Long Terminal Repeats

Long Terminal Repeats

Long Terminal Repeats © 2013 Elsevier Inc. All rights reserved. This article is reproduced from the previous edition, volume 2, p 1120, © 2001, Elsev...

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Long Terminal Repeats © 2013 Elsevier Inc. All rights reserved.

This article is reproduced from the previous edition, volume 2, p 1120, © 2001, Elsevier Inc., with revisions made by the Editor.

Glossary Downstream A region of DNA at and near a terminus of transcription.

Long terminal repeats (LTRs) are identical DNA sequences (several hundred nucleotides in length) found at the ends of transposons and retrovirus-derived DNA. LTRs contain inverted repeats and are thought to play an essential role in the integration of the transposon or provirus into the host DNA. In

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Upstream A region of DNA at and near an origin of transcription.

proviruses, the upstream LTR acts as a promoter and enhancer and the downstream LTR as a polyadenylation site.

See also: Provirus; Retroviruses; Transposable Elements.

Brenner’s Encyclopedia of Genetics, 2nd edition, Volume 4

doi:10.1016/B978-0-12-374984-0.00880-9