Merkel cell carcinoma and chronic lymphocytic leukemia

s301

Posters - Skin cancer

able to produce stimulating factors for keratinocytes that lead to carcinogenesis. Clinical recognition of this rare association may be of both practical and conceptual interest. References [I] Duhra P et al., Clin Exp Dermatol 1991; 16,63-5. [2] Feinmesser M. et al., Am J Dermato pathol, 1997; 19,575-g.

IP491

Merkel cell carcinoma lymphocytic leukemia

and chronic

A.M. Viallard, N. Mathon, J. Kanitakis, X. Thomas, L. Misery, M. Faure, A. Claudy. H6pital Edouard Hcrrior, Lyott, France Merkel cell carcinoma (MCC) is an uncommon malignancy of the skin with a high rate of recurrence and metastasis. Several associations of MCC with skin carcinomas and malignant hemopathy have been reported which seem not to be fortuitous. We report a case of a 74-year-old Caucasian female patient who simultaneously presented with MCC and chronic lymphocytic leukaemia (CLL). Immunohistochemical stains were consistent with the histopathological diagnosis of MCC. CLL remained untreated. During a fifteen months follow up, two local and regional recurrences of MCC occurred whereas there was no evidence of progression of CLL. It is the eleventh case of association between MCC and CLL reported. CLL seems to be a thousand times more frequent in patients with MCC than in the general population. The simultaneous discovery of MCC and CLL does not seem to be a chance association, even though the relationship between the two tumours remains unclear. It has been suggested that actinic damage, radiation therapy, and immunologic disorders may contribute to its development. The prognosis of MCC implies that immunodepression is a possible contributory factor. P492 El

An epitheloid hemangio endothelioma treated with adriamycine-vancomycine

N. Doss, M.R. Dhaoui, A. Bouziani, A. Ben Rejeb, N. Ben Tekaya, K. Jaber, M. Touati. Dermarology Clinic, Miliraty Hospiral

of Tunis,

Ttmisia

A 15 year old white man, had a numerous nodular lesions on the left arm which have appeared nine months earlier. Otherwise, the general exam was unremarquable. The radiography of the left arm revealed areas of decalcification. A biopsy specimen from these lesions and the various histologic markers concluded to an epitheloid hemangio endothelioma. Treatment by the association: Vincistine and Adriamycine produced an improvement in three months. We will discuss the different treatments which have been proposed in the epitheloid hemangio enthelioma and their different results. P493 El

Coastal microclimate: of coastal areas

High skin cancer

B. Kirby, H. Saunders, P.V. Harrison. Deparmtetrl Dertttarology,

Queen

Wcroria

Hospital,

rate

of

Morecatttbe,

There are many risk factors for the development melanoma skin cancers (NMSC).

UK

of non-

Epidemiological data suggests that our coastal area has a higher rate compared to inland regions. The amount of solar radiation reaching the earth’s surface is dependent upon cloud cover and local ozone levels. Pollution increases ozone production and hence the amount of solar radiation. Low pollution on the coast line therefore leads to higher levels of radiation. This combined with coastal breezes results in a 5-10% increase in coastal sunshine over an entire year. Measurements from weather stations along our coast and inland show a significantly higher sunshine level along the coast. This was also seen in measurements from the Isle of Man where NMSC rates are also higher. We suggest that this maybe a factor in the higher NMSC rates in our area. I P494 Face and scalp angiosarcoma A.C.F.S. Dionysio, C.L. Moraes, M.J.L.C. Marques. I.A.S.E.R.J.,

Rio de Janeiro,

Brazil

Angiosarcoma is a rare tumor of vascular endothelium. Cutaneous angiosarcoma predominantly occurs on the scalp and face of elderly men. Initial clinical presentation and inconclusive histology may lead to a delay in diagnosis. The effective treatment and prognosis relies on early diagnosis due to the tumor’s tendency to be highly aggressive, multicentric and deeply invasive with ill defined borders. A 70-year-old woman was referred to us presenting a indurated well demarcated bluish-violaceous erythematous plaque with 2 x 4 cm on the left retroauricular area, which have appeared three months before.The second biopsy specimen was compatible with angiosarcoma. The tumor evolved with rapid progressive local spread extending to the left hemiface and with development of new lesions on the right temporal, retroauricular and occipital areas. Due to the extension of the tumor, the patient has been considered beyond any possibility of therapy after six months of the beginning of the symptoms and died after 11 months. The authors clarify the clinical presentation and emphasise the crucial importance of a early diagnosis. I P495

Skin cancer registry (1992-l 996)

in Santiago,

Chile

V. Zemelman, 0. Alvarado. I. Araya, R von Beck, C. de la Cruz, V. Garcia, E. Faundez, N. Navarrete, G. Pino, J. Sandoval, G. Zamalloa. Dermatology Department, Universidad

de Chile,

SanGago,

Chile

The world-wide concern about the rising incidence of skin cancer and the fact that the ozone hole has expanded over the southern cities of South America has motivated us to investigate the skin cancer cases registered in five hospitals of Santiago, Chile, between 1st January 1992 until 31st of December 1996. Aproximately 250000 pathology reports were studied. The participating pathology laboratories served the population covered by aproximately 4000000 people. All cases with primary Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC) and Malignant Melanoma (MM) were registered. Pathological data included sex, age of patient and anatomical site of lesion. A total of 3228 primary tumours was retrieved, (1510 males, 1718 females) with 2147 (66.5%) BCC (928 males, 1219 females) 767 (23.8%) SCC (452 males, 315 females); 314 (9.7%) MM