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Maternal and umbilical cord blood lead levels in Tehran, Iran
THURSDAY,
SEPTEMBER
7
FC4.09.06 PECULIARITIES OF IMMUNE SYSTEM OF NEONATES OF MOTHERS WITH ANTIPHOSPHOLIPID SYNDROME L.P.Ponomarova. L.V. Vanko, O.E. Bondar, N.K. Matveeva, N.S. Loginova, Russian Research Center for Perinatology, Obstetric and Gynaecology, Moscow, Russia Antiphospholipid syndrome includes habitual miscarriages with hyperproduction of specific antiphospholipid autoantibodies and disorders of haemostasis. complex therapy includes prednisolon in low dosage and lets women save pregnancies. the aim of research was to reveal the peculareties of immune system of neonatis born from mothers with antiphospholipid syndrome. was examined immune status of 84 mature newborn of mothers with antiphospholipid syndrome and 32 newborn of control group. we examened subpopulational division of lymphocytes by flowing cytometria. functional activity of leucocytes was checked with luminoldepended chemiluminescention. we evaluate the interferon status by the method of soloviev-bechtemirov. was revealed significantly higt number of cd3+, cd4+, cd19+ lymphocytes and cells with adhesive molecules (cdllb+) in 5-7 days, high level of serum interferon, significant decrease of y-interferonproductive activity of umbilical and venouse blood cells in 5-7 days and elevated level of spontaneus chemiluminescention of leucocytes. level of umbilical cdllb+ correlattes with every day dosage of hormone taken by mother during the pregnancy. our results demonstrate tensive immunity of children born to mothers with antiphospholipid syndrom in first 7 days of neonatal adaptation.
FC4.09.07 MATERNAL AND UMBILICAL CORD BLOOD LEAD LEVELS IN TEHRAN, IRAN A. A. Mehdizadeh, M. Khalilipour, M. Moshfegi, M. Mogtahedi, R. Alaghehbandan, Dept. OBIGYN, Iran University of Medical Sciences, Nyayesh Street, Sattarkhan Avenue, Tehran, Iran
37
FC4.09.08 THE EFFECT OF MODE OF DELIVERY ON NEONATAL OUTCOME OF TWINS WITH BIRTHWEIGHT UNDER 15OOg. S.M.Ziadeh. E. Sunna, L.F. Badria, Dept. OBIGYN, Jordan University of Science and Technology, Amman, Jordan. Objective: The purpose of this retrospective study was to evaluate the mode of delivery on neonatal outcome of twins weighing < 15OOg. Study Methods We reviewed the effect of birth order, presentation, and method of delivery on neonatal outcome in twin gestation under 15OOg. at Princess Badeea’ Teaching Hospital in North Jordan over the 6 years from 1994 1999. Results: During the study period, there were 51, 475 deliveries of which 695 were twin gestations. One hundred and eight (108) sets of twins weighing < 15OOg. were included in this study (15.5%), of which 41 were in vertex-vertex presentation, 40 in vertex-nonvertex presentation, and 27 with first twin in nonvertex presentation. The second twin pregnancies characterized by a higher incidence of respiratory distress syndrome (82 vs 70%; P=.O2), more neonatal mortality (23 vs 17.6%), and lower Apgar score at 1 and 5 minutes. Cesarean delivery for vertexvertex presentation did not improve the neonatal outcome. Rather, the incidence of RDS was significantly greater in this group delivered by cesarean section (65.6 vs 42%; P=.O12). For nonvertex presentation, those delivered by cesarean section had a lower incidence of neonatal mortality. Conclusion: We concluded that there was no advantage for cesarean delivery could be demonstrated after multivariate analysis to correct the differences in birthweight between the groups. Therefore, the differences in the neonatal outcome of nonvertex twins presentation accounted for the difference in birthweight, rather than in mode of delivery. Keywords: Twin pregnancy <15OOg., mode of delivery, neonatal outcome
FC4.10 Objectives: In Tehran, as in many other capitals in the world, environmental lead exposure with its concomitant risk of neurotoxicity remains a major health hazard for the population. Prenatal exposure to lead has been associated with abnormal nemobehavioral development in children. The lack of safe and cost-effective treatments for low-level lead poisoning has promoted environmental interventions to control different sources of lead. The aim of this study was to evaluate the maternal and umbilical cord blood lead levels in 80 consecutive motherinfant pairs in order to determine whether neonates in Tehran are in the high -risk group. Study Methods: During 1997-98, we conducted a survey of maternal and umbilical cord blood lead levels of 80 pregnant women and their healthy newborns at two teaching hospitals affiliated to Iran University of Medical Sciences, Tehran. Lead levels in umbilical cord blood and maternal venous blood were measured by atomic absorption spectrophotometry. Results: The mean maternal age was 25.7 years, ranging from 17 to 39 years. The mean of parity was 2. Maternal blood lead levels ranged from 3.7 to 57.6 pg/dl with a mean of 26.8 pg/dl and a standard deviation of 2.9 pg/dl. The umbilical cord blood lead levels varied between 0.3 to 110 pg/dl with a mean of 31.7 pg/dl and a standard deviation of 2.9 pg/dl. Concentrations of above 10 pg/dl were found in 86% of the neonates. There was significant correlation between the maternal and cord blood lead levels (r = 0.3, P < 0.02). There was also significant correlation between the cord blood lead levels and birth weight (r = 0.2, P < 0.05). However no significant correlation was found between maternal lead levels and birth weight. Conclusions: It seems that prenatal lead exposure has become an important health issue for young children in Tehran. It is necessary to reduce atmospheric lead as one of the most important primary environmental sources of lead by replacing leaded gasoline with unleaded gasoline.
OVARIAN CANCER: ASSESSMENT
RISK OF MALIGNANCY
FC4.10.01 OVARIAN CANCER DETECTED NON-INVASIVELY BY CONTRAST ENHANCED POWER DOPPLER ULTRASOUND T. D’ArcL Dept. Gynaecology, CoombeWomen’s Hospital.Dublin 8 V. Jayaram, Dept. Imaging, Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. M. Lynch, Dept. Imaging, Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. P. Soutter, Dept. Gynaecology Oncology. Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. D. Cosgrove, Dept. Imaging, Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. Objectives: the purpose of this study was to assess the effect of intravenous contrast enhanced high-resolution grey-scale ultrasound with power doppler in detecting small ovarian malignancies. Methods: Twenty women undergoing a laparotomy for suspected early ovarian malignancy were scanned with high-resolution grey-scale ultrasound and power Doppler before and after the administration of Levovist. A vascular morphological score was devised, based on ovarian tumoral vessel location, complexity and density. A score of 8 or above was used to identify malignancy. This was compared with the relative malignancy index described by Jacobs in which a value greater than 250 was regarded as suspicious of malignancy. Results: There were 13 benign, 3 borderline and 4 malignant turnours. Their respective mean diameter and range were 9cm (5 to 17 cm), 1Ocm (8 to 11 cm) and 1Ocm (7 to 13 cm). Half the invasive tumours were identified before contrast enhansement. All were identified after contrast enhansement with excellent interobserver agreement. The RMI identified 2 of the 4 invasive lesions. The 3 borderline tumours were indistinguishable from the benign lesions by all parameters. Conclusion: A vascular morphology score, facilitated by intravenous contrast enhanced Power Doppler may be an accurate way of selecting women who require surgery
SEPTEMBER
7
FC4.09.06 PECULIARITIES OF IMMUNE SYSTEM OF NEONATES OF MOTHERS WITH ANTIPHOSPHOLIPID SYNDROME L.P.Ponomarova. L.V. Vanko, O.E. Bondar, N.K. Matveeva, N.S. Loginova, Russian Research Center for Perinatology, Obstetric and Gynaecology, Moscow, Russia Antiphospholipid syndrome includes habitual miscarriages with hyperproduction of specific antiphospholipid autoantibodies and disorders of haemostasis. complex therapy includes prednisolon in low dosage and lets women save pregnancies. the aim of research was to reveal the peculareties of immune system of neonatis born from mothers with antiphospholipid syndrome. was examined immune status of 84 mature newborn of mothers with antiphospholipid syndrome and 32 newborn of control group. we examened subpopulational division of lymphocytes by flowing cytometria. functional activity of leucocytes was checked with luminoldepended chemiluminescention. we evaluate the interferon status by the method of soloviev-bechtemirov. was revealed significantly higt number of cd3+, cd4+, cd19+ lymphocytes and cells with adhesive molecules (cdllb+) in 5-7 days, high level of serum interferon, significant decrease of y-interferonproductive activity of umbilical and venouse blood cells in 5-7 days and elevated level of spontaneus chemiluminescention of leucocytes. level of umbilical cdllb+ correlattes with every day dosage of hormone taken by mother during the pregnancy. our results demonstrate tensive immunity of children born to mothers with antiphospholipid syndrom in first 7 days of neonatal adaptation.
FC4.09.07 MATERNAL AND UMBILICAL CORD BLOOD LEAD LEVELS IN TEHRAN, IRAN A. A. Mehdizadeh, M. Khalilipour, M. Moshfegi, M. Mogtahedi, R. Alaghehbandan, Dept. OBIGYN, Iran University of Medical Sciences, Nyayesh Street, Sattarkhan Avenue, Tehran, Iran
37
FC4.09.08 THE EFFECT OF MODE OF DELIVERY ON NEONATAL OUTCOME OF TWINS WITH BIRTHWEIGHT UNDER 15OOg. S.M.Ziadeh. E. Sunna, L.F. Badria, Dept. OBIGYN, Jordan University of Science and Technology, Amman, Jordan. Objective: The purpose of this retrospective study was to evaluate the mode of delivery on neonatal outcome of twins weighing < 15OOg. Study Methods We reviewed the effect of birth order, presentation, and method of delivery on neonatal outcome in twin gestation under 15OOg. at Princess Badeea’ Teaching Hospital in North Jordan over the 6 years from 1994 1999. Results: During the study period, there were 51, 475 deliveries of which 695 were twin gestations. One hundred and eight (108) sets of twins weighing < 15OOg. were included in this study (15.5%), of which 41 were in vertex-vertex presentation, 40 in vertex-nonvertex presentation, and 27 with first twin in nonvertex presentation. The second twin pregnancies characterized by a higher incidence of respiratory distress syndrome (82 vs 70%; P=.O2), more neonatal mortality (23 vs 17.6%), and lower Apgar score at 1 and 5 minutes. Cesarean delivery for vertexvertex presentation did not improve the neonatal outcome. Rather, the incidence of RDS was significantly greater in this group delivered by cesarean section (65.6 vs 42%; P=.O12). For nonvertex presentation, those delivered by cesarean section had a lower incidence of neonatal mortality. Conclusion: We concluded that there was no advantage for cesarean delivery could be demonstrated after multivariate analysis to correct the differences in birthweight between the groups. Therefore, the differences in the neonatal outcome of nonvertex twins presentation accounted for the difference in birthweight, rather than in mode of delivery. Keywords: Twin pregnancy <15OOg., mode of delivery, neonatal outcome
FC4.10 Objectives: In Tehran, as in many other capitals in the world, environmental lead exposure with its concomitant risk of neurotoxicity remains a major health hazard for the population. Prenatal exposure to lead has been associated with abnormal nemobehavioral development in children. The lack of safe and cost-effective treatments for low-level lead poisoning has promoted environmental interventions to control different sources of lead. The aim of this study was to evaluate the maternal and umbilical cord blood lead levels in 80 consecutive motherinfant pairs in order to determine whether neonates in Tehran are in the high -risk group. Study Methods: During 1997-98, we conducted a survey of maternal and umbilical cord blood lead levels of 80 pregnant women and their healthy newborns at two teaching hospitals affiliated to Iran University of Medical Sciences, Tehran. Lead levels in umbilical cord blood and maternal venous blood were measured by atomic absorption spectrophotometry. Results: The mean maternal age was 25.7 years, ranging from 17 to 39 years. The mean of parity was 2. Maternal blood lead levels ranged from 3.7 to 57.6 pg/dl with a mean of 26.8 pg/dl and a standard deviation of 2.9 pg/dl. The umbilical cord blood lead levels varied between 0.3 to 110 pg/dl with a mean of 31.7 pg/dl and a standard deviation of 2.9 pg/dl. Concentrations of above 10 pg/dl were found in 86% of the neonates. There was significant correlation between the maternal and cord blood lead levels (r = 0.3, P < 0.02). There was also significant correlation between the cord blood lead levels and birth weight (r = 0.2, P < 0.05). However no significant correlation was found between maternal lead levels and birth weight. Conclusions: It seems that prenatal lead exposure has become an important health issue for young children in Tehran. It is necessary to reduce atmospheric lead as one of the most important primary environmental sources of lead by replacing leaded gasoline with unleaded gasoline.
OVARIAN CANCER: ASSESSMENT
RISK OF MALIGNANCY
FC4.10.01 OVARIAN CANCER DETECTED NON-INVASIVELY BY CONTRAST ENHANCED POWER DOPPLER ULTRASOUND T. D’ArcL Dept. Gynaecology, CoombeWomen’s Hospital.Dublin 8 V. Jayaram, Dept. Imaging, Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. M. Lynch, Dept. Imaging, Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. P. Soutter, Dept. Gynaecology Oncology. Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. D. Cosgrove, Dept. Imaging, Imperial College of Science Technology and Medicine Hammersmith Hospital, London W12 OHS. Objectives: the purpose of this study was to assess the effect of intravenous contrast enhanced high-resolution grey-scale ultrasound with power doppler in detecting small ovarian malignancies. Methods: Twenty women undergoing a laparotomy for suspected early ovarian malignancy were scanned with high-resolution grey-scale ultrasound and power Doppler before and after the administration of Levovist. A vascular morphological score was devised, based on ovarian tumoral vessel location, complexity and density. A score of 8 or above was used to identify malignancy. This was compared with the relative malignancy index described by Jacobs in which a value greater than 250 was regarded as suspicious of malignancy. Results: There were 13 benign, 3 borderline and 4 malignant turnours. Their respective mean diameter and range were 9cm (5 to 17 cm), 1Ocm (8 to 11 cm) and 1Ocm (7 to 13 cm). Half the invasive tumours were identified before contrast enhansement. All were identified after contrast enhansement with excellent interobserver agreement. The RMI identified 2 of the 4 invasive lesions. The 3 borderline tumours were indistinguishable from the benign lesions by all parameters. Conclusion: A vascular morphology score, facilitated by intravenous contrast enhanced Power Doppler may be an accurate way of selecting women who require surgery