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Macrophage plasma membrane receptors: structure and function
292 Izui, S., Zaldivar, N. M,, Scher, I. & Lambert, P. H. (1977). Mechanism for mduction of anti-DNA antibodies by bacterial lipopolysaccharides in mice. I. Anti-DNA induction by LPS without significant release of DNA in &;;ating blood. Journal of Immwwlogy, 119, 2151Oriih, A. V. & Nussenzweig, R. S. (1979). Plasmodium berg&i: suppression of a&body response to sporozoite stage by acute blood stage infection. Clinical and Ex&ri&tal Zmmunology,33, 1-8. Primi, D., Smith, C. I. E., H ammarstrom, L., Ludquist, P. G. & Moller, G. (1977). Evidence for the existence of self reactive human B lymphocytes. Clinical and Experimental Immunology, 29, 316-319. Rosenberg, Y. J. (1978). Autoimmune and polyclonal B-cell responsesduring murine malaria. Nature, 274, 170-172.
TRANSACTIONS OF THE ROYAL SOCIETY OF Tm~rcar
1 BookReview
MED~NE
(
Macrophage plasma membrane receptors: st~cture and function. Siamon Gordon (editor). Supplement 9,3oumul of CeNScienc~,1988.Cambridge: The Company of Biologists Lirmted. This book presents papers from a meeting on the structure and function of macrophage receptors held in Oxford in March 1987. In the first chapter, Siamon Gordon and his colleagues introduce (with useful summary tables and source references) all of the known plasma membrane receptors of macrophages which function in growth, differentiation and activation, migration, recognition, endocytosis and secretion. Chapters which follow examine specific receptors such as the CSF-1 receptor (C. W. Rettenmier and colleagues); Fc receptors (I. Mellman and colleagues); complement (CR1 and CR3) receptors (S. K. A. Law); adhesion promoting (CR3, LFA-1 and ~150, 95) receptors (S. D. Wright and P. A.
Wangel, A. G., Milton, A. & Egan, J. B. (1982). Spontaneous plaque forming cells in the peripheral blood of patients with systemic lupus erythematosus. Clinical and Experimental Immunelogy, 19, 41-49. Zavala, F., Tam, J. P., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S. & Nussenzweig, V. (1985). Rationale for development of a synthetic vaccine against Plasmodiumfalcipanrm malaria. Science,228, 1436-1440. Zavala, F., Tam, J. P. & Masuda, A. (1986). Synthetic peptides as antigens for the detection of humoral immunity to Plusmodiumfalciparumsporozoites. Journal of Immwwlogical Methods, 93, 55-61. Received 25 January 1988; accepted for publication 6 June 1988
AND HYGIENE (1989) 83, OooMx)
Detmers);‘mannose &tin-like receptors (R. A. B. Ezekowitz and P. D. Stahl); lipoprotein receptors (A. M. Fogehnan and colleagues); and novel surface adhesion receptors involved in interaction between stromal macriphages and haematopoietic cells (P. R. Cracker and colleazues1.A chanter bv H. L. Yin and J. H. Hartwig
ex&&es
the kruc&e
of the mac-
rophage action skeleton, while another by A. A. Aderem looks at protem myristoylation as an intermediate step in signal transduction following priming of macrophageswith bacterial lipopolysaccharide or activation with interferon-gamma. Although the book does not deal speci6cally with the role of macrophages in infection, it provides a useful and up-to-date reference for those interested in tropical disease research since many of the interactions between bacteria or parasites (e.g. Salmonella, Legionella, Mycobacteriu, Histoplasmu, Leishmania, Toxoplasma, Typanosoma cruzz>and macrophagesare
mediated by the receptors described in this book. Jennie Blackwell
TRANSACTIONS OF THE ROYAL SOCIETY OF Tm~rcar
1 BookReview
MED~NE
(
Macrophage plasma membrane receptors: st~cture and function. Siamon Gordon (editor). Supplement 9,3oumul of CeNScienc~,1988.Cambridge: The Company of Biologists Lirmted. This book presents papers from a meeting on the structure and function of macrophage receptors held in Oxford in March 1987. In the first chapter, Siamon Gordon and his colleagues introduce (with useful summary tables and source references) all of the known plasma membrane receptors of macrophages which function in growth, differentiation and activation, migration, recognition, endocytosis and secretion. Chapters which follow examine specific receptors such as the CSF-1 receptor (C. W. Rettenmier and colleagues); Fc receptors (I. Mellman and colleagues); complement (CR1 and CR3) receptors (S. K. A. Law); adhesion promoting (CR3, LFA-1 and ~150, 95) receptors (S. D. Wright and P. A.
Wangel, A. G., Milton, A. & Egan, J. B. (1982). Spontaneous plaque forming cells in the peripheral blood of patients with systemic lupus erythematosus. Clinical and Experimental Immunelogy, 19, 41-49. Zavala, F., Tam, J. P., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S. & Nussenzweig, V. (1985). Rationale for development of a synthetic vaccine against Plasmodiumfalcipanrm malaria. Science,228, 1436-1440. Zavala, F., Tam, J. P. & Masuda, A. (1986). Synthetic peptides as antigens for the detection of humoral immunity to Plusmodiumfalciparumsporozoites. Journal of Immwwlogical Methods, 93, 55-61. Received 25 January 1988; accepted for publication 6 June 1988
AND HYGIENE (1989) 83, OooMx)
Detmers);‘mannose &tin-like receptors (R. A. B. Ezekowitz and P. D. Stahl); lipoprotein receptors (A. M. Fogehnan and colleagues); and novel surface adhesion receptors involved in interaction between stromal macriphages and haematopoietic cells (P. R. Cracker and colleazues1.A chanter bv H. L. Yin and J. H. Hartwig
ex&&es
the kruc&e
of the mac-
rophage action skeleton, while another by A. A. Aderem looks at protem myristoylation as an intermediate step in signal transduction following priming of macrophageswith bacterial lipopolysaccharide or activation with interferon-gamma. Although the book does not deal speci6cally with the role of macrophages in infection, it provides a useful and up-to-date reference for those interested in tropical disease research since many of the interactions between bacteria or parasites (e.g. Salmonella, Legionella, Mycobacteriu, Histoplasmu, Leishmania, Toxoplasma, Typanosoma cruzz>and macrophagesare
mediated by the receptors described in this book. Jennie Blackwell