- Email: [email protected]
Metabolism Under Control
the cardiovascular complications of diabetes from a somewhat non-traditional perspective and contains a good discussion of some of the vasoactive properties of nitric oxide. The final section of Volume II contains two chapters on non-type 2 diabetes insulin resistance syndromes, chapters on dietary and lifestyle man-
agement of diabetes and obesity, which don’t quite fit with the rest of the book, and a superb closing chapter on Syndrome X. Both volumes of this textbook are good references for type 2 diabetes mellitus and should be valuable to a wide range of physicians, scientists, and students in training as well as re-
Metabolism Under Control Understanding the Control of Metabolism. Frontiers in Metabolism 2. By David Fell. London, Portland Press, 1997, £18.95/$30.00 (xii + 301 pages), ISBN 1-85578-047-X. Understanding the Control of Metabolism presents the theory, experimental strategies, and application of metabolic control analysis as it applies to biochemical pathways and processes. The book is appropriate for advanced undergraduate and graduate students studying enzymology and metabolism, and uses examples from plant biology to human organ systems. In this age of molecular biology and genetics, the traditional areas such as metabolic regulation are given little attention and are generally regarded as resolved long ago. Clearly this is not true. The author presents a coherent
update on the regulation of metabolism, and makes a clear argument for the utility of metabolic control analysis. Overall, this is a well written presentation of 20 plus years of metabolic control analysis. The author clearly knows his field and has strong opinions, and is not shy about presenting his arguments. He uses a broad range of examples to demonstrate complex concepts, and has a personable writing style that adds continuity and cohesion to the text. He presents solid and constructive attacks on traditional misconceptions of metabolic regulation, and gives a multitude of examples of how metabolic systems appear to function. Much of the book is spent debunking widely held misconceptions on metabolic regulation that predated the era of metabolic control analysis, such as the concept of a ‘rate-limiting enzyme’ in metabolic pathways. This discussion is particularly useful and im-
searchers and specialist practitioners in diabetes. The companion volumes will be excellent additions to any academic or hospital library. Lester B. Salans Rockefeller University and Mt. Sinai Medical School New York, NY 10021, USA PII: S1043-2760(98)00012-5
portant, and should be of great utility to anyone entering the field of metabolic regulation. While the book is thorough, it is clear that the field of metabolic control analysis is still young, and that this book is far from the last word. With the current onslaught of transgenic animals and subsequent manipulation of enzyme levels there is now a need for a more realistic and accurate analysis of regulation of metabolic systems. This book may be of special interest to those working in this aspect of metabolism. Most of the examples given are from classic studies of net flux through an enzyme or pathway. There is limited discussion of tracer methodology and the use of tracers to study metabolic regulation in vivo. The book would have been strengthened if this area had been addressed more fully. William C. Stanley Department of Physiology and Biophysics Case Western Reserve University Cleveland, OH 44106, USA PII: S1043-2760(98)00008-3
BOOKS RECEIVED We thank the publishers for sending us the books listed here. Those of interest to the readership of Trends in Endocrinology and Metabolism will be reviewed. Readers are invited to write book reviews by informing the Book Review Editor of the title and publisher
44
of books you wish to review. Please address all books and correspondence for book reviews to Lee A. Meserve, PhD, Book Reviews, Trends in Endocrinology and Metabolism, c/o Department of Biological Sciences, Room 217 Life Sciences Building, Bowling Green State
© 1998, Elsevier Science Ltd, 1043-2760/98/$19.00.
University, Bowling Green, OH 434030212, USA. Nitric Oxide Protocols. Edited by Michael A. Titheradge. Totowa, Humana, 1998, $59.50 (xi + 324 pages), ISBN 0-896-03537-9.
TEM Vol. 9, No. 1, 1998
agement of diabetes and obesity, which don’t quite fit with the rest of the book, and a superb closing chapter on Syndrome X. Both volumes of this textbook are good references for type 2 diabetes mellitus and should be valuable to a wide range of physicians, scientists, and students in training as well as re-
Metabolism Under Control Understanding the Control of Metabolism. Frontiers in Metabolism 2. By David Fell. London, Portland Press, 1997, £18.95/$30.00 (xii + 301 pages), ISBN 1-85578-047-X. Understanding the Control of Metabolism presents the theory, experimental strategies, and application of metabolic control analysis as it applies to biochemical pathways and processes. The book is appropriate for advanced undergraduate and graduate students studying enzymology and metabolism, and uses examples from plant biology to human organ systems. In this age of molecular biology and genetics, the traditional areas such as metabolic regulation are given little attention and are generally regarded as resolved long ago. Clearly this is not true. The author presents a coherent
update on the regulation of metabolism, and makes a clear argument for the utility of metabolic control analysis. Overall, this is a well written presentation of 20 plus years of metabolic control analysis. The author clearly knows his field and has strong opinions, and is not shy about presenting his arguments. He uses a broad range of examples to demonstrate complex concepts, and has a personable writing style that adds continuity and cohesion to the text. He presents solid and constructive attacks on traditional misconceptions of metabolic regulation, and gives a multitude of examples of how metabolic systems appear to function. Much of the book is spent debunking widely held misconceptions on metabolic regulation that predated the era of metabolic control analysis, such as the concept of a ‘rate-limiting enzyme’ in metabolic pathways. This discussion is particularly useful and im-
searchers and specialist practitioners in diabetes. The companion volumes will be excellent additions to any academic or hospital library. Lester B. Salans Rockefeller University and Mt. Sinai Medical School New York, NY 10021, USA PII: S1043-2760(98)00012-5
portant, and should be of great utility to anyone entering the field of metabolic regulation. While the book is thorough, it is clear that the field of metabolic control analysis is still young, and that this book is far from the last word. With the current onslaught of transgenic animals and subsequent manipulation of enzyme levels there is now a need for a more realistic and accurate analysis of regulation of metabolic systems. This book may be of special interest to those working in this aspect of metabolism. Most of the examples given are from classic studies of net flux through an enzyme or pathway. There is limited discussion of tracer methodology and the use of tracers to study metabolic regulation in vivo. The book would have been strengthened if this area had been addressed more fully. William C. Stanley Department of Physiology and Biophysics Case Western Reserve University Cleveland, OH 44106, USA PII: S1043-2760(98)00008-3
BOOKS RECEIVED We thank the publishers for sending us the books listed here. Those of interest to the readership of Trends in Endocrinology and Metabolism will be reviewed. Readers are invited to write book reviews by informing the Book Review Editor of the title and publisher
44
of books you wish to review. Please address all books and correspondence for book reviews to Lee A. Meserve, PhD, Book Reviews, Trends in Endocrinology and Metabolism, c/o Department of Biological Sciences, Room 217 Life Sciences Building, Bowling Green State
© 1998, Elsevier Science Ltd, 1043-2760/98/$19.00.
University, Bowling Green, OH 434030212, USA. Nitric Oxide Protocols. Edited by Michael A. Titheradge. Totowa, Humana, 1998, $59.50 (xi + 324 pages), ISBN 0-896-03537-9.
TEM Vol. 9, No. 1, 1998