- Email: [email protected]
Mo-P1:164 Levels of serum lipoprotein (A) in patients with primary hypothyroidism and euthyroid goiter
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P1
Mon&ty, June 19, 2006: Poster Session Epidemiology of cardiovascular disease
medication,whereas 3 of them exhibited symptoms of Coronary Artery Disease,which was later objectively confirmed.Detailed family history revealed that 26 persons,aged from 39 to 65 had died,presumably due to Coronary Artery Disease. Conclusions: Health professionals do not adequately inform relatives of patients with FH about the possibility of themselves too suffering from FH.Thus,and due to the significant percentage of (52% in our study)of relatives with the same disease,screening families is absolutely necessary. Funding: No funding was available.
i Mo-P 1 : 1631 P R E V A L E N C E O F D Y S L I P I D E M I A IN M E X I C A N i U R B A N ADOLESCENTS R. Posadas-Sanchez 1, j. Zamora-Gonzalez 1, L. Yamamoto-Kimura 2 , G. Cardoso-Saldafia I , C. Posadas-Romero I . lbtstituto Nacional de
Cardiologia Ignacio Chcn'ez, Mexico Ci~, Mexico." 2 Facultad de Medicina, Unam, Mexico City, Mexico Objectives: To determine the prevalence of dyslipidemia in Mexican adolescents. Metbods: A cross sectional study was conducted in 1846 students from 8 randomly selected public junior high schools in Mexico City. Anthropometry, blood pressure and 12-hour fasting lipids and lipoproteins were measured. Results: We studied 770 males and 1076 females (mean age 13.2 -4- 1 years). Elevated cholesterol (TC > 200 MG/DL), LDL cholesterol (LDL-C> 130 mg/dl) and triglycerides ( T G > 1 5 0 MG/DL) were found in 5.5%, 7.3%, and 9.2% of the population, no gender differences were observed. The most prevalent dyslipidimia was low HDL cholesterol (HDL-C<35 mg/dl) Either combined with other abnormalities (17.5% for males and 12.7% for females, P=0.01) or isolated (12.2% and 8.9% for males and females, respectively, P<0.05). Obese subjects showed the highest prevalence of low HDL-C (50% for males, 37% for females) and of high TC, LDL-C and TG (19.2%, 25%, 32.7%, respectively, for males; 9.9%, 12.3%, 27.2%, respectively, for females). Multiple regresion analysis showed that waist circumference was independently associated with HDL-C, LDL-C and TG LEVELS, while tanner and gender were independently assodated with TC, LDL-C and TG concentrations. Conclusions: As in Mexican adults, low HDL-C and high TG levels were the more prevalent dyslipidemias. The occurrence of tracking suggests that as adults, these adolescents will be facing a higher risk for atherosclerosis. This will contribute to the increasing incidence of cardiovascular disease in our country. Funding: Grant 0187P-M9506 from Conacyt. i Mo-P 1 : 1641 L E V E L S O F S E R U M L I P O P R O T E I N (A) IN P A T I E N T S WITH PRIMARY HYPOTHYROIDISM AND EUTI-IYROID G O I T E R M. Djeric, S. Kojic-Damjanov, M. Ninkovic. Cl#zical Center=Novi SaN, Novi
SaN, Serbia - Montenegro Objective: Alteration of the lipid profile axe a well known phenomenon in thyroid dysfunction. Thyroid hormones regulate lipid metabolism through various mechanismus, but a key role is played by the LDL receptor pathway. Thyroid hormone influence on lipoprotein (a) metabolism is unknown. Methods: We investigated Lp(a) lipoprotein concentrations (RID method) in a group of 20 patients with primary hypothyroidism (PM) (T4 82-t-46.54 Itmol/l; T3 1.27-t-0.56 Itmol/l; TSH 22.15-t-19.48 mJ/1) and in a group of 16 patients with euthyroid goiter (lEG) (T4 129.37-t-23.57 Itmol/l; T3 1.68-t-0.21 Itmol/l; TSH 1.82-t-2.87 mJ/l) as well as in 213 healthy persons (CG). Results: Plasma Lp(a) levels in 20 women aged 17 to 69 (mean 48) years with PH ranged from 0.01 to 0.91 (mean-t-SD; 0.23-t-0.20) g/l and frequency of elevated levels was 40% (35% moderate and 5% extremly). Those of 16 women aged 23 to 79 (mean 54) years with EG ranged from 0.01 to 0.66 (0.24-t-0.20) g/l and frequency of elevated levels was 31.25% (12.50% and 18.75%). The mean values for Lp(a) in PH as well as in EG were significantly higher (p < 0.001 in a both group) than those of the healthy subjects (0.11-4-0.13 g/l). Conclusions: Elevated concentrations of Lp(a) in combination with LDL cholesterol may be involved in the increased risk of cardiovascular disease assumed to be associated with hypothyroidism. Funding: Clinical Center-Novi Sad, Novi Sad, Serbia&Montenegro
I Mo-P1 165
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ATHEROSCLEROSIS, H E M O R H E O L O G I C A L PARAMETERS AND AGING
G. Feher I , K. KoltaJ 1 , P. Kenyeres I , H. Rapp I , G. Kesmarky I , L. Szapary 2, I. Juricskay 1 , K. Toth 1.1First Department of Medicine Division of
Cardiology, Universi~ of Pecs School of Medicbw, Pets, Hungary: 2Department of Neurology, Universi~ of Pecs School of Medicine, Pecs, Hungary Background: There is increasing evidence that impaired hemorheological parameters are associated with the development of atherosclerosis and thereby with increased risk of cardio -and cerebrovasculax events. The aim of our present study was to examine the relationship of these parameters to advancing age. Methods: The data of 6236 cardio- and cerebrovasculax patients were included into this analysis. Males and females were divided into three groups, A < 45 years of age (young), B 45-65 years (middle-aged), C > 65 years (old). To exclude the effect of risk profile, previous diseases and medication, a homogenous group of 623 patients were selected from the examined group with matching parameters. Results: All the measured hemorheological parameters correlated significantly with advancing age in the whole population (p < 0.01), however the values of the correlation coefficients were very low. On the other hand, examining the different age-groups we found that these parameters did not consequently correlate with age, in fact hematocrit, red blood cell aggregation and whole blood viscosity values were negatively correlated with age in old males (p< 0.05). In the selected population these parameters did not correlate with advancing age. Condusions: In the whole population the correlation of hemorheological parameters and advancing age may be just statistically, but not clinically significant. In the selected population these parameters did not correlate with advancing age. Our results suggest that though atherosclerosis is associated with impaired hemorheological parameters, these are mostly independent of aging.
I Mo-P 1 167
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YOUNGER MENOPAUSE AGE PREDICTS ADVERSE OUTCOME AFTER MYOCARDIAL INFARCTION ~ J. Lichtman 3 , N. Dawood 1 , S. Mallik 1, J.A. Spertus-, K.J. Reid-, N. Wenger ] , V. Vaccarino 1.1Emory Universi~, Atlanta, USA." 2Mid America i
Heart btstitute, Kansas Ci~, USA." 3 Yale Universi~, New Haven, USA Background: Young age at menopause is a risk factor for premature CHD. It is unknown whether it is a prognostic factor after myocardial infarction (MI). Methods: We examined whether younger age at menopause (_<40 years) confers increased risk of adverse outcomes in 572 post-menopausal women enrolled in prospective multicenter MI registry-PREMIER. Outcome measures at 1 yr post-MI included rehospitalization, rehospitalization or mortality, and health status (angina frequency and quality of life (QOL) using the Seattle Angina Questionnaire and physical function (PF) using the Physical Component Scale (PCS) Short-Form 12). Linear regression models were used with A A M as continuous variable controlling for baseline health status, demographics, comorbidities and quality of care indicators. Results: Women with early age at menopause (_< 40 yr; N=128; 28 natural, 97 surgical) were younger and more often smokers but were as likely to have hypertension, prior MI, diabetes and lower ejection fraction compared with women with late age at menopause (>50 yr). At 1 yr, for each 10yr younger age at menopause the probability of having angina (OR 1.45; 95% CI 1.79-1.15), rehospitalization (HR 1.22; 95% CI 1.47, 1.01) and rehospitalization or mortality (HR 1.22; 95% CI 1.47, 1.00) increased. The association of age at menopause with 1-yr PF was non-linear: women with age at menopause around 45 yr had highest 1-yr PF, which decreased as age decreased or increased. There was no association between age at menopause and 1-yr QOL. Conclusion: Younger menopause age is a risk factor for adverse outcomes after MI. O U S H O L D F O O D S E C U R I T Y A N D C.V.D A N D ITS IMo-P1:4611HRISK FACTORS IN I R A N I
M. Rafiei 1, M. Boshtam 2. 1Medical Education Development Center; Isfidzan, h'an." 2Cardiovascular Research Center; Isfahan, h'an
Objective: The nutrition transition in Iran is taking place in many contexts. Problem of micronutrients deficiencies still dominate the public health nutrition agenda; however, researches report obesity and other nutritional risk factors of CVD in a major part of the society as the first mortality cause.
XIV bzterTtational Symposium on Atherosclerosis, Rome, Italy, June 18-22, 2006
P1
Mon&ty, June 19, 2006: Poster Session Epidemiology of cardiovascular disease
medication,whereas 3 of them exhibited symptoms of Coronary Artery Disease,which was later objectively confirmed.Detailed family history revealed that 26 persons,aged from 39 to 65 had died,presumably due to Coronary Artery Disease. Conclusions: Health professionals do not adequately inform relatives of patients with FH about the possibility of themselves too suffering from FH.Thus,and due to the significant percentage of (52% in our study)of relatives with the same disease,screening families is absolutely necessary. Funding: No funding was available.
i Mo-P 1 : 1631 P R E V A L E N C E O F D Y S L I P I D E M I A IN M E X I C A N i U R B A N ADOLESCENTS R. Posadas-Sanchez 1, j. Zamora-Gonzalez 1, L. Yamamoto-Kimura 2 , G. Cardoso-Saldafia I , C. Posadas-Romero I . lbtstituto Nacional de
Cardiologia Ignacio Chcn'ez, Mexico Ci~, Mexico." 2 Facultad de Medicina, Unam, Mexico City, Mexico Objectives: To determine the prevalence of dyslipidemia in Mexican adolescents. Metbods: A cross sectional study was conducted in 1846 students from 8 randomly selected public junior high schools in Mexico City. Anthropometry, blood pressure and 12-hour fasting lipids and lipoproteins were measured. Results: We studied 770 males and 1076 females (mean age 13.2 -4- 1 years). Elevated cholesterol (TC > 200 MG/DL), LDL cholesterol (LDL-C> 130 mg/dl) and triglycerides ( T G > 1 5 0 MG/DL) were found in 5.5%, 7.3%, and 9.2% of the population, no gender differences were observed. The most prevalent dyslipidimia was low HDL cholesterol (HDL-C<35 mg/dl) Either combined with other abnormalities (17.5% for males and 12.7% for females, P=0.01) or isolated (12.2% and 8.9% for males and females, respectively, P<0.05). Obese subjects showed the highest prevalence of low HDL-C (50% for males, 37% for females) and of high TC, LDL-C and TG (19.2%, 25%, 32.7%, respectively, for males; 9.9%, 12.3%, 27.2%, respectively, for females). Multiple regresion analysis showed that waist circumference was independently associated with HDL-C, LDL-C and TG LEVELS, while tanner and gender were independently assodated with TC, LDL-C and TG concentrations. Conclusions: As in Mexican adults, low HDL-C and high TG levels were the more prevalent dyslipidemias. The occurrence of tracking suggests that as adults, these adolescents will be facing a higher risk for atherosclerosis. This will contribute to the increasing incidence of cardiovascular disease in our country. Funding: Grant 0187P-M9506 from Conacyt. i Mo-P 1 : 1641 L E V E L S O F S E R U M L I P O P R O T E I N (A) IN P A T I E N T S WITH PRIMARY HYPOTHYROIDISM AND EUTI-IYROID G O I T E R M. Djeric, S. Kojic-Damjanov, M. Ninkovic. Cl#zical Center=Novi SaN, Novi
SaN, Serbia - Montenegro Objective: Alteration of the lipid profile axe a well known phenomenon in thyroid dysfunction. Thyroid hormones regulate lipid metabolism through various mechanismus, but a key role is played by the LDL receptor pathway. Thyroid hormone influence on lipoprotein (a) metabolism is unknown. Methods: We investigated Lp(a) lipoprotein concentrations (RID method) in a group of 20 patients with primary hypothyroidism (PM) (T4 82-t-46.54 Itmol/l; T3 1.27-t-0.56 Itmol/l; TSH 22.15-t-19.48 mJ/1) and in a group of 16 patients with euthyroid goiter (lEG) (T4 129.37-t-23.57 Itmol/l; T3 1.68-t-0.21 Itmol/l; TSH 1.82-t-2.87 mJ/l) as well as in 213 healthy persons (CG). Results: Plasma Lp(a) levels in 20 women aged 17 to 69 (mean 48) years with PH ranged from 0.01 to 0.91 (mean-t-SD; 0.23-t-0.20) g/l and frequency of elevated levels was 40% (35% moderate and 5% extremly). Those of 16 women aged 23 to 79 (mean 54) years with EG ranged from 0.01 to 0.66 (0.24-t-0.20) g/l and frequency of elevated levels was 31.25% (12.50% and 18.75%). The mean values for Lp(a) in PH as well as in EG were significantly higher (p < 0.001 in a both group) than those of the healthy subjects (0.11-4-0.13 g/l). Conclusions: Elevated concentrations of Lp(a) in combination with LDL cholesterol may be involved in the increased risk of cardiovascular disease assumed to be associated with hypothyroidism. Funding: Clinical Center-Novi Sad, Novi Sad, Serbia&Montenegro
I Mo-P1 165
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I I
ATHEROSCLEROSIS, H E M O R H E O L O G I C A L PARAMETERS AND AGING
G. Feher I , K. KoltaJ 1 , P. Kenyeres I , H. Rapp I , G. Kesmarky I , L. Szapary 2, I. Juricskay 1 , K. Toth 1.1First Department of Medicine Division of
Cardiology, Universi~ of Pecs School of Medicbw, Pets, Hungary: 2Department of Neurology, Universi~ of Pecs School of Medicine, Pecs, Hungary Background: There is increasing evidence that impaired hemorheological parameters are associated with the development of atherosclerosis and thereby with increased risk of cardio -and cerebrovasculax events. The aim of our present study was to examine the relationship of these parameters to advancing age. Methods: The data of 6236 cardio- and cerebrovasculax patients were included into this analysis. Males and females were divided into three groups, A < 45 years of age (young), B 45-65 years (middle-aged), C > 65 years (old). To exclude the effect of risk profile, previous diseases and medication, a homogenous group of 623 patients were selected from the examined group with matching parameters. Results: All the measured hemorheological parameters correlated significantly with advancing age in the whole population (p < 0.01), however the values of the correlation coefficients were very low. On the other hand, examining the different age-groups we found that these parameters did not consequently correlate with age, in fact hematocrit, red blood cell aggregation and whole blood viscosity values were negatively correlated with age in old males (p< 0.05). In the selected population these parameters did not correlate with advancing age. Condusions: In the whole population the correlation of hemorheological parameters and advancing age may be just statistically, but not clinically significant. In the selected population these parameters did not correlate with advancing age. Our results suggest that though atherosclerosis is associated with impaired hemorheological parameters, these are mostly independent of aging.
I Mo-P 1 167
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YOUNGER MENOPAUSE AGE PREDICTS ADVERSE OUTCOME AFTER MYOCARDIAL INFARCTION ~ J. Lichtman 3 , N. Dawood 1 , S. Mallik 1, J.A. Spertus-, K.J. Reid-, N. Wenger ] , V. Vaccarino 1.1Emory Universi~, Atlanta, USA." 2Mid America i
Heart btstitute, Kansas Ci~, USA." 3 Yale Universi~, New Haven, USA Background: Young age at menopause is a risk factor for premature CHD. It is unknown whether it is a prognostic factor after myocardial infarction (MI). Methods: We examined whether younger age at menopause (_<40 years) confers increased risk of adverse outcomes in 572 post-menopausal women enrolled in prospective multicenter MI registry-PREMIER. Outcome measures at 1 yr post-MI included rehospitalization, rehospitalization or mortality, and health status (angina frequency and quality of life (QOL) using the Seattle Angina Questionnaire and physical function (PF) using the Physical Component Scale (PCS) Short-Form 12). Linear regression models were used with A A M as continuous variable controlling for baseline health status, demographics, comorbidities and quality of care indicators. Results: Women with early age at menopause (_< 40 yr; N=128; 28 natural, 97 surgical) were younger and more often smokers but were as likely to have hypertension, prior MI, diabetes and lower ejection fraction compared with women with late age at menopause (>50 yr). At 1 yr, for each 10yr younger age at menopause the probability of having angina (OR 1.45; 95% CI 1.79-1.15), rehospitalization (HR 1.22; 95% CI 1.47, 1.01) and rehospitalization or mortality (HR 1.22; 95% CI 1.47, 1.00) increased. The association of age at menopause with 1-yr PF was non-linear: women with age at menopause around 45 yr had highest 1-yr PF, which decreased as age decreased or increased. There was no association between age at menopause and 1-yr QOL. Conclusion: Younger menopause age is a risk factor for adverse outcomes after MI. O U S H O L D F O O D S E C U R I T Y A N D C.V.D A N D ITS IMo-P1:4611HRISK FACTORS IN I R A N I
M. Rafiei 1, M. Boshtam 2. 1Medical Education Development Center; Isfidzan, h'an." 2Cardiovascular Research Center; Isfahan, h'an
Objective: The nutrition transition in Iran is taking place in many contexts. Problem of micronutrients deficiencies still dominate the public health nutrition agenda; however, researches report obesity and other nutritional risk factors of CVD in a major part of the society as the first mortality cause.
XIV bzterTtational Symposium on Atherosclerosis, Rome, Italy, June 18-22, 2006