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Lymphokines, vol. 6, lymphokines in antibody and cytotoxic responses
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Lymphokines, Vol. 6, Lymphokines in Antibody and Cytotoxic Responses, edited by S.M. Mizel. Academic Press, New York, 1982 (xv + 318 pp., illus.) $39.00 Like its predecessor, this volume is concerned with the relation between certain lymphokines and T cells, though the focus here is on conventional rather than monoclonal products. Interleukin-1, a protein released in vitro by mitogen-stimulated macrophages and known to activate T cells, mediate B-cell clonal expansion, and induce inflammatory phenomena, is the subject of the first 4 chapters. K.-C. Lee discusses mouse macrophage subsets at different maturation and activation stages and their respective ability to express surface Ia and to produce IL-1, D:I. Beller and E.R. Unanue present the results of their studies on the control of macrophage Ia expression and IL-1 secretion, P.L. Simon and W.F. Willoughby describe the purification and characterization of rabbit IL-1, and K.M. Gilbert and M.K. H o f f m a n n examine the role of IL-1 in inducing B-cell differentiation. The next 3 chapters, by J. Watson et al., B.M. Stadler and J.J. Oppenheim, and J.W. Mier and R.C. Gallo, deal with interleukin-2, its production, purification, properties, and effects on T-cell proliferation; the first containing data on both murine and human IL-2 and the other two devoted mainly to human IL-2. Next J.F. Warner and G. Dennert prove that the IL-2 activity is both sufficient and necessary for NK-cell proliferation and maintenance of cytotoxicity. The murine non-antigen-specific T-cell replacing factor(s), its action on target B cells, production, assay, purification, and chemical characterization are the subject of 3 papers by A. Schimpl et al., T. Osawa and K.-I. Naruo, and S.L. Swain and R.W. Dutton. Interleukin-3, a lymphokine obtained from Con A-stimulated T cells that induces the expression of the enzyme 20c~-hydroxysteroid dehydrogenase in Thyl-positive cells and thought to regulate early T-cell differentiation, is described by J.N. Ihle et al. In the closing chapter A.M. Mastro discusses the biological activities of phorbol esters, substances of plant origin known to promote the mouse skin tumor growth, be capable of replacing IL-1, and stimulate IL-2 production in vitro. A point ought to be made about the lymph okine nomenclature used in this and the preceding volumes of the series. To simplify the terms 'lymphocyte activating factor' (LAF) and 'T-cell growth factor' ( T C G F ) at the 2nd International Lymphokine Workshop in 1979 LAF was renamed 'interleukin-1' and T C G F 'interleukin-2'. However these changes have not been yet universally adopted and the new as well as the old names are employed. A striking example of this practice is provided by 2 chapters of the book reviewed here, one entitled ' H u m a n Interleukin-2' and the other ' H u m a n T Cell Growth Factor (TCGF)'. Their synonymous nature is mentioned in the first but not in the second paper and, though pointed out in the editor's preface, it has been disregarded in preparing the subject index. Of course the authors are free to use the terms they favor, but uninitiated readers deserve a suitable explanation to avoid a possible confusion. Apart from the above discrepancy this book meets the high standard set by the previous volumes of the series and it can be recommended as a source of information on the subject of lymphokines and T cells. F.Borek
Lymphokines, Vol. 6, Lymphokines in Antibody and Cytotoxic Responses, edited by S.M. Mizel. Academic Press, New York, 1982 (xv + 318 pp., illus.) $39.00 Like its predecessor, this volume is concerned with the relation between certain lymphokines and T cells, though the focus here is on conventional rather than monoclonal products. Interleukin-1, a protein released in vitro by mitogen-stimulated macrophages and known to activate T cells, mediate B-cell clonal expansion, and induce inflammatory phenomena, is the subject of the first 4 chapters. K.-C. Lee discusses mouse macrophage subsets at different maturation and activation stages and their respective ability to express surface Ia and to produce IL-1, D:I. Beller and E.R. Unanue present the results of their studies on the control of macrophage Ia expression and IL-1 secretion, P.L. Simon and W.F. Willoughby describe the purification and characterization of rabbit IL-1, and K.M. Gilbert and M.K. H o f f m a n n examine the role of IL-1 in inducing B-cell differentiation. The next 3 chapters, by J. Watson et al., B.M. Stadler and J.J. Oppenheim, and J.W. Mier and R.C. Gallo, deal with interleukin-2, its production, purification, properties, and effects on T-cell proliferation; the first containing data on both murine and human IL-2 and the other two devoted mainly to human IL-2. Next J.F. Warner and G. Dennert prove that the IL-2 activity is both sufficient and necessary for NK-cell proliferation and maintenance of cytotoxicity. The murine non-antigen-specific T-cell replacing factor(s), its action on target B cells, production, assay, purification, and chemical characterization are the subject of 3 papers by A. Schimpl et al., T. Osawa and K.-I. Naruo, and S.L. Swain and R.W. Dutton. Interleukin-3, a lymphokine obtained from Con A-stimulated T cells that induces the expression of the enzyme 20c~-hydroxysteroid dehydrogenase in Thyl-positive cells and thought to regulate early T-cell differentiation, is described by J.N. Ihle et al. In the closing chapter A.M. Mastro discusses the biological activities of phorbol esters, substances of plant origin known to promote the mouse skin tumor growth, be capable of replacing IL-1, and stimulate IL-2 production in vitro. A point ought to be made about the lymph okine nomenclature used in this and the preceding volumes of the series. To simplify the terms 'lymphocyte activating factor' (LAF) and 'T-cell growth factor' ( T C G F ) at the 2nd International Lymphokine Workshop in 1979 LAF was renamed 'interleukin-1' and T C G F 'interleukin-2'. However these changes have not been yet universally adopted and the new as well as the old names are employed. A striking example of this practice is provided by 2 chapters of the book reviewed here, one entitled ' H u m a n Interleukin-2' and the other ' H u m a n T Cell Growth Factor (TCGF)'. Their synonymous nature is mentioned in the first but not in the second paper and, though pointed out in the editor's preface, it has been disregarded in preparing the subject index. Of course the authors are free to use the terms they favor, but uninitiated readers deserve a suitable explanation to avoid a possible confusion. Apart from the above discrepancy this book meets the high standard set by the previous volumes of the series and it can be recommended as a source of information on the subject of lymphokines and T cells. F.Borek