- Email: [email protected]
Metabolic patterns associated with depressive symptoms in schizophrenia
604
Abstracls
nlO1.IISYClUATRY 19%:39:500-666
351. METABOLIC PATTERNS ASSOCIATED WITH DEPRESSIVE SYMPTOMS IN SCHIZOPHRENIA C. Kohler, R.C. OUf, L. Harper Mozley, C.L. Swanson Jr.. & R.E. Our Mentnt Health Clinical Research Ccntllr, Universily of Pennsylvania. Philac.lelphiil. PA 19104 Symptom!i of depression are common in patients with schizophrenia anti tho pathophysiology is um:lcar. 1n organic mood dL~ordcrs and in affective disorders reduced lert relative to right frontal metabolic activity has been associated with depressed mood. We examined 28 patienl~ wilh schizophrenia (DSM-III-R), who underwent comprehensive evaluations during exacerb::uion of symptoms. These included PET fluorodeoxyglucase (FOG) scans to tletenninc cerebrJt glucose metabolism lind the Hamilton Depression Rating Scale (HDRS). with subscores for cognitive and vegetative symptoms, The patients (19 men and 9 women) were off neuroleptics and were matched with 28 heallhy controls. FDG·PET images were cross-rcgL~tcrcd with MRI selms and cerebral metabolic rates for glucl'tse were determined for 10 regions. selected a priori ~causc thcy were implicatctl in earlier studics of depression. Eltumina· lion of regional brain metabolism revealed no differences between healthy controls and patient'>. and no signiricam correlation with toull HRDS score (rnnge 8-31. mean: 18.75). For region to whole broin metabolism. positive correlations (all p
352. FDOPA UPTAKE IN SCHIZOPHRENIA: A PET STUDY S.O. Potkin, J.e. Wu, E.A. Klein, N. Khosla, A. Najafi, & L. LaCasse Brain Imaging Center. Departmcnt of Psychiatry, University of California ill Irvine. Irvine. CA 92717 The objective of this study WIIS to lIssess dopamincrgic function in schizophrenic patients relativc 10 nonnal controls using positron emission tomography studies of FDOPA uptake. Ten schizophrenic inpatients (llge 24,S ± 6.0 YLlllrs. 9m. 10 meeting DSM-IlI-R (]illgnoslic criteria for schizophrenia were j;tudied along with IS normul controls (llge==2S.5 :: 9.7 years. 9m. 60. five of the paticnls were on placebo ond the other live were in double-blind studies for which the code hml not been broken. PET studies were pcrfonned on tl Neuroccot IV system wilh FWHM of 7.6mm In·pl:mt. Each subject rcccivctl 2.0-4,0 mCi of 6-FD. Twelve len minute scans were performed. FDOPA uptake WIlS detcnnined (Martin et
=
al 1989). FDOPA uptake was gr..lphically represented pixel by pixel. Nonnal conlrols had significantly (p
353. SEX DIFFERENCES IN PET FDOPA UPTAKE
E.A. Klein &
J.e. Wu
Brain Imaging Centcr. Departmenl of Psychiatry, University of California at Irvine. Irvine. CA 92717 The objective of this slUdy WtlS to uscenain h, 1';1'0 sex differences in dopamine mctabolism in hllallhy individuals, Five females (28.6 :!: 11.15 years) and eight males (30.88 ± 15.56 yean» who were free of psychiatric illness were scanned on a Ncuroecat lV system 'With FWHM of 7.6mm in-plane. Each subject received 2.0 - 4.0 mCi of 6-FD. Twelve len·minute scans were pcrfonned and uscd to calculate FDOPA uptake based on a prolocol developed by Martin el al (Martin WR. Palmer MR. Patlnk CS. et al. Antlals of Nt'urofogy 1989;26(4):535-42). For each individual. uptake values were calculated 10 generate a two-dimensionlll brain FDOPA uptake mllp. Group images were averaged together and subjcclcd to a Student's t·test to yield statistical parametric mllps of significant between-group differences. Regions of statistical significance were then subjccted to MANOVA analysis. Overall mOPA uptake throughout the striale was 34% higher in females al a non-sigi111icllnt level (p=O.23). However, this elevation was significanl in areas corre!'Ip-onding 10 the left pUlamen (p
354. THE EFFECTS OF METABOLIC AND COGNITIVE STRESS ON CEREBRAL BLOOD FLOW I. Elman, N. Wiesenfeld, T.P. Su, A.K. Malhotra, D. Pickar, & A. Breier Experimental Therapcutics Bmnch, Nalional Institute of Mental Health. NIH. Bethesda. MD Illuminating the effects of stress on bruin function would have important impliclltions for understanding normal cognitive processes und the pathophysiology of neuropsychiatric illness. Allhough extcnsively investigated in laboratory animals. there is relatively lillie infonnlltion about the direct impact of stress on local cerebral brain function from humlln studies, Since there Drc different "types" of stress. it Is likely that individual bruin regions may have cJifferential responses predicated on the type of stressor. With the aim of dctcnnining the differential impact of strcliS on humlln bruin function, we examined the effecls of two
Abstracls
nlO1.IISYClUATRY 19%:39:500-666
351. METABOLIC PATTERNS ASSOCIATED WITH DEPRESSIVE SYMPTOMS IN SCHIZOPHRENIA C. Kohler, R.C. OUf, L. Harper Mozley, C.L. Swanson Jr.. & R.E. Our Mentnt Health Clinical Research Ccntllr, Universily of Pennsylvania. Philac.lelphiil. PA 19104 Symptom!i of depression are common in patients with schizophrenia anti tho pathophysiology is um:lcar. 1n organic mood dL~ordcrs and in affective disorders reduced lert relative to right frontal metabolic activity has been associated with depressed mood. We examined 28 patienl~ wilh schizophrenia (DSM-III-R), who underwent comprehensive evaluations during exacerb::uion of symptoms. These included PET fluorodeoxyglucase (FOG) scans to tletenninc cerebrJt glucose metabolism lind the Hamilton Depression Rating Scale (HDRS). with subscores for cognitive and vegetative symptoms, The patients (19 men and 9 women) were off neuroleptics and were matched with 28 heallhy controls. FDG·PET images were cross-rcgL~tcrcd with MRI selms and cerebral metabolic rates for glucl'tse were determined for 10 regions. selected a priori ~causc thcy were implicatctl in earlier studics of depression. Eltumina· lion of regional brain metabolism revealed no differences between healthy controls and patient'>. and no signiricam correlation with toull HRDS score (rnnge 8-31. mean: 18.75). For region to whole broin metabolism. positive correlations (all p
352. FDOPA UPTAKE IN SCHIZOPHRENIA: A PET STUDY S.O. Potkin, J.e. Wu, E.A. Klein, N. Khosla, A. Najafi, & L. LaCasse Brain Imaging Center. Departmcnt of Psychiatry, University of California ill Irvine. Irvine. CA 92717 The objective of this study WIIS to lIssess dopamincrgic function in schizophrenic patients relativc 10 nonnal controls using positron emission tomography studies of FDOPA uptake. Ten schizophrenic inpatients (llge 24,S ± 6.0 YLlllrs. 9m. 10 meeting DSM-IlI-R (]illgnoslic criteria for schizophrenia were j;tudied along with IS normul controls (llge==2S.5 :: 9.7 years. 9m. 60. five of the paticnls were on placebo ond the other live were in double-blind studies for which the code hml not been broken. PET studies were pcrfonned on tl Neuroccot IV system wilh FWHM of 7.6mm In·pl:mt. Each subject rcccivctl 2.0-4,0 mCi of 6-FD. Twelve len minute scans were performed. FDOPA uptake WIlS detcnnined (Martin et
=
al 1989). FDOPA uptake was gr..lphically represented pixel by pixel. Nonnal conlrols had significantly (p
353. SEX DIFFERENCES IN PET FDOPA UPTAKE
E.A. Klein &
J.e. Wu
Brain Imaging Centcr. Departmenl of Psychiatry, University of California at Irvine. Irvine. CA 92717 The objective of this slUdy WtlS to uscenain h, 1';1'0 sex differences in dopamine mctabolism in hllallhy individuals, Five females (28.6 :!: 11.15 years) and eight males (30.88 ± 15.56 yean» who were free of psychiatric illness were scanned on a Ncuroecat lV system 'With FWHM of 7.6mm in-plane. Each subject received 2.0 - 4.0 mCi of 6-FD. Twelve len·minute scans were pcrfonned and uscd to calculate FDOPA uptake based on a prolocol developed by Martin el al (Martin WR. Palmer MR. Patlnk CS. et al. Antlals of Nt'urofogy 1989;26(4):535-42). For each individual. uptake values were calculated 10 generate a two-dimensionlll brain FDOPA uptake mllp. Group images were averaged together and subjcclcd to a Student's t·test to yield statistical parametric mllps of significant between-group differences. Regions of statistical significance were then subjccted to MANOVA analysis. Overall mOPA uptake throughout the striale was 34% higher in females al a non-sigi111icllnt level (p=O.23). However, this elevation was significanl in areas corre!'Ip-onding 10 the left pUlamen (p
354. THE EFFECTS OF METABOLIC AND COGNITIVE STRESS ON CEREBRAL BLOOD FLOW I. Elman, N. Wiesenfeld, T.P. Su, A.K. Malhotra, D. Pickar, & A. Breier Experimental Therapcutics Bmnch, Nalional Institute of Mental Health. NIH. Bethesda. MD Illuminating the effects of stress on bruin function would have important impliclltions for understanding normal cognitive processes und the pathophysiology of neuropsychiatric illness. Allhough extcnsively investigated in laboratory animals. there is relatively lillie infonnlltion about the direct impact of stress on local cerebral brain function from humlln studies, Since there Drc different "types" of stress. it Is likely that individual bruin regions may have cJifferential responses predicated on the type of stressor. With the aim of dctcnnining the differential impact of strcliS on humlln bruin function, we examined the effecls of two