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Magnesium, calcium, phosphorus and renal function in pregnant women with chronic renal diseases and proteinuria
96
kPa, p
P3.06.13 MAGNESIUM, CALCIUM, PHOSPHORUS AND RENAL FUNCTION IN PREGNANT WOMEN WITH PRIMARY HYPERTENSION AND PROTEINURIA R. Smolarczvk, P. Piekarski, E. Romejko, .I. Wojcicka-Jagodzinska, K. Czajkowski, .I. Teliga, T. Maciejewski, 2”d Dept. OBIGYN, Warsaw Medical School, Warsaw, Poland. Objectives: The effect of primary hypertension with proteinuria on calcium-phosphorus-magnesium homeostasis in the third trimester of pregnancy was investigated. Methods: 22 women with primary hypertension with proteinuria (the studied group) and 30 healthy women (the control group) entered the study. All women were in the third trimester of pregnancy. Concentrations of calcium, phosphorous and magnesium were determined in the serum and diurnal urine. The biochemical assessment of renal function was also performed. Results: There was no significant difference in gestational age between the studied and the control groups (36.3e2.28 vs. 36.Oe2.20 weeks). Women of the studied group presented blood pressure 164~12/101~6 mmHg and proteinuria 2.44e1.628124 hrs. Women of the studied group vs. control group showed following serum concentrations of: magnesium 0.65*0.085 vs. 0.70*0.10 mmoVL, ~~0.05; total calcium 2.18*0.11 vs. 2.25e.12 mmol/L, ~~0.04; ionized Ca’+ 1.00*0.054 vs. 1.05*0.07 mmoVL, ~~0.05; inorganic phosphorus 1.63*0.11 vs. 1.31*0.22 mmoVL, p
P3.06.14 MAGNESIUM, CALCIUM, PHOSPHORUS AND RENAL FUNCTION IN PREGNANT WOMEN WITH CHRONIC RENAL DISEASES AND PROTEINURIA R. Smolarczvk, P. Piekarski, E. Romejko, .I. Wojcicka-Jagodzinska, K. Czajkowski, J. Teliga, T. Maciejewski, 2”d Dept. OBIGYN, Warsaw Medical School, Warsaw, Poland. Objectives: The effect of chronic renal diseases with proteinuria on calcium-phosphorous-magnesium homeostasis in the third trimester of pregnancy was investigated. Methods: 20 women (the studied group): 10 with chronic glomerulonephritis, 4 with chronic pyelonephritis, 1 with renal hypoplasia, 3 after reflux operation, 2 with nephrolithiasis and 30 healthy women (the control group) entered the study. All women were in the third trimester of pregnancy. Concentrations of calcium, phosphorous and magnesium were determined in the serum and diurnal urine. The biochemical assessment of renal function was also performed. Results: There was no significant difference in gestational age between the studied and the control groups (36.4e2.61 vs. 36.Oe2.20 weeks). Women of the studied group presented blood pressure 166~17/104~12 mmHg and proteinuria 3.84*2.61g/24 hrs. Women of the studied group vs. control group showed following serum concentrations of: magnesium
WEDNESDAY,
SEPTEMBER
6
0.63*0.15 vs. 0.70*0.10 mmoVL, ~~0.04; total calcium 2.19*0.11 vs. 2.25e.12 mmol/L, NS; ionized Ca’+ 1.08*0.065 vs. 1.05*0.07 mmoVL, NS; inorganic phosphorus 1.55*0.21 vs. 1.31*0.22 mmoVL, p
P3.06.15 PREGNANCY AFTER RENAL TRANSPLANTATION: EXPERIENCE IN SINGAPORE GENERAL HOSPITAL P.K. V. Anantharaman, A. Tan, Dept OBIGYN, Dept of Renal Medicine, Singapore General Hospital, Singapore Objectives: The aim of the study was to examine the overall outcome of pregnancy after renal transplantation in Singapore General Hospital (SGH). Study Methods: 22 women whose pregnancies after renal transplantation were jointly managed by the department of OB/GYN and Renal medicine in SGH between December 1986 and November 1998, formed the subjects of this retrospective study. Antenatal and postnatal details of the pregnancies for each woman were retrieved from their obstetric and neonatal records respectively. Results: Of the 34 post-transplant among the 22 women, 12 (35.2%) were unsuccessful because of 6 (50%) spontaneous miscarriages, 3 (25.0%) therapeutic abortions, 2 (16.7%) ectopic pregnancies and 1 (8.3%) stillbirth. The remaining 22 (64.87)0 successful pregnancies were complicated by maternal anemia (63.6%), superimposed hypertension (45.5%), premature rupture of membranes (31.8%), urinary and lower genital tract infections (22.7% each), abnormal glucose tolerance test (13.6%), premature delivery (45.5%), low birth weight babies (45.5%) and intrauterine growth retardation (22.7%). 19 (86.4%) of the pregnancies were delivered by caesarean section and 3 (13.6%) by the vaginal route. There were no documented cases of multiple pregnancies, congenital anomalies or intrapartum or postpartum deterioration of renal function. Conclusions: Successful pregnancy is possible in women after renal transplantation. Such pregnancies are often associated with increased maternal and fetal morbidity and should be managed with a multidisciplinary approach in a tertiary center.
P3.06.16 PREVENTION OF P.E.T. P., Dept. OBIGYN, Narishikshaashram
Hospital, Silchar, India.
Objectives: The aim of this study is to prevent development of Preeclamptic Toxemia (P.E.T.)of pregnant women to reduce the morbidity and mortality of both mother and fetus. Study Method: 200 cases of primigravida of average wt and obese were selected for the study. At every antenatal visit, urine R.E., W.T., B.P. oedema were recorded along with other routine exams. From the beginning of pregnancy they were advised not to take butter, ghee, egg, milk, milk product, fried food, oily fish, fatty food, and use as little oil as possible during cooking. Strict advice was given to drink 6 - 10 glasses of water daily. Medication was given liberally to prevent constipation, acidity, indigestion. In a few cases, women developed edema around 24 - 30 weeks and were promptly treated with bed rest, reduction of carbohydrates and fatty foods in their diet. They responded well. Results: Not a single case developed high BP, albuminuria, or excessive gaining of WT.
kPa, p
P3.06.13 MAGNESIUM, CALCIUM, PHOSPHORUS AND RENAL FUNCTION IN PREGNANT WOMEN WITH PRIMARY HYPERTENSION AND PROTEINURIA R. Smolarczvk, P. Piekarski, E. Romejko, .I. Wojcicka-Jagodzinska, K. Czajkowski, .I. Teliga, T. Maciejewski, 2”d Dept. OBIGYN, Warsaw Medical School, Warsaw, Poland. Objectives: The effect of primary hypertension with proteinuria on calcium-phosphorus-magnesium homeostasis in the third trimester of pregnancy was investigated. Methods: 22 women with primary hypertension with proteinuria (the studied group) and 30 healthy women (the control group) entered the study. All women were in the third trimester of pregnancy. Concentrations of calcium, phosphorous and magnesium were determined in the serum and diurnal urine. The biochemical assessment of renal function was also performed. Results: There was no significant difference in gestational age between the studied and the control groups (36.3e2.28 vs. 36.Oe2.20 weeks). Women of the studied group presented blood pressure 164~12/101~6 mmHg and proteinuria 2.44e1.628124 hrs. Women of the studied group vs. control group showed following serum concentrations of: magnesium 0.65*0.085 vs. 0.70*0.10 mmoVL, ~~0.05; total calcium 2.18*0.11 vs. 2.25e.12 mmol/L, ~~0.04; ionized Ca’+ 1.00*0.054 vs. 1.05*0.07 mmoVL, ~~0.05; inorganic phosphorus 1.63*0.11 vs. 1.31*0.22 mmoVL, p
P3.06.14 MAGNESIUM, CALCIUM, PHOSPHORUS AND RENAL FUNCTION IN PREGNANT WOMEN WITH CHRONIC RENAL DISEASES AND PROTEINURIA R. Smolarczvk, P. Piekarski, E. Romejko, .I. Wojcicka-Jagodzinska, K. Czajkowski, J. Teliga, T. Maciejewski, 2”d Dept. OBIGYN, Warsaw Medical School, Warsaw, Poland. Objectives: The effect of chronic renal diseases with proteinuria on calcium-phosphorous-magnesium homeostasis in the third trimester of pregnancy was investigated. Methods: 20 women (the studied group): 10 with chronic glomerulonephritis, 4 with chronic pyelonephritis, 1 with renal hypoplasia, 3 after reflux operation, 2 with nephrolithiasis and 30 healthy women (the control group) entered the study. All women were in the third trimester of pregnancy. Concentrations of calcium, phosphorous and magnesium were determined in the serum and diurnal urine. The biochemical assessment of renal function was also performed. Results: There was no significant difference in gestational age between the studied and the control groups (36.4e2.61 vs. 36.Oe2.20 weeks). Women of the studied group presented blood pressure 166~17/104~12 mmHg and proteinuria 3.84*2.61g/24 hrs. Women of the studied group vs. control group showed following serum concentrations of: magnesium
WEDNESDAY,
SEPTEMBER
6
0.63*0.15 vs. 0.70*0.10 mmoVL, ~~0.04; total calcium 2.19*0.11 vs. 2.25e.12 mmol/L, NS; ionized Ca’+ 1.08*0.065 vs. 1.05*0.07 mmoVL, NS; inorganic phosphorus 1.55*0.21 vs. 1.31*0.22 mmoVL, p
P3.06.15 PREGNANCY AFTER RENAL TRANSPLANTATION: EXPERIENCE IN SINGAPORE GENERAL HOSPITAL P.K. V. Anantharaman, A. Tan, Dept OBIGYN, Dept of Renal Medicine, Singapore General Hospital, Singapore Objectives: The aim of the study was to examine the overall outcome of pregnancy after renal transplantation in Singapore General Hospital (SGH). Study Methods: 22 women whose pregnancies after renal transplantation were jointly managed by the department of OB/GYN and Renal medicine in SGH between December 1986 and November 1998, formed the subjects of this retrospective study. Antenatal and postnatal details of the pregnancies for each woman were retrieved from their obstetric and neonatal records respectively. Results: Of the 34 post-transplant among the 22 women, 12 (35.2%) were unsuccessful because of 6 (50%) spontaneous miscarriages, 3 (25.0%) therapeutic abortions, 2 (16.7%) ectopic pregnancies and 1 (8.3%) stillbirth. The remaining 22 (64.87)0 successful pregnancies were complicated by maternal anemia (63.6%), superimposed hypertension (45.5%), premature rupture of membranes (31.8%), urinary and lower genital tract infections (22.7% each), abnormal glucose tolerance test (13.6%), premature delivery (45.5%), low birth weight babies (45.5%) and intrauterine growth retardation (22.7%). 19 (86.4%) of the pregnancies were delivered by caesarean section and 3 (13.6%) by the vaginal route. There were no documented cases of multiple pregnancies, congenital anomalies or intrapartum or postpartum deterioration of renal function. Conclusions: Successful pregnancy is possible in women after renal transplantation. Such pregnancies are often associated with increased maternal and fetal morbidity and should be managed with a multidisciplinary approach in a tertiary center.
P3.06.16 PREVENTION OF P.E.T. P., Dept. OBIGYN, Narishikshaashram
Hospital, Silchar, India.
Objectives: The aim of this study is to prevent development of Preeclamptic Toxemia (P.E.T.)of pregnant women to reduce the morbidity and mortality of both mother and fetus. Study Method: 200 cases of primigravida of average wt and obese were selected for the study. At every antenatal visit, urine R.E., W.T., B.P. oedema were recorded along with other routine exams. From the beginning of pregnancy they were advised not to take butter, ghee, egg, milk, milk product, fried food, oily fish, fatty food, and use as little oil as possible during cooking. Strict advice was given to drink 6 - 10 glasses of water daily. Medication was given liberally to prevent constipation, acidity, indigestion. In a few cases, women developed edema around 24 - 30 weeks and were promptly treated with bed rest, reduction of carbohydrates and fatty foods in their diet. They responded well. Results: Not a single case developed high BP, albuminuria, or excessive gaining of WT.