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Male fertility regulation: Recent advances
336 deoxwridine. The drugs viwristine and vindesine do not appear to have a direct effect on DNA synthesis rate across S phase, whereas DHAD, a compound that has been found previously to affect DNA synthesis, does appear by this technique to inhibit DNA synthesis at specific segments of S phase. That vincristine does not block cells in S phase by inhibiting DNA synthesis is borne out of the observation that cells blocked in S or G, + M can still incorporate BrdUrd at a high rate in these phases of the cell cycle.
Male fertility regulation: Recent advances Waites GMH BULL. WHO; 64/2 (151--158)/1986/ Acceptable antifertility drugs for men are proving difficult to produce. Such drugs must aim to achieve complete axoospermia over a long period. This requirement may be relaxed only if it can be shown that the residual sperm produced by men whose spermatogenesis had been suppressed by ~tifertility drugs to oligospermia am incapable of fertilizing ova. Hormonal methods involving suppression of the secretion of gonadotrophin hormones by the pituitary gland invariably require androgen supplementation, and the use of steroids either alone or in combination requires careful monitoring for their sideeffects. A chemical (non-hormonal) approach involving the incapacitation of sperm in the epididymis has been shown to be feasible in animal studies using alpha-chlorohydrin and 6-chloro-6-deoxy sugars, although such compounds cannot be developed for human use because of their toxicity. Immunological approaches have the inherent problem of delivery of the antibody to the target. While the search for new and safer chemical and hormonal approaches goes on, the recent evidence that vasectomy offers a safe surgical option leaves responsible men with some choice to add to the condom.
Medicinal plants in therapy Farnsworth NR; Akerele 0; Binge1 AS; et al BULL. WHO; 63/6 (965-981)/1985) One of the prerequisites for the success of primary health care is the availability and use of suitable drugs. Plants have always been a common source of medicaments, either in the form of traditional preparations or as pure active principles. It is thus reasonable for decision-makers to identify locally available plants or plant extracts that could usefully be added to the national list of drugs, or that could even replace some pharmaceutical preparations that need to be purchased and imported. This uptake article presents a list of plant-derived drugs, with the names of the plant sources, and their actions or uses in therapy.
Naturally occurring cardiac glycosides Radford DJ; Gillies AD, Hinds JA; Duffy P MED. J. AUST.; 144/10 (540-544)1986) Cardiac glycoside poisoning from the ingestion of plants, particularly of oleanders, occurs with reasonable frequency in tropical and subtropical areas. We have assessed a variety of plant specimens for their cardiac glycoside content by means of radioimmunoassays with antibodies that differ in their specificity for cardiac glycosides. Significant amounts of immunoreactive cardiac glycoside were found to be present in the ornamental shrubs: yellow oleander (Tbevetia peruviana); oleander (Nerium oleander); wintersweet (Carissa spectabilis); buschman’s poison (Carissa acokanthera); sea-mango (Cerbera manghas);
Male fertility regulation: Recent advances Waites GMH BULL. WHO; 64/2 (151--158)/1986/ Acceptable antifertility drugs for men are proving difficult to produce. Such drugs must aim to achieve complete axoospermia over a long period. This requirement may be relaxed only if it can be shown that the residual sperm produced by men whose spermatogenesis had been suppressed by ~tifertility drugs to oligospermia am incapable of fertilizing ova. Hormonal methods involving suppression of the secretion of gonadotrophin hormones by the pituitary gland invariably require androgen supplementation, and the use of steroids either alone or in combination requires careful monitoring for their sideeffects. A chemical (non-hormonal) approach involving the incapacitation of sperm in the epididymis has been shown to be feasible in animal studies using alpha-chlorohydrin and 6-chloro-6-deoxy sugars, although such compounds cannot be developed for human use because of their toxicity. Immunological approaches have the inherent problem of delivery of the antibody to the target. While the search for new and safer chemical and hormonal approaches goes on, the recent evidence that vasectomy offers a safe surgical option leaves responsible men with some choice to add to the condom.
Medicinal plants in therapy Farnsworth NR; Akerele 0; Binge1 AS; et al BULL. WHO; 63/6 (965-981)/1985) One of the prerequisites for the success of primary health care is the availability and use of suitable drugs. Plants have always been a common source of medicaments, either in the form of traditional preparations or as pure active principles. It is thus reasonable for decision-makers to identify locally available plants or plant extracts that could usefully be added to the national list of drugs, or that could even replace some pharmaceutical preparations that need to be purchased and imported. This uptake article presents a list of plant-derived drugs, with the names of the plant sources, and their actions or uses in therapy.
Naturally occurring cardiac glycosides Radford DJ; Gillies AD, Hinds JA; Duffy P MED. J. AUST.; 144/10 (540-544)1986) Cardiac glycoside poisoning from the ingestion of plants, particularly of oleanders, occurs with reasonable frequency in tropical and subtropical areas. We have assessed a variety of plant specimens for their cardiac glycoside content by means of radioimmunoassays with antibodies that differ in their specificity for cardiac glycosides. Significant amounts of immunoreactive cardiac glycoside were found to be present in the ornamental shrubs: yellow oleander (Tbevetia peruviana); oleander (Nerium oleander); wintersweet (Carissa spectabilis); buschman’s poison (Carissa acokanthera); sea-mango (Cerbera manghas);