=706 XBD=388 XBD=528 XBD=695 XBD=958 XBD=1099 XHG=137 XHG=312 XHG=398 XHG=538 XHG=970YBD=1975 XHG=1109 YBD=1974 YBD=1982 YBD=1981 YBD=1982 YBD=1976 YHG=1944>minutes. YHG=1944>The YHG=1944>patient YHG=1943>regained YHG=1944>consciousness YHG=1944>shortly YHG=1944>afterwards. " XBD=1321 XBD=391 XHG=583 XBD=506 XBD=566 XBD=969 XBD=1032 XBD=1106 XBD=1264 XHG=181 XHG=411 XHG=526 XHG=986YBD=2022 XHG=1048 XHG=1122 XHG=1280 YBD=2028 YBD=2020 YBD=2029 YBD=2022 YBD=2021 YHG=1990>Laboratory YHG=2000>assay YHG=1990>of YHG=1990>serum-cholinesterase YHG=1991>by YHG=1991>the YHG=1991>method YHG=1990>of " XBD=1314 XBD=258 XHG=781 XBD=344 XBD=496 XBD=524 XBD=696 XBD=760 XBD=921 XBD=1077 XHG=137 XHG=277 XHG=366 XHG=513 XHG=544 XHG=715 XHG=941YBD=2076 XHG=1096 YBD=2067 YBD=2054 YBD=2068 YBD=2076 YBD=2069YHG=2047>enzyme YHG=2036>Kalow YHG=2037>and YHG=2036>Genest YHG=2037>6 YHG=2036>revealed YHG=2047>no YHG=2038>activity YHG=2038>whatsoever. " XBD=1316 XBD=620 XHG=641 XBD=782 XBD=1044 XBD=1212 XHG=138 XHG=804YBD=2123 XHG=1063 XHG=1230 YBD=2115 YBD=2122 YBD=2122YHG=2084>atypical YBD=2116 YHG=2083>Suxamethonium-sensitive YHG=2084>homozygotes YHG=2085>(E1aEla) YHG=2084>have " XBD=1316 XBD=200 XHG=838 XBD=353 XBD=503 XBD=795 XBD=825 XBD=925 XBD=1005 XBD=1119 XHG=134 XHG=213 XHG=367 XHG=517 XHG=807 XHG=938YBD=2169 XHG=1018 XHG=1134 YBD=2161 YBD=2168 YBD=2162 YBD=2162 YBD=2163 YBD=2162 YHG=2130>low YHG=2139>enzyme YHG=2130>activity YHG=2130>(approximately YHG=2141>a YHG=2131>half) YHG=2132>and YHG=2131>low &dquo; YHG=2131>dibucaine " XBD=965 XBD=378 XHG=898 XBD=580 XBD=880 XHG=134 YBD=2216 XHG=399 XHG=601 YBD=2215 YHG=2178>25). YBD=2208 YBD=2217 YHG=2176>(cinchocaine) YHG=2177>number YHG=2177>(approximately &dquo; " XBD=1314 XBD=323 XHG=793 XBD=457 XBD=665 XBD=773 XBD=892 XBD=1000 XBD=1079 XBD=1240 XHG=177 XHG=344 XHG=478 XHG=686 XHG=911YBD=2256 XHG=1021 XHG=1099 XHG=1260 YBD=2254 YBD=2255 YBD=2262 YBD=2256 YBD=2263YHG=2225>taken YBD=2256 YHG=2223>Further YHG=2233>serum YHG=2224>specimens YHG=2235>were YHG=2225>from YHG=2225>the YHG=2225>patient, YHG=2224>his " XBD=1314 XBD=279 XHG=706 XBD=393 XBD=564 XBD=650 XBD=686 XBD=835 XBD=1052 XBD=1163 XHG=130 XHG=298 XHG=412 XHG=583 XHG=669 XHG=855YBD=2303 XHG=1085 XHG=1182 YBD=2308 YBD=2302 YBD=2303 YBD=2302 YHG=2277>parents, YHG=2270>three YHG=2271>siblings, YHG=2271>and YHG=2281>a YHG=2272>control YHG=2272>individual. YHG=2271>The YHG=2272>control " XBD=1313 XBD=198 XHG=897 XBD=252 XBD=406 XBD=554 XBD=605 XBD=654 XBD=757 XBD=886 XBD=950 XBD=1059 XHG=129 XHG=210 XHG=265 XHG=417 XHG=565 XHG=613 XHG=666 XHG=770 XHG=961YBD=2349 XHG=1070 YBD=2347 YBD=2355 YBD=2348 YBD=2356 YBD=2349 YBD=2356YHG=2318>for YHG=2316>had YHG=2326>an YHG=2327>enzyme YHG=2317>activity YHG=2318>of YHG=2319>52 YHG=2319>units YHG=2318>(range YHG=2318>usual YHG=2318>homozygotes " XBD=1312 XBD=232 XHG=889 XBD=376 XBD=494 XBD=660 XBD=785 XBD=864 XBD=947 XBD=1082 XBD=1164 XHG=129 XHG=259 XHG=417 XHG=519 XHG=684 XHG=811 XHG=972YBD=2395 XHG=1108 XHG=1191 YBD=2394 YBD=2402 YBD=2395 YBD=2402 YHG=2364>35-75 YHG=2364>units). YHG=2364>The YHG=2373>enzyme YHG=2365>levels YHG=2365>for YHG=2365>the YHG=2364>father YHG=2365>(43 YHG=2365>years), " XBD=1313 XBD=262 XHG=886 XBD=334 XBD=470 XBD=552 XBD=634 XBD=803 XBD=874 XBD=979 XBD=1060 XBD=1092 XBD=1213 XHG=128 XHG=277 XHG=349 XHG=485 XHG=566 XHG=649 XHG=818 XHG=992YBD=2449 XHG=1073 XHG=1104 XHG=1224 YBD=2448 YBD=2441 YBD=2442 YBD=2442 YBD=2441 YBD=2449 YBD=2442 YHG=2410>mother YHG=2410>(43 YHG=2411>years), YHG=2411>and YHG=2417>two YHG=2411>brothers YHG=2411>(15 YHG=2420>years YHG=2411>and YHG=2412>8 YHG=2411>years) YHG=2421>were " XBD=1312 XBD=182 XHG=920 XBD=264 XBD=347 XBD=443 XBD=513 XBD=634 XBD=891 XBD=987 XBD=1103 XHG=127 XHG=210 XHG=292 XHG=376 XHG=471 XHG=541 XHG=661 XHG=1015YBD=2488 XHG=1130 YBD=2493 YBD=2494 YBD=2489 YBD=2497 YBD=2489YHG=2458>and YHG=2457>43, YHG=2458>40, YHG=2458>42, YHG=2459>37 YHG=2458>units YHG=2458>respectively, YHG=2457>their YHG=2458>dibucaine " XBD=1530 XBD=1588 XBD=1712 XBD=1862 XBD=2026 XBD=2239 XBD=2296 XBD=2514 XHG=1376 XHG=1553 XHG=1608 XHG=1739 XHG=1886 XHG=2047 XHG=2261 XHG=2317 YBD=2518 YBD=2523 YBD=2517 YBD=2522 YHG=2492>Pedigree YHG=2492>of YHG=2493>Negro YHG=2492>family, YHG=2492>showing YHG=2491>inheritance YHG=2491>of YHG=2491>haemoglobins " XBD=288 XBD=395 XBD=467 XBD=539 XBD=610 XBD=695 XBD=755 XBD=1003 XBD=1112 XBD=1311 XHG=125 XHG=307 XHG=412 XHG=485 XHG=557 XHG=628 XHG=713 XHG=772 XHG=1035 XHG=1130 YBD=2541 YBD=2542 YBD=2535 YBD=2536 YBD=2543 YBD=2536 YBD=2535 YHG=2504>numbers YHG=2515>were YHG=2505>81, YHG=2506>74, YHG=2506>79, YHG=2505>and YHG=2506>80 YHG=2504>respectively. YHG=2504>The " XBD=2054 XBD=1784 XHG=1936 XBD=1814 XBD=1893 XBD=1921 XHG=1612 YBD=2554 XHG=1798 XHG=1830 XHG=1906 YBD=2559 YHG=2504>dibucaine YHG=2529>abnormal YHG=2529>0 YHG=2529>and YHG=2530>8 YHG=2529>chains. containin; " XBD=1310 XBD=272 XHG=874 XBD=334 XBD=409 XBD=562 XBD=650 XBD=715 XBD=853 XBD=927 XBD=1045 XHG=125 XHG=293 XHG=351 XHG=432 XHG=584 XHG=673 XHG=737 XHG=948YBD=2582 XHG=1067 YBD=2589 YBD=2582 YBD=2589 YHG=2551>number YHG=2552>of YHG=2551>the YHG=2552>control YHG=2561>was YHG=2553>74 YHG=2552>(range YHG=2551>for YHG=2552>usual YHG=2551>homozygotes " XBD=1310 XBD=259 XHG=710 XBD=371 XBD=504 XBD=611 XBD=688 XBD=920 XBD=1036 XBD=1095 XBD=1167 XHG=125 XHG=294 XHG=390 XHG=523 XHG=631 XHG=941YBD=2636 XHG=1055 XHG=1109 XHG=1180 YBD=2635 YBD=2628 YBD=2629 YBD=2628 YBD=2628 YBD=2636 YHG=2598>71-83). YHG=2598>The YHG=2607>serum YHG=2597>from YHG=2598>the YHG=2597>11-year-old YHG=2597>sister YHG=2598>of YHG=2598>the YHG=2598>patient " XBD=1415 XBD=1452 XBD=1542 XBD=1581 XBD=1730 XBD=1843 XBD=2116 XBD=2175 XBD=2248 XBD=2310 XBD=2391 XHG=1374 XHG=1435 XHG=1474 XHG=1564 XHG=1602 XHG=1766 XHG=1864 XHG=2135 XHG=2191 XHG=2269 XHG=2330 XHG=2410 YBD=2667 YBD=2660 YBD=2659 YBD=2666 YHG=2629>of YHG=2631>P YHG=2629>and YHG=2630>8 YHG=2629>chains. YHG=2629>The YHG=2629>concentration YHG=2628>of YHG=2628>Hb YHG=2629>B2 YHG=2638>was YHG=2635>greater " XBD=2513 XBD=191 XHG=266 XBD=252 XBD=413 XHG=123 XHG=206 YBD=2675 YBD=2682 YHG=2643>had YHG=2654>no YHG=2644>activity. "" XBD=2515 XBD=1457 XBD=1546 XBD=1601 XBD=1672 XBD=1733 XBD=1785 XBD=1903 XBD=2198 XBD=2253 XBD=2472 XHG=1374 XHG=1473 XHG=1561 XHG=1612 XHG=1688 XHG=1750 XHG=1801 XHG=1918 XHG=2214 XHG=2263 XHG=2485 YBD=2707 YBD=2714 YBD=2713 YBD=2706 YHG=2675>than YHG=2675>that YHG=2676>of YHG=2676>Hb YHG=2675>A2 YHG=2676>in YHG=2685>many YHG=2675>electrophoreses YHG=2675>of YHG=2675>haemolysates YHG=2674>of XBD=200 XHG=923 XBD=326 XBD=417 XBD=493 XBD=639 XBD=723 XBD=792 XBD=906 XBD=978 XBD=1237 XBD=1310 XHG=168 XHG=219 XHG=344 XHG=435 XHG=509 XHG=656 XHG=740 XHG=811 XHG=995YBD=2721 XHG=1255 YBD=2728 YBD=2722 YBD=2728 YBD=2721 YHG=2691>It YHG=2700>seems YHG=2690>that YHG=2691>the YHG=2691>patient YHG=2691>and YHG=2690>his YHG=2690>sister YHG=2700>are YHG=2690>homozygotes YHG=2690>for "" XBD=2510 XBD=1432 XBD=1614 XBD=1681 XBD=1816 XBD=1898 XBD=1964 XBD=2040 XBD=2136 XBD=2205 XBD=2383 XBD=2411 XHG=1373 XHG=1446 XHG=1628 XHG=1695 XHG=1831 XHG=1911 XHG=1979 XHG=2054 XHG=2148 XHG=2217 XHG=2396 XHG=2423 YBD=2761 YBD=2760 YBD=2754 YBD=2751 YBD=2753 YHG=2722>proband, YHG=2723>father, YHG=2723>and YHG=2723>his YHG=2732>son YHG=2722>with YHG=2722>the YHG=2721>abnormal YHG=2722>8 YHG=2722>chain. XBD=733 XBD=809 XBD=961 XBD=1047 XBD=1133 XBD=1308 XHG=666 XHG=751 XHG=980YBD=2775 XHG=1066 XHG=1152 YBD=2768 YBD=2768 (EE), YBD=2768 YBD=2769 YHG=2737>and YHG=2737>the YHG=2744>parents YHG=2738>and YHG=2744>two YHG=2737>brothers XBD=363 XHG=826 XBD=468 XHG=122 XHG=382 YBD=2769 YHG=2747>gene &dquo; silent &dquo; " XBD=1452 XBD=1578 XBD=1752 XBD=1812 XBD=1886 XBD=1989 XBD=2049 XBD=2123 XBD=2184 XBD=2238 XBD=2314 XBD=2375 XBD=2450 XBD=2510 XHG=1373 XHG=1471 XHG=1599 XHG=1772 XHG=1828 XHG=1905 XHG=2009 XHG=2064 XHG=2143 XHG=2204 XHG=2257 XHG=2333 XHG=2393 XHG=2466 YBD=2801 YBD=2807 YBD=2806 YBD=2800 YBD=2799 YHG=2769>The YHG=2769>visual YHG=2769>estimate YHG=2770>of YHG=2769>the YHG=2769>ratio YHG=2769>of YHG=2769>B2 YHG=2775>to YHG=2769>Hb YHG=2768>A2 YHG=2778>was YHG=2768>the " XBD=1306 XBD=176 XHG=738 XBD=450 XBD=524 XBD=601 XBD=717 XBD=990 XBD=1122 XBD=1262 XHG=121 XHG=196 XHG=471 XHG=543 XHG=621 XHG=1011 XHG=1144 XHG=1269 YBD=2822 YBD=2814 YBD=2815 YBD=2815 YBD=2822 YHG=2793>are YHG=2784>heterozygotes YHG=2784>for YHG=2784>the YHG=2784>usual YHG=2783>and YHG=2784>alleles YHG=2784>(E1UE1 YHG=2784>S). &dquo; silent&dquo; " XBD=1465 XBD=1521 XBD=1622 XBD=1829 XBD=1931 XBD=2043 XBD=2311 XHG=1373 XHG=1484 XHG=1541 XHG=1641 XHG=1848 XHG=1948 XHG=2061 XHG=2330 YBD=2846 YBD=2847 YBD=2854 YHG=2826>same YHG=2816>in YHG=2816>each YHG=2816>individual YHG=2816>with YHG=2816>these YHG=2815>haemoglobins, YHG=2815>irrespective " XBD=2510 XBD=236 XHG=876 XBD=318 XBD=379 XBD=514 XBD=568 XBD=644 XBD=811 XBD=865 XBD=933 XBD=1065 XBD=1204 XBD=1308 XHG=122 XHG=251 XHG=333 XHG=394 XHG=528 XHG=579 XHG=658 XHG=825 XHG=947YBD=2861 XHG=1079 XHG=1219 YBD=2860 YBD=2869 YBD=2862 YBD=2868 YBD=2868 YBD=2862 YHG=2831>There YHG=2841>was YHG=2841>no YHG=2831>record YHG=2830>of YHG=2840>any YHG=2831>member YHG=2831>of YHG=2830>the YHG=2830>family YHG=2831>having YHG=2831>been "" XBD=2512 XBD=1413 XBD=1577 XBD=1651 XBD=1752 XBD=1820 XBD=1895 XBD=1935 XBD=2019 XBD=2179 XBD=2266 XBD=2305 XBD=2383 XBD=2467 XHG=1372YBD=2908 XHG=1426 XHG=1592 XHG=1666 XHG=1767 XHG=1836 XHG=1914 XHG=1953 XHG=2035 XHG=2209 XHG=2284 XHG=2322 XHG=2397 XHG=2483 YBD=2894YHG=2877>suxamethonium. YBD=2901 YBD=2893 YBD=2900 YBD=2892 YHG=2863>of YHG=2862>whether YHG=2863>the YHG=2872>gene YHG=2863>for YHG=2863>Hb YHG=2863>S YHG=2872>was YHG=2869>present. YHG=2862>Hb YHG=2862>S YHG=2871>was YHG=2862>34% YHG=2860>of XBD=221 XHG=237 XBD=546 XHG=121 YBD=2915 YHG=2877>given " XBD=2508 XBD=1431 XHG=2407 XBD=1527 XBD=1771 XBD=1821 XBD=1894 XBD=2073 XBD=2123 XBD=2341 XBD=2395 XHG=1371 YBD=2939 XHG=1445 XHG=1541 XHG=1785 XHG=1835 XHG=1907 XHG=2088 XHG=2137 XHG=2354 YBD=2947 YHG=2908>starchYBD=2940 YBD=2946 YHG=2908>the YHG=2909>total YHG=2909>haemoglobin YHG=2909>in YHG=2909>the YHG=2909>proband, YHG=2918>as YHG=2907>determined YHG=2908>by " XBD=346 XBD=441 XBD=633 XBD=948 XBD=1158 XBD=1226 XHG=165 XHG=373 XHG=470 XHG=974 XHG=1186 XHG=1248 YBD=2970 YBD=2969 YBD=2969 YBD=2969 reported YHG=2939>Lehmann YHG=2939>and YHG=2938>Liddell YHG=2938>slight YHG=2938>inhibition YHG=2939>of YHG=2938>the " XBD=1307 XBD=1472XHG=846 XBD=1774 XBD=1940 XBD=1995 XBD=2217 XBD=2271 XBD=2385 XBD=2454 XBD=2509 XHG=1372YBD=2976 XHG=1487 XHG=1806 XHG=1955 XHG=2004 XHG=2231 XHG=2279 XHG=2397 XHG=2465 YBD=2986 YBD=2994 YBD=2993 YBD=2985 YHG=2955>block YHG=2955>electrophoresis. YHG=2955>Studies YHG=2955>populations YHG=2955>of YHG=2963>young YHG=2954>and YHG=2952>old "" XBD=1311 XBD=217 XBD=374 XBD=528 XBD=583 XBD=708 XBD=823 XBD=952 XBD=1050 XBD=1123 XBD=1253 XHG=119 XHG=233 XHG=390 XHG=543 XHG=594 XHG=723 XHG=838 XHG=968 XHG=1066 XHG=1140 XHG=1270 YBD=3016 YBD=3024 YBD=3022 YBD=3015 YBD=3015 YBD=3015 YHG=2986>usual YHG=2995>enzyme YHG=2985>activity YHG=2985>of YHG=2994>serum YHG=2985>when YHG=2984>mixed YHG=2985>with YHG=2984>the YHG=2994>serum XBD=1451 XHG=2473 XBD=1648 XBD=1715 XBD=1998 XBD=2185 XBD=2276 XBD=2383 XBD=2457 XBD=2508 XHG=1372 YBD=3031 XHG=1473 XHG=1670 XHG=1736 XHG=2018 XHG=2205 XHG=2295 XHG=2401 YBD=3039 YHG=2985>of YBD=3032 YHG=3001>cells YHG=3001>separated YHG=3001>by YHG=3001>centrifugation YHG=3001>indicated YHG=3001>that YHG=3000>there YHG=3010>was YHG=3008>no " XBD=162 XBD=374 XBD=480 XBD=548 XBD=961 XBD=1129 XBD=1225 XBD=1307 XHG=120 XHG=185 XHG=397 XHG=502 XHG=571 XHG=983 XHG=1168 XHG=1248 YBD=3063 YBD=3062 YBD=3069 YBD=3062 YHG=3041>an YHG=3031>individual YHG=3031>with YHG=3041>no YHG=3031>serum-cholinesterase YHG=3031>activity. YHG=3030>On " XBD=2507 XBD=1587 XHG=2394 XBD=1812 XBD=1864 XBD=1932 XBD=1971 XBD=2021 XBD=2090 XBD=2255 XBD=2384 XHG=1371 YBD=3078 XHG=1601 XHG=1824 XHG=1873 XHG=1949 XHG=1985 XHG=2034 XHG=2102 XHG=2268 YBD=3079 YHG=3031>the YBD=3086 YBD=3085 YHG=3047>preferential YHG=3048>destruction YHG=3047>of YHG=3047>Hb YHG=3047>S YHG=3048>in YHG=3048>the YHG=3047>proband YHG=3046>during YHG=3045>red-cell found XBD=217 XBD=343 XBD=530 XBD=586 XBD=664 XBD=754 XBD=894 XBD=950 XBD=1030 XHG=119 XHG=238 XHG=366 XHG=553 XHG=608 XHG=687 XHG=777 XHG=972 YBD=3115 YBD=3116 YBD=3109 YBD=3108 YHG=3078>other YHG=3078>hand, YHG=3078>Hogdkin YHG=3077>al. YHG=3078>and YHG=3077>Locati YHG=3077>al. " XBD=1230 XHG=1184 XHG=1253 YBD=3109 YBD=3108 YHG=3088>no YHG=3078>inlocus " XBD=1305 XBD=1500XHG=917 XBD=1616 XBD=1705 XBD=1853 XBD=1917 XBD=1994 XBD=2056 XBD=2254 XBD=2335 XBD=2463 XBD=2507 XHG=1370YBD=3108 XHG=1539 XHG=1640 XHG=1729 XHG=1877 XHG=1936 XHG=2020 XHG=2197 XHG=2277 XHG=2356 XHG=2481 YBD=3133YHG=3084>et YBD=3126 YBD=3132 YBD=3125 YHG=3093>ageing. YHG=3094>The YHG=3094>low YHG=3101>output YHG=3094>of YHG=3093>the YHG=3094>β YHG=3094>did YHG=3100>not YHG=3103>appear YHG=3100>to " XBD=266 XBD=318 XBD=581 XBD=833 XBD=975 XBD=1049 XBD=1180 XBD=1236 XBD=1307 XHG=119 XHG=282 XHG=334 XHG=598 XHG=864 XHG=990 XHG=1065 XHG=1196 XHG=1247 YBD=3156 YBD=3162 YBD=3155 YBD=3155 YBD=3154 YBD=3155 YHG=3124>hibition YHG=3126>in YHG=3125>mixed-serum YHG=3125>experiments. YHG=3124>When YHG=3124>the YHG=3134>serum YHG=3125>of YHG=3124>the " XBD=2506 XBD=1541 XHG=2444 XBD=1617 XBD=1760 XBD=1819 XBD=1892 XBD=1929 XBD=2041 XBD=2095 XBD=2180 XBD=2320 XBD=2427 XHG=1371 YBD=3171 XHG=1559 XHG=1636 XHG=1779 XHG=1834 XHG=1912 XHG=1948 XHG=2060 XHG=2114 XHG=2198 XHG=2351 YBD=3170 YHG=3150>conYBD=3179 YHG=3140>influence YHG=3147>output YHG=3141>of YHG=3141>the YHG=3141>8 YHG=3141>locus YHG=3141>in YHG=3140>this YHG=3140>family. YHG=3140>This " XBD=248 XBD=438 XBD=529 XBD=606 XBD=732 XBD=825 XBD=931 XBD=1068 XBD=1114 XHG=119 XHG=260 XHG=449 XHG=540 XHG=618 XHG=743 XHG=944 XHG=1080 XHG=1127 YBD=3209 YBD=3202 YBD=3201 YBD=3207 YBD=3201 YHG=3171>patient YHG=3171>described YHG=3171>here YHG=3180>was YHG=3170>mixed YHG=3170>with YHG=3180>serum, YHG=3180>as YHG=3170>described " XBD=1306 XBD=1503XHG=835 XBD=1555 XBD=1741 XBD=1832 XBD=1948 XBD=2015 XBD=2233 XBD=2291 XBD=2367 XBD=2461 XBD=2508 XHG=1371YBD=3200 XHG=1527 XHG=1580 XHG=1765 XHG=1856 XHG=1973 XHG=2040 XHG=2257 XHG=2314 XHG=2388 XHG=2479 YBD=3218YHG=3170>usual YBD=3225 YBD=3217 YHG=3186>clusion YHG=3186>is YHG=3187>tentative YHG=3187>and YHG=3192>must YHG=3187>be YHG=3187>considered YHG=3187>in YHG=3186>the YHG=3186>light YHG=3185>of " XBD=165 XBD=345 XBD=392 XBD=466 XBD=576 XBD=657 XBD=718 XBD=919 XBD=1043 XBD=1153 XBD=1305 XHG=120 XHG=181 XHG=361 XHG=408 XHG=481 XHG=591 XHG=673 XHG=734 XHG=934 XHG=1074 XHG=1169 YBD=3255 YBD=3248 YBD=3253 YBD=3247 YBD=3254 YBD=3248 YBD=3247 YHG=3218>by YHG=3217>Hodgkin YHG=3224>et YHG=3217>al,3 YHG=3217>there YHG=3226>was YHG=3227>no YHG=3216>inhibitory YHG=3217>effect. YHG=3217>In &dquo; &dquo; " XBD=2505 XBD=1584 XHG=2333 XBD=1715 XBD=1818 XBD=1938 XBD=2077 XBD=2131 XBD=2323 XHG=1371 YBD=3271 XHG=1599 XHG=1729 XHG=1831 XHG=1952 XHG=2090 XHG=2139 YBD=3264alYHG=3216>silent YBD=3263 YBD=3270 YHG=3232>conclusions YHG=3233>drawn YHG=3233>from YHG=3232>larger YHG=3233>studies YHG=3233>of YHG=3233>hereditary YHG=3233>persistence " XBD=858 XBD=1001 XBD=1056 XBD=1307 XHG=740 XHG=877 XHG=1020 XHG=1076 YBD=3294 YBD=3294 YBD=3294 YHG=3263>3 YHG=3263>unable YHG=3270>to YHG=3263>demonstrate were XBD=205 XBD=308 XBD=440 XBD=623 XBD=676 XHG=120 XHG=224 XHG=328 XHG=460 XHG=643 YBD=3301 YBD=3299 YBD=3300 YBD=3293 YHG=3273>gene YHG=3272>sera, YHG=3263>whilst YHG=3262>Hodgkin YHG=3269>et " XBD=2505 XBD=1412 XHG=2491 XBD=1532 XBD=1827 XBD=1919 XBD=2001 XBD=2281 XBD=2345 XBD=2468 XHG=1371 YBD=3309 XHG=1439 XHG=1556 XHG=1851 XHG=1946 XHG=2025 XHG=2311 XHG=2373 YBD=3317 YHG=3288>a YBD=3310 YHG=3279>of YHG=3279>foetal YHG=3279>hacmoglobin YHG=3279>and YHG=3280>p-8 YHG=3279>thalassxmia YHG=3279>in YHG=3279>which 12 13 " XBD=178 XBD=363 XBD=432 XBD=523 XBD=684 XBD=948 XBD=1106 XBD=1175 XHG=119 XHG=202 XHG=392 XHG=457 XHG=550 XHG=980 XHG=1139 XHG=1208 YBD=3340 YBD=3347 YBD=3339 YBD=3340 YBD=3339 YHG=3310>the YHG=3318>presence YHG=3310>of YHG=3319>any YHG=3309>protein YHG=3309>antigenically YHG=3309>similar YHG=3316>to YHG=3309>usual " XBD=1306 XBD=1551XHG=713 XBD=1651 XBD=1719 XBD=1819 XBD=1854 XBD=1937 XBD=1971 XBD=2084 XBD=2297 XBD=2409 XBD=2452 XBD=2505 XHG=1371 XHG=1566 XHG=1666 XHG=1735 XHG=1836 XHG=1870 XHG=1953 XHG=1986 XHG=2098 XHG=2312 XHG=2423 XHG=2464 YBD=3355 YBD=3363 YBD=3356 YHG=3325>controller YHG=3335>gene YHG=3325>for YHG=3325>both YHG=3327>j3 YHG=3326>and YHG=3326>8 YHG=3325>chain YHG=3325>production YHG=3334>seems YHG=3332>to YHG=3331>act 1. Liddell, J., Lehmann, H., Silk, E. YHG=3370>and Nature, Lond. 1962, 193, 561. " XBD=2504 XBD=1407 XBD=1481 XBD=1541 XBD=1715 XBD=1894 XBD=1968 XBD=2222 XBD=2361 XBD=2412 XBD=2439 XHG=1371 XHG=1423 XHG=1498 XHG=1557 XHG=1746 XHG=1910 XHG=1985 XHG=2239 XHG=2376 XHG=2424 XHG=2452 YBD=3401 YBD=3403 YBD=3409 YBD=3402 YHG=3371>in YHG=3372>the YHG=3371>cis YHG=3371>position. YHG=3371>Perhaps YHG=3371>the YHG=3371>simultaneous YHG=3370>control YHG=3372>of YHG=3373>p 2. Doenicke, A., Gurtner, T., Kreutzberg, G., Remes, I., Speiss, W., " XBD=2503 XBD=1390 XBD=1515 XBD=1745 XBD=1848 XBD=1916 XBD=2135 XBD=2192 XBD=2234 XBD=2359 XBD=2436 XHG=1372 XHG=1416 XHG=1540 XHG=1770 XHG=1873 XHG=1940 XHG=2160 XHG=2217 XHG=2259 XHG=2381 XHG=2456 YBD=3446 YBD=3447 YBD=3455 YBD=3448 YHG=3418>8 YHG=3417>chain YHG=3417>production YHG=3427>may YHG=3417>be YHG=3417>modulated YHG=3424>at YHG=3427>a YHG=3417>single YHG=3417>site YHG=3418>but Steinbereithner, K. Acta anœsth. scand. 1963, 7, 59.

5.

Hodgkin, W. E., Giblett, E. R., Levine, H., Bauer, W., Motulsky, A. G., J. clin. Invest. 1965, 44, 486. Goedde, H. W., Fuss, W., Ritter, H., Baitsch, H. Humangenetik, 1965, 1, 311. Locati, G., Macchi, L., Acerboni, F. Minerva Med., Roma, 1967, 58,

6. 7.

Kalow, W., Genest, K. Can. J. Biochem. Physiol. 1957, 35, 339. Lehmann, H., Liddell, J. Prog. med. Genet. 1964, 3, 75.

3. 4.

972.

Goedde, H. W., Gehring, D., Hofmann, R. A. Biochim. Biophys. Acta, 1965, 107, 391. 9. Huehns, E. R., Shooter, E. M. J. med. Genet. 1965, 2, 48. 10. Ceppellini, R. N. in Biochemistry of Human Genetics (edited by G. E. W. Wolstenholme and C. M. O’Connor); p. 133. Boston, 1959. 11. Pearson, H. A., Moore, M. M. Am. J. hum. Genet. 1965, 17, 125. 12. Neel, J. V. Blood, 1961, 18, 769. 13. Comings, D. E., Motulsky, A. G. ibid. 1966, 28, 54. 8.

1423

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XBD=2542 XBD=1438 XBD=1538 XBD=1572 XBD=1682 XBD=1838 XBD=1938 XBD=2001 XBD=2043 XBD=2302 XBD=2365 XBD=2398 XHG=1357 XHG=1453 XHG=1554 XHG=1588 XHG=1699 XHG=1854 XHG=1969 XHG=2016 XHG=2060 XHG=2319 XHG=2380 XHG=2413 YBD=354 YBD=353 YBD=360 YHG=322>they YHG=322>have YHG=332>more YHG=322>delicate YHG=322>skin. YHG=322>It YHG=323>is YHG=322>characterised YHG=323>by YHG=332>a YHG=322>feeling XBD=341 XHG=834 XBD=419 XBD=810 XBD=974 XBD=1200 XBD=1294 XHG=119 XHG=365 XHG=701 XHG=997independent XHG=1224 YBD=356 YBD=354 YBD=362 YBD=355 YBD=362 YHG=323>mechanisms YHG=323>for YHG=324>and YHG=323>chain YHG=323>production YHG=323>also XBD=211 YBD=403 YHG=370>exist. XBD=1397XHG=119 XBD=1564 XBD=1625 XBD=1699 XBD=1805 XBD=2041 XBD=2096 XBD=2174 XBD=2387 XBD=2539 XHG=1356 XHG=1414 XHG=1584 XHG=1641 XHG=1720 XHG=1826 XHG=2061 XHG=2117 XHG=2196 XHG=2408 YBD=407 YBD=399 YBD=400 YBD=406 YHG=368>burning YHG=369>of YHG=369>skin, YHG=369>particularly YHG=369>in YHG=369>the YHG=368>submental YHG=368>region, XBD=1442XHG=795 XBD=1572 XBD=1683 XBD=1882 XBD=2017 XBD=2096 XBD=2277 XBD=2476 XBD=2543 XHG=1356 XHG=1468 XHG=1597 XHG=1708 XHG=1905 XHG=2041 XHG=2119 XHG=2303 XHG=2502 YBD=453 YBD=446 YHG=416>6-48 YHG=415>hours YHG=415>after YHG=424>exposure. YHG=415>There YHG=425>are YHG=415>localised YHG=415>erythema YHG=415>of XBD=230 XBD=335 XBD=417 XBD=612 XBD=675 XBD=772 XBD=903 XBD=1038 XBD=1183 XBD=1293 XHG=155 XHG=252 XHG=356 XHG=440 XHG=633 XHG=697 XHG=925 XHG=1062 XHG=1204 YBD=460 YBD=458 YBD=465 YBD=459 YBD=459 YBD=459 YBD=465 YHG=431>This YHG=429>work YHG=438>was YHG=430>supported YHG=431>by YHG=431>U.S. YHG=431>Public YHG=430>Health YHG=430>Service YHG=436>grant XBD=163 XBD=380 XHG=116 YBD=498 YHG=483>nn. YHG=472>HDO-2777. XBD=1412XHG=180 XBD=1509 XBD=1600 XBD=1779 XBD=1990 XBD=2077 XBD=2378 XBD=2536 XHG=1354 XHG=1435 XHG=1532 XHG=1623 XHG=1800 XHG=2010 XHG=2098 XHG=2397 YBD=499 YBD=492 YBD=493 YBD=500 YHG=461>the YHG=461>skin YHG=461>enlarged YHG=461>submental YHG=461>and YHG=461>submandibular YHG=461>lymph-

" " " " "

the of Pediatrics XBD=2535Department XBD=1484 XBD=1621 XBD=1677 XBD=1864 XBD=1953 XBD=2224 XBD=2394 XBD=2453 XHG=1353 XHG=1508 XHG=1642 XHG=1700 XHG=1887 XHG=1976 XHG=2245 XHG=2416 XHG=2476 YBD=546andYHG=507>the YBD=545 YBD=547 YBD=538 YBD=539 YHG=508>glands, YHG=508>owing YHG=514>to YHG=508>irritation YHG=508>and YHG=508>inflammatory YHG=508>reaction YHG=508>in Foundation forYBD=585 Cardeza XHG=2438 HematologicYHG=554>show Research, XBD=1427 XBD=1507 XBD=1724 XBD=1865 XBD=1970 XBD=2084 XBD=2136 XBD=2238 XBD=2341 XBD=2425 XBD=2535 XHG=1353 XHG=1440 XHG=1521 XHG=1736 XHG=1894 XHG=1983 XHG=2096 XHG=2144 XHG=2251 XHG=2354 YBD=592 YBD=586 YHG=554>skin YHG=553>and YHG=553>underlying YHG=554>tissues. YHG=554>The YHG=561>worst YHG=554>of YHG=554>these YHG=564>cases YHG=554>also College,YHG=607>present Jefferson Medical XBD=1584 XBD=1730 XBD=1812 XBD=1989 XBD=2072 XBD=2144 XBD=2287 XBD=2380 XBD=2534 XHG=1352 XHG=1600 XHG=1745 XHG=1829 XHG=2005 XHG=2086 XHG=2158 XHG=2302 XHG=2394 YBD=638 YBD=631 YBD=639 YHG=600>considerable YHG=600>oedema YHG=601>swelling, YHG=601>and YHG=601>the YHG=601>patient YHG=610>may ELIAS SCHWARTZ. Philadelphia, Pennsylvania 19107, U.S.A. XBD=1416 XHG=2456 XBD=1449 XBD=1649 XBD=1887 XBD=1959 XBD=2036 XBD=2158 XBD=2319 XBD=2369 XBD=2441 XBD=2533 XHG=1350 YBD=685 XHG=1430 XHG=1463 XHG=1663 XHG=1918 XHG=1974 XHG=2050 XHG=2172 XHG=2333 XHG=2383 YBD=684 YBD=678 YBD=677 YBD=679 YHG=646>like YHG=657>a YHG=646>puffed-up YHG=646>frigate-bird. YHG=647>In YHG=656>our YHG=656>group YHG=647>practice YHG=647>in YHG=647>the YHG=653>past Department of Pediatrics, DONALD SMITH XBD=1418 XHG=2445 XBD=1516 XBD=1551 XBD=1653 XBD=1748 XBD=1808 XBD=1924 XBD=2005 XBD=2111 XBD=2165 XBD=2231 XBD=2431 XBD=2532 XHG=1350 XHG=1435 XHG=1535 XHG=1568 XHG=1670 XHG=1768 XHG=1821 XHG=1938 XHG=2017 XHG=2125 XHG=2173 XHG=2244 YBD=723 YBD=730 YBD=724 YBD=731 YBD=725 YHG=700>two YHG=693>days YHG=693>I YHG=702>seen YHG=694>14 YHG=703>cases, YHG=693>and YHG=693>three YHG=693>of YHG=703>my YHG=693>colleagues Harvard Medical School,YHG=693>have

" XBD=1607 XBD=1429 XBD=1488 XHG=1350 XHG=1449 XHG=1505 YBD=770 YBD=769 YHG=748>seen YHG=740>12 YHG=748>cases. DAVID G. NATHAN. Massachusetts Boston, 02115, U.S.A.

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XBD=2536 XHG=2495 XBD=1472 XBD=1579 XBD=1747 XBD=1943 XBD=2068 XBD=2121 XBD=2180 XBD=2254 XBD=2477 XHG=1395 YBD=816 XHG=1488 XHG=1596 XHG=1764 XHG=1960 XHG=2085 XHG=2138 XHG=2196 XHG=2271 YBD=815 YHG=785>of YBD=823 YHG=785>The YHG=791>most YHG=784>effective YHG=791>treatment YHG=794>seems YHG=791>to YHG=785>be YHG=784>the YHG=785>application XBD=1392 XHG=2276 XBD=1580 XBD=1783 XBD=1841 XBD=1953 XBD=2062 XBD=2121 XBD=2258 XBD=2531 XHG=1349 YBD=862 XHG=1411 XHG=1599 XHG=1801 XHG=1855 XHG=1971 XHG=2081 XHG=2135 YBD=868 YHG=831>antihistamine YBD=861 YBD=869 YHG=840>an YHG=831>ointment YHG=830>consisting YHG=831>equal YHG=838>parts YHG=831>of YHG=830>topical XBD=1416 XHG=2263 XBD=1689 XBD=1948 XBD=2130 XBD=2205 XBD=2244 XBD=2530 XHG=1348 YBD=909 XHG=1435 XHG=1706 XHG=1968 XHG=2148 XHG=2223 YBD=908 YBD=915 YBD=914 YBD=907 YHG=877>and YHG=876>corticosteroid YHG=877>preparations, YHG=877>although YHG=877>the YHG=878>2 YHG=877>worst-affected INDIVIDUAL XBD=1494SATELLITE-ASSOCIATION XBD=1667 XBD=1883 XBD=2009 XBD=2058 XBD=2328 XBD=2531 XHG=1347 YBD=961 XHG=1508 XHG=1681 XHG=1898 XHG=2022 XHG=2072 XHG=2342 YBD=959 YHG=924>secondary YBD=960 YBD=954 YHG=923>patients YHG=923>required YHG=922>antibiotics, YHG=923>owing YHG=930>to YHG=923>superimposed PATTERNS

" XBD=1521 XHG=1347 YBD=1000 YHG=968>infection.

"|>"XBD=1272 XBD=427 XBD=532 XBD=693 XBD=771 XBD=938 XBD=1001 XBD=1079 XBD=1194 XBD=327XHG=791 XHG=347 XHG=448 XHG=553 XHG=713 XHG=960 XHG=1017 XHG=1103 XHG=1215 XHG=147YBD=1046 YBD=1037 YBD=1038 YBD=1039 YBD=1039 YBD=1045YHG=1009>findings YBD=1040 YBD=1041 YHG=1007>read YHG=1007>with YHG=1006>interest YHG=1008>the YHG=1009>of YHG=1008>SIR,-We YHG=1009>Dr. YHG=1010>Ford YHG=1020>anc " XBD=1267 XBD=162 XHG=798 XBD=356 XBD=477 XBD=534 XBD=594 XBD=679 XBD=773 XBD=861 XBD=1068 XBD=1198 XHG=101 XHG=190 XHG=384 XHG=504 XHG=560 XHG=622 XHG=706 XHG=888YBD=1085 XHG=1094 XHG=1225 YBD=1088 YBD=1089 YBD=1091 YBD=1084 YBD=1092 YBD=1093YHG=1055>Dr. YBD=1086 YHG=1057>Dr. YHG=1054>Woollam YHG=1053>(July YHG=1054>1, YHG=1062>p. YHG=1054>26) YHG=1054>and YHG=1055>Engmann YHG=1055>(Nov. YHG=1057>25

A. J. SMITH.

" XBD=1272 XBD=132 XHG=765 XBD=256 XBD=383 XBD=547 XBD=744 XBD=832 XBD=1072 XBD=1128 XHG=99 XHG=158 XHG=278 XHG=404 XHG=568 XHG=854YBD=1142 XHG=1093 XHG=1149 YBD=1138 YBD=1130 YBD=1131 YBD=1131 YBD=1132 YHG=1112>p. YHG=1100>1114) YHG=1100>about YHG=1099>satellite YHG=1099>incidence YHG=1100>and YHG=1100>distribution YHG=1101>in YHG=1104>norma. " XBD=1267 XBD=226 XHG=755 XBD=371 XBD=638 XBD=741 XBD=861 XBD=1076 XBD=1156 XHG=99 XHG=239 XHG=383 XHG=651 XHG=873 XHG=1089 XHG=1169 YBD=1179 YBD=1177 YBD=1176 YBD=1183 YBD=1177 YBD=1177 YBD=1178 YHG=1148>human YHG=1145>mitotic YHG=1145>chromosomes YHG=1145>from YHG=1146>single YHG=1146>individuals YHG=1147>and YHG=1147>twins SEVERE RESPIRATORY DISTRESS " XBD=1204 |>" XBD=211 XBD=372 XBD=578 XBD=632 XBD=684 XBD=835 XBD=906 XBD=1116 XBD=1272 XHG=99 XHG=224 XHG=389 XHG=593 XHG=648 XHG=699 XHG=849 XHG=920 XHG=1132 XHG=1218 YBD=1225 YBD=1229 YBD=1222 YBD=1230 YBD=1223 YBD=1230 YBD=1223 YBD=1224 YHG=1193>These YHG=1192>findings YHG=1200>encourage YHG=1201>us YHG=1198>to YHG=1199>suggest YHG=1192>the YHG=1192>hypothesis YHG=1193>that YHG=1200>no1 XBD=176 XHG=830 XBD=262 XBD=477 XBD=546 XBD=728 XBD=802 XBD=888 XBD=1011 XBD=1127 XBD=1196 XBD=1272 XHG=98 XHG=204 XHG=289 XHG=505 XHG=571 XHG=757 XHG=917 XHG=1038 XHG=1156 XHG=1220 YBD=1276 YBD=1276 YBD=1268 YBD=1269 YBD=1269 YBD=1269 YBD=1270 YHG=1238>only YHG=1238>frequency YHG=1237>of YHG=1237>satellites YHG=1248>on YHG=1238>the YHG=1238>short YHG=1248>arms YHG=1239>of YHG=1239>the " XBD=2524 XBD=1570 XBD=1767 XBD=1852 XBD=1924 XBD=2129 XBD=2255 XBD=2337 XBD=2393 XHG=1388 XHG=1591 XHG=1786 XHG=1871 XHG=1944 XHG=2152 XHG=2283 XHG=2359 XHG=2423 YBD=1274 YBD=1280 YBD=1282 YBD=1281 YHG=1244>SIR,-Dr. YHG=1244>Roberton YHG=1244>and YHG=1244>his YHG=1243>colleagues YHG=1244>(Nov. YHG=1244>25, YHG=1253>p. YHG=1243>1108) " XBD=300 XBD=589 XBD=688 XBD=792 XBD=884 XHG=96 XHG=334 XHG=625 XHG=722 XHG=919 YBD=1316 YBD=1314 YBD=1315 YBD=1315 YHG=1284>acrocentric YHG=1284>chromosomes YHG=1284>but YHG=1284>also YHG=1284>the YHG=1284>satellite-association " XBD=1272 XBD=1451XHG=826 XBD=1572 XBD=1784 XBD=1937 XBD=2003 XBD=2082 XBD=2292 XBD=2525 XHG=1340 XHG=1481 XHG=1599 XHG=1810 XHG=1962 XHG=2024 XHG=2107 XHG=2318 YBD=1320 YBD=1321 YBD=1328 YBD=1327 YHG=1290>write: An YHG=1290>&dquo; YHG=1290>important YHG=1290>variety YHG=1290>of YHG=1290>the YHG=1289>idiopathic YHG=1289>respiratory " XBD=1272 XBD=243 XBD=305 XBD=378 XBD=653 XBD=714 XBD=824 XBD=967 XBD=1079 XBD=1140 XBD=1207 XHG=94 XHG=264 XHG=319 XHG=397 XHG=673 XHG=729 XHG=988 XHG=1104 XHG=1166 XHG=1232 YBD=1370 YBD=1360 YBD=1361 YBD=1368 YBD=1361 YBD=1362 YBD=1361 YHG=1337>patterns YHG=1330>the YHG=1330>chromosomes YHG=1330>of YHG=1330>these YHG=1340>groups YHG=1340>seem YHG=1337>to YHG=1331>be YHG=1340>an XBD=1478XHG=843 XBD=1684 XBD=1821 XBD=2011 XBD=2160 XBD=2264 XBD=2305 XBD=2523 XHG=1340 XHG=1501 XHG=1706 XHG=1844 XHG=2033 XHG=2182 XHG=2286 XHG=2326 YBD=1367 YBD=1371 YBD=1366 YBD=1365 YBD=1373 YHG=1336>distress YHG=1336>syndrome YHG=1336>affects YHG=1336>full-term YHG=1336>babies, YHG=1345>runs YHG=1345>a YHG=1335>protracted " XBD=280 XHG=94 YBD=1407 YBD=1407 YHG=1375>individual YHG=1376>feature. " XBD=435 XBD=1454XHG=296 XBD=1595 XBD=1669 XBD=1739 XBD=1768 XBD=1867 XBD=2092 XBD=2195 XBD=2314 XBD=2366 XBD=2521 XHG=1339 XHG=1464 XHG=1608 XHG=1679 XHG=1750 XHG=1778 XHG=1878 XHG=2119 XHG=2206 XHG=2326 XHG=2372 YBD=1417 YBD=1412 YBD=1419 YBD=1411 YBD=1418 YHG=1391>severe YHG=1391>course, YHG=1382>but YHG=1382>has YHG=1391>a YHG=1381>good YHG=1381>prognosis.&dquo; YHG=1381>The YHG=1390>group YHG=1381>of YHG=1381>patients XBD=198 XHG=840 XBD=297 XBD=459 XBD=510 XBD=564 XBD=686 XBD=769 XBD=823 XBD=990 XBD=1063 XBD=1223 XBD=1272 XHG=135 XHG=211 XHG=311 XHG=474 XHG=524 XHG=583 XHG=702 XHG=784 XHG=1005 XHG=1076 XHG=1237 YBD=1452 YBD=1453 YBD=1458 YBD=1453 YBD=1452 YHG=1422>We YHG=1422>have YHG=1421>studied, YHG=1422>in YHG=1422>males YHG=1422>and YHG=1423>31 YHG=1421>females, YHG=1421>the YHG=1422>number YHG=1422>of " XBD=2520 XBD=1497 XBD=1620 XBD=1685 XBD=1800 XBD=1896 XBD=1944 XBD=2120 XBD=2190 XBD=2407 XHG=1336 XHG=1528 XHG=1649 XHG=1714 XHG=1829 XHG=1926 XHG=1975 XHG=2150 XHG=2216 XHG=2438 YBD=1465 YBD=1456 YBD=1458 YBD=1457 YBD=1463 YHG=1427>reported YHG=1437>seem YHG=1434>to YHG=1427>have YHG=1427>had YHG=1436>a YHG=1427>mixture YHG=1427>of YHG=1426>conditions YHG=1426>and, XBD=290 XHG=915 XBD=731 XBD=809 XBD=895 XBD=955 XBD=1028 XBD=1184 XBD=1272 XHG=91 XHG=310 XHG=751 XHG=829 XHG=970 XHG=1047 XHG=1204 YBD=1506 YBD=1506 YBD=1499 YBD=1498 YBD=1506 YBD=1498 YHG=1467>associating YHG=1468>chromosomes/mitoses, YHG=1468>the YHG=1468>size YHG=1468>of YHG=1468>the YHG=1477>groups, YHG=1467>and " XBD=2519 XBD=1501 XBD=1625 XBD=1708 XBD=1802 XBD=1946 XBD=2011 XBD=2096 XBD=2205 XBD=2292 XHG=1336 XHG=1529 XHG=1652 XHG=1735 XHG=1830 XHG=1976 XHG=2039 XHG=2124 XHG=2234 XHG=2321 YBD=1511 YBD=1508 YBD=1503 YBD=1510 YHG=1473>although YHG=1473>there YHG=1482>are YHG=1473>few YHG=1472>details YHG=1473>in YHG=1479>text, YHG=1473>the YHG=1472>suggestion " XBD=1271 XBD=147 XBD=380 XBD=529 XBD=584 XBD=652 XBD=700 XBD=783 XBD=833 XBD=1098 XHG=90 XHG=161 XHG=393 XHG=543 XHG=594 XHG=667 XHG=716 XHG=847 XHG=1112 YBD=1544 YBD=1553 YBD=1546 YBD=1544 YBD=1545 YBD=1545 YBD=1545 YHG=1513>the YHG=1513>distribution YHG=1521>pattern YHG=1514>of YHG=1515>the YHG=1515>D YHG=1514>and YHG=1514>G YHG=1514>chromosomes YHG=1513>involved XBD=1449XHG=799 XBD=1622 XBD=1794 XBD=1887 XBD=2003 XBD=2054 XBD=2131 XBD=2241 XBD=2302 XBD=2413 XBD=2517 XHG=1336 XHG=1472 XHG=1644 XHG=1814 XHG=1909 XHG=2023 XHG=2070 XHG=2152 XHG=2262 XHG=2319 XHG=2435 YBD=1550 YBD=1556 YBD=1548 YBD=1549 YBD=1555 YHG=1528>comes YHG=1519>through YHG=1518>strongly YHG=1518>that YHG=1528>some YHG=1519>if YHG=1525>not YHG=1525>most YHG=1519>of YHG=1519>them YHG=1518>had, " XBD=1271 XBD=125 XBD=371 XBD=469 XBD=599 XBD=638 XBD=802 XBD=1020 XBD=1192 XHG=90 XHG=144 XHG=406 XHG=488 XHG=620 XHG=821 XHG=1040 XHG=1212 YBD=1589 YBD=1591 YBD=1598 YBD=1590 YBD=1590 YHG=1558>in YHG=1560>associations. YHG=1560>We YHG=1560>found YHG=1571>a YHG=1560>striking YHG=1560>correlation YHG=1560>between YHG=1560>the XBD=1368XHG=659 XBD=1460 XBD=1599 XBD=1742 XBD=1801 XBD=1992 XBD=2144 XBD=2229 XBD=2516 XHG=1334 XHG=1394 XHG=1484 XHG=1624 XHG=1765 XHG=1825 XHG=2017 XHG=2168 XHG=2252 YBD=1595 YBD=1602 YBD=1600 YBD=1594 YBD=1601 YHG=1574>as YHG=1574>one YHG=1564>would YHG=1571>expect YHG=1564>in YHG=1564>full-term YHG=1564>babies, YHG=1570>not YHG=1564>hyaline-mem" XBD=186 XBD=313 XBD=368 XBD=473 XBD=617 XBD=700 XBD=772 XBD=964 XBD=1019 XBD=1086 XBD=1187 XHG=89 XHG=200 XHG=328 XHG=378 XHG=487 XHG=632 XHG=714 XHG=979 XHG=1029 XHG=1100 XHG=1201 YBD=1635 YBD=1636 YBD=1637 YBD=1636 YBD=1636 YBD=1635 YHG=1614>mean YHG=1606>values YHG=1606>of YHG=1606>these YHG=1606>indices YHG=1606>and YHG=1606>the YHG=1605>variations YHG=1605>of YHG=1605>the YHG=1605>male YHG=1604>and " XBD=1269 XBD=1438XHG=786 XBD=1598 XBD=1680 XBD=1717 XBD=1811 XBD=1944 XBD=2025 XBD=2155 XBD=2277 XBD=2334 XBD=2404 XBD=2515 XHG=1333 XHG=1458 XHG=1617 XHG=1699 XHG=1735 XHG=1828 XHG=1962 XHG=2041 XHG=2171 XHG=2294 XHG=2346 XHG=2421 YBD=1646 YBD=1647 YBD=1640 YBD=1641 YHG=1610>brane YHG=1610>disease, YHG=1619>nor YHG=1620>a YHG=1619>new YHG=1610>entity, YHG=1610>but YHG=1619>severe YHG=1609>forms YHG=1610>of YHG=1610>the YHG=1609>well&dquo; XBD=208 XHG=714 XBD=461 XBD=689 XBD=878 XBD=1088 XBD=1186 XBD=1268 XHG=88 XHG=232 XHG=488 XHG=903 XHG=1112 XHG=1210 YBD=1681 YBD=1688 YBD=1683 YBD=1689 YBD=1689 YBD=1681 YHG=1650>female YHG=1651>populations, YHG=1652>considered YHG=1652>together, YHG=1651>indicating YHG=1651>that YHG=1651>the " XBD=2512 XBD=1530 XBD=1568 XBD=1765 XBD=1963 XBD=2080 XBD=2277 XHG=1331 XHG=1548 XHG=1583 XHG=1781 XHG=2014 XHG=2095 XHG=2291 YBD=1669 YBD=1686 YBD=1693 YBD=1694 YHG=1656>recognised YHG=1656>&dquo; YHG=1656>syndrome YHG=1655>or YHG=1655>aspiration YHG=1655>pneumonia. " XBD=1266 XBD=118 XBD=368 XBD=465 XBD=544 XBD=759 XBD=810 XBD=1051 XHG=87 XHG=133 XHG=385 XHG=482 XHG=559 XHG=826 XHG=1083 YBD=1726 YBD=1727 YBD=1736 YBD=1728 YBD=1728 YBD=1728 YHG=1696>Y YHG=1696>chromosome YHG=1697>does YHG=1704>not YHG=1698>participate YHG=1697>in YHG=1697>associations. YHG=1697>ConsiderXBD=1363XHG=775 XBD=1447 XBD=1527 XBD=1679 XBD=2042 XBD=2227 XBD=2285 XBD=2406 XBD=2512 XHG=1331 XHG=1386 XHG=1469 XHG=1549 XHG=1693 XHG=2064 XHG=2249 XHG=2307 XHG=2429 YBD=1739 YBD=1732 YHG=1702>(I YHG=1711>use YHG=1702>the YHG=1702>term YHG=1701>hyaline-membrane YHG=1701>disease YHG=1708>to YHG=1702>avoid YHG=1711>con&dquo; &dquo; " XBD=1266 XBD=142 XBD=219 XBD=345 XBD=583 XBD=654 XBD=783 XBD=992 XBD=1209 XHG=86 XHG=161 XHG=239 XHG=364 XHG=604 XHG=673 XHG=1011 XHG=1230 YBD=1779 YBD=1772 YBD=1779 YBD=1774 YBD=1781 YBD=1773 YBD=1772 YHG=1742>ing YHG=1742>the YHG=1741>single YHG=1742>individuals, YHG=1753>we YHG=1743>found YHG=1743>significant YHG=1743>differences YHG=1742>in XBD=1456XHG=803 XBD=1569 XBD=1651 XBD=1848 XBD=1934 XBD=2006 XBD=2215 XBD=2286 XBD=2371 XBD=2513 XHG=1329 XHG=1477 XHG=1589 XHG=1672 XHG=1867 XHG=1954 XHG=2030 XHG=2241 XHG=2309 XHG=2395 YBD=1783 YBD=1777 YBD=1784 YBD=1778 YHG=1748>fusion, YHG=1748>since YHG=1748>Dr. YHG=1748>Roberton YHG=1747>and YHG=1747>his YHG=1747>colleagues YHG=1747>do YHG=1754>not YHG=1748>follow XBD=141 XHG=611 XBD=315 XBD=450 XBD=512 XBD=589 XBD=864 XBD=1054 XBD=1110 XBD=1206 XBD=1263 XHG=85 XHG=162 XHG=336 XHG=472 XHG=529 XHG=885 XHG=1075 XHG=1133 XHG=1228 YBD=1818 YBD=1818 YBD=1819 YBD=1824 YBD=1819 YBD=1818 YBD=1817 YHG=1787>the YHG=1788>absolute YHG=1788>values YHG=1788>of YHG=1789>the YHG=1789>chromosomes YHG=1788>involved, YHG=1798>as YHG=1788>well YHG=1797>as " XBD=2510 XBD=1386 XBD=1662 XBD=1946 XBD=2097 XBD=2249 XHG=1328 XHG=1425 XHG=1703 XHG=1987 XHG=2136 XHG=2288 YBD=1828 YBD=1823 YBD=1831 YHG=1793>the YHG=1793>international YHG=1792>classification, YHG=1792>which YHG=1792>makes YHG=1793>respiratoryXBD=280 XHG=652 XBD=330 XBD=400 XBD=501 XBD=626 XBD=826 XBD=1055 XBD=1214 XBD=1268 XHG=86 XHG=294 XHG=342 XHG=413 XHG=513 XHG=838 XHG=1067 XHG=1228 YBD=1864 YBD=1863 YBD=1871 YBD=1864 YBD=1872 YBD=1872 YBD=1864 YBD=1863 YHG=1833>differences YHG=1833>in YHG=1833>the YHG=1833>D/G YHG=1833>ratios. YHG=1834>Repeated YHG=1834>lymphocyte YHG=1834>cultures YHG=1833>of " XBD=2509 XBD=1466 XBD=1674 XBD=1825 XBD=1917 XBD=2125 XHG=1328 XHG=1491 XHG=1698 XHG=1849 XHG=1940 XHG=2148 YBD=1869 YBD=1876 YHG=1839>distress YHG=1839>syndrome YHG=1838>(R.D.S.) YHG=1838>and YHG=1838>idiopathic YHG=1839>respiratory-distress " XBD=140 XBD=243 XBD=460 XBD=615 XBD=701 XBD=808 XBD=1018 XBD=1133 XBD=1206 XHG=84 XHG=153 XHG=256 XHG=475 XHG=628 XHG=821 XHG=1032 XHG=1145 XHG=1220 YBD=1910 YBD=1909 YBD=1910 YBD=1910 YBD=1910 YBD=1909 YHG=1879>the YHG=1889>same YHG=1879>individuals YHG=1879>showed YHG=1879>that YHG=1880>these YHG=1880>differences YHG=1879>could YHG=1886>not YHG=1880>be " XBD=1262 XBD=1510XHG=713 XBD=1693 XBD=1907 XBD=1975 XBD=2347 XBD=2508 XHG=1327 XHG=1539 XHG=1723 XHG=1935 XHG=1999 XHG=2377 YBD=1915 YBD=1922 YBD=1916 YHG=1885>syndrome YHG=1884>(LR.D.S.) YHG=1894>synonyms YHG=1884>of YHG=1884>hyaline-membrane YHG=1885>disease " XBD=1262 XBD=243 XBD=306 XBD=456 XBD=530 XBD=565 XBD=879 XBD=1036 XBD=1093 XBD=1124 XHG=85 XHG=260 XHG=321 XHG=488 XHG=547 XHG=582 XHG=894 XHG=1052 XHG=1104 XHG=1140 YBD=1963 YBD=1963 YBD=1955 YBD=1956 YBD=1963 YBD=1956 YBD=1955 YHG=1925>expected YHG=1926>by YHG=1925>chance. YHG=1925>In YHG=1935>a YHG=1925>double-variance YHG=1925>analysis YHG=1926>of YHG=1927>8 XBD=1487 XHG=2447 XBD=1574 XBD=1708 XBD=1821 XBD=1880 XBD=2005 XBD=2123 XBD=2216 XBD=2362 XBD=2424 XBD=2507 XHG=1326 YBD=1962 XHG=1511 XHG=1596 XHG=1731 XHG=1845 XHG=1903 XHG=2026 XHG=2149 XHG=2238 XHG=2388 YBD=1960 YHG=1925>female YBD=1968 YBD=1961 YHG=1930>(H.M.D.), YHG=1930>but YHG=1930>rather YHG=1940>seem YHG=1937>to YHG=1930>apply YHG=1938>R.D.S. YHG=1930>and YHG=1938>LR.D.S. YHG=1938>to YHG=1931>the " XBD=226 XBD=297 XBD=424 XBD=517 XBD=595 XBD=794 XBD=965 XBD=1077 XBD=1184 XHG=84 XHG=247 XHG=315 XHG=443 XHG=536 XHG=614 XHG=983 XHG=1096 XHG=1202 YBD=2002 YBD=2001 YBD=2002 YBD=2001 YBD=2001 YHG=1971>controls YHG=1981>we YHG=1971>found YHG=1971>that YHG=1971>the YHG=1971>variations YHG=1972>between YHG=1971>them YHG=1980>were YHG=1977>ten " XBD=1260 XBD=1434XHG=814 XBD=1564 XBD=1627 XBD=1834 XBD=2040 XBD=2144 XBD=2346 XBD=2505 XHG=1324 XHG=1456 XHG=1587 XHG=1644 XHG=1856 XHG=2061 XHG=2164 XHG=2368 YBD=2014 YBD=2006 YBD=2007 YHG=1976>whole YHG=1985>group YHG=1976>of YHG=1976>conditions YHG=1976>associated YHG=1976>with YHG=1976>distressed YHG=1976>breathXBD=177 XHG=954 XBD=230 XBD=340 XBD=393 XBD=509 XBD=682 XBD=720 XBD=882 XBD=941 XBD=995 XBD=1151 XBD=1258 XHG=82 XHG=196 XHG=248 XHG=358 XHG=411 XHG=528 XHG=700 XHG=739 XHG=901 XHG=1014 XHG=1169 YBD=2047 YBD=2047 YBD=2054 YBD=2046 YBD=2047 YBD=2046 YHG=2017>times YHG=2023>great YHG=2026>as YHG=2016>those YHG=2017>between YHG=2017>4 YHG=2016>samples YHG=2016>of YHG=2017>25 YHG=2016>mitoses YHG=2016>from " XBD=2506 XBD=1381 XBD=1446 XBD=1534 XBD=1752 XBD=1884 XBD=2022 XBD=2197 XBD=2269 XBD=2391 XHG=1323 XHG=1410 XHG=1476 XHG=1563 XHG=1808 XHG=1913 XHG=2050 XHG=2228 XHG=2292 XHG=2420 YBD=2051 YBD=2058 YBD=2059 YBD=2052 YHG=2022>ing YHG=2021>in YHG=2021>the YHG=2021>newborn.) YHG=2022>The YHG=2022>X-ray YHG=2022>findings YHG=2022>of YHG=2022>those YHG=2022>with |>" " XBD=136 XBD=242 XBD=444 XBD=494 XBD=532 XBD=718 XBD=751 XBD=874 XBD=929 XBD=960 XBD=1078 XBD=1152 XBD=1258 XBD=644 XHG=81 XHG=152 XHG=256 XHG=460 XHG=506 XHG=676 XHG=733 XHG=766 XHG=889 XHG=941 XHG=975 XHG=1093 XHG=1167 XHG=542 YBD=2093 YBD=2093 YBD=2099 YBD=2091 YBD=2100 YBD=2092 YBD=2092 YBD=2099 YBD=2092 YHG=2062>the YHG=2072>same YHG=2062>individual YHG=2062>(p YHG=2069>< YHG=2062>In YHG=2071>a YHG=2071>group YHG=2062>of YHG=2063>5 YHG=2062>males YHG=2062>0-05). YHG=2062>the YHG=2070>same XBD=1344 XBD=1455 XBD=1545 XBD=1752 XBD=1955 XBD=2139 XBD=2296 XBD=2504 XHG=1323 XHG=1358 XHG=1477 XHG=1568 XHG=1775 XHG=1979 XHG=2161 XHG=2318 YBD=2080 YBD=2097 YBD=2105 YHG=2067>&dquo; YHG=2067>lobar YHG=2067>and YHG=2067>segmental YHG=2067>collapse YHG=2068>certainly YHG=2074>suggest YHG=2068>aspiration &dquo; XBD=175 XHG=812 XBD=288 XBD=343 XBD=533 XBD=621 XBD=800 XBD=954 XBD=1006 XBD=1071 XBD=1256 XHG=80 XHG=188 XHG=301 XHG=355 XHG=547 XHG=633 XHG=965 XHG=1013 XHG=1083 YBD=2139 YBD=2139 YBD=2144 YBD=2145 YBD=2138 YBD=2138 YBD=2138 YHG=2108>trend YHG=2108>could YHG=2108>be YHG=2108>observed, YHG=2108>but, YHG=2108>probably YHG=2107>because YHG=2107>of YHG=2107>the YHG=2107>smallness " XBD=2503 XBD=1505 XBD=1548 XBD=1603 XBD=1655 XBD=1807 XBD=1906 XBD=1998 XBD=2215 XBD=2338 XBD=2384 XHG=1322 XHG=1520 XHG=1576 XHG=1628 XHG=1682 XHG=1832 XHG=1931 XHG=2025 XHG=2243 XHG=2366 XHG=2411 YBD=2149 YBD=2143 YBD=2144 YBD=2151 YHG=2112>syndrome YHG=2113>2; YHG=2112>it YHG=2113>is YHG=2113>known YHG=2113>that YHG=2113>this YHG=2113>conditions YHG=2113>bears YHG=2123>a YHG=2113>good |>" XBD=117 XBD=195 XBD=333 XBD=567 XBD=651 XBD=730 XBD=888 XBD=1099 XBD=996 XBD=1209 XHG=79 XHG=129 XHG=212 XHG=351 XHG=585 XHG=669 XHG=746 XHG=1008 XHG=906 XHG=1108 YBD=2185 YBD=2185 YBD=2192 YBD=2191 YBD=2184 YBD=2191 YBD=2184 YBD=2191 YHG=2154>of YHG=2154>this YHG=2163>group, YHG=2153>significance YHG=2163>was YHG=2160>not YHG=2153>reached YHG=2154>(0-05 YHG=2161>< YHG=2153>0-10). p < " XBD=1510 XBD=1649 XBD=1704 XBD=1813 XBD=1873 XBD=2030 XBD=2231 XBD=2290 XBD=2502 XHG=1319 XHG=1531 XHG=1668 XHG=1723 XHG=1833 XHG=1888 XHG=2049 XHG=2250 XHG=2304 YBD=2189 YBD=2197 YBD=2190 YHG=2159>prognosis, YHG=2165>except YHG=2159>in YHG=2168>cases YHG=2159>of YHG=2160>massive YHG=2159>aspiration YHG=2160>of YHG=2160>meconium " XBD=1255 XBD=182 XBD=267 XBD=405 XBD=460 XBD=672 XBD=772 XBD=846 XBD=1009 XBD=1068 XBD=1143 XHG=121 XHG=199 XHG=284 XHG=424 XHG=477 XHG=690 XHG=863 XHG=1028 XHG=1080 XHG=1164 YBD=2231 YBD=2236 YBD=2229 YBD=2237 YBD=2230 YBD=2238 YBD=2230 YHG=2200>We YHG=2200>also YHG=2199>found, YHG=2199>in YHG=2206>agreement YHG=2199>with YHG=2199>the YHG=2199>findings YHG=2200>of YHG=2200>Dr. YHG=2198>Ford XBD=1357XHG=789 XBD=1494 XBD=1563 XBD=1778 XBD=1920 XBD=1969 XBD=2064 XBD=2254 XBD=2441 XBD=2501 XHG=1319 XHG=1380 XHG=1531 XHG=1586 XHG=1801 XHG=1941 XHG=1992 XHG=2086 XHG=2278 XHG=2464 YBD=2235 YBD=2242 YBD=2243 YBD=2236 YHG=2215>or YHG=2204>blood. YHG=2205>A YHG=2205>protracted YHG=2214>course YHG=2205>is YHG=2212>not, YHG=2206>however, YHG=2206>expected YHG=2206>in " XBD=1254 XBD=141 XBD=228 XBD=434 XBD=534 XBD=624 XBD=769 XBD=882 XBD=1100 XBD=1171 XHG=77 XHG=167 XHG=256 XHG=461 XHG=559 XHG=648 XHG=907 XHG=1125 XHG=1195 YBD=2276 YBD=2277 YBD=2281 YBD=2276 YBD=2283 YBD=2276 YBD=2275 YHG=2246>and YHG=2246>Dr. YHG=2245>Woollam, YHG=2245>that YHG=2255>our YHG=2245>results YHG=2255>were YHG=2245>dependent YHG=2254>on YHG=2245>the XBD=1339XHG=796 XBD=1538 XBD=1740 XBD=1788 XBD=1900 XBD=2165 XBD=2211 XBD=2363 XBD=2501 XHG=1319 XHG=1354 XHG=1558 XHG=1755 XHG=1808 XHG=1918 XHG=2183 XHG=2231 XHG=2382 YBD=2264 YBD=2287 YBD=2290 YBD=2289 YBD=2282 YHG=2251>&dquo; YHG=2250>aspiration YHG=2251>syndrome YHG=2251>&dquo;, YHG=2251>since YHG=2251>improvement YHG=2251>is YHG=2251>usually YHG=2251>earlier " XBD=2499 XBD=1399 XBD=1452 XBD=1586 XBD=1701 XBD=1743 XBD=1786 XBD=1863 XBD=1967 XBD=2072 XBD=2150 XBD=2344 XBD=2428 XHG=1315 XHG=1415 XHG=1468 XHG=1633 XHG=1717 XHG=1758 XHG=1803 XHG=1880 XHG=1983 XHG=2088 XHG=2168 XHG=2360 XHG=2444 YBD=2327 YBD=2328 YHG=2297>than YHG=2297>in YHG=2304>H.M.D. YHG=2297>But YHG=2297>it YHG=2297>is YHG=2304>not YHG=2297>clear YHG=2297>what YHG=2297>Dr. YHG=2297>Roberton YHG=2298>and YHG=2297>his XBD=286 XHG=627 XBD=491 XBD=615 XBD=882 XBD=1059 XBD=1253 XHG=75 XHG=298 XHG=519 XHG=894 XHG=1073 YBD=2330 YBD=2329 YBD=2322 YBD=2329 YHG=2291>preparation YHG=2291>technique. YHG=2291>With YHG=2291>microcultures YHG=2291>prepared YHG=2291>according |>" XBD=109 XBD=272 XBD=362 XBD=559 XHG=74 XHG=130 XHG=296 XHG=388 YBD=2368 YBD=2367 YHG=2344>to YHG=2337>Arakaki YHG=2337>and YHG=2337>Sparkes XBD=939 XBD=1014 XBD=1177 XBD=1252 XHG=788 XHG=963 XHG=1039 XHG=1200 YBD=2368 YBD=2374 YBD=2375 YBD=2368 1 (McCoy’s YHG=2336>medium YHG=2338>5a, YHG=2337>Gibco), YHG=2346>we " XBD=1502 XBD=1688 XBD=1826 XBD=1881 XBD=2103 XBD=2181 XBD=2259 XBD=2344 XBD=2440 XBD=2498 XHG=1315 XHG=1523 XHG=1707 XHG=1846 XHG=1901 XHG=2140 XHG=2200 XHG=2279 XHG=2365 XHG=2461 YBD=2380 YBD=2376 YBD=2381 YBD=2374 YBD=2373 YHG=2343>colleagues YHG=2343>precisely YHG=2343>regard YHG=2353>as YHG=2343>protracted. YHG=2344>In YHG=2344>the YHG=2353>one YHG=2352>case YHG=2343>in XBD=180 XHG=627 XBD=232 XBD=456 XBD=593 XBD=914 XBD=1063 XBD=1180 XBD=1250 XHG=74 XHG=214 XHG=266 XHG=489 XHG=949 XHG=1098 XHG=1214 YBD=2415 YBD=2421 YBD=2415 YBD=2414 YBD=2422 YBD=2414 YHG=2384>found YHG=2393>a YHG=2383>constantly YHG=2383>lower YHG=2383>association-rate YHG=2384>(70%) YHG=2384>than YHG=2384>in " XBD=2497 XBD=1426 XBD=1713 XBD=1799 XBD=2034 XBD=2089 XBD=2145 XBD=2298 XBD=2409 XHG=1314 XHG=1455 XHG=1743 XHG=1826 XHG=2064 XHG=2117 XHG=2174 XHG=2329 XHG=2437 YBD=2426 YBD=2420 YBD=2421 YHG=2389>which YHG=2389>time-intervals YHG=2399>are YHG=2389>mentioned, YHG=2389>it YHG=2389>is YHG=2389>stated: YHG=2389>&dquo; YHG=2389>the In 2 XBD=331 XHG=805 XBD=540 XBD=764 XBD=841 XBD=1074 XBD=1150 XBD=1248 XHG=73 XHG=373 XHG=583 XHG=882 XHG=1117 XHG=1191 YBD=2461 YBD=2468 YBD=2467 YBD=2460 YBD=2460 YBD=2461 YHG=2429>macrocultures YHG=2430>prepared YHG=2429>according YHG=2436>to YHG=2430>Moorhead YHG=2436>et YHG=2430>al. " XBD=2495 XBD=1439 XBD=1678 XBD=1796 XBD=1852 XBD=1921 XBD=1993 XBD=2124 XBD=2315 XHG=1313 XHG=1454 XHG=1692 XHG=1812 XHG=1861 XHG=1934 XHG=2008 XHG=2141 XHG=2331 YBD=2473 YBD=2466 YHG=2435>second YHG=2436>twenty-four YHG=2436>hours YHG=2436>of YHG=2436>life YHG=2436>the YHG=2435>baby’s YHG=2436>condition YHG=2435>deterior" XBD=1248 XBD=339 XBD=420 XBD=456 XBD=606 XBD=686 XBD=845 XBD=1049 XHG=73 XHG=358 XHG=435 XHG=473 XHG=623 XHG=861 XHG=1066 YBD=2513 YBD=2511 YBD=2513 YBD=2506 YBD=2513 YBD=2507 YHG=2475>(medium YHG=2477>199 YHG=2476>’, YHG=2476>Difco), YHG=2476>but YHG=2475>without YHG=2476>significant YHG=2476>difference XBD=1388XHG=702 XBD=1524 XBD=1724 XBD=1919 XBD=2008 XBD=2221 XBD=2331 XBD=2492 XHG=1311 XHG=1412 XHG=1561 XHG=1747 XHG=1941 XHG=2030 XHG=2245 XHG=2354 YBD=2519 YBD=2517 YBD=2511 YBD=2512 YBD=2513 YHG=2482>ated ’ TC YHG=2481>...&dquo;. YHG=2482>Digoxin, YHG=2481>diuretics, YHG=2481>and YHG=2481>antibiotics YHG=2491>were YHG=2482>started. XBD=106 XHG=408 XBD=178 XBD=393 XBD=553 XHG=72 XHG=121 XHG=194 YBD=2552 YBD=2552 YBD=2559 YHG=2521>in YHG=2521>the YHG=2521>association YHG=2527>pattern. " XBD=2491 XBD=1332 XBD=1487 XBD=1592 XBD=1677 XBD=1755 XBD=1892 XBD=2087 XBD=2215 XBD=2269 XBD=2443 XHG=1312 XHG=1349 XHG=1506 XHG=1611 XHG=1698 XHG=1775 XHG=1914 XHG=2107 XHG=2234 XHG=2289 XHG=2458 YBD=2540 YBD=2557 YBD=2558 YBD=2565 YBD=2559 YHG=2528>&dquo; YHG=2527>Shortly YHG=2527>after YHG=2527>this YHG=2527>the YHG=2527>baby’s YHG=2526>condition YHG=2527>began YHG=2534>to YHG=2527>improve YHG=2527>&dquo;.

IN BABIES

" XBD=1435 XBD=1534 XBD=1669 XBD=1753 XBD=1805 XBD=2004 XHG=1310 XHG=1453 XHG=1550 XHG=1686 XHG=1771 XHG=1824 XHG=2020 YBD=2604 YBD=2603 YBD=2605 YHG=2573>Would YHG=2573>thev YHG=2573>regard YHG=2573>this YHG=2582>as YHG=2573>unusuallv YHG=2573>protracted ? " XBD=2236 XBD=183 XHG=805 XBD=291 XBD=366 XBD=464 XBD=554 XBD=623 XBD=791 XBD=969 XBD=1021 XBD=1111 XBD=1246 XHG=109 XHG=199 XHG=306 XHG=383 XHG=480 XHG=571 XHG=639 XHG=985YBD=2609 XHG=1033 XHG=1129 YBD=2615 YBD=2608 YBD=2609 YBD=2609 YBD=2616 YHG=2582>This YHG=2582>study YHG=2589>was YHG=2581>done YHG=2581>with YHG=2581>the YHG=2581>technical YHG=2581>assistance YHG=2582>of YHG=2582>Mrs. YHG=2582>Regine

" XBD=2486 XBD=209 XHG=884 XBD=304 XBD=397 XBD=604 XBD=680 XBD=730 XBD=851 XBD=965 XBD=1051 XBD=1244 XBD=1395 XBD=1517 XBD=1669 XBD=1774 XBD=1924 XBD=2140 XBD=2359 XHG=70 XHG=242 XHG=337 XHG=433 XHG=638 XHG=713 XHG=763 XHG=999 XHG=1085 XHG=1353 XHG=1431 XHG=1552 XHG=1708 XHG=1811 XHG=1959 XHG=2177 XHG=2395 YBD=2656 YBD=2649 YBD=2656 YBD=2650 YBD=2650 YBD=2651 YBD=2656 YBD=2649 YHG=2622>Heiland, YHG=2622>and YHG=2630>was YHG=2622>supported YHG=2622>by YHG=2631>a YHG=2628>grant YHG=2622>from YHG=2623>the YHG=2624>Deutsche YHG=2619>In YHG=2618>both YHG=2626>H.M.D. YHG=2619>and YHG=2628>severe YHG=2619>aspiration YHG=2618>syndrome YHG=2625>most " XBD=1076 XBD=498 XBD=540 XBD=619 XBD=675 XBD=857 XBD=904 XBD=976 XHG=70 XHG=515 XHG=557 XHG=635 XHG=691 XHG=871 XHG=991 YBD=2698 YBD=2698 YBD=2691 YBD=2691 YHG=2663>Forschungsgemeinschaft; YHG=2663>it YHG=2663>will YHG=2663>be YHG=2663>published YHG=2663>in YHG=2663>full YHG=2663>later. XBD=1463XHG=919 XBD=1632 XBD=1770 XBD=1889 XBD=1984 XBD=2269 XBD=2381 XBD=2488 XHG=1307 XHG=1486 XHG=1656 XHG=1793 XHG=1912 XHG=2008 XHG=2291 XHG=2406 YBD=2696 YBD=2702 YBD=2695 YHG=2665>neonatal YHG=2665>workers YHG=2665>would YHG=2674>agree YHG=2664>that YHG=2664>differentiation YHG=2664>from YHG=2674>conof Neuropathology, " XBD=2488 XBD=1429 XBD=1691 XBD=1736 XBD=1948 XBD=2121 XBD=2173 XBD=2273 XBD=2336 XHG=1306 XHG=1447 XHG=1708 XHG=1755 XHG=1967 XHG=2140 XHG=2190 XHG=2291 YBD=2748 YHG=2710>clinical YBD=2742 YBD=2747 YBD=2740 YBD=2741 YHG=2711>genital YHG=2711>heart-disease YHG=2711>is YHG=2711>sometimes YHG=2711>difficult, YHG=2717>at YHG=2711>least YHG=2720>on DepartmentXHG=2355 InstituteYBD=2787 Max-Planck " XBD=2485 XBD=1467 XBD=1519 XBD=1580 XBD=1770 XBD=1888 XBD=2099 XBD=2181 XBD=2353 XHG=1304 XHG=1486 XHG=1537 XHG=1598 XHG=1788 XHG=1921 XHG=2117 XHG=2199 XHG=2374 YBD=2786 YBD=2794 YBD=2792 YHG=2757>grounds, YHG=2763>at YHG=2766>an YHG=2756>advanced YHG=2763>stage. YHG=2757>However, YHG=2766>one YHG=2756>wonders YHG=2766>someK. D. ZANG for Psychiatry, Munich, " XBD=2484 XBD=1401 XBD=1575 XBD=1652 XBD=1847 XBD=2084 XBD=2342 XHG=1303 XHG=1423 XHG=1595 XHG=1673 XHG=1867 XHG=2103 XHG=2357 YBD=2833 YBD=2832 YBD=2839 YBD=2840 YHG=2802>times YHG=2802>whether YHG=2802>the YHG=2802>condition YHG=2802>customarily YHG=2802>designated YHG=2802>aspiraELKE BACK. &dquo; Western Germany. " XBD=2483 XBD=1374 XHG=2420 XBD=1625 XBD=1702 XBD=1862 XBD=1960 XBD=2100 XBD=2276 XBD=2389 XHG=1302 YBD=2877 XHG=1405 XHG=1656 XHG=1733 XHG=1893 XHG=1991 XHG=2129 XHG=2308 YBD=2886 YHG=2854>not YBD=2885 YBD=2884 YBD=2878 YHG=2848>tion YHG=2848>syndrome YHG=2857>on YHG=2847>clinical YHG=2848>and YHG=2848>X-ray YHG=2847>findings YHG=2848>does &dquo; " XBD=2480 XBD=1381 XHG=2443 XBD=1515 XBD=1655 XBD=1719 XBD=1805 XBD=1905 XBD=2047 XBD=2136 XBD=2251 XBD=2415 XHG=1301 YBD=2923 XHG=1408 XHG=1544 XHG=1684 XHG=1747 XHG=1832 XHG=1931 XHG=2077 XHG=2165 XHG=2280 YBD=2931 YHG=2893>in YBD=2924 YHG=2894>bear YHG=2894>closer YHG=2893>study, YHG=2893>the YHG=2903>way YHG=2900>H.M.D. YHG=2893>has YHG=2894>been YHG=2893>studied " XBD=2480 XBD=1413 XHG=2392 XBD=1536 XBD=1669 XBD=1839 XBD=1935 XBD=1988 XBD=2171 XBD=2335 XBD=2373 XHG=1298 YBD=2969 XHG=1431 XHG=1571 XHG=1682 XHG=1858 XHG=1955 XHG=2008 XHG=2191 XHG=2357 YBD=2970 YHG=2939>have YBD=2977 YBD=2976 YBD=2968 YHG=2946>recent YHG=2948>years. YHG=2939>On YHG=2938>standing YHG=2939>by&dquo; YHG=2945>at YHG=2948>cxsarean YHG=2938>sections YHG=2939>I &dquo; SNOWBURN " XBD=2478 XBD=1384 XHG=2374 XBD=1596 XBD=1703 XBD=1783 XBD=1995 XBD=2052 XBD=2157 XBD=2215 XBD=2351 XHG=1298 YBD=3015 XHG=1408 XHG=1620 XHG=1725 XHG=1806 XHG=2016 XHG=2075 XHG=2180 XHG=2239 YBD=3016 YBD=3023 YBD=3022 YBD=3014 YHG=2986>been YHG=2984>impressed YHG=2984>with YHG=2984>the YHG=2984>variability YHG=2985>time YHG=2985>in YHG=2984>which YHG=2985>moist " XBD=2475 XBD=1424 XBD=1518 XBD=1682 XBD=1750 XBD=1856 XBD=2029 XBD=2095 XBD=2174 XBD=2298 XBD=2413 XHG=1296 XHG=1451 XHG=1544 XHG=1710 XHG=1770 XHG=1882 XHG=2055 XHG=2116 XHG=2199 XHG=2325 XHG=2438 YBD=3062 YBD=3069 YBD=3068 YBD=3061 YBD=3067 YBD=3060 YHG=3031>sounds YHG=3030>and YHG=3031>patches YHG=3030>of YHG=3039>poor YHG=3030>aeration YHG=3031>of YHG=3030>the YHG=3030>lungs YHG=3030>clear YHG=3030>in XBD=262 XHG=830 XBD=340 XBD=542 XBD=603 XBD=677 XBD=810 XBD=947 XBD=1153 XBD=1231 XHG=101 XHG=282 XHG=360 XHG=562 XHG=618 XHG=696 XHG=968YBD=3072 XHG=1171 YBD=3073 YBD=3068 YBD=3066 YBD=3067 YBD=3067 YHG=3037>SIR,-As YHG=3037>the YHG=3036>aftermath YHG=3036>of YHG=3035>the YHG=3042>recent YHG=3042>storm, YHG=3037>snowburn YHG=3036>has " XBD=2475 XBD=1493 XBD=1646 XBD=1851 XBD=1925 XBD=2094 XBD=2212 XBD=2373 XHG=1294 XHG=1508 XHG=1661 XHG=1884 XHG=1942 XHG=2110 XHG=2227 XHG=2391 YBD=3115 YBD=3107 YBD=3113 YBD=3114 YBD=3106 YHG=3077>apparently YHG=3076>healthy YHG=3076>newborns. YHG=3076>In YHG=3076>addition YHG=3085>many YHG=3076>patients YHG=3076>with XBD=139 XHG=806 XBD=324 XBD=375 XBD=454 XBD=578 XBD=740 XBD=791 XBD=980 XBD=1096 XBD=1230 XHG=59 XHG=153 XHG=339 XHG=390 XHG=468 XHG=594 XHG=755 XHG=1011 XHG=1112 YBD=3114 YBD=3113 YBD=3120 YBD=3112 YBD=3119 YBD=3112 YHG=3082>been YHG=3083>prevalent YHG=3083>in YHG=3092>our YHG=3091>group YHG=3082>practice YHG=3082>in YHG=3082>Brighton. YHG=3082>This YHG=3082>condi" XBD=2473 XBD=1456 XBD=1665 XBD=1873 XBD=1979 XBD=2050 XBD=2134 XBD=2232 XBD=2325 XBD=2391 XHG=1293 XHG=1483 XHG=1693 XHG=1901 XHG=2006 XHG=2077 XHG=2160 XHG=2259 XHG=2350 XHG=2412 YBD=3159 YBD=3160 YBD=3152 YBD=3153 YHG=3122>so-called YHG=3122>aspiration YHG=3122>syndrome YHG=3131>seen YHG=3131>on YHG=3122>the YHG=3122>first YHG=3122>day YHG=3122>of YHG=3122>life XBD=134 XHG=843 XBD=277 XBD=369 XBD=418 XBD=595 XBD=645 XBD=716 XBD=830 XBD=883 XBD=1068 XBD=1153 XBD=1230 XHG=57 XHG=147 XHG=291 XHG=383 XHG=430 XHG=609 XHG=658 XHG=728 XHG=897 XHG=1085 XHG=1169 YBD=3165 YBD=3166 YBD=3158 YBD=3159 YBD=3164 YBD=3158 YHG=3128>tion, YHG=3128>though YHG=3138>seen YHG=3128>practices YHG=3128>in YHG=3128>the YHG=3128>north YHG=3128>of YHG=3128>Scotland, YHG=3128>had YHG=3135>not " XBD=2468 XBD=1376 XBD=1411 XBD=1513 XBD=1744 XBD=1916 XBD=1970 XBD=2101 XBD=2299 XBD=2349 XHG=1290 XHG=1393 XHG=1427 XHG=1528 XHG=1756 XHG=1932 XHG=1986 XHG=2117 XHG=2315 XHG=2367 YBD=3206 YBD=3205 YBD=3198 YBD=3199 YHG=3168>have YHG=3178>a YHG=3177>poor YHG=3167>history--of YHG=3167>asphyxia YHG=3177>or YHG=3168>undue YHG=3167>aspiration YHG=3174>at YHG=3168>birth. XBD=240 XHG=859 XBD=349 XBD=452 XBD=522 XBD=603 XBD=777 XBD=836 XBD=916 XBD=1033 XBD=1228 XHG=55 XHG=264 XHG=373 XHG=476 XHG=544 XHG=624 XHG=800 XHG=939 XHG=1055 YBD=3212 YBD=3212 YBD=3204 YBD=3205 YBD=3204 YHG=3174>previously YHG=3174>been YHG=3184>seen YHG=3174>by YHG=3183>my YHG=3181>partners YHG=3174>in YHG=3174>the YHG=3183>more YHG=3174>moderate " XBD=285 XBD=181 XHG=55 YBD=3251 YBD=3250 YHG=3219>climate YHG=3220>here. XBD=1381XHG=196 XBD=1432 XBD=1544 XBD=1685 XBD=1784 XBD=1899 XBD=2097 XBD=2230 XBD=2287 XBD=2469 XHG=1290 XHG=1396 XHG=1450 XHG=1560 XHG=1704 XHG=1802 XHG=1916 XHG=2115 XHG=2248 XHG=2300 YBD=3252 YBD=3250 YBD=3244 YBD=3245 YHG=3214>Why YHG=3214>in YHG=3224>some YHG=3214>infants YHG=3214>does YHG=3213>frank YHG=3213>atelectasis YHG=3223>ensue, YHG=3214>of YHG=3214>sufficient " XBD=2467 XBD=1432 XBD=1484 XBD=1600 XBD=1838 XBD=1968 XBD=2084 XBD=2212 XBD=2284 XHG=1288 XHG=1448 XHG=1500 XHG=1616 XHG=1854 XHG=1986 XHG=2100 XHG=2230 XHG=2301 YBD=3298 YBD=3297 YBD=3296 YBD=3291 YBD=3290 YHG=3260>severity YHG=3267>to YHG=3270>cause YHG=3260>right-to-left YHG=3260>shunt, YHG=3260>while YHG=3260>others YHG=3270>are YHG=3260>observed XBD=283 XHG=874 XBD=325 XBD=517 XBD=580 XBD=612 XBD=859 XBD=913 XBD=1030 XBD=1141 XBD=1224 XHG=95 XHG=298 XHG=340 XHG=533 XHG=594 XHG=628 XHG=925 XHG=1045 XHG=1158 YBD=3295 YBD=3303 YBD=3295 YBD=3296 YBD=3301 YBD=3301 YBD=3295 YHG=3265>Snowburn YHG=3265>is YHG=3265>produced YHG=3266>by YHG=3275>a YHG=3265>combination YHG=3265>of YHG=3274>snow, YHG=3265>frost, YHG=3265>and " XBD=2464 XBD=1322 XBD=1454 XBD=1562 XBD=1738 XBD=1799 XBD=1925 XBD=2054 XBD=2100 XBD=2251 XHG=1286 XHG=1341 XHG=1472 XHG=1582 XHG=1759 XHG=1813 XHG=1944 XHG=2074 XHG=2120 XHG=2270 YBD=3335 YBD=3343 YBD=3336 YHG=3313>to YHG=3306>inhale YHG=3306>large YHG=3313>amounts YHG=3306>of YHG=3305>liquor YHG=3306>which YHG=3306>is YHG=3306>rapidly YHG=3306>absorbed ? XBD=177 XHG=588 XBD=235 XBD=395 XBD=505 XBD=571 XBD=971 XBD=1037 XBD=1115 XBD=1222 XHG=53 XHG=195 XHG=249 XHG=413 XHG=525 XHG=997 XHG=1058 XHG=1142 YBD=3347 YBD=3340 YBD=3348 YBD=3341 YBD=3341 YBD=3340 YHG=3309>chafing YHG=3311>of YHG=3310>exposed YHG=3318>parts YHG=3311>by YHG=3310>fabrics-particularly YHG=3311>of YHG=3311>the YHG=3311>sub" XBD=2462 XBD=1360 XBD=1611 XBD=1678 XBD=1792 XBD=1905 XBD=1966 XBD=2091 XBD=2297 XBD=2371 XHG=1328 XHG=1388 XHG=1639 XHG=1702 XHG=1821 XHG=1932 XHG=1995 XHG=2117 XHG=2325 XHG=2399 YBD=3383 YBD=3381 YBD=3389 YBD=3382 YHG=3351>A YHG=3352>break-down YHG=3352>of YHG=3361>cases YHG=3351>such YHG=3361>as YHG=3352>those YHG=3352>presented YHG=3352>by YHG=3352>Dr. XBD=168 XHG=867 XBD=314 XBD=392 XBD=514 XBD=678 XBD=783 XBD=850 XBD=970 XBD=1218 XHG=51 XHG=187 XHG=334 XHG=412 XHG=534 XHG=697 XHG=804 XHG=990 YBD=3386 YBD=3392 YBD=3387 YBD=3394 YBD=3393 YBD=3387 YHG=3355>mental YHG=3355>region, YHG=3357>the YHG=3363>worst YHG=3356>affected YHG=3363>part, YHG=3357>by YHG=3356>nylon YHG=3356>headscarves. " XBD=2463 XBD=1459 XBD=1554 XBD=1634 XBD=1848 XBD=1947 XBD=2037 XBD=2226 XHG=1282 XHG=1486 XHG=1581 XHG=1662 XHG=1875 XHG=1980 XHG=2070 XHG=2259 YBD=3435 YBD=3428 YBD=3429 YBD=3436 YHG=3398>Roberton YHG=3398>and YHG=3398>his YHG=3398>colleagues YHG=3397>into YHG=3398>the YHG=3398>different YHG=3398>respiratory XBD=162 XHG=847 XBD=324 XBD=472 XBD=532 XBD=605 XBD=743 XBD=829 XBD=904 XBD=1035 XBD=1120 XBD=1218 XHG=89 XHG=179 XHG=342 XHG=492 XHG=546 XHG=623 XHG=762 XHG=922 XHG=1053 XHG=1138 YBD=3431 YBD=3431 YBD=3439 YBD=3438 YBD=3432 YBD=3439 YBD=3432 YBD=3439 YHG=3401>The YHG=3401>anterior YHG=3409>aspects YHG=3402>of YHG=3402>wrists, YHG=3402>and YHG=3402>the YHG=3401>thighs YHG=3402>and YHG=3401>legs, " XBD=2462 XBD=1481 XBD=1575 XBD=1644 XBD=1810 XBD=1876 XBD=1984 XBD=2152 XBD=2287 XHG=1282 XHG=1507 XHG=1601 XHG=1669 XHG=1837 XHG=1897 XHG=2009 XHG=2178 XHG=2312 YBD=3480 YBD=3473 YBD=3474 YBD=3481 YBD=3475 YHG=3443>syndromes YHG=3444>and YHG=3453>an YHG=3443>analysis YHG=3443>of YHG=3443>their YHG=3444>features YHG=3444>might YHG=3444>increase XBD=98 XHG=49 XBD=183 XBD=397 XBD=575 XBD=707 XBD=761 XBD=914 XBD=1021 XBD=1131 XBD=1218 XHG=115 XHG=202 XHG=415 XHG=595 XHG=725 XHG=781 XHG=932 XHG=1041 XHG=1152 YBD=3475 YBD=3476 YBD=3478 YBD=3477 YBD=3484 YBD=3477 YBD=3477 YHG=3454>are YHG=3446>also YHG=3447>commonly YHG=3447>involved YHG=3448>owing YHG=3454>to YHG=3447>chafing YHG=3447>from YHG=3454>coats YHG=3447>and " XBD=1343 |>" XBD=1638 XHG=1280 XHG=1358 YBD=3519 YBD=3519 YHG=3498>our YHG=3489>understanding. " XBD=136 XBD=325 XBD=430 XBD=619 XBD=748 XBD=888 XBD=1049 XBD=1216 XHG=48 XHG=148 XHG=353 XHG=443 XHG=633 XHG=762 XHG=899 XHG=1062 YBD=3520 YBD=3527 YBD=3522 YBD=3529 YBD=3527 YBD=3529 YHG=3490>other YHG=3498>garments. YHG=3492>The YHG=3492>condition YHG=3493>affects YHG=3492>mainly YHG=3492>females, YHG=3491>pr’esum-

" XBD=1215 XBD=117 XHG=834 XBD=270 XBD=323 XBD=391 XBD=485 XBD=539 XBD=702 XBD=819 XBD=901 XBD=1059 XHG=47 XHG=130 XHG=284 XHG=333 XHG=404 XHG=499 XHG=549 XHG=715 XHG=914YBD=3572 XHG=1074 YBD=3566 YBD=3574 YBD=3573 YBD=3567 YBD=3575 YBD=3567 YHG=3534>ably YHG=3536>because YHG=3536>of YHG=3537>the YHG=3543>type YHG=3537>of YHG=3537>clothing YHG=3547>worn, YHG=3537>and YHG=3537>perhaps YHG=3537>because 1. 2.

Arakaki, D. T., Sparkes, R. S. Cytogenetics, 1963, 2, 57. Moorhead, P., Nowell, P., Mellmann, W., Battips, D., Hungerford, Expl Cell Res. 1960, 20, 613.

Canberra Community Hospital, Canberra 2601, A.C.T., Australia. D.

1. 2.

HELEN WILES.

Schaffer, A. J. Diseases of the Newborn; p. 76. 1965. Peterson, H. G., Jr., Pendleton, M. E. Am. J. Rœntg. 1955, 74, 800.