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Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men
Abstracts / Bone 44 (2009) S339–S450
longer duration of stroke hospitalization (> 2 weeks) further increased the risk of hip fracture (adj. OR 2.09; 95% CI, 1.53–2.88) compared to shorter durations (adj. OR 1.46; 95% CI, 1.12–1.91). Haemorrhagic strokes accounted for the largest increase in hip fracture risk (adj. OR 1.91; 95% CI, 1.25–2.92) compared to an adj. OR of 1.67 (95% CI, 1.29–2.17) with ischaemic stroke. Conclusions: Stroke is associated with a 1.8-fold increase in hip/ femur fracture. The risk was highest among patients who were younger than 71 years and who had recently sustained a stroke. A longer duration of hospitalization further increased the risk. Fall prevention programs, fracture risk measurement and targeting of bone protection may be necessary to reduce the risk of hip fractures during and after stroke rehabilitation. Conflict of interest: “The division of Pharmacoepidemiology and Pharmacotherapy employing all authors except Prof Cooper, has received unrestricted funding for pharmacoepidemiological research from GlaxoSmithKline, Novo Nordisk, the private–public funded Top Institute Pharma (www.tipharma.nl, includes co-funding from universities, government, and industry), the Dutch Medicines Evaluation Board, and the Dutch Ministry of Health”. doi:10.1016/j.bone.2009.03.342
P431 N-telopeptide and bone mineral density in older men and women: The Rancho Bernardo Study S.R. Johnsona,*, D. McCarthya, G.A. Laughlinb, E. Barrett-Connorb a Research and Development, SPD, Bedford, UK b Department of Family and Preventative Medicine, UCSD, San Diego, USA N-telopeptide (NTx) can be measured in urine or serum to provide clinically relevant information on bone resorption. Population studies have found that higher levels are associated with low bone mineral density (BMD), however, the relationship has not been well-examined in the older population or in men. Therefore, the cross-sectional relationship between urinary and serum NTx and BMD was examined in older adults. The population included 386 female and 327 male participants in the Rancho Bernardo Study, a community-based study of older (mean age 72), white residents of a southern California community, who had no missing data and were not using osteoporosis medications. Total hip BMD was assessed using DXA Hologic. Osteoporosis and osteopenia were defined according to WHO criteria. Standardized questionnaires were used to collect lifestyle and medical data, which were considered as covariates in analyses. Analyses were performed separately for men and for women currently using estrogen (ET) (n = 108) and women not using ET (n = 278). Urine and serum NTx was measured using ELISA (Ostex) in a laboratory blinded to BMD. Levels of NTx were log transformed prior to analyses. For both serum and urinary NTx, levels in women not using ET were statistically significantly higher than those of men and women using ET. Serum NTx was significantly negatively associated with total hip BMD for men (p = 0.004) and women not using ET (p = 0.0003), but not for women using ET (p = 0.19). In contrast, urine NTx showed a significant negative relationship with total hip BMD in both groups of women (p = 0.0012 for ET users, p = 0.0006 for non-ET users), but not in men (p = 0.5). Levels of serum and urine NTx increased across BMD category (normal, osteopenic, osteoporotic) for each group, with the exception of serum NTx in ET users (Table 1). In conclusion, higher levels of both serum and urine NTx are, in general, associated with lower BMD in older adults of both sexes, independent of current estrogen therapy in women.
S417
Table 1 Mean levels NTx in WHO osteoporosis categories. Serum NTx
(nM BCE)
Urine NTx
(nM BCE/
mM creat)
WHO diag. criteria
Men
Women ET
No ET
Men
Women ET
No ET
Normal O-penia O-porosis
12.4 13.4 15.2
12.3 13.2 11.9
14.2 15.8 17
70.1 80.6 95.2
80.7 116.2 184.7
107.2 120.3 174.4
Conflict of interest: S. Johnson, employee of SPD and D. McCarthy, employee of SPD. doi:10.1016/j.bone.2009.03.343
P432 Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men S. Beer*, C.H. Saely, G. Hoefle, P. Rein, A. Vonbank, M. Woess, J. Breuss, H. Drexel VIVIT Institute, Landeskrankenhaus Feldkirch, Feldkirch, Austria Background: The association of low bone mineral density (BMD) with angiographically determined coronary atherosclerosis in men is unclear. Methods: We enrolled 623 consecutive men undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). BMD was assessed by dual X-ray absorptiometry. CAD was diagnosed in the presence of any coronary artery lumen narrowing at angiography, and coronary stenoses with lumen narrowing >=50% were considered significant. Results: From the total study cohort (mean age of 64 ± 11 years), 207 patients (33.2%) had osteopenia and 65 (10.4%) had osteoporosis; at angiography, CAD was diagnosed in 558 patients (89.6%) and 403 (64.7%) had significant coronary stenoses. In multivariate logistic regression, neither osteopenia nor osteoporosis was associated with CAD (adjusted odds ratios (ORs) = 0.71 [95% confidence interval, 0.40–1.23], p = 0.222 and 1.03 [0.38–2.80]; p = 0.955, respectively) nor with significant coronary stenoses (OR = 0.74 [0.52–1.07], p = 0.112 and 0.72 [0.41–1.26]; p = 0.251, respectively). Conclusions: The prevalence of low BMD is high in men undergoing coronary angiography; however, low BMD is not associated with angiographically determined coronary atherosclerosis in men. Conflict of interest: None declared. doi:10.1016/j.bone.2009.03.344
P433 Protein and vitamin D deficiencies induce osteopenia in female rats C. Marotea, M.M.S. Gonzales Chavesb, P. Mandalunisc, S.M. Friedmanb, S.N. Zenid,* a Metabolic Osteopathies, Clinical Hospital. UBA, Buenos Aires, Argentina b General and Oral Biochemistry, UBA, Buenos Aires, Argentina c Histology, School of Dentistry, UBA, Buenos Aires, Argentina d General and Oral Biochemistry, School of Dentistry, UBA, Buenos Aires, Argentina Background: Malnutrition, specifically a low protein intake and/or solar exposition, is common in elderly people. These deficiencies are associated with osteoporosis, reduction of muscle mass, and impairment of activities and loss of independence. In the present study we evaluated the influence of low protein and/or vitamin D intakes in rats feeding a normal calcium diet.
longer duration of stroke hospitalization (> 2 weeks) further increased the risk of hip fracture (adj. OR 2.09; 95% CI, 1.53–2.88) compared to shorter durations (adj. OR 1.46; 95% CI, 1.12–1.91). Haemorrhagic strokes accounted for the largest increase in hip fracture risk (adj. OR 1.91; 95% CI, 1.25–2.92) compared to an adj. OR of 1.67 (95% CI, 1.29–2.17) with ischaemic stroke. Conclusions: Stroke is associated with a 1.8-fold increase in hip/ femur fracture. The risk was highest among patients who were younger than 71 years and who had recently sustained a stroke. A longer duration of hospitalization further increased the risk. Fall prevention programs, fracture risk measurement and targeting of bone protection may be necessary to reduce the risk of hip fractures during and after stroke rehabilitation. Conflict of interest: “The division of Pharmacoepidemiology and Pharmacotherapy employing all authors except Prof Cooper, has received unrestricted funding for pharmacoepidemiological research from GlaxoSmithKline, Novo Nordisk, the private–public funded Top Institute Pharma (www.tipharma.nl, includes co-funding from universities, government, and industry), the Dutch Medicines Evaluation Board, and the Dutch Ministry of Health”. doi:10.1016/j.bone.2009.03.342
P431 N-telopeptide and bone mineral density in older men and women: The Rancho Bernardo Study S.R. Johnsona,*, D. McCarthya, G.A. Laughlinb, E. Barrett-Connorb a Research and Development, SPD, Bedford, UK b Department of Family and Preventative Medicine, UCSD, San Diego, USA N-telopeptide (NTx) can be measured in urine or serum to provide clinically relevant information on bone resorption. Population studies have found that higher levels are associated with low bone mineral density (BMD), however, the relationship has not been well-examined in the older population or in men. Therefore, the cross-sectional relationship between urinary and serum NTx and BMD was examined in older adults. The population included 386 female and 327 male participants in the Rancho Bernardo Study, a community-based study of older (mean age 72), white residents of a southern California community, who had no missing data and were not using osteoporosis medications. Total hip BMD was assessed using DXA Hologic. Osteoporosis and osteopenia were defined according to WHO criteria. Standardized questionnaires were used to collect lifestyle and medical data, which were considered as covariates in analyses. Analyses were performed separately for men and for women currently using estrogen (ET) (n = 108) and women not using ET (n = 278). Urine and serum NTx was measured using ELISA (Ostex) in a laboratory blinded to BMD. Levels of NTx were log transformed prior to analyses. For both serum and urinary NTx, levels in women not using ET were statistically significantly higher than those of men and women using ET. Serum NTx was significantly negatively associated with total hip BMD for men (p = 0.004) and women not using ET (p = 0.0003), but not for women using ET (p = 0.19). In contrast, urine NTx showed a significant negative relationship with total hip BMD in both groups of women (p = 0.0012 for ET users, p = 0.0006 for non-ET users), but not in men (p = 0.5). Levels of serum and urine NTx increased across BMD category (normal, osteopenic, osteoporotic) for each group, with the exception of serum NTx in ET users (Table 1). In conclusion, higher levels of both serum and urine NTx are, in general, associated with lower BMD in older adults of both sexes, independent of current estrogen therapy in women.
S417
Table 1 Mean levels NTx in WHO osteoporosis categories. Serum NTx
(nM BCE)
Urine NTx
(nM BCE/
mM creat)
WHO diag. criteria
Men
Women ET
No ET
Men
Women ET
No ET
Normal O-penia O-porosis
12.4 13.4 15.2
12.3 13.2 11.9
14.2 15.8 17
70.1 80.6 95.2
80.7 116.2 184.7
107.2 120.3 174.4
Conflict of interest: S. Johnson, employee of SPD and D. McCarthy, employee of SPD. doi:10.1016/j.bone.2009.03.343
P432 Low bone mineral density is not associated with angiographically determined coronary atherosclerosis in men S. Beer*, C.H. Saely, G. Hoefle, P. Rein, A. Vonbank, M. Woess, J. Breuss, H. Drexel VIVIT Institute, Landeskrankenhaus Feldkirch, Feldkirch, Austria Background: The association of low bone mineral density (BMD) with angiographically determined coronary atherosclerosis in men is unclear. Methods: We enrolled 623 consecutive men undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease (CAD). BMD was assessed by dual X-ray absorptiometry. CAD was diagnosed in the presence of any coronary artery lumen narrowing at angiography, and coronary stenoses with lumen narrowing >=50% were considered significant. Results: From the total study cohort (mean age of 64 ± 11 years), 207 patients (33.2%) had osteopenia and 65 (10.4%) had osteoporosis; at angiography, CAD was diagnosed in 558 patients (89.6%) and 403 (64.7%) had significant coronary stenoses. In multivariate logistic regression, neither osteopenia nor osteoporosis was associated with CAD (adjusted odds ratios (ORs) = 0.71 [95% confidence interval, 0.40–1.23], p = 0.222 and 1.03 [0.38–2.80]; p = 0.955, respectively) nor with significant coronary stenoses (OR = 0.74 [0.52–1.07], p = 0.112 and 0.72 [0.41–1.26]; p = 0.251, respectively). Conclusions: The prevalence of low BMD is high in men undergoing coronary angiography; however, low BMD is not associated with angiographically determined coronary atherosclerosis in men. Conflict of interest: None declared. doi:10.1016/j.bone.2009.03.344
P433 Protein and vitamin D deficiencies induce osteopenia in female rats C. Marotea, M.M.S. Gonzales Chavesb, P. Mandalunisc, S.M. Friedmanb, S.N. Zenid,* a Metabolic Osteopathies, Clinical Hospital. UBA, Buenos Aires, Argentina b General and Oral Biochemistry, UBA, Buenos Aires, Argentina c Histology, School of Dentistry, UBA, Buenos Aires, Argentina d General and Oral Biochemistry, School of Dentistry, UBA, Buenos Aires, Argentina Background: Malnutrition, specifically a low protein intake and/or solar exposition, is common in elderly people. These deficiencies are associated with osteoporosis, reduction of muscle mass, and impairment of activities and loss of independence. In the present study we evaluated the influence of low protein and/or vitamin D intakes in rats feeding a normal calcium diet.