Mesenteric Ischemia-Reperfusion (IR) Injury Enhances Mouse Chemokine Production and Results in Injury to Multiple Organs

ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS 14.4. Insulin Activates JNK in Primary Rat Hepatocytes. I. C. Nweze, J. W. Smith, J. Lakshmanan, B. Zhang, B. G. Harbrecht; University of Louisville Department of Surgery, Louisville, KY

14.5. Examination of the Effect of Host-microbe Dynamics on Bacterial Virulence Activation in the Pathogenesis of Surgical Site Infection Using an Agent-based Model. V. Gopalakrishnan,1 M. Kim,2 J. Alverdy,2 G. An2; 1Johns Hopkins University, Baltimore, MD; 2University of Chicago, Chicago, IL

14.6. Bilateral Lower Extremity Amputation Wounds are associated With Distinct Local and Systemic Cytokine Response. F. A. Lisboa,1,2,4 T. S. Brown,1,2 D. K. Tadaki,1 F. A. Gage,1,2,4 B. K. Potter,3 J. A. Forsberg,1,3 E. A. Elster1,2,4; 1 Naval Medical Research Center, Silver Spring, Maryland; 2 Walter Reed National Military Medical Center, Bethesda, Maryland; 3Walter Reed National Military Medical Center, Bethesda, Maryland; 4Uniformed Services University of the Health Sciences, Bethesda, Maryland

14.7. A Closed-Abdomen Hemorrhagic Shock and Resuscitation Injury Model in Non-Human Primates: A Novel Approach to Investigating the Physiologic and Immunologic Effects of Trauma and Resuscitative Interventions. J. S. Radowsky,1,2,3 E. H. Lee,1,2,3 T. A. Davis,1 D. K. Tadaki,1,3 E. A. Elster1,2,3; 1Naval Medical Research Center, Silver Spring, Maryland; 2Walter Reed National Military Medical Center, Department of Surgery, Bethesda, Maryland; 3 Uniformed Services University of the Health Sciences, Department of Surgery, Bethesda, Maryland

14.8. Exposure to Stored Blood Products Induces A Proinflammatory Response in Primary Hepatocytes. J. R. Klune,1 M. D. Neal,1 L. McDaniel,1 G. W. Nace,1 R. Simmons,1 D. A. Geller,1 J. S. Raval,2,3 A. Tsung1; 1University of Pittsburgh Medical Center - Department of Surgery, Pittsburgh, PA; 2University of Pittsburgh Medical Center Department of Pathology, Pittsburgh, PA; 3University of North Carolina - Department of Pathology, Chapel Hill, NC

14.9. Aged Mice are More Susceptible to Candida Infection Than Young Mice in A Multi-compartment Trauma Model. K. R. Zettel,1 S. S. Darwiche,1 B. Geyer,1 M. J. Scott,1 R. A. Hoffman,1 R. S. Hotchkiss,3 R. E. Southard,2 T. R. Billiar1; 1University of Pittsburgh - Department of Surgery, Pittsburgh, PA; 2Washington University in St Louis - Dept. of Surgery, St Louis, MO; 3Washington University in St. Louis Dept. of Anesthesiology, St. Louis, MO

14.10. Flutamide Does Not Confer Benefit in Reducing Resuscitation Requirements in A Porcine Ischemia-Reperfusion Model. S. A. Satterly, M. J. Martin, M. Wingerd, Z. Hoffer, J. Stallings; Madigan Army Medical Center, Tacoma, WA

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14.11. Accelerated Lipid Metabolism After Severe Trauma. D. Burneikis,1 J. R. Stringham,1 E. E. Moore,1,2 T. L. Chin,1,2 A. Ghasabyan,2 K. C. Hansen,1 C. C. Silliman,1 A. Banerjee1; 1 University of Colorado Denver, Aurora, CO; 2Denver Health Medical Center, Denver, CO

14.12. Comparison of Viscoelastometric Assays to Traditional Activated Clotting Time for Assessing Heparin Activity in Whole Blood. M. P. Chapman,1 E. E. Moore,2 T. L. Chin,1 A. Ghasabyan,2 C. R. Ramos,1 J. R. Stringham,1 A. Banerjee1; 1 University of Colorado Denver, Aurora, CO; 2Denver Health Medical Center, Denver, CO

14.13. Outer Membrane Vesicles From Pathogenic Bacteria Initiate an Inflammatory Response in Human Endothelial Cells. M. C. Soult, N. E. Lonergan, B. Shah, L. D. Britt, C. J. Sullivan; Eastern Virginia Medical School Department of Surgery, Norfolk, VA

14.14. Interleukin-6 Neutralizing Antibody Treatment Restores Th1/Th2 Balance in Mice With Pseudo-Fracture and Hemorrhage. Y. Zhang,1,2 W. Xiang,1 K. Sebastian,1 K. Zettel,1 S. Darwiche,1 C. Cai,1 F. Ayoob,1 T. Billiar1; 1 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Hepatobiliary Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei

14.15. Xanthine Oxidase Does Not Produce Reactive Oxygen Species in Early Life-Threatening Trauma. J. R. Stringham,1 E. E. Moore,2 T. L. Chin,1 A. Ghasabyan,2 C. R. Ramos,1 M. Chapman,1 K. C. Hansen,1 C. C. Silliman,1 A. Banerjee1; 1University of Colorado Denver, Aurora, CO; 2 Denver Health Medical Center, Denver, CO

14.16. Ethanol Decreases Microvascular Leak Due to Ischemia-Reperfusion Injury. A. Garcia, G. P. Victorino; UCSF-East Bay Department of Surgery, Oakland, CA

14.17. Bilateral Near Infrared Spectroscopy: A Potential Tool for Detecting Traumatic Vascular Injury. R. M. Van Haren, M. L. Ryan, C. M. Thorson, E. Curia, A. M. Busko, N. Namias, A. S. Livingstone, K. G. Proctor; Daughtry Dept of Surgery, University of Miami Miller School of Medicine and Ryder Trauma Center, Miami, FL

14.18. Mesenteric Ischemia-Reperfusion (IR) Injury Enhances Mouse Chemokine Production and Results in Injury to Multiple Organs. R. S. Jawa, C. W. Boyer, E. E. Quist, V. K. Shostrom, D. W. Mercer; University of Nebraska Medical Center, Omaha, NE