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LONG-TERM PROGNOSTIC VALUE OF CORONARY CT ANGIOGRAPHY FOR PREDICTION OF CARDIOVASCULAR EVENTS AND MORTALITY
E1108 JACC March 12, 2013 Volume 61, Issue 10
Imaging Long-Term Prognostic Value of Coronary CT Angiography for Prediction of Cardiovascular Events and Mortality Moderated Poster Contributions Poster Sessions, Expo North Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: CT/Multimodality IX Abstract Category: 20. Imaging: CT/Multimodality Presentation Number: 1314M-354 Authors: Marcio Sommer Bittencourt, Edward Hulten, Brian Ghoshhajra, Daniel O’Leary, Mitalee Patil, Quynh Truong, Michael L. Steigner, Khurram Nasir, Wafa Osmani, Jon Hainer, Josh Klein, Frank Rybicki, Tom Brady, Marcelo Di Carli, Udo Hoffmann, Suhny Abbara, Ron Blankstein, Brigham and Women’s Hospital - Harvard Medical School, Boston, MA, USA Background: Few studies have evaluated the prognostic value of coronary computed tomography angiography (CCTA) beyond 2 years. We aimed to evaluate the ability of CCTA results to predict mortality, myocardial infarction (MI) or late revascularization (>90 days after CCTA). Methods: We included all consecutive patients patients > 18 years old with no known prior CAD referred for CCTA at two large tertiary hospitals within Partners Healthcare Inc. from 09/2004 to 10/2011. Severity of CAD was categorized as none, non-obstructive (<50% stenosis), or obstructive (≥50% stenosis). Blinded event adjudication was performed using electronic medical records, SS death index, and patient questionnaire. All selfreported events were verified using medical records. Results: Among the 3552 patients (58% males, 56±13 years), 126 (3.9%) deaths, 45 (1.4%) MIs and 87 (2.7%) late revascularizations occurred over a median follow up of 3.6 years (IQ: 2.1 - 5.0). 1301 (40%) of the patients had a normal CCTA, 1224 (38%) non-obstructive and 717 (22%) obstructive CAD. The presence of CAD was associated with higher major cardiovascular events with a HR of 2.3 (p<0.0001) for non-obstructive and 5.6 (p<0.0001) for obstructive CAD (figure). The findings remained significant in a multivariate adjusted model. Conclusion: In a large population of patients referred to CCTA, the presence and severity of CAD predict increased risk of subsequent MI, late coronary revascularizations and mortality.
Imaging Long-Term Prognostic Value of Coronary CT Angiography for Prediction of Cardiovascular Events and Mortality Moderated Poster Contributions Poster Sessions, Expo North Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: CT/Multimodality IX Abstract Category: 20. Imaging: CT/Multimodality Presentation Number: 1314M-354 Authors: Marcio Sommer Bittencourt, Edward Hulten, Brian Ghoshhajra, Daniel O’Leary, Mitalee Patil, Quynh Truong, Michael L. Steigner, Khurram Nasir, Wafa Osmani, Jon Hainer, Josh Klein, Frank Rybicki, Tom Brady, Marcelo Di Carli, Udo Hoffmann, Suhny Abbara, Ron Blankstein, Brigham and Women’s Hospital - Harvard Medical School, Boston, MA, USA Background: Few studies have evaluated the prognostic value of coronary computed tomography angiography (CCTA) beyond 2 years. We aimed to evaluate the ability of CCTA results to predict mortality, myocardial infarction (MI) or late revascularization (>90 days after CCTA). Methods: We included all consecutive patients patients > 18 years old with no known prior CAD referred for CCTA at two large tertiary hospitals within Partners Healthcare Inc. from 09/2004 to 10/2011. Severity of CAD was categorized as none, non-obstructive (<50% stenosis), or obstructive (≥50% stenosis). Blinded event adjudication was performed using electronic medical records, SS death index, and patient questionnaire. All selfreported events were verified using medical records. Results: Among the 3552 patients (58% males, 56±13 years), 126 (3.9%) deaths, 45 (1.4%) MIs and 87 (2.7%) late revascularizations occurred over a median follow up of 3.6 years (IQ: 2.1 - 5.0). 1301 (40%) of the patients had a normal CCTA, 1224 (38%) non-obstructive and 717 (22%) obstructive CAD. The presence of CAD was associated with higher major cardiovascular events with a HR of 2.3 (p<0.0001) for non-obstructive and 5.6 (p<0.0001) for obstructive CAD (figure). The findings remained significant in a multivariate adjusted model. Conclusion: In a large population of patients referred to CCTA, the presence and severity of CAD predict increased risk of subsequent MI, late coronary revascularizations and mortality.