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Mild N-deacylation of secondary amides by alkylation with organocerium reagents
Chinese Chemical Letters 26 (2015) 1055–1058
Contents lists available at ScienceDirect
Chinese Chemical Letters journal homepage: www.elsevier.com/locate/cclet
Original article
Mild N-deacylation of secondary amides by alkylation with organocerium reagents Ai-E Wang *, Zong Chang 1, Yong-Peng Liu 1, Pei-Qiang Huang * Department of Chemistry, College of Chemistry and Chemical Engineering, and Fujian Provincial Key Laboratory of Chemical Biology, Xiamen University, Xiamen 361005, China
A R T I C L E I N F O
A B S T R A C T
Article history: Received 3 April 2015 Received in revised form 4 May 2015 Accepted 11 May 2015 Available online 30 May 2015
Secondary amides are a class of highly stable compounds serving as versatile starting materials, intermediates and directing groups (amido groups) in organic synthesis. The direct deacylation of secondary amides to release amines is an important transformation in organic synthesis. Here, we report a protocol for the deacylation of secondary amides and isolation of amines. The method is based on the activation of amides with Tf2O, followed by addition of organocerium reagents, and acidic work-up. The reaction proceeded under mild conditions and afforded the corresponding amines, isolated as their hydrochloride salts, in good yields. In combination with the C–H activation functionalization methodology, the method is applicable to the functionalization of aniline as well as conversion of carboxylic derivatives to functionalized ketones. ß 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Keywords: N-Deacylation Amides Amines Organocerium
1. Introduction Amines are a class of organic compounds that are widespread in natural products, pharmaceuticals and biologically important compounds, and they have attracted extensive synthetic efforts [1]. Because of their high nucleophilicity, basicity and susceptibility to oxidation, amines are usually protected in the course of organic transformations to avoid undesired side reactions. The acylation of amines to amides is one of the most frequently used methods for the protection of amines. The acylated amines (amides) are well utilized in asymmetric hydrogenation of enamides [2], kinetic resolutions [3], and C–H activation reactions [4], as a result of the important protecting/directing role of acyl group. Cleavage of the amide bond, however, is difficult, because of the delocalization of the electrons across the amide. The conventional N-deacylation of amides, such as hydrolysis, alcoholysis and transamidation, are usually performed under harsh reaction conditions, such as use of strong acids or bases, and at high temperature [5]. In the last decade, as the C–H bond activation has progressively become a well-established synthetic tool [4], the
* Corresponding authors. E-mail addresses: [email protected] (A.-E. Wang), [email protected] (P.-Q. Huang). 1 The authors contributed equally to this work.
development of new methodologies for the facile deprotection of secondary amides has attracted special attention from synthetic chemists. For example, using triphenylphosphite chlorine complex [6] and oxalyl chloride [7] as the activating reagent respectively, Prati and Koenig have developed mild alcoholysis methods for the deacylation of secondary amides. Recently, a catalytic combination system of scandium triflate and boronic ester has been applied by Mashima [8] for the deprotection of acetylaniline derivatives under mild and neutral conditions. Ohshima and Morimoto have recently reported the cleavage of unactivated secondary amides bonds by ammonium salt-accelerated transamidation [9] and hydrazinolysis [10]. Using the Schwartz reagent at room temperature, Bhat [11] has developed a mild and efficient method for the chemoselective deprotection of acetamides in the presence of NBoc or N-Cbz moieties. In connection with our longstanding interest in the synthesis of bioactive alkaloids [12], our group has been in recent years engaged in the development of new C–C bond formation reactions that employ stable amides as substrates [13]. Charette’s [14] and our group [13b,c] have independently reported the transformation of secondary amides into ketones by alkylation with Grignard and organocerium reagents, respectively (Scheme 1). In this transformation, the stable secondary amides, upon activation by triflic anhydride (Tf2O) [15], are converted to reactive nitrilium ions, which react with organometallic reagents to give imines that are hydrolyzed under acidic conditions to give ketones. It is evident
http://dx.doi.org/10.1016/j.cclet.2015.05.033 1001-8417/ß 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
A.-E. Wang et al. / Chinese Chemical Letters 26 (2015) 1055–1058
1056
1) Tf 2O, 2-F-Py, DCM (0.044 mol/L) 2) RMgBr; 3) aq. HCl O R
1
O
Charette's method N H
R2
Our method
R
1
R
+ H2NR2
(1) Tf 2O, 2-F-Py, DCM (0.25 mol/L) (2) RMgBr/ CeCl3; (3) aq. HCl Scheme 1. Reductive alkylation of secondary amides with Grignard and organocerium reagents.
that acidic work-up of imines would produce amines as well. The method could thus, on the other hand, serve as an alternative way for the deprotection of secondary amides to produce primary amines. Using Grignard reagents as alkylation reagents, Charette et al. [14] have showed one example of isolation of amine moiety by an acid/base workup after hydrolysis of the corresponding imine. Such transformation, however, was performed in an extremely diluted dichloromethane solution (0.044 mol/L), which is environmentally harmful, thus preventing the scale-up of the reaction. As a result of recent interest in the development of methods for the deprotection of secondary amides, herein we report our own results on the N-deacylation of secondary amides by alkylation with organocerium reagents. 2. Experimental Melting points were uncorrected. Infrared spectra were measured using film KBr pellet techniques. 1H NMR and 13C NMR spectra were recorded on Bruker 400 MHz or 500 MHz spectrometer. Chemical shifts are expressed in d (ppm) units downfield from TMS. High-resolution mass spectra (HRMS) were recorded on a Bruker APEX II FT mass spectrometer. Silica gel (300–400 mesh) was used for flash column chromatography, eluting (unless otherwise stated) with ethyl acetate/n-hexane mixture. Ether and THF were distilled over sodium benzophenone ketyl under N2. Dichloromethane was distilled over calcium hydride under N2. Trifluoromethanesulfonic anhydride (Tf2O) was distilled over phosphorous pentoxide and was stored for no more than a week before redistilling. All other commercially available compounds were used as received. Anhydrous cerium chloride was prepared from CeCl37H2O according to the reported procedure [16]. General procedure for N-deacylation of secondary amides: Tf2O (185 mL, 1.1 mmol) was added dropwise to a cooled (0 8C) solution of amide (1.0 mmol) and 2-fluoropyridine (103 mL, 1.2 mmol) in dichloromethane (4 mL). After stirring at 0 8C for 30 min, the mixture was cannulated to a freshly prepared organocerium reagent/complex (3.0 mmol) in THF (15 mL) at 78 8C and stirred for 2 h. Aqueous HCl solution (3 mol/L, 5 mL) was added to quench the reaction and the mixture was allowed to warm to r.t. and stirred for 2 h. Ammonium hydroxide solution (25%, 5 mL) was then added to the mixture. The organic layer was separated and the aqueous phase was extracted with diethyl ether (3 10 mL). The combined organic layers were washed with brine (3 3 mL) and concentrated under reduced pressure to about 1/3 volume. The residual organic phase was then extracted with aqueous HCl solution (3 mol/L, 3 5 mL). The separated organic phase was washed with brine (5 mL), dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure, and the residue was purified by flash column chromatography on silica gel to afford ketone. The aqueous phases were combined, washed with diethyl ether (5 mL), basified with an ammonium hydroxide solution (25%, 5 mL) and back-extracted with diethyl ether (5 20 mL). The ether layers were combined, washed with brine (5 mL), dried over anhydrous MgSO4, filtered, acidified with a solution of HCl in ethyl
acetate (3 mol/L, 5 mL) and concentrated under reduced pressure to afford the desired amine hydrochloride salt. The characterization data of amine hydrochlorides 2 and ketone 3 were provided in Supporting information. 3. Results and discussion Our investigation is based on the direct alkylative deamination of secondary amides, a method developed recently from our laboratory for the synthesis of ketones [13b,c]. The N-deacylation of secondary amide 1a was chosen as the model reaction. Following the general procedure reported for the transformation of secondary amides into ketones [13b,c], a dichloromethane solution of amide 1a and 2fluoropyridine (1.2 equiv) was treated successively with 1.1 equiv of Tf2O (0 8C, 30 min) and 3.0 equiv of freshly prepared ethyl cerium regent (78 8C, 2 h), and the reaction was quenched with aqueous HCl solution. After work-up through simple acid–base extraction, only 62% of the corresponding primary amine was obtained. In our further trials to improve the yield, we found that there might be some magnesium complex of amines produced. So after the reaction was quenched with aqueous HCl solution, aqueous ammonia was added to facilitate the liberation of amines from amine–Mg complexes. In view of high volatility of amines, the final products were isolated as amine hydrochloride salts. In this way, the yield of deacylation of 1a was improved to 88%. With the optimized reaction procedures in hand, we next examined the scope of structurally different benzoylated aliphatic amines (entries 1–6, Table 1). Various acylated primary amines (1a–f) were deprotected to afford the corresponding amine hydrochloride salts 2a–f in good yield upon isolation. It should be mentioned that chiral substrates 1f, which has an a-chiral center, underwent facile N-deacylation smoothly to afford the corresponding amine hydrochloride salt 2f without any epimerization (ee value was determined by HPLC, for details see Supporting information). In addition to benzoyl group, other acyl groups such as acetyl, pivaloyl and isovaleroyl groups in 1g–k could be removed to afford amine hydrochloride salts in high yields (entries 7–11).
Table 1 Deacylation of secondary amides.a
Entry 1 2 3 4 5 6
7 8 9 10 11 12 13 14 15 16 17
Amide
R
R0
R2NH2HCl (yield %)
1a 1b 1c 1d 1e 1f
Ph(CH2)4 Ph(CH2)2 Bn c-Hex n-Bu
Ph Ph Ph Ph Ph Ph
88 76 63 87 70 77
1g 1h 1i 1j 1k 1l 1m 1n 1o 1p 1q
c-Hex c-Hex c-Hex c-Hex c-Hex Ph Ph 3,5-diMeC6H3 p-EtOC6H4 p-FC6H4 p-NCC6H4
Me t-Bu Me2CHCH2 n-C10H21 1-Adamantyl Me2CHCH2 Me Me Me Me Me
90 74 83 71 82 63 70 69 67 73 77
a Reaction conditions: Tf2O (1.1 equiv.), 2-F-Py (1.2 equiv.), DCM (0.25 mol/L), 0 8C, 30 min; then organocerium reagent (3.0 equiv.), 78 8C, 2 h; then HCl (3 mol/L, 5 mL), r.t., 2 h.
A.-E. Wang et al. / Chinese Chemical Letters 26 (2015) 1055–1058
1057
Scheme 2. Application of the deacylation in combination with functionalization methodologies.
The reaction conditions could also be applied to the deprotection of a variety of anilides derivatives (entries 12–17). The electronic properties of the functional groups did not have significant impact on the reaction time and yield. Substrates with both electron donating (1n–o) and withdrawing (1p–q) functional moieties underwent N-deacylation rapidly, affording the corresponding amine hydrochloride salts (2n–q) in excellent yields. The deprotection of cyano substituted anilide 1q went chemoselectively to furnish the corresponding p-cyano aniline hydrochloride salt 2q in 77% yield. As the secondary amides have been recently used as powerful directing groups in C–H activation/functionalization [4], several acylated amine intermediates obtained from Pd-catalyzed C–H bond activations are examined (Scheme 2). The deprotection of anilines 1r–t, the ortho-functionalization products of aniline reported respectively by Tremont, Shi and Wang [17], proceeded smoothly to give ortho-substituted anilines hydrochloride 2r–t. The deacylation method, in combination with acylation and catalytic C–H bond activations, could thus be used for orthofunctionalization of aniline. The method was also applicable to deacylation of acetanilide 1u, the b-arylation product of sp3 C–H bond reported by Daugulis [18], giving anilines hydrochloride 2u as well as ketone 3 in 91% and 87% yield, respectively. The recovered aniline hydrochloride 2u could be used for the next run of conversion of propionyl halide to ketone 3. It should be mentioned that the steric factor in substrates 1r–u did not have obvious impact on the rate of deprotection.
4. Conclusion In summary, we have reported a reliable protocol for the Ndeacylation of secondary amides by alkylation with organocerium reagents. The deprotection proceeded smoothly at 78 8C to produce the corresponding amine hydrochloride salts in good yield. In combination with C–H activation/functionalization, the method is applicable to the functionalization of aniline as well as conversion of carboxylic derivatives to functionalized ketones. Acknowledgments The authors are grateful for financial support from the National Natural Science Foundation of China (No. 21332007), the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) of Ministry of Education, the Fundamental Research Funds for the Central Universities (No. 20720150044), and the Natural Science Foundation of Fujian Province of China (No. 2014J01062).
Appendix A. Supplementary data Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.cclet.2015.05.033.
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Contents lists available at ScienceDirect
Chinese Chemical Letters journal homepage: www.elsevier.com/locate/cclet
Original article
Mild N-deacylation of secondary amides by alkylation with organocerium reagents Ai-E Wang *, Zong Chang 1, Yong-Peng Liu 1, Pei-Qiang Huang * Department of Chemistry, College of Chemistry and Chemical Engineering, and Fujian Provincial Key Laboratory of Chemical Biology, Xiamen University, Xiamen 361005, China
A R T I C L E I N F O
A B S T R A C T
Article history: Received 3 April 2015 Received in revised form 4 May 2015 Accepted 11 May 2015 Available online 30 May 2015
Secondary amides are a class of highly stable compounds serving as versatile starting materials, intermediates and directing groups (amido groups) in organic synthesis. The direct deacylation of secondary amides to release amines is an important transformation in organic synthesis. Here, we report a protocol for the deacylation of secondary amides and isolation of amines. The method is based on the activation of amides with Tf2O, followed by addition of organocerium reagents, and acidic work-up. The reaction proceeded under mild conditions and afforded the corresponding amines, isolated as their hydrochloride salts, in good yields. In combination with the C–H activation functionalization methodology, the method is applicable to the functionalization of aniline as well as conversion of carboxylic derivatives to functionalized ketones. ß 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Keywords: N-Deacylation Amides Amines Organocerium
1. Introduction Amines are a class of organic compounds that are widespread in natural products, pharmaceuticals and biologically important compounds, and they have attracted extensive synthetic efforts [1]. Because of their high nucleophilicity, basicity and susceptibility to oxidation, amines are usually protected in the course of organic transformations to avoid undesired side reactions. The acylation of amines to amides is one of the most frequently used methods for the protection of amines. The acylated amines (amides) are well utilized in asymmetric hydrogenation of enamides [2], kinetic resolutions [3], and C–H activation reactions [4], as a result of the important protecting/directing role of acyl group. Cleavage of the amide bond, however, is difficult, because of the delocalization of the electrons across the amide. The conventional N-deacylation of amides, such as hydrolysis, alcoholysis and transamidation, are usually performed under harsh reaction conditions, such as use of strong acids or bases, and at high temperature [5]. In the last decade, as the C–H bond activation has progressively become a well-established synthetic tool [4], the
* Corresponding authors. E-mail addresses: [email protected] (A.-E. Wang), [email protected] (P.-Q. Huang). 1 The authors contributed equally to this work.
development of new methodologies for the facile deprotection of secondary amides has attracted special attention from synthetic chemists. For example, using triphenylphosphite chlorine complex [6] and oxalyl chloride [7] as the activating reagent respectively, Prati and Koenig have developed mild alcoholysis methods for the deacylation of secondary amides. Recently, a catalytic combination system of scandium triflate and boronic ester has been applied by Mashima [8] for the deprotection of acetylaniline derivatives under mild and neutral conditions. Ohshima and Morimoto have recently reported the cleavage of unactivated secondary amides bonds by ammonium salt-accelerated transamidation [9] and hydrazinolysis [10]. Using the Schwartz reagent at room temperature, Bhat [11] has developed a mild and efficient method for the chemoselective deprotection of acetamides in the presence of NBoc or N-Cbz moieties. In connection with our longstanding interest in the synthesis of bioactive alkaloids [12], our group has been in recent years engaged in the development of new C–C bond formation reactions that employ stable amides as substrates [13]. Charette’s [14] and our group [13b,c] have independently reported the transformation of secondary amides into ketones by alkylation with Grignard and organocerium reagents, respectively (Scheme 1). In this transformation, the stable secondary amides, upon activation by triflic anhydride (Tf2O) [15], are converted to reactive nitrilium ions, which react with organometallic reagents to give imines that are hydrolyzed under acidic conditions to give ketones. It is evident
http://dx.doi.org/10.1016/j.cclet.2015.05.033 1001-8417/ß 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
A.-E. Wang et al. / Chinese Chemical Letters 26 (2015) 1055–1058
1056
1) Tf 2O, 2-F-Py, DCM (0.044 mol/L) 2) RMgBr; 3) aq. HCl O R
1
O
Charette's method N H
R2
Our method
R
1
R
+ H2NR2
(1) Tf 2O, 2-F-Py, DCM (0.25 mol/L) (2) RMgBr/ CeCl3; (3) aq. HCl Scheme 1. Reductive alkylation of secondary amides with Grignard and organocerium reagents.
that acidic work-up of imines would produce amines as well. The method could thus, on the other hand, serve as an alternative way for the deprotection of secondary amides to produce primary amines. Using Grignard reagents as alkylation reagents, Charette et al. [14] have showed one example of isolation of amine moiety by an acid/base workup after hydrolysis of the corresponding imine. Such transformation, however, was performed in an extremely diluted dichloromethane solution (0.044 mol/L), which is environmentally harmful, thus preventing the scale-up of the reaction. As a result of recent interest in the development of methods for the deprotection of secondary amides, herein we report our own results on the N-deacylation of secondary amides by alkylation with organocerium reagents. 2. Experimental Melting points were uncorrected. Infrared spectra were measured using film KBr pellet techniques. 1H NMR and 13C NMR spectra were recorded on Bruker 400 MHz or 500 MHz spectrometer. Chemical shifts are expressed in d (ppm) units downfield from TMS. High-resolution mass spectra (HRMS) were recorded on a Bruker APEX II FT mass spectrometer. Silica gel (300–400 mesh) was used for flash column chromatography, eluting (unless otherwise stated) with ethyl acetate/n-hexane mixture. Ether and THF were distilled over sodium benzophenone ketyl under N2. Dichloromethane was distilled over calcium hydride under N2. Trifluoromethanesulfonic anhydride (Tf2O) was distilled over phosphorous pentoxide and was stored for no more than a week before redistilling. All other commercially available compounds were used as received. Anhydrous cerium chloride was prepared from CeCl37H2O according to the reported procedure [16]. General procedure for N-deacylation of secondary amides: Tf2O (185 mL, 1.1 mmol) was added dropwise to a cooled (0 8C) solution of amide (1.0 mmol) and 2-fluoropyridine (103 mL, 1.2 mmol) in dichloromethane (4 mL). After stirring at 0 8C for 30 min, the mixture was cannulated to a freshly prepared organocerium reagent/complex (3.0 mmol) in THF (15 mL) at 78 8C and stirred for 2 h. Aqueous HCl solution (3 mol/L, 5 mL) was added to quench the reaction and the mixture was allowed to warm to r.t. and stirred for 2 h. Ammonium hydroxide solution (25%, 5 mL) was then added to the mixture. The organic layer was separated and the aqueous phase was extracted with diethyl ether (3 10 mL). The combined organic layers were washed with brine (3 3 mL) and concentrated under reduced pressure to about 1/3 volume. The residual organic phase was then extracted with aqueous HCl solution (3 mol/L, 3 5 mL). The separated organic phase was washed with brine (5 mL), dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure, and the residue was purified by flash column chromatography on silica gel to afford ketone. The aqueous phases were combined, washed with diethyl ether (5 mL), basified with an ammonium hydroxide solution (25%, 5 mL) and back-extracted with diethyl ether (5 20 mL). The ether layers were combined, washed with brine (5 mL), dried over anhydrous MgSO4, filtered, acidified with a solution of HCl in ethyl
acetate (3 mol/L, 5 mL) and concentrated under reduced pressure to afford the desired amine hydrochloride salt. The characterization data of amine hydrochlorides 2 and ketone 3 were provided in Supporting information. 3. Results and discussion Our investigation is based on the direct alkylative deamination of secondary amides, a method developed recently from our laboratory for the synthesis of ketones [13b,c]. The N-deacylation of secondary amide 1a was chosen as the model reaction. Following the general procedure reported for the transformation of secondary amides into ketones [13b,c], a dichloromethane solution of amide 1a and 2fluoropyridine (1.2 equiv) was treated successively with 1.1 equiv of Tf2O (0 8C, 30 min) and 3.0 equiv of freshly prepared ethyl cerium regent (78 8C, 2 h), and the reaction was quenched with aqueous HCl solution. After work-up through simple acid–base extraction, only 62% of the corresponding primary amine was obtained. In our further trials to improve the yield, we found that there might be some magnesium complex of amines produced. So after the reaction was quenched with aqueous HCl solution, aqueous ammonia was added to facilitate the liberation of amines from amine–Mg complexes. In view of high volatility of amines, the final products were isolated as amine hydrochloride salts. In this way, the yield of deacylation of 1a was improved to 88%. With the optimized reaction procedures in hand, we next examined the scope of structurally different benzoylated aliphatic amines (entries 1–6, Table 1). Various acylated primary amines (1a–f) were deprotected to afford the corresponding amine hydrochloride salts 2a–f in good yield upon isolation. It should be mentioned that chiral substrates 1f, which has an a-chiral center, underwent facile N-deacylation smoothly to afford the corresponding amine hydrochloride salt 2f without any epimerization (ee value was determined by HPLC, for details see Supporting information). In addition to benzoyl group, other acyl groups such as acetyl, pivaloyl and isovaleroyl groups in 1g–k could be removed to afford amine hydrochloride salts in high yields (entries 7–11).
Table 1 Deacylation of secondary amides.a
Entry 1 2 3 4 5 6
7 8 9 10 11 12 13 14 15 16 17
Amide
R
R0
R2NH2HCl (yield %)
1a 1b 1c 1d 1e 1f
Ph(CH2)4 Ph(CH2)2 Bn c-Hex n-Bu
Ph Ph Ph Ph Ph Ph
88 76 63 87 70 77
1g 1h 1i 1j 1k 1l 1m 1n 1o 1p 1q
c-Hex c-Hex c-Hex c-Hex c-Hex Ph Ph 3,5-diMeC6H3 p-EtOC6H4 p-FC6H4 p-NCC6H4
Me t-Bu Me2CHCH2 n-C10H21 1-Adamantyl Me2CHCH2 Me Me Me Me Me
90 74 83 71 82 63 70 69 67 73 77
a Reaction conditions: Tf2O (1.1 equiv.), 2-F-Py (1.2 equiv.), DCM (0.25 mol/L), 0 8C, 30 min; then organocerium reagent (3.0 equiv.), 78 8C, 2 h; then HCl (3 mol/L, 5 mL), r.t., 2 h.
A.-E. Wang et al. / Chinese Chemical Letters 26 (2015) 1055–1058
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Scheme 2. Application of the deacylation in combination with functionalization methodologies.
The reaction conditions could also be applied to the deprotection of a variety of anilides derivatives (entries 12–17). The electronic properties of the functional groups did not have significant impact on the reaction time and yield. Substrates with both electron donating (1n–o) and withdrawing (1p–q) functional moieties underwent N-deacylation rapidly, affording the corresponding amine hydrochloride salts (2n–q) in excellent yields. The deprotection of cyano substituted anilide 1q went chemoselectively to furnish the corresponding p-cyano aniline hydrochloride salt 2q in 77% yield. As the secondary amides have been recently used as powerful directing groups in C–H activation/functionalization [4], several acylated amine intermediates obtained from Pd-catalyzed C–H bond activations are examined (Scheme 2). The deprotection of anilines 1r–t, the ortho-functionalization products of aniline reported respectively by Tremont, Shi and Wang [17], proceeded smoothly to give ortho-substituted anilines hydrochloride 2r–t. The deacylation method, in combination with acylation and catalytic C–H bond activations, could thus be used for orthofunctionalization of aniline. The method was also applicable to deacylation of acetanilide 1u, the b-arylation product of sp3 C–H bond reported by Daugulis [18], giving anilines hydrochloride 2u as well as ketone 3 in 91% and 87% yield, respectively. The recovered aniline hydrochloride 2u could be used for the next run of conversion of propionyl halide to ketone 3. It should be mentioned that the steric factor in substrates 1r–u did not have obvious impact on the rate of deprotection.
4. Conclusion In summary, we have reported a reliable protocol for the Ndeacylation of secondary amides by alkylation with organocerium reagents. The deprotection proceeded smoothly at 78 8C to produce the corresponding amine hydrochloride salts in good yield. In combination with C–H activation/functionalization, the method is applicable to the functionalization of aniline as well as conversion of carboxylic derivatives to functionalized ketones. Acknowledgments The authors are grateful for financial support from the National Natural Science Foundation of China (No. 21332007), the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) of Ministry of Education, the Fundamental Research Funds for the Central Universities (No. 20720150044), and the Natural Science Foundation of Fujian Province of China (No. 2014J01062).
Appendix A. Supplementary data Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.cclet.2015.05.033.
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