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Meloxicam effects on plasma iohexol clearance
A D VA N C E S
oxicam in a masked, randomized, crossover study. Iohexol clearance studies were performed as a marker of GFR before the treatment period began (baseline) and on the final day of the treatment period.
Results No significant treatment effect was detected. Mean iohexol clearance for cats having been administered meloxicam was not significantly different from mean baseline (pre-treatment) value.
Author Conclusion
MELOXICAM EFFECTS ON PLASMA IOHEXOL CLEARANCE Background Prostaglandins produced by cyclooxygenase (COX) enzymes are important mediators of vascular tone, salt and water balance, and renin release. In dogs, prostaglandins increase renal blood flow by counteracting vasoconstriction in the renal vasculature caused by angiotensin II and norepinephrine. They therefore maintain normal glomerular filtration rate (GFR) under physiologic conditions associated with decreased intravascular volume. Nonsteroidal anti-inflammatory drugs (NSAID) inhibit COX enzymes and significantly lowers renal blood flow in dogs under specific conditions, such as during anesthesia and laparotomy and in conscious and anesthetized salt-depleted dogs. However, in clinically normal, conscious dogs, the administration of NSAIDs (indomethacin and meclofenamate) have no effect on renal blood flow. Indomethacin and meclofenamate increase renal vascular resistance in anesthetized cats. However, the effect of NSAIDs on renal blood flow or GFR in conscious cats is not known.
Objectives To investigate the effect of therapeutic dosages of meloxicam on the plasma clearance of iohexol (measurement of GFR) in healthy, euvolemic, conscious cats fed on sodium-replete diet.
Procedure Six healthy adult, neutered, male cats were administered either no treatment or mel-
Short-term meloxicam administration does not measurably alter the GFR as assessed via plasma clearance of iohexol. Therefore, renal prostaglandins in cats do not have a measurable effect on GFR in healthy, euvolemic, conscious states.
Inclusions Three figures, 1 table, 26 references.
Editor Annotation This study investigated the effect of therapeutic dosages of meloxicam on the plasma clearance of iohexal in healthy, euvolemic, conscious cats fed a sodium replete diet. There have been no studies in cats confirming the expression of COX isoenzymes in feline kidneys. Meloxicam was chosen, because it is presently the only NSAID approved for use in cats in the United States. Meloxicam was administered orally at 0.2 mg/kg, once daily on day 1 and 0.1 mg/kg, once daily on days 2 through 5. An iohexal clearance study was performed on day 0 (baseline) and on day 5 at 4 to 5 hours post-drug administration. A 12-day washout period was observed between treatments. During the iohexal studies, 20 ml of saline was administered to cover for maintenance fluids. Results of the study indicated that shortterm administration of meloxicam did not measurably alter the GFR in healthy, euvolemic conscious cats and assessed via plasma clearance of iohexol. Meloxicam should be well tolerated in healthy, hydrated cats at dosages and intervals used in this study. Additional studies need to be done assessing meloxicam administration in cats with renal compromise. (MM) Goodman LA, Brown SA, Torres BT, et al. Effects of meloxicam on plasma iohexol clearance as a marker of glomerular filtration rate in conscious healthy cats. Am J Vet Res 2009; 70:826-830.
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oxicam in a masked, randomized, crossover study. Iohexol clearance studies were performed as a marker of GFR before the treatment period began (baseline) and on the final day of the treatment period.
Results No significant treatment effect was detected. Mean iohexol clearance for cats having been administered meloxicam was not significantly different from mean baseline (pre-treatment) value.
Author Conclusion
MELOXICAM EFFECTS ON PLASMA IOHEXOL CLEARANCE Background Prostaglandins produced by cyclooxygenase (COX) enzymes are important mediators of vascular tone, salt and water balance, and renin release. In dogs, prostaglandins increase renal blood flow by counteracting vasoconstriction in the renal vasculature caused by angiotensin II and norepinephrine. They therefore maintain normal glomerular filtration rate (GFR) under physiologic conditions associated with decreased intravascular volume. Nonsteroidal anti-inflammatory drugs (NSAID) inhibit COX enzymes and significantly lowers renal blood flow in dogs under specific conditions, such as during anesthesia and laparotomy and in conscious and anesthetized salt-depleted dogs. However, in clinically normal, conscious dogs, the administration of NSAIDs (indomethacin and meclofenamate) have no effect on renal blood flow. Indomethacin and meclofenamate increase renal vascular resistance in anesthetized cats. However, the effect of NSAIDs on renal blood flow or GFR in conscious cats is not known.
Objectives To investigate the effect of therapeutic dosages of meloxicam on the plasma clearance of iohexol (measurement of GFR) in healthy, euvolemic, conscious cats fed on sodium-replete diet.
Procedure Six healthy adult, neutered, male cats were administered either no treatment or mel-
Short-term meloxicam administration does not measurably alter the GFR as assessed via plasma clearance of iohexol. Therefore, renal prostaglandins in cats do not have a measurable effect on GFR in healthy, euvolemic, conscious states.
Inclusions Three figures, 1 table, 26 references.
Editor Annotation This study investigated the effect of therapeutic dosages of meloxicam on the plasma clearance of iohexal in healthy, euvolemic, conscious cats fed a sodium replete diet. There have been no studies in cats confirming the expression of COX isoenzymes in feline kidneys. Meloxicam was chosen, because it is presently the only NSAID approved for use in cats in the United States. Meloxicam was administered orally at 0.2 mg/kg, once daily on day 1 and 0.1 mg/kg, once daily on days 2 through 5. An iohexal clearance study was performed on day 0 (baseline) and on day 5 at 4 to 5 hours post-drug administration. A 12-day washout period was observed between treatments. During the iohexal studies, 20 ml of saline was administered to cover for maintenance fluids. Results of the study indicated that shortterm administration of meloxicam did not measurably alter the GFR in healthy, euvolemic conscious cats and assessed via plasma clearance of iohexol. Meloxicam should be well tolerated in healthy, hydrated cats at dosages and intervals used in this study. Additional studies need to be done assessing meloxicam administration in cats with renal compromise. (MM) Goodman LA, Brown SA, Torres BT, et al. Effects of meloxicam on plasma iohexol clearance as a marker of glomerular filtration rate in conscious healthy cats. Am J Vet Res 2009; 70:826-830.
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