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Mo-P1:15 Hemoglobin level as an independent predictor for cardiovascular diseases in Chin-Shan community cohort in Taiwan
P1
48
Mo-P1:12
Mon&ty, June 19, 2006: Poster Session Epidemiology of cardiovascular disease
SERUM C-REACTIVE PROTEIN AND ITS RELATION TO CARDIOVASCULAR RISK FACTORS AND ADIPOCYTOKINES IN JAPANESE CHILDREN
T. Ohta I , T. Yoshida I , T. Shimabukuro I , T. Kaneshi I , K. Takada 2.
1Department of Pediatrics, Ryukyu Universi~, Nishihara, Japan." "-Hiroshima Railway Hospital, Hiroshima-Ci~, Japan C-reactive protein (CRP) is an independent risk factor for coronary heart disease (CHD) in adults. To help prevent CHD, it may be useful to understand risk factors during childhood. In the present study, we investigated CRP and factors that influence CRP in children. Methods: CRR conventional risk factors for CHD and 3 cytokines (adiponectin, IL-6 and TNF-alpha) were determined in 568 children aged 7 to 10 years. Results: Boys with high CRP levels (>90th percentile) have more atherogenic profiles than other boys [high levels of BMI percentile (BMI%), insulin, HOMA-R, LDL-C, apoB, uric acid and IL-6, and low levels of HDL-C, apoA-I and adiponectin]. All of these parameters, triglyceride (TG) and TNF-alpha were significantly correlated with CRE In contrast, girls with high CRP levels only showed higher levels of BMI% and IL-6 than other girls. However, in addition to BMI% and IL-6, significant correlations with CRP were found for HOMA-R, TG, HDL-C, apoB and uric acid. In a stepwise multiple regression analysis, IL-6 was the strongest predictive wxiable for CRP in both boys and girls. IL-6 accounted for 26.2% and 26.6% of the variability in CRP levels in boys and girls, respectively. Serum levels of IL-6 were partly dependent on BMI%, TNF-alpha and apoA-I in boys and uric acid, TNF-alpha and BMI% in girls. Conclusion: Although CRP levels axe partly regulated by adipocytokines and conventional risk factors for CHD, high CRP levels were associated with atherogenic profiles of cardiovascular risk factors. These findings suggest that high CRP levels in children may play a role in the future development of CHD. I
I Mo-P 1 131i CHANGES OF DEVELOPMENT OF THE RISK FACTORS OF CVD IN CZECH REPUBLIC (CZECH-POST-MONICA STUDY) V. Adamkova, Z. Skodova, R. Cifkova, R. Poledne, P. Stavek, V. Lanska.
Institute of Clinical attcl Experimanel Medicine, Prague, Czech Republic Objective: Cardiovascular diseases caused more than half deaths of adult population in Czech republic (in 2003 died for CVD > 26000 men and > 30 000 women). Despite the progress in the treatment and education of CVD, the satisfied effect was not achieved. Methods and group: In 1997/8 we examinated 1% random sample Czech inhabitants (25-64 years - 1560 men, 1689 women), in 2000/1 we examinated 1237 men, 1428 women again. We watched obesity, lipids, hypertension-treatment and its effectivity. Body mass index = kg/m 2, total cholesterol (mmol/1) by standard method, blood pressure was measured by mercury sphygmomanometer (2 m m scale,average from the last 2 measurements was used). Statistical methods: t-test, BrownForsyth, Levenes, Welch tests. Results: 1. Hypertension was ascertained in 32,7% men, 25,3% women, 45,1% hypertensives male, resp.65,2% female were treated 2. BP above 140/90 m m Hg was achieved in 19% hypertensives males, resp. 32% females 3. Treated dyslipidaemia , but total cholesterol > 5 mmol/1 was in 4% persons 4. Total cholesterol < 5 mmol/1 achieved only 0,6% male and 2,8% female 5. BMI > 2 7 k g / m 2 was found in 1997/8 in 641 men and 597 women, but in 2000/1, practically 90% of them had the same BMI Conclusion: Development of risk factors of CVD in Czech republic is alarmed.Or education or effectivity of treatment axe not satisfied. Funding: This project was supported by Internal Grant Agency of Health Ministry of Czech republic, N-3635/6
INFLUENCE OF SMOKING HABIT ON RESIDUAL LIFETIME RISK OF CARDIOVASCULAR DISEASES IN JAPANESE REPRESENTATIVE POPULATION
Mo-P 1 : 14
Y. Murakami;, H. Ueshima;, T. Okamura;, Y. Kita;, T. Kadowaki;, T. Hayakawa 2, A. Okayama 3. 1Shiga Universi~ of Medical Science, Otsu,
Japan." 2Shimane Universi~, Izumo, Japan." 3National Cardiovascular Center; Suita, Japan Objective: Residual lifetime risks of cardiovascular diseases (CVD) among Japanese population from age 40 until age 80 were calculated for investigating an impact of smoking habit on CVD mortality using a nationwide cohort study (NIPPON DATA80) data. Participants and Methods Age-specific mortality rates of cardiovascular disease were calculated from the NIPPON DATA80, which included 8,939 persons (male: 3,912 and female: 5,027). Smoking habit at baseline survey was categorized into four in men (non-smokers, ex-smokers, smokers less than one pack per day, smokers more than one pack per day) and three in women (non-smokers, ex-smokers, smokers) respectively. Residual lifetime risks of CVD and its subtype (stroke and CHD) were calculated by summing up age-specific incidence proportions from age 40 until age 80, adjusting for competing risks. Results: A m o n g men, the residual lifetime risk (from age 40 until 80) of CVD, stoke and CHD mortality were 6.09%, 1.34%, 4.16% in non-smokers, 9.80%, 4.30%, 4.79% in ex-smokers, 12.59%, 6.97%, 5.05% in smokers less than one pack/day, 16.04%, 7.63%, 7.52% in smokers more than one pack/day, respectively. The residual lifetime risk became larger as amount of cigarette packs increased. In women, residual life risks of ex-smokers and smokers were larger than that of non-smokers in CVD, stroke and CHD. C o n d u s i o n s : The residual lifetime risk of CVD and its subtype among smokers and ex-smokers were larger than those among non-smokers both men and women in Japanese population.
IMo-P1:151
I i
HEMOGLOBIN LEVEL AS AN INDEPENDENT PREDICTOR FOR CARDIOVASCULAR DISEASES IN CHIN-SHAN COMMUNITY COHORT IN TAIWAN
° ° K.L. Chien 1'2, EC. C h e n 3, H.C. Hsu-, T.C. Su -, M.F. Chen ~, F.C. Sung 3, Y.T. Lee 2'5. l bzstitute of Preventive Medicine, College of Public Health,
National Taiwan Universi~, Taipei, Taiwan: 2Department of bttetTtal Medicine, National Taiwan Universi~ Hospital, Taipei, Taiwan." ~bzstitute of Em,ironnwntal Health, National Taiwan Universi~ College of Public Health, Taipei, Taiwan." 4Ittstitute of Em,ironmental Health, China Medical Universi~ College of Public Health, Taichung, Taiwan; 5Ming-Sheng Healthcare, Taoyuang, Taiwan Objective: Low Hgb level has been reported as an independent predictor of adverse CVD outcomes in patients with acute myocardial infarction, heart failure or kidney disease. There are limited studies on this association for Asian populations. We investigated the relationship between hemoglobin (Hgb) level and adverse cardiovascular disease (CVD) outcomes in a community population in Taiwan with follow-up data. Methods: In 1990, a prospective cohort of 3602 adults, aged 35 years or above with no CVD was established in Chin-Sham a suburban community in the northern Taiwan. Participants were invited to have biennial follow-up heath check-up. At the baseline, 76 (or 4.48%) men and 145 (or 7.60%) women were anemia with the Hgb levels of < 13.0 g/dl and < 12.0/dl, respectively. Results: A m o n g 2231 subjects (1000 men and 1231 women) with complete data by the 13-yeax follow-up evaluation, 115 persons (or 5.15%) have had CVD events. After adjustment for CVD covariates, the Cox proportional hazards regression analysis revealed an elevated risk of CVD (hazard ratio = 2.27, 95% CI 1.00-5.17) for women with anemia, compared with the reference group with the Hgb levels of 12-14. Women with Hgb levels >14 g/dl also had a higher hazard ratio (1.33) but not significant. In men, no significant association was found between their Hgb levels and the CVD risk. C o n d u s i o n s : A low Hgb level may increased risk for adverse CVD outcomes among Asia women.
XIV bztetTtational Symposium on Atherosclerosis, Rome, Italy, June 18-22, 2006
48
Mo-P1:12
Mon&ty, June 19, 2006: Poster Session Epidemiology of cardiovascular disease
SERUM C-REACTIVE PROTEIN AND ITS RELATION TO CARDIOVASCULAR RISK FACTORS AND ADIPOCYTOKINES IN JAPANESE CHILDREN
T. Ohta I , T. Yoshida I , T. Shimabukuro I , T. Kaneshi I , K. Takada 2.
1Department of Pediatrics, Ryukyu Universi~, Nishihara, Japan." "-Hiroshima Railway Hospital, Hiroshima-Ci~, Japan C-reactive protein (CRP) is an independent risk factor for coronary heart disease (CHD) in adults. To help prevent CHD, it may be useful to understand risk factors during childhood. In the present study, we investigated CRP and factors that influence CRP in children. Methods: CRR conventional risk factors for CHD and 3 cytokines (adiponectin, IL-6 and TNF-alpha) were determined in 568 children aged 7 to 10 years. Results: Boys with high CRP levels (>90th percentile) have more atherogenic profiles than other boys [high levels of BMI percentile (BMI%), insulin, HOMA-R, LDL-C, apoB, uric acid and IL-6, and low levels of HDL-C, apoA-I and adiponectin]. All of these parameters, triglyceride (TG) and TNF-alpha were significantly correlated with CRE In contrast, girls with high CRP levels only showed higher levels of BMI% and IL-6 than other girls. However, in addition to BMI% and IL-6, significant correlations with CRP were found for HOMA-R, TG, HDL-C, apoB and uric acid. In a stepwise multiple regression analysis, IL-6 was the strongest predictive wxiable for CRP in both boys and girls. IL-6 accounted for 26.2% and 26.6% of the variability in CRP levels in boys and girls, respectively. Serum levels of IL-6 were partly dependent on BMI%, TNF-alpha and apoA-I in boys and uric acid, TNF-alpha and BMI% in girls. Conclusion: Although CRP levels axe partly regulated by adipocytokines and conventional risk factors for CHD, high CRP levels were associated with atherogenic profiles of cardiovascular risk factors. These findings suggest that high CRP levels in children may play a role in the future development of CHD. I
I Mo-P 1 131i CHANGES OF DEVELOPMENT OF THE RISK FACTORS OF CVD IN CZECH REPUBLIC (CZECH-POST-MONICA STUDY) V. Adamkova, Z. Skodova, R. Cifkova, R. Poledne, P. Stavek, V. Lanska.
Institute of Clinical attcl Experimanel Medicine, Prague, Czech Republic Objective: Cardiovascular diseases caused more than half deaths of adult population in Czech republic (in 2003 died for CVD > 26000 men and > 30 000 women). Despite the progress in the treatment and education of CVD, the satisfied effect was not achieved. Methods and group: In 1997/8 we examinated 1% random sample Czech inhabitants (25-64 years - 1560 men, 1689 women), in 2000/1 we examinated 1237 men, 1428 women again. We watched obesity, lipids, hypertension-treatment and its effectivity. Body mass index = kg/m 2, total cholesterol (mmol/1) by standard method, blood pressure was measured by mercury sphygmomanometer (2 m m scale,average from the last 2 measurements was used). Statistical methods: t-test, BrownForsyth, Levenes, Welch tests. Results: 1. Hypertension was ascertained in 32,7% men, 25,3% women, 45,1% hypertensives male, resp.65,2% female were treated 2. BP above 140/90 m m Hg was achieved in 19% hypertensives males, resp. 32% females 3. Treated dyslipidaemia , but total cholesterol > 5 mmol/1 was in 4% persons 4. Total cholesterol < 5 mmol/1 achieved only 0,6% male and 2,8% female 5. BMI > 2 7 k g / m 2 was found in 1997/8 in 641 men and 597 women, but in 2000/1, practically 90% of them had the same BMI Conclusion: Development of risk factors of CVD in Czech republic is alarmed.Or education or effectivity of treatment axe not satisfied. Funding: This project was supported by Internal Grant Agency of Health Ministry of Czech republic, N-3635/6
INFLUENCE OF SMOKING HABIT ON RESIDUAL LIFETIME RISK OF CARDIOVASCULAR DISEASES IN JAPANESE REPRESENTATIVE POPULATION
Mo-P 1 : 14
Y. Murakami;, H. Ueshima;, T. Okamura;, Y. Kita;, T. Kadowaki;, T. Hayakawa 2, A. Okayama 3. 1Shiga Universi~ of Medical Science, Otsu,
Japan." 2Shimane Universi~, Izumo, Japan." 3National Cardiovascular Center; Suita, Japan Objective: Residual lifetime risks of cardiovascular diseases (CVD) among Japanese population from age 40 until age 80 were calculated for investigating an impact of smoking habit on CVD mortality using a nationwide cohort study (NIPPON DATA80) data. Participants and Methods Age-specific mortality rates of cardiovascular disease were calculated from the NIPPON DATA80, which included 8,939 persons (male: 3,912 and female: 5,027). Smoking habit at baseline survey was categorized into four in men (non-smokers, ex-smokers, smokers less than one pack per day, smokers more than one pack per day) and three in women (non-smokers, ex-smokers, smokers) respectively. Residual lifetime risks of CVD and its subtype (stroke and CHD) were calculated by summing up age-specific incidence proportions from age 40 until age 80, adjusting for competing risks. Results: A m o n g men, the residual lifetime risk (from age 40 until 80) of CVD, stoke and CHD mortality were 6.09%, 1.34%, 4.16% in non-smokers, 9.80%, 4.30%, 4.79% in ex-smokers, 12.59%, 6.97%, 5.05% in smokers less than one pack/day, 16.04%, 7.63%, 7.52% in smokers more than one pack/day, respectively. The residual lifetime risk became larger as amount of cigarette packs increased. In women, residual life risks of ex-smokers and smokers were larger than that of non-smokers in CVD, stroke and CHD. C o n d u s i o n s : The residual lifetime risk of CVD and its subtype among smokers and ex-smokers were larger than those among non-smokers both men and women in Japanese population.
IMo-P1:151
I i
HEMOGLOBIN LEVEL AS AN INDEPENDENT PREDICTOR FOR CARDIOVASCULAR DISEASES IN CHIN-SHAN COMMUNITY COHORT IN TAIWAN
° ° K.L. Chien 1'2, EC. C h e n 3, H.C. Hsu-, T.C. Su -, M.F. Chen ~, F.C. Sung 3, Y.T. Lee 2'5. l bzstitute of Preventive Medicine, College of Public Health,
National Taiwan Universi~, Taipei, Taiwan: 2Department of bttetTtal Medicine, National Taiwan Universi~ Hospital, Taipei, Taiwan." ~bzstitute of Em,ironnwntal Health, National Taiwan Universi~ College of Public Health, Taipei, Taiwan." 4Ittstitute of Em,ironmental Health, China Medical Universi~ College of Public Health, Taichung, Taiwan; 5Ming-Sheng Healthcare, Taoyuang, Taiwan Objective: Low Hgb level has been reported as an independent predictor of adverse CVD outcomes in patients with acute myocardial infarction, heart failure or kidney disease. There are limited studies on this association for Asian populations. We investigated the relationship between hemoglobin (Hgb) level and adverse cardiovascular disease (CVD) outcomes in a community population in Taiwan with follow-up data. Methods: In 1990, a prospective cohort of 3602 adults, aged 35 years or above with no CVD was established in Chin-Sham a suburban community in the northern Taiwan. Participants were invited to have biennial follow-up heath check-up. At the baseline, 76 (or 4.48%) men and 145 (or 7.60%) women were anemia with the Hgb levels of < 13.0 g/dl and < 12.0/dl, respectively. Results: A m o n g 2231 subjects (1000 men and 1231 women) with complete data by the 13-yeax follow-up evaluation, 115 persons (or 5.15%) have had CVD events. After adjustment for CVD covariates, the Cox proportional hazards regression analysis revealed an elevated risk of CVD (hazard ratio = 2.27, 95% CI 1.00-5.17) for women with anemia, compared with the reference group with the Hgb levels of 12-14. Women with Hgb levels >14 g/dl also had a higher hazard ratio (1.33) but not significant. In men, no significant association was found between their Hgb levels and the CVD risk. C o n d u s i o n s : A low Hgb level may increased risk for adverse CVD outcomes among Asia women.
XIV bztetTtational Symposium on Atherosclerosis, Rome, Italy, June 18-22, 2006