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Meta-analysis of antimicrobial prophylaxis for recurrent acute otitis media
INTERNATW4LJOMLNALOF
Pediatric
ELSEVIER SClENCt IRELAND
International
Journal of Pediatric Otorhinolaryngology 28 (1994) 261-275
Selected abstracts and references generated from EMBASE
Abstracts Sudden cardiac arrest during adenotonsillectomy Benton N.C.; Wolgat R.A.
in a patient with subclinical Duchenne’s muscular dystrophy
EAR NOSE THROAT J. (1993) 72/2 (130-133) We describe a four-year-old boy of Indian descent who had elective adenotonsillectomy for chronic sore throat and partial airway obstruction. About IO min into the procedure, the patient suddenly developed cardiac asystole. After prolonged cardiac resuscitation, recovery was achieved. No permanent neurologic deficits resulted. The child was later found to have a strong family history of Duchenne’s muscular dystrophy (DMD) and an elevated serum creatine kinase level documented since shortly after birth. We reviewed several case reports substantiating the risk for cardiac arrest during general anesthesia in DMD patients, and we concluded that DMD is a little-known risk for cardiac arrest during general anesthesia. The otolaryngologist must be aware of this potential complication. because tonsillectomy and adenoidectomy are commonly indicated for children at an age when DMDmay be subclinical. Meta-analysis of antimicrobial prophylaxis for recurrent acute otitis media Bonati M.; Marchetti F.; Pistotti V.; Agostini M.; Bisogno G.; Russi R.; Davico S.; De Santis M.; Forno S.; Gangemi M.; Merlin D.; Merlo M.; Murgia V.; Pivetta S.; Raimo F.; Tamburlini G. CLIN. TRIALS META-ANAL YS. (1992) 2811 (39-50) Eight randomised controlled trials of the chemoprophylaxis of recurrent otitis media in children made over the past 15 years were reviewed as part of a training project by a group of paediatric practitioners. A total of 420 children were treated using five drugs. Comparisons made using odds ratios with conlidence intervals provided significant evidence of prevention of recurrence with all agents. Deficiencies of quality apparent in some of the studies did not diminish the significance of the findings. A large enough collaborative trial is needed with careful long-term follow-up to confirm that chemoprophylaxis not only prevents acute otitis media but also reduces the frequency of possible sequelae (otitis media with effusion associated with learning disabilities and behavioural problems). Future findings could help better define the whole management of this challenging and controversial paediatric condition. The prevalence of tympanostomy tubes in children in the United States, I988 Bright R.A.; Moore R.M. Jr.; Jeng L.L.; Sharkness C.M.; Hamburger S.E.; Hamilton P.M. AM. J. PUBLIC HEALTH (1993) 8317 (1026-1028) Information from the 1988 National Health Interview Survey Medical Device Implant Supplement was used to obtain the first population estimates of the prevalence of implanted tympanostomy tubes. a common treatment for otitis media. The prevalence rate was estimated to be I3 per 1000 chrldren aged younger than 18 years. Statistically significant differences in prevalence were found for sex (boys. I511000: girls, 1011000). race (Whites, 15/1000; others. 411000). and activity level (‘limited.’ 4411000; others. I l/1000). Thirty percent of the tubes were replacements; infection was the reason for 75% of the original implants. The morbidity and costs associated with tympanostomy !ubes are of public health importance.
0165-5876/94/$07.00 0 1994 Elsevier Science Ireland SSDI 016%5876(93)01005-5
Ltd. All rights reserved.
Pediatric
ELSEVIER SClENCt IRELAND
International
Journal of Pediatric Otorhinolaryngology 28 (1994) 261-275
Selected abstracts and references generated from EMBASE
Abstracts Sudden cardiac arrest during adenotonsillectomy Benton N.C.; Wolgat R.A.
in a patient with subclinical Duchenne’s muscular dystrophy
EAR NOSE THROAT J. (1993) 72/2 (130-133) We describe a four-year-old boy of Indian descent who had elective adenotonsillectomy for chronic sore throat and partial airway obstruction. About IO min into the procedure, the patient suddenly developed cardiac asystole. After prolonged cardiac resuscitation, recovery was achieved. No permanent neurologic deficits resulted. The child was later found to have a strong family history of Duchenne’s muscular dystrophy (DMD) and an elevated serum creatine kinase level documented since shortly after birth. We reviewed several case reports substantiating the risk for cardiac arrest during general anesthesia in DMD patients, and we concluded that DMD is a little-known risk for cardiac arrest during general anesthesia. The otolaryngologist must be aware of this potential complication. because tonsillectomy and adenoidectomy are commonly indicated for children at an age when DMDmay be subclinical. Meta-analysis of antimicrobial prophylaxis for recurrent acute otitis media Bonati M.; Marchetti F.; Pistotti V.; Agostini M.; Bisogno G.; Russi R.; Davico S.; De Santis M.; Forno S.; Gangemi M.; Merlin D.; Merlo M.; Murgia V.; Pivetta S.; Raimo F.; Tamburlini G. CLIN. TRIALS META-ANAL YS. (1992) 2811 (39-50) Eight randomised controlled trials of the chemoprophylaxis of recurrent otitis media in children made over the past 15 years were reviewed as part of a training project by a group of paediatric practitioners. A total of 420 children were treated using five drugs. Comparisons made using odds ratios with conlidence intervals provided significant evidence of prevention of recurrence with all agents. Deficiencies of quality apparent in some of the studies did not diminish the significance of the findings. A large enough collaborative trial is needed with careful long-term follow-up to confirm that chemoprophylaxis not only prevents acute otitis media but also reduces the frequency of possible sequelae (otitis media with effusion associated with learning disabilities and behavioural problems). Future findings could help better define the whole management of this challenging and controversial paediatric condition. The prevalence of tympanostomy tubes in children in the United States, I988 Bright R.A.; Moore R.M. Jr.; Jeng L.L.; Sharkness C.M.; Hamburger S.E.; Hamilton P.M. AM. J. PUBLIC HEALTH (1993) 8317 (1026-1028) Information from the 1988 National Health Interview Survey Medical Device Implant Supplement was used to obtain the first population estimates of the prevalence of implanted tympanostomy tubes. a common treatment for otitis media. The prevalence rate was estimated to be I3 per 1000 chrldren aged younger than 18 years. Statistically significant differences in prevalence were found for sex (boys. I511000: girls, 1011000). race (Whites, 15/1000; others. 411000). and activity level (‘limited.’ 4411000; others. I l/1000). Thirty percent of the tubes were replacements; infection was the reason for 75% of the original implants. The morbidity and costs associated with tympanostomy !ubes are of public health importance.
0165-5876/94/$07.00 0 1994 Elsevier Science Ireland SSDI 016%5876(93)01005-5
Ltd. All rights reserved.