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MECHANISM OF EDGE RESTENOSIS OF SIROLIMUS-ELUTING STENTS: SERIAL INTRAVASCULAR ULTRASOUND ANALYSIS
A203.E1916 JACC March 9, 2010 Volume 55, issue 10A
i2 SUMMIT MECHANISM OF EDGE RESTENOSIS OF SIROLIMUS-ELUTING STENTS: SERIAL INTRAVASCULAR ULTRASOUND ANALYSIS i2 Poster Contributions Georgia World Congress Center, Hall B5 Monday, March 15, 2010, 9:30 a.m.-10:30 a.m.
Session Title: Intravascular Diagnostics and Complex Lesions Abstract Category: Intravascular Diagnostics Presentation Number: 2503-504 Authors: Eiji Ichimoto, Yoshio Kobayashi, Nakabumi Kuroda, Issei Komuro, Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan Background: The mechanism of edge restenosis after paclitaxel-eluting stent implantation has been shown. On the other hand, there is little information about it after sirolimus-eluting stent (SES) implantation. Methods: Serial intravascular ultrasound (IVUS) examinations were performed in 25 lesions with SES edge restenosis. The reference lumen and external elastic membrane (EEM) areas 5-mm proximal and distal to the stent edges were manually traced at 1-mm intervals. Results: Figure demonstrates IVUS measurements at 5 consecutive 1-mm subsegments adjacent to the stent edge. Between post-intervention and follow-up IVUS studies, there were significant decrease in lumen and EEM areas and increase in plaque plus media area in the subsegment closest to the stent edge. On the other hand, decrease in lumen area was mainly due to decrease in EEM area within the other subsegments. Conclusions: SES edge restenosis occurs due to the combination of negative vessel remodeling and progression of plaque in the segment closest to the stent edge. Beyond this segment, negative vessel remodeling is the mechanism of SES edge restenosis.
i2 SUMMIT MECHANISM OF EDGE RESTENOSIS OF SIROLIMUS-ELUTING STENTS: SERIAL INTRAVASCULAR ULTRASOUND ANALYSIS i2 Poster Contributions Georgia World Congress Center, Hall B5 Monday, March 15, 2010, 9:30 a.m.-10:30 a.m.
Session Title: Intravascular Diagnostics and Complex Lesions Abstract Category: Intravascular Diagnostics Presentation Number: 2503-504 Authors: Eiji Ichimoto, Yoshio Kobayashi, Nakabumi Kuroda, Issei Komuro, Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan Background: The mechanism of edge restenosis after paclitaxel-eluting stent implantation has been shown. On the other hand, there is little information about it after sirolimus-eluting stent (SES) implantation. Methods: Serial intravascular ultrasound (IVUS) examinations were performed in 25 lesions with SES edge restenosis. The reference lumen and external elastic membrane (EEM) areas 5-mm proximal and distal to the stent edges were manually traced at 1-mm intervals. Results: Figure demonstrates IVUS measurements at 5 consecutive 1-mm subsegments adjacent to the stent edge. Between post-intervention and follow-up IVUS studies, there were significant decrease in lumen and EEM areas and increase in plaque plus media area in the subsegment closest to the stent edge. On the other hand, decrease in lumen area was mainly due to decrease in EEM area within the other subsegments. Conclusions: SES edge restenosis occurs due to the combination of negative vessel remodeling and progression of plaque in the segment closest to the stent edge. Beyond this segment, negative vessel remodeling is the mechanism of SES edge restenosis.