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Low testosterone levels are associated with metabolic syndrome, through triggering hypertriglyceridemia and low grade inflammation in elderly men. ikaria study
Abstracts / Atherosclerosis 235 (2014) e84–e191
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EAS-0089. MODELING SERUM PROLACTIN CHOLESTEROL CONCENTRATIONS IN OLDER SUBJECTS WITH MULTIPLE CV RISK FACTORS
prolactin concentrations in higher age for both males and females (Median values for M>65, F>65, M<¼65, F<¼65 were as follows: 121.25, 103.26, 44.15 and 72.27 mIU/L) and when subjects were classified as with higher or lower serum cholesterol concentrations. Additional checks on difference in age showed that subjects with higher serum cholesterol concentrations were also significantly older, implicating the importance of age and not of serum cholesterol concentrations as a factor influencing variations in serum prolactin concentrations. Conclusion: Older age seems to be the common denominator of increased serum prolactin concentrations in older population, independently on the presence of CV risk factors.
L. Majnarica, A. Vcevb, S. Balenc
24 - Hormones and atherosclerosis
Conclusion: Since electrical and mechanical events in cardiac muscle overlap in time, it may be speculated that the nongenomically-mediated increase in monophasic action potential duration by Aldo could result in increase of myocardial contraction duration, a hypothesis supported indirectly by the found regression. 24 - Hormones and atherosclerosis
a Internal Medicine of General Medicine, Osijek University School of Medicine, Osijek, Croatia; b Internal Medicine of General Medicine, Clinic of Internal Medicine Osijek University School of Medicine, Osijek, Croatia; c Clinical Institute for Transfusion Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia
Objectives: The role of variations in serum prolactin concentrations as CV risk biomarker has not yet been clarified. Evidence indicate the associations with insulin resistance syndrome, inflammation and chronic renal impairment. Methods: Serum prolactin concentrations were measured in a group of older primary health care subjects with multiple CV risk factors (N¼93, age 50-89 years, median 69, M/F 35/58) and correlated, using partial correlations, with the set of ten CV risk factors indicating: increased serum cholesterol concentrations, insulin resistance syndrome (serum triglycerides, HDL-cholesterol, fasting insulin, BMI and w/h ratio), inflammation (total leukocyte count and C-reactive protein) and chronic renal impairment (creatinine clearance rates and serum homocysteine concentrations). Age-adjusted multiple regression model was performed. Results: Of all measured CV risk factors, only C-reactive protein, indicating low level chronic inflammation, achieved the statistically significant performances to enter the multivariate model, based on forward stepwise selection (F¼67.00, p¼0.00). Conclusion: When considering variations in serum prolactin concentrations as CV risk biomarker, the role of prolactin in modulating inflammation should be taken into account. 24 - Hormones and atherosclerosis EAS-0088. SERUM PROLACTIN CONCENTRATIONS AND CARDIOVASCULAR RISK FACTORS L. Majnarica, A. Vcevb, S. Balenc a Internal Medicine Of General Medicine, Osijek University School of Medicine, Osijek, Croatia; b Clinic of Internal Medicine, Clinical Hospital Center Osijek Osijek University School of Medicine, Osijek, Croatia; c Clinical Institute for Transfusion Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia
Objectives: Variations in serum prolactin concentrations have been shown to be associated with adverse CV profiles, but the exact modes of the relationships with certain CV risk factors are still poorly clarified. Methods: In a group of 93 older subjects (Median age 69 years, M 35), with multiple CV risk factors, average serum prolactin concentrations were estimated, using non-parametric kruskal wallis or mann whitney u tests, according to the age and sex (M, F, under 65 or 65 and over), serum cholesterol concentrations (6.5 and over or under 6.5), or whether or not subjects were classified with the diagnosis of hypertension, the diagnosis of diabetes type 2 or impaired glucose tolerance, the cognitive impairment (measured using MMSE), or whether or not they have used non steroidal anti inflammatory drugs. All subgroups were additionally checked on difference in their age status. Results: Significant differences in serum prolactin concentrations were found in the sex and age distribution indicating towards higher serum
EAS-0938. LOW TESTOSTERONE LEVELS ARE ASSOCIATED WITH METABOLIC SYNDROME, THROUGH TRIGGERING HYPERTRIGLYCERIDEMIA AND LOW GRADE INFLAMMATION IN ELDERLY MEN. IKARIA STUDY C. Chrysohoou, D. Pitsavos, D. Panagiotakos, E. Oikonomou, G. Lazaros, V. Metaxa, G. Vogiatzi, M. Zaromytidou, N. Galiatsatos, G. Marinos, C. Stefanadis 1st Cardiology Clinic, University of Athens, Athens, Greece Objectives: Introduction: Hypogonadism is a commonly undiagnosed disease that has been associated with increased cardiovascular risk (CVD), but the underlying mechanisms are not fully understood. The aim of this work was to evaluate the relationship between total serum testosterone levels with metabolic syndrome (MS) factors and prevalence of MS in elderly individuals from Ikaria study, a place with increased rates of longevity. Methods: Methods: Under the context of Ikaria elderly study, we recruited 545 elderly individuals, permanent inhabitants of Ikaria Island (mean age 75+/- 6 years old, 47% males). Among several bioclinical, lifestyle and antrhopometric characteristics, total serum testosterone and serum insulin levels were measured in serum; while MS was defined according to ATPIII criteria. Results: Results MS was diagnosed in 52% of men and 64% of women. Serum total testosterone levels were reduced among participants with MS; 10 ng/dl increase of testosterone was associated with 3% lower odds of having MS in men (95%CI: 0.995-0.999), but not in women, after several adjustments. Serum testosterone levels was inversely associated with abnormal waist circumference (p¼0.01), hs CRP (p¼0.001) and with elevated triglyceride levels (p¼0.005), only in men; whereas the effect of testosterone levels on triglycerides levels was more significant as compared with the effect on abnormal waist circumference. Moreover, serum testosterone levels explained 6.5% of the variation of the MS in the studied male population (Nagelkerke R Square), and were inversely correlated with log serum insulin levels (r¼-0.225, p¼0.01) only in men, after same adjustments. Linear regressions analysis revealed that testosterone levels were related with loghs-CRP levels (B¼-0.001+/-0.00, p¼0.08), in men. Conclusion: Conclusion: Low serum testosterone promotes the development of MS, via the elevation of triclycerides concentration and related accumulation of central fat tissue, in elderly men. This finding state a research hypothesis relating serum testosterone levels with low cardiometabolic risk linked with longevity. 24 - Hormones and atherosclerosis EAS-0079. ASSOCIATION BETWEEN NT-PROBNP AND CAVI J. Suwa MD Preventive Medicine, St. Luke's Affiliated Clinic, Tokyo, Japan Objectives: The natriuetic peptide; pro-BNP, is released from cardiac muscle into the circulation when cardiac function is disturbed. Pro-BNP is
e155
EAS-0089. MODELING SERUM PROLACTIN CHOLESTEROL CONCENTRATIONS IN OLDER SUBJECTS WITH MULTIPLE CV RISK FACTORS
prolactin concentrations in higher age for both males and females (Median values for M>65, F>65, M<¼65, F<¼65 were as follows: 121.25, 103.26, 44.15 and 72.27 mIU/L) and when subjects were classified as with higher or lower serum cholesterol concentrations. Additional checks on difference in age showed that subjects with higher serum cholesterol concentrations were also significantly older, implicating the importance of age and not of serum cholesterol concentrations as a factor influencing variations in serum prolactin concentrations. Conclusion: Older age seems to be the common denominator of increased serum prolactin concentrations in older population, independently on the presence of CV risk factors.
L. Majnarica, A. Vcevb, S. Balenc
24 - Hormones and atherosclerosis
Conclusion: Since electrical and mechanical events in cardiac muscle overlap in time, it may be speculated that the nongenomically-mediated increase in monophasic action potential duration by Aldo could result in increase of myocardial contraction duration, a hypothesis supported indirectly by the found regression. 24 - Hormones and atherosclerosis
a Internal Medicine of General Medicine, Osijek University School of Medicine, Osijek, Croatia; b Internal Medicine of General Medicine, Clinic of Internal Medicine Osijek University School of Medicine, Osijek, Croatia; c Clinical Institute for Transfusion Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia
Objectives: The role of variations in serum prolactin concentrations as CV risk biomarker has not yet been clarified. Evidence indicate the associations with insulin resistance syndrome, inflammation and chronic renal impairment. Methods: Serum prolactin concentrations were measured in a group of older primary health care subjects with multiple CV risk factors (N¼93, age 50-89 years, median 69, M/F 35/58) and correlated, using partial correlations, with the set of ten CV risk factors indicating: increased serum cholesterol concentrations, insulin resistance syndrome (serum triglycerides, HDL-cholesterol, fasting insulin, BMI and w/h ratio), inflammation (total leukocyte count and C-reactive protein) and chronic renal impairment (creatinine clearance rates and serum homocysteine concentrations). Age-adjusted multiple regression model was performed. Results: Of all measured CV risk factors, only C-reactive protein, indicating low level chronic inflammation, achieved the statistically significant performances to enter the multivariate model, based on forward stepwise selection (F¼67.00, p¼0.00). Conclusion: When considering variations in serum prolactin concentrations as CV risk biomarker, the role of prolactin in modulating inflammation should be taken into account. 24 - Hormones and atherosclerosis EAS-0088. SERUM PROLACTIN CONCENTRATIONS AND CARDIOVASCULAR RISK FACTORS L. Majnarica, A. Vcevb, S. Balenc a Internal Medicine Of General Medicine, Osijek University School of Medicine, Osijek, Croatia; b Clinic of Internal Medicine, Clinical Hospital Center Osijek Osijek University School of Medicine, Osijek, Croatia; c Clinical Institute for Transfusion Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia
Objectives: Variations in serum prolactin concentrations have been shown to be associated with adverse CV profiles, but the exact modes of the relationships with certain CV risk factors are still poorly clarified. Methods: In a group of 93 older subjects (Median age 69 years, M 35), with multiple CV risk factors, average serum prolactin concentrations were estimated, using non-parametric kruskal wallis or mann whitney u tests, according to the age and sex (M, F, under 65 or 65 and over), serum cholesterol concentrations (6.5 and over or under 6.5), or whether or not subjects were classified with the diagnosis of hypertension, the diagnosis of diabetes type 2 or impaired glucose tolerance, the cognitive impairment (measured using MMSE), or whether or not they have used non steroidal anti inflammatory drugs. All subgroups were additionally checked on difference in their age status. Results: Significant differences in serum prolactin concentrations were found in the sex and age distribution indicating towards higher serum
EAS-0938. LOW TESTOSTERONE LEVELS ARE ASSOCIATED WITH METABOLIC SYNDROME, THROUGH TRIGGERING HYPERTRIGLYCERIDEMIA AND LOW GRADE INFLAMMATION IN ELDERLY MEN. IKARIA STUDY C. Chrysohoou, D. Pitsavos, D. Panagiotakos, E. Oikonomou, G. Lazaros, V. Metaxa, G. Vogiatzi, M. Zaromytidou, N. Galiatsatos, G. Marinos, C. Stefanadis 1st Cardiology Clinic, University of Athens, Athens, Greece Objectives: Introduction: Hypogonadism is a commonly undiagnosed disease that has been associated with increased cardiovascular risk (CVD), but the underlying mechanisms are not fully understood. The aim of this work was to evaluate the relationship between total serum testosterone levels with metabolic syndrome (MS) factors and prevalence of MS in elderly individuals from Ikaria study, a place with increased rates of longevity. Methods: Methods: Under the context of Ikaria elderly study, we recruited 545 elderly individuals, permanent inhabitants of Ikaria Island (mean age 75+/- 6 years old, 47% males). Among several bioclinical, lifestyle and antrhopometric characteristics, total serum testosterone and serum insulin levels were measured in serum; while MS was defined according to ATPIII criteria. Results: Results MS was diagnosed in 52% of men and 64% of women. Serum total testosterone levels were reduced among participants with MS; 10 ng/dl increase of testosterone was associated with 3% lower odds of having MS in men (95%CI: 0.995-0.999), but not in women, after several adjustments. Serum testosterone levels was inversely associated with abnormal waist circumference (p¼0.01), hs CRP (p¼0.001) and with elevated triglyceride levels (p¼0.005), only in men; whereas the effect of testosterone levels on triglycerides levels was more significant as compared with the effect on abnormal waist circumference. Moreover, serum testosterone levels explained 6.5% of the variation of the MS in the studied male population (Nagelkerke R Square), and were inversely correlated with log serum insulin levels (r¼-0.225, p¼0.01) only in men, after same adjustments. Linear regressions analysis revealed that testosterone levels were related with loghs-CRP levels (B¼-0.001+/-0.00, p¼0.08), in men. Conclusion: Conclusion: Low serum testosterone promotes the development of MS, via the elevation of triclycerides concentration and related accumulation of central fat tissue, in elderly men. This finding state a research hypothesis relating serum testosterone levels with low cardiometabolic risk linked with longevity. 24 - Hormones and atherosclerosis EAS-0079. ASSOCIATION BETWEEN NT-PROBNP AND CAVI J. Suwa MD Preventive Medicine, St. Luke's Affiliated Clinic, Tokyo, Japan Objectives: The natriuetic peptide; pro-BNP, is released from cardiac muscle into the circulation when cardiac function is disturbed. Pro-BNP is