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Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: A randomized, double-blind, placebo-controlled intervention study
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Abstracts / Atherosclerosis 252 (2016) e1ee196
calories increased in by +15% in boys and +10% in girls as did the consumption of protein, carbohydrates and fat. However, among parents (BMI increase by 0.6 kg/m2) the intake of energy significantly decreased in fathers by -7% and in mothers by -5%. Furthermore, total fat decreased by10%, saturated fat in fathers by -14% and in mothers by -15% as did cholesterol by -11% respectively -15%. The ratio of polyunsaturated to saturated fat increased by +15% in fathers respectively +25% in mothers as did the intake of fiber (+9% respectively +7%). Conclusions: This observational study demonstrates that healthy nutrition can be implemented and sustained throughout 5 years in healthy families under daily life conditions.
EAS16-0452, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. SPANISH OBESE CHILDREN AND BIOCHEMICAL PARAMETERS: NONHEALTHY NUTRITIVE PATTERNS C. Rodriguez-Leal 1, B. Ruiz-Estevez 1, E. Segura 1, I. Tinoco-Racero 1, N. Caro 1, C. Perez 2, I. Garcia-Campanario 2, A. Perez 1, M. QuezadaFeijoo 2, A. Mangas 2, R. Toro 2. 1 Universitary Hospital Puerta del Mar, diz, diz, Spain; 2 Medicine School. University of Ca Internal Medicine, Ca Medicine Department, CADIZ, Spain Objectives
1. Establish the prevalence of overweight and obesity in a school children population of Cadiz (Spain) 2. Determine the influence of diet on the biochemical parameters in a childhood population with overweight and obesity. Methods: We have selected a population of 127 subjects aged between 12 and 18, excluding those with any chronic disease. We have determined BMI (body mass index), skin folds, anthropometrics data, total cholesterol (TC), HDL-C, LDL-C, triglycerides and glucose. Diets were monitored through dietary surveys. Results: The nutritional parameters showed a lower calories intake in overweight and obese population,also, an increased carbohydrates, lipids and proteins levels in the group with BMI> 25 (P <0.004). However, the fat contribution analysis exposed a decreased consumption of saturated and polyunsaturated fatty acids in the overweight and obese population (P <0.004), with no evidence of significant differences regarding the consumption of unsaturated fatty acids. The group with a normal BMI showed a lipid profile with an inverse correlation between HDL-c and consumed vegetables (P <0.05). The children who had a lower saturated fat intake, but consume more calories did not showed to increase their weight Conclusions: Our conclusions show a very high obesity prevalence, matched by age and sex. Spanish childhood obese population has a high calories diet with increased fats intake, especially saturated and polyunsaturated in people with BMI < 25. More calories were not related to weight. Obese population shows higher glucose plasmatic levels and decreased HDL-C serum concentration.
EAS16-0460, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. LONG-TERM MAGNESIUM SUPPLEMENTATION IMPROVES ARTERIAL STIFFNESS IN OVERWEIGHT AND OBESE ADULTS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED INTERVENTION STUDY P.J. Joris 1, J. Plat 1, S.J.L. Bakker 2, R.P. Mensink 1. 1 Maastricht University Medical Center, Department of Human Biology, Maastricht, Netherlands; 2 University Medical Center Groningen, Department of Internal Medicine, Groningen, Netherlands Objectives: Epidemiological studies have suggested a protective effect of magnesium intake on cardiovascular risk. However, intervention trials of magnesium supplementation on blood pressure and conventional cardiometabolic risk markers are inconsistent. Effects on vascular function markers related to cardiovascular risk, have hardly been studied. We therefore investigated longer-term effects of magnesium supplementation on arterial stiffness.
Methods: We performed a 24-week, randomized, double-blind, placebocontrolled intervention study. Fifty-one overweight and obese individuals (29 men and 22 postmenopausal women, age 62 ± 6 years) were randomized to receive either magnesium (350 mg daily) or placebo. Carotidto-femoral pulse wave velocity (PWVc-f) was assessed at baseline, after 12 weeks, and at week 24. Results: Serum magnesium concentrations did not differ after 12 weeks, but tended to increase after 24-week magnesium supplementation compared with placebo by 0.02 mmol/L (95% CI: -0.00 to 0.04 mmol/L; P ¼ 0.09). Twenty-four-hour urinary magnesium excretion increased by 2.01 mmol (95% CI: 1.22 to 2.93 mmol; P < 0.001) at the end of the study. PWVc-f was not changed after 12 weeks, but was improved in the magnesium group compared with the placebo group by 1.0 m/s (95% CI: 0.4 to 1.6 m/s; P ¼ 0.001) after 24 weeks. Office and 24-hour ambulatory blood pressure were not changed. No adverse events related to magnesium intake were observed. Conclusions: Our data indicate for the first time that in overweight and obese adults magnesium supplementation for 24 weeks improves arterial stiffness, suggesting a potential mechanism by which an increased magnesium intake beneficially affects cardiovascular health. ClinicalTrials.gov identifier: NCT02235805.
EAS16-0471, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. THIRTEEN YEAR FOLLOWUP OF MANAGING PATIENTS WITH KNOWN CORONARY ARTERY DISEASE USING A LECTIN-LIMITED, HIGH DOSE OLIVE OIL AND POLYPHENOL RICH DIET S. Gundry 1, J. epstein 2. 1 The International Heart and Lung Institute, Palm Springs, USA; 2 The International Heart and Lung Institute, Restorative Medicine, Palm Springs, USA Objectives: Coronary Artery Disease (CAD) is thought to be progressive; standard treatment protocols call for instituting/instructing a low fat/low cholesterol diet program, exercise, and lipid lowering agents. This results in an approximate 30-40% new event rate in 5 yrs. Methods: Based upon experience using a Nutrigenomic-based, Lectinlimited diet to prevent/reverse CAD, we enrolled and followed 978 pts (aged 42-89 yrs) with known CAD, defined as previous MI, stent, CABG, or positive stress test/angiogram, into a diet and supplement based,program, using leafy green vegetables, olive oil, reduction of grain, legumes, nightshades, and fruits; and 4 oz amts of animal proteins (Matrix Protocol). All Apo E 4 genotypes ate shellfish and avoided animal fats and cheeses. All pts took 2-4,000 mg of high DHA fish oil, 200mg of Grape Seed Extract, and 50 mg of Pycnogenol per day. Additional Supplements were individualized based on results of Advanced Cardiovascular Risk Markers, which were sent to core labs, (Singulex, Alameda, CA, True Health Diagnostics, Richmond, VA) every three months to institute changes in Nutrigenomic-based supplement/eating regimens. Results: Pts have been followed for 1.5 to 13 years (mean 9 yrs). While enrolled, only 13/978 pts (1.3%) have received a new stent. There have been no MI’s, unstable angina. Total CV events over 13 years is 16/978 (1.6%). Conclusions: We conclude that Nutrigenomic-based dietary interventions, emphasizing lectin avoidance, with compliance and supplement choices based upon every three month assessment of cardiovascular risk markers, represents a quantum leap forward in preventing/modifying Cardiovascular events in known CAD patients.
EAS16-0547, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. SERUM CONTENT OF OLEIC ACID IS ASSOCIATED WITH HIGHER PLATELET-, ENDOTHELIAL- AND LEUKOCYTE-DERIVED CIRCULATING MICROPARTICLES IN NORWEGIAN NORMOLIPIDEMIC ELDERLY PATIENTS AFTER AN ACUTE MYOCARDIAL INFARCTION G. Chiva-Blanch 1, V. Bratseth 2, K. Laake 2, P. Myhre 2, H. Arnesen 2, S. Solheim 2, E. Berg-Schmidt 3, L. Badimon 1, I. Seljeflot 2. 1 Centro de n Cardiovascular - CSIC-ICCC. Instituto de Investigacio n, Investigacio Diagnostic and prognostic biomarkers in cardiovascular disease,
Abstracts / Atherosclerosis 252 (2016) e1ee196
calories increased in by +15% in boys and +10% in girls as did the consumption of protein, carbohydrates and fat. However, among parents (BMI increase by 0.6 kg/m2) the intake of energy significantly decreased in fathers by -7% and in mothers by -5%. Furthermore, total fat decreased by10%, saturated fat in fathers by -14% and in mothers by -15% as did cholesterol by -11% respectively -15%. The ratio of polyunsaturated to saturated fat increased by +15% in fathers respectively +25% in mothers as did the intake of fiber (+9% respectively +7%). Conclusions: This observational study demonstrates that healthy nutrition can be implemented and sustained throughout 5 years in healthy families under daily life conditions.
EAS16-0452, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. SPANISH OBESE CHILDREN AND BIOCHEMICAL PARAMETERS: NONHEALTHY NUTRITIVE PATTERNS C. Rodriguez-Leal 1, B. Ruiz-Estevez 1, E. Segura 1, I. Tinoco-Racero 1, N. Caro 1, C. Perez 2, I. Garcia-Campanario 2, A. Perez 1, M. QuezadaFeijoo 2, A. Mangas 2, R. Toro 2. 1 Universitary Hospital Puerta del Mar, diz, diz, Spain; 2 Medicine School. University of Ca Internal Medicine, Ca Medicine Department, CADIZ, Spain Objectives
1. Establish the prevalence of overweight and obesity in a school children population of Cadiz (Spain) 2. Determine the influence of diet on the biochemical parameters in a childhood population with overweight and obesity. Methods: We have selected a population of 127 subjects aged between 12 and 18, excluding those with any chronic disease. We have determined BMI (body mass index), skin folds, anthropometrics data, total cholesterol (TC), HDL-C, LDL-C, triglycerides and glucose. Diets were monitored through dietary surveys. Results: The nutritional parameters showed a lower calories intake in overweight and obese population,also, an increased carbohydrates, lipids and proteins levels in the group with BMI> 25 (P <0.004). However, the fat contribution analysis exposed a decreased consumption of saturated and polyunsaturated fatty acids in the overweight and obese population (P <0.004), with no evidence of significant differences regarding the consumption of unsaturated fatty acids. The group with a normal BMI showed a lipid profile with an inverse correlation between HDL-c and consumed vegetables (P <0.05). The children who had a lower saturated fat intake, but consume more calories did not showed to increase their weight Conclusions: Our conclusions show a very high obesity prevalence, matched by age and sex. Spanish childhood obese population has a high calories diet with increased fats intake, especially saturated and polyunsaturated in people with BMI < 25. More calories were not related to weight. Obese population shows higher glucose plasmatic levels and decreased HDL-C serum concentration.
EAS16-0460, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. LONG-TERM MAGNESIUM SUPPLEMENTATION IMPROVES ARTERIAL STIFFNESS IN OVERWEIGHT AND OBESE ADULTS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED INTERVENTION STUDY P.J. Joris 1, J. Plat 1, S.J.L. Bakker 2, R.P. Mensink 1. 1 Maastricht University Medical Center, Department of Human Biology, Maastricht, Netherlands; 2 University Medical Center Groningen, Department of Internal Medicine, Groningen, Netherlands Objectives: Epidemiological studies have suggested a protective effect of magnesium intake on cardiovascular risk. However, intervention trials of magnesium supplementation on blood pressure and conventional cardiometabolic risk markers are inconsistent. Effects on vascular function markers related to cardiovascular risk, have hardly been studied. We therefore investigated longer-term effects of magnesium supplementation on arterial stiffness.
Methods: We performed a 24-week, randomized, double-blind, placebocontrolled intervention study. Fifty-one overweight and obese individuals (29 men and 22 postmenopausal women, age 62 ± 6 years) were randomized to receive either magnesium (350 mg daily) or placebo. Carotidto-femoral pulse wave velocity (PWVc-f) was assessed at baseline, after 12 weeks, and at week 24. Results: Serum magnesium concentrations did not differ after 12 weeks, but tended to increase after 24-week magnesium supplementation compared with placebo by 0.02 mmol/L (95% CI: -0.00 to 0.04 mmol/L; P ¼ 0.09). Twenty-four-hour urinary magnesium excretion increased by 2.01 mmol (95% CI: 1.22 to 2.93 mmol; P < 0.001) at the end of the study. PWVc-f was not changed after 12 weeks, but was improved in the magnesium group compared with the placebo group by 1.0 m/s (95% CI: 0.4 to 1.6 m/s; P ¼ 0.001) after 24 weeks. Office and 24-hour ambulatory blood pressure were not changed. No adverse events related to magnesium intake were observed. Conclusions: Our data indicate for the first time that in overweight and obese adults magnesium supplementation for 24 weeks improves arterial stiffness, suggesting a potential mechanism by which an increased magnesium intake beneficially affects cardiovascular health. ClinicalTrials.gov identifier: NCT02235805.
EAS16-0471, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. THIRTEEN YEAR FOLLOWUP OF MANAGING PATIENTS WITH KNOWN CORONARY ARTERY DISEASE USING A LECTIN-LIMITED, HIGH DOSE OLIVE OIL AND POLYPHENOL RICH DIET S. Gundry 1, J. epstein 2. 1 The International Heart and Lung Institute, Palm Springs, USA; 2 The International Heart and Lung Institute, Restorative Medicine, Palm Springs, USA Objectives: Coronary Artery Disease (CAD) is thought to be progressive; standard treatment protocols call for instituting/instructing a low fat/low cholesterol diet program, exercise, and lipid lowering agents. This results in an approximate 30-40% new event rate in 5 yrs. Methods: Based upon experience using a Nutrigenomic-based, Lectinlimited diet to prevent/reverse CAD, we enrolled and followed 978 pts (aged 42-89 yrs) with known CAD, defined as previous MI, stent, CABG, or positive stress test/angiogram, into a diet and supplement based,program, using leafy green vegetables, olive oil, reduction of grain, legumes, nightshades, and fruits; and 4 oz amts of animal proteins (Matrix Protocol). All Apo E 4 genotypes ate shellfish and avoided animal fats and cheeses. All pts took 2-4,000 mg of high DHA fish oil, 200mg of Grape Seed Extract, and 50 mg of Pycnogenol per day. Additional Supplements were individualized based on results of Advanced Cardiovascular Risk Markers, which were sent to core labs, (Singulex, Alameda, CA, True Health Diagnostics, Richmond, VA) every three months to institute changes in Nutrigenomic-based supplement/eating regimens. Results: Pts have been followed for 1.5 to 13 years (mean 9 yrs). While enrolled, only 13/978 pts (1.3%) have received a new stent. There have been no MI’s, unstable angina. Total CV events over 13 years is 16/978 (1.6%). Conclusions: We conclude that Nutrigenomic-based dietary interventions, emphasizing lectin avoidance, with compliance and supplement choices based upon every three month assessment of cardiovascular risk markers, represents a quantum leap forward in preventing/modifying Cardiovascular events in known CAD patients.
EAS16-0547, GENETICS, NUTRITION, BIOMARKERS: NUTRITION. SERUM CONTENT OF OLEIC ACID IS ASSOCIATED WITH HIGHER PLATELET-, ENDOTHELIAL- AND LEUKOCYTE-DERIVED CIRCULATING MICROPARTICLES IN NORWEGIAN NORMOLIPIDEMIC ELDERLY PATIENTS AFTER AN ACUTE MYOCARDIAL INFARCTION G. Chiva-Blanch 1, V. Bratseth 2, K. Laake 2, P. Myhre 2, H. Arnesen 2, S. Solheim 2, E. Berg-Schmidt 3, L. Badimon 1, I. Seljeflot 2. 1 Centro de n Cardiovascular - CSIC-ICCC. Instituto de Investigacio n, Investigacio Diagnostic and prognostic biomarkers in cardiovascular disease,