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Mini-Review
An international journal providing a forum for original and pertinent contributions in cancer research
Aims and scope CANCER LETTERS is a journal providing rapid publication of brief articles in the broad area of cancer research. The journal places emphasis on the molecular and cell biology of cancer, oncogenes, carcinogenesis, radiation biology, molecular pathology, hormones and cancer, viral oncology, biology of cancer and metastasis, molecular cytogenetics, epidemiology; and experimental therapeutics. The primary criterion for publication is interest to a multidisciplinary audience. Papers should be brief but technically sound and substantiated by sufficient experimental detail. Clinical papers will be accepted if they contribute to the understanding of the basic mechanisms underlying disease. Managing Editors Dr. R. Muschel Dr. F. Beland Prof. M. Schwab (Philadelphia, USA) (Jefferson, USA) (Heidelberg, Germany) Associate Editor: Prof. N. Ito (Nagoya, Japan) Honorary Founding Editor: Dr. P. Shubik (Oxford, UK) Honorary Editor: Dr. T. Sugimura (Tokyo, Japan) Editorial Board Carcinogenesis, Epidemiology & Experimental Therapeutics P. Bannasch, Heidelberg, Germany H. Bartsch, Heidelberg, Germany J. DiGiovanni, Smithville, TX, USA S. Fukushima, Osaka, Japan S.S. Hecht, Minnesota, USA Y. Konishi, Nara, Japan H.W.J. Marquardt, Hamburg, Germany R. Mehta, Ottawa, Canada S. Nesnow, Research Triangle Park, NC, USA D.H. Phillips, Sutton, UK H. Pitot, Madison, WI, USA S. Plesnicar, Ljubljana, Slovenia M.C. Poirier, Maryland, USA J.M. Rice, MD, USA N. Rothman, Maryland, USA B. Stewart, Sydney, Australia R.J. Turesky, AR, USA A. Weston, West Virginia, USA Y. Yamazoe, Sendai, Japan
Cell Biology, Radiation Biology & Molecular Biology H. Bartelink, Amsterdam, The Netherlands J.M. Brown, CA, USA S. Evans, Philadelphia, USA P. Furmanski, NY, USA P. Glazer, CT, USA E. Kohn, Bethesda, MD H. Mukhtar, WI, USA E. Sausville, Bethesda, MD M. Seiki, Tokyo, Japan Y.-J. Surh, Seoul, South Korea A.J. van der Kogel, Nijmegen, The Netherlands J.F. Whitfield, Ontario, Canada H. Yamasaki, Nishinomiya, Japan Molecular Biology, Oncogenes, Viral Oncology, Molecular Cytogenetics & Oncogenomics R. Bernards, Amsterdam, The Netherlands A. Burkle, Konstanz, Germany W.K. Cavenee, CA, USA G. Christofori, Basel, Switzerland V.P. Collins, Cambridge, UK
C.J. Der, North Carolina, USA S.M. Evans, Philadelphia, USA P. Gaudray, Nice, France T.D. Gilmore, Boston, MA, USA O. Gimm, Halle, Germany P. Hainaut, Lyon, France J.D. Hayes, Dundee, Scotland P. Kleihues, Lyon, France J.C. Lacal, Madrid, Spain W. Lutz, Marburg, Germany D.J. Marsh, Sydney, Australia A. Nakagawara, Chiba, Japan M.A. Pierotti, Milan, Italy I. Roninson, Chicago, USA F.V. Rassool, London, UK L.J. Rush, OH, USA A.H. Schonthal, CA, USA P.S. Steeg, Bethesda, USA D. Theodorescu, VA, USA D.J. Tindall, MN, USA T. von Zglinicki, Newcastle upon Tyne, UK C. Wicking, Queensland, Australia L.R. Zacharski, NH, USA
Submission of manuscripts Authors should mark with their manuscript which of the following subject areas they wish their paper to be published in: – Carcinogenesis and cancer prevention – Experimental therapeutics – Epidemiology and molecular epidemiology – Molecular and cell biology – Tumour biology Manuscripts should be submitted to one of the Editors as described below: Carcinogenesis, epidemiology, experimental therapeutics: Dr F. Beland, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079-9502, USA. Tel: +1 870 543 7202; Fax: +1 870 543 7136; e-mail: [email protected] Cell biology, radiation biology, molecular pathology, experimental therapeutics: Dr R. Muschel, Department of Pathology, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA. Tel: +1 267 426 5481; Fax: +1 267 426 5483; e-mail: [email protected] Molecular biology, oncogenes, viral oncology, molecular cytogenetics, oncogenomics: Prof M. Schwab, CANCER LETTERS Editorial Office, Deutsches Krebsforschungzentrum - DKFZ, Im Neuenheimer Feld 280, D-69 120 Heidelberg, Germany. Tel. +49 6221 423220, Fax. +49 6221 423281, e-mail: [email protected] Manuscripts from Japan may be submitted directly to: Prof. N. Ito, c/o 1st Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. Tel: +81 52 853 8156; Fax: +81 52 842 0817. Advertising Information: Advertising orders and enquiries can be sent to: USA, Canada and South America: Mr Tino DeCarlo, The Advertising Department, Elsevier Inc., 360 Park Avenue South, New York, NY 10010-1710, USA; phone: (+1) (212) 633 3815; fax: (+1) (212) 633 3820; e-mail: [email protected] Japan: The Advertising Department, Elsevier K.K., 4F Higashi-Azabu, 1-Chome Bldg., 1-9-15 Higashi-Azabu, Minato-ku, Tokyo 106-0044, Japan; phone: (+81) (3) 5561 5037; fax: (+81) (3) 5561 5047; e-mail: [email protected] Europe and ROW: Commercial Sales Department, Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK; phone: (+44) 1865 843016; fax: (+44) 1865 843976; e-mail: [email protected] ∞ The paper used in this publication meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper) Printed in the UK
Aims and scope CANCER LETTERS is a journal providing rapid publication of brief articles in the broad area of cancer research. The journal places emphasis on the molecular and cell biology of cancer, oncogenes, carcinogenesis, radiation biology, molecular pathology, hormones and cancer, viral oncology, biology of cancer and metastasis, molecular cytogenetics, epidemiology; and experimental therapeutics. The primary criterion for publication is interest to a multidisciplinary audience. Papers should be brief but technically sound and substantiated by sufficient experimental detail. Clinical papers will be accepted if they contribute to the understanding of the basic mechanisms underlying disease. Managing Editors Dr. R. Muschel Dr. F. Beland Prof. M. Schwab (Philadelphia, USA) (Jefferson, USA) (Heidelberg, Germany) Associate Editor: Prof. N. Ito (Nagoya, Japan) Honorary Founding Editor: Dr. P. Shubik (Oxford, UK) Honorary Editor: Dr. T. Sugimura (Tokyo, Japan) Editorial Board Carcinogenesis, Epidemiology & Experimental Therapeutics P. Bannasch, Heidelberg, Germany H. Bartsch, Heidelberg, Germany J. DiGiovanni, Smithville, TX, USA S. Fukushima, Osaka, Japan S.S. Hecht, Minnesota, USA Y. Konishi, Nara, Japan H.W.J. Marquardt, Hamburg, Germany R. Mehta, Ottawa, Canada S. Nesnow, Research Triangle Park, NC, USA D.H. Phillips, Sutton, UK H. Pitot, Madison, WI, USA S. Plesnicar, Ljubljana, Slovenia M.C. Poirier, Maryland, USA J.M. Rice, MD, USA N. Rothman, Maryland, USA B. Stewart, Sydney, Australia R.J. Turesky, AR, USA A. Weston, West Virginia, USA Y. Yamazoe, Sendai, Japan
Cell Biology, Radiation Biology & Molecular Biology H. Bartelink, Amsterdam, The Netherlands J.M. Brown, CA, USA S. Evans, Philadelphia, USA P. Furmanski, NY, USA P. Glazer, CT, USA E. Kohn, Bethesda, MD H. Mukhtar, WI, USA E. Sausville, Bethesda, MD M. Seiki, Tokyo, Japan Y.-J. Surh, Seoul, South Korea A.J. van der Kogel, Nijmegen, The Netherlands J.F. Whitfield, Ontario, Canada H. Yamasaki, Nishinomiya, Japan Molecular Biology, Oncogenes, Viral Oncology, Molecular Cytogenetics & Oncogenomics R. Bernards, Amsterdam, The Netherlands A. Burkle, Konstanz, Germany W.K. Cavenee, CA, USA G. Christofori, Basel, Switzerland V.P. Collins, Cambridge, UK
C.J. Der, North Carolina, USA S.M. Evans, Philadelphia, USA P. Gaudray, Nice, France T.D. Gilmore, Boston, MA, USA O. Gimm, Halle, Germany P. Hainaut, Lyon, France J.D. Hayes, Dundee, Scotland P. Kleihues, Lyon, France J.C. Lacal, Madrid, Spain W. Lutz, Marburg, Germany D.J. Marsh, Sydney, Australia A. Nakagawara, Chiba, Japan M.A. Pierotti, Milan, Italy I. Roninson, Chicago, USA F.V. Rassool, London, UK L.J. Rush, OH, USA A.H. Schonthal, CA, USA P.S. Steeg, Bethesda, USA D. Theodorescu, VA, USA D.J. Tindall, MN, USA T. von Zglinicki, Newcastle upon Tyne, UK C. Wicking, Queensland, Australia L.R. Zacharski, NH, USA
Submission of manuscripts Authors should mark with their manuscript which of the following subject areas they wish their paper to be published in: – Carcinogenesis and cancer prevention – Experimental therapeutics – Epidemiology and molecular epidemiology – Molecular and cell biology – Tumour biology Manuscripts should be submitted to one of the Editors as described below: Carcinogenesis, epidemiology, experimental therapeutics: Dr F. Beland, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079-9502, USA. Tel: +1 870 543 7202; Fax: +1 870 543 7136; e-mail: [email protected] Cell biology, radiation biology, molecular pathology, experimental therapeutics: Dr R. Muschel, Department of Pathology, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., Philadelphia, PA 19104, USA. Tel: +1 267 426 5481; Fax: +1 267 426 5483; e-mail: [email protected] Molecular biology, oncogenes, viral oncology, molecular cytogenetics, oncogenomics: Prof M. Schwab, CANCER LETTERS Editorial Office, Deutsches Krebsforschungzentrum - DKFZ, Im Neuenheimer Feld 280, D-69 120 Heidelberg, Germany. Tel. +49 6221 423220, Fax. +49 6221 423281, e-mail: [email protected] Manuscripts from Japan may be submitted directly to: Prof. N. Ito, c/o 1st Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. Tel: +81 52 853 8156; Fax: +81 52 842 0817. Advertising Information: Advertising orders and enquiries can be sent to: USA, Canada and South America: Mr Tino DeCarlo, The Advertising Department, Elsevier Inc., 360 Park Avenue South, New York, NY 10010-1710, USA; phone: (+1) (212) 633 3815; fax: (+1) (212) 633 3820; e-mail: [email protected] Japan: The Advertising Department, Elsevier K.K., 4F Higashi-Azabu, 1-Chome Bldg., 1-9-15 Higashi-Azabu, Minato-ku, Tokyo 106-0044, Japan; phone: (+81) (3) 5561 5037; fax: (+81) (3) 5561 5047; e-mail: [email protected] Europe and ROW: Commercial Sales Department, Elsevier Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK; phone: (+44) 1865 843016; fax: (+44) 1865 843976; e-mail: [email protected] ∞ The paper used in this publication meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper) Printed in the UK