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Midface trauma and reconstruction
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Abstracts
Midface trauma and reconstruction
flap reconstruction. The latter is much better in providing linear delineation and volume replacement but not volume outline and configuration. Despite significant advances in 3D material printing, the potential of 3D printing for patient specific implants and tissue reconstruction has not been fully exploited. One of the main challenges remains the use of 3D printed scaffolds with or without the additional use of biodegradable materials as foundations for prefabricated flaps. This leads to an improved outline configuration, which in conjunction with a more accurate surgical planning may improve the facial symmetry in “difficult” areas and may also improve the accurate representation of the reconstructed soft/bone tissue “envelope”. We present results of 3D printed scaffolds integrated with soft tissue flap reconstruction; we also present results of combined biodegradable materials with flap prefabrication in addressing issues such inner mucosal lining of the upper aerodigestive tract.
D. Kademani
http://dx.doi.org/10.1016/j.ijom.2017.02.097
North Memorial and Hubert Humphrey Cancer Center, MN, United States
Translation medicine in oral cancer detection and prevention
identification of these specific genes in salivary gland tumour leads to the recognition of new entities and reclassification of other salivary gland tumours. We analysed the frequencies and clinicopathological features of salivary carcinomas using molecular analysis and could confirm multiple correlations. We studied the mucoepidermoid carcinomas and found that the tumours with CRTC1/3-MAML2 fusion may be associated with favourable clinicopathological features. Further, in MASC an unknown (non-NTRK) gene appeared to fuse with ETV6 (ETV6-X fusion) and the MASC-possessing ETV6-X fusion might show an invasive histology. These findings provide a novel insight into the oncogenesis, histopathology, diagnosis, treatment, and prognosis of salivary gland carcinomas. http://dx.doi.org/10.1016/j.ijom.2017.02.094
Midfacial reconstruction is one of the most complex areas of facial reconstruction. This lecture will review current contemporary methods for midface reconstruction for post ablative and traumatic defects using current technology. http://dx.doi.org/10.1016/j.ijom.2017.02.095 Novel strategies for management of early oral cancer and dysplasia D. Kademani North Memorial and Hubert Humphrey Cancer Center, MN, United States Oral cancer continues to be a significant global health care issue. In the past 30 years there have been limited improvements in patient survival primarily due to over 50% of patients being diagnosed with advanced stage disease at presentation. Currently effective screening tools and risk assessment of preneoplastic diseases are unreliable. This lecture will highlight the current data related to the management of early stage oral cancer and dysplasia and provide guidelines for treatment based on current available evidence. http://dx.doi.org/10.1016/j.ijom.2017.02.096 Head and neck surgery: integration of technology and reconstruction (three-dimensional planning, materials and reconstruction) N. Kalavrezos University College London Hospitals, London, United Kingdom Successful facial reconstruction aims to provide external wound coverage, creation of a stable oral cavity, bony restoration, resumption of oral diet, dental restoration and cosmesis. Most of those goals are achieved by conventional free flap reconstruction. Some of the most notable exceptions leading to repetitive surgical procedures include the reconstruction of the mid-face and the provision of “one-stop” dental rehabilitation with osseointegrated dental implants. This is because areas with complex three-dimensional (3D) anatomy pose indeed a substantial problem in conventional
S. Kao Taipei Veterans General Hospital, Taipei, Chinese Taipei Oral cancer (OC), mostly oral squamous cell carcinoma, is a very prevalent cancer worldwide. This cancer is also the fourth leading malignancy in the male population of Taiwan due to the abuse of areca (betel) chewing, tobacco smoking and alcohol drinking. Besides, there is a tendency that the incidence of OC continuously climbed up in the past decades, and OC is now the most prevalent malignancy in men below 40 years old in Taiwan. The survival for OC patients around the world has remained unimproved in the past decades. About 50% patients die of disease during 5-year period. The local recurrence, metastases and resistance to conventional therapy are the major reasons for the treatment failure. OC is aetiologically linked to the exposure to chemical carcinogens, which renders field cancerisation and clonal expansion of neoplastic cells. The pathogenesis of OC takes a multi-step and multi-hit process. The understanding of impaired molecules involved in initiation, progression and metastasis will help to improve the prognosis of OC and to develop novel therapeutic regiments. The establishment of effective prevention, early diagnosis and interception of tumour development that could increase the survival are the main goal of the translation research in OC. I will use this presentation to introduce how we conduct this translation medicine research at the OC in Taipei Veterans General Hospital. This integrated teamwork will establish new diagnosis and therapeutic attempts. http://dx.doi.org/10.1016/j.ijom.2017.02.098 Augmentation of severe bony defects with intraoral bone grafts: biological approach and long-term results F. Khoury University of Muenster, Muenster, Germany Autogenous bone graft is still the gold standard for the reconstruction of severe atrophy of the maxilla or the mandible. Two and three-dimensional bony defects need for the reconstruction special surgical procedures with autogenous bone grafts to assure at longterm an acceptable functional and esthetical result. Biomaterials
Abstracts
Midface trauma and reconstruction
flap reconstruction. The latter is much better in providing linear delineation and volume replacement but not volume outline and configuration. Despite significant advances in 3D material printing, the potential of 3D printing for patient specific implants and tissue reconstruction has not been fully exploited. One of the main challenges remains the use of 3D printed scaffolds with or without the additional use of biodegradable materials as foundations for prefabricated flaps. This leads to an improved outline configuration, which in conjunction with a more accurate surgical planning may improve the facial symmetry in “difficult” areas and may also improve the accurate representation of the reconstructed soft/bone tissue “envelope”. We present results of 3D printed scaffolds integrated with soft tissue flap reconstruction; we also present results of combined biodegradable materials with flap prefabrication in addressing issues such inner mucosal lining of the upper aerodigestive tract.
D. Kademani
http://dx.doi.org/10.1016/j.ijom.2017.02.097
North Memorial and Hubert Humphrey Cancer Center, MN, United States
Translation medicine in oral cancer detection and prevention
identification of these specific genes in salivary gland tumour leads to the recognition of new entities and reclassification of other salivary gland tumours. We analysed the frequencies and clinicopathological features of salivary carcinomas using molecular analysis and could confirm multiple correlations. We studied the mucoepidermoid carcinomas and found that the tumours with CRTC1/3-MAML2 fusion may be associated with favourable clinicopathological features. Further, in MASC an unknown (non-NTRK) gene appeared to fuse with ETV6 (ETV6-X fusion) and the MASC-possessing ETV6-X fusion might show an invasive histology. These findings provide a novel insight into the oncogenesis, histopathology, diagnosis, treatment, and prognosis of salivary gland carcinomas. http://dx.doi.org/10.1016/j.ijom.2017.02.094
Midfacial reconstruction is one of the most complex areas of facial reconstruction. This lecture will review current contemporary methods for midface reconstruction for post ablative and traumatic defects using current technology. http://dx.doi.org/10.1016/j.ijom.2017.02.095 Novel strategies for management of early oral cancer and dysplasia D. Kademani North Memorial and Hubert Humphrey Cancer Center, MN, United States Oral cancer continues to be a significant global health care issue. In the past 30 years there have been limited improvements in patient survival primarily due to over 50% of patients being diagnosed with advanced stage disease at presentation. Currently effective screening tools and risk assessment of preneoplastic diseases are unreliable. This lecture will highlight the current data related to the management of early stage oral cancer and dysplasia and provide guidelines for treatment based on current available evidence. http://dx.doi.org/10.1016/j.ijom.2017.02.096 Head and neck surgery: integration of technology and reconstruction (three-dimensional planning, materials and reconstruction) N. Kalavrezos University College London Hospitals, London, United Kingdom Successful facial reconstruction aims to provide external wound coverage, creation of a stable oral cavity, bony restoration, resumption of oral diet, dental restoration and cosmesis. Most of those goals are achieved by conventional free flap reconstruction. Some of the most notable exceptions leading to repetitive surgical procedures include the reconstruction of the mid-face and the provision of “one-stop” dental rehabilitation with osseointegrated dental implants. This is because areas with complex three-dimensional (3D) anatomy pose indeed a substantial problem in conventional
S. Kao Taipei Veterans General Hospital, Taipei, Chinese Taipei Oral cancer (OC), mostly oral squamous cell carcinoma, is a very prevalent cancer worldwide. This cancer is also the fourth leading malignancy in the male population of Taiwan due to the abuse of areca (betel) chewing, tobacco smoking and alcohol drinking. Besides, there is a tendency that the incidence of OC continuously climbed up in the past decades, and OC is now the most prevalent malignancy in men below 40 years old in Taiwan. The survival for OC patients around the world has remained unimproved in the past decades. About 50% patients die of disease during 5-year period. The local recurrence, metastases and resistance to conventional therapy are the major reasons for the treatment failure. OC is aetiologically linked to the exposure to chemical carcinogens, which renders field cancerisation and clonal expansion of neoplastic cells. The pathogenesis of OC takes a multi-step and multi-hit process. The understanding of impaired molecules involved in initiation, progression and metastasis will help to improve the prognosis of OC and to develop novel therapeutic regiments. The establishment of effective prevention, early diagnosis and interception of tumour development that could increase the survival are the main goal of the translation research in OC. I will use this presentation to introduce how we conduct this translation medicine research at the OC in Taipei Veterans General Hospital. This integrated teamwork will establish new diagnosis and therapeutic attempts. http://dx.doi.org/10.1016/j.ijom.2017.02.098 Augmentation of severe bony defects with intraoral bone grafts: biological approach and long-term results F. Khoury University of Muenster, Muenster, Germany Autogenous bone graft is still the gold standard for the reconstruction of severe atrophy of the maxilla or the mandible. Two and three-dimensional bony defects need for the reconstruction special surgical procedures with autogenous bone grafts to assure at longterm an acceptable functional and esthetical result. Biomaterials