Malignant melanomas of the urogenital tract

11 Malignant melanomas of the urogenital tract Szabó B.F.1, Szűcs M.1, Székely E.2, Pánczél G.3, Liszkay G.3, Nyirády P.1 1 Semmelweis University, Dept. of Urology, Budapest, Hungary, 2Semmelweis University, 2nd Dept. of Pathology, Budapest, Hungary, 3National Institute of Oncology, Budapest, Hungary INTRODUCTION & OBJECTIVES: Malignant melanoma is a rare tumor typically occurs in the skin but may rarely occurs in the genitourinary tract. Only 4-5% of all primary melanomas do not arise from the skin. Extracutaneous melanomas has a complex clinical presentation but what these aggressive tumors have in common is poor prognosis. MATERIAL & METHODS: In our department we found 5 patients with malignant melanoma of the genitourinary tract in the past few years. The 5 cases were: primary amelanotic melanoma of the female urethra, a primary melanoma of the bladder, a primary melanoma of the penis, a metastatic melanoma of the testis and a metastatic melanoma of the bladder with melanuria. We retrospectively analyzed the available data to describe the presentation, management, and clinical outcome of the patients. RESULTS: The presentation and management of the patients with urogenital melanoma were varied. The prognosis was poor, in primary cases radical surgery was the first line treatment and patients received adjuvant chemotherapy. In metastatic diseases a palliative surgery was performed. CONCLUSIONS: Urogenital melanomas have a poor prognosis. The most important factors to improve the therapeutic results are early diagnosis and radical surgery. Radiation therapy and chemotherapy are used mostly as adjuvant or palliative therapy.

Eur Urol Suppl 2015; 14(6): e1180