- Email: [email protected]
Mo-P1:82 Analysis and study of sudden cardiac deaths in a region of central Greece
P1
64
Mon&ty, June 19, 2006: Poster Session Epidemiology of cardiovascular disease
Results: During the survey period, the age-adjusted event rate for A M I / C D per 100,000 persons/yeax in this area was 68 (101 in m e n and 32 in women). This was approximately two-fold increase c o m p a r e d to the incident rate for a comparable rural area of J a p a n surveyed f r o m 1989 to 97. In addition, the 28-day case-fatality rate for the present survey was clearly higher than that of the previous report (55% versus 40%). Conclusion: The current incidence and case-fatality of A M I / C D axe considerably increased in a rural area of northern Japan. These data suggest that changes in life style and population composition m a y have a clear i m p a c t on the clinical and epidemiological features of AMI/CD.
the difference was not significant b y multivariate analysis of variance adjusted for BMI and age (P=0.71 for m e n and P=0.32 for women). C o n d u s i o n : BMI has a significant effect on MetSx and adiponectin in Japanese.
I
Mo-P1:84 [ PREMATURE MYOCARDIAL INFARCTION AS A i S E R I O U S P U B L I C H E A L T H IN I R A N . A N EPIDEMILOGIC SURVEY OF PREMATURE M Y O C A R D I A L I N F A R C T I O N IN S O U T H O F I R A N M. Shoiaie. Cardiology Department, Jahrom Medical School, h'an
IM o - P 1 : 8 2 1
I i
ANALYSIS AND STUDY OF SUDDEN CARDIAC D E A T H S IN A R E G I O N O F C E N T R A L G R E E C E
T. Galeas I , T. Potsis I , K. Koutrakis I , S. Betsimeas I , A. Xifoli I , V. G a l e a I , S. Mylonas i E. Z a g g e h d o u ~ , R. L e o n t a n ~ . General Hospztal of Trikala,
Trikala, Greece: 2 Forensic Medicine Sen,ice, lxlrisa, Greece Objective: 1)To analyse and study the cases of sudden cardiac deaths (SCDs) that occured in an area of Central Greece during the period 2000-2004 2)To examine the effects of gender and age on circadian variability in SCDs. M a t e r i a l a n d M e t h o d s : We recorded 98 cases of out-of-hospital SCDs, in subjects over 18 years. The 5-year material was classified according to the year of death, gender, age group, p e r m a n e n t residence of the necrotomized, cause of death and was distributed according to the time of death in 24 hourly intervals. Results: A. Year of death: 2000: 33, 2001: 27, 2002: 10, 2003: 14, 2004: 14. B. Sex: 73 men (75,5%) and 25 w o m e n (20%). C. A g e group: 1 5 - 2 4 : 4 men, 2 5 - 3 4 : 5 (3 men, 2 women), 3 5 - 4 4 : 8 (6 men, 2 women), 4 5 - 5 4 : 2 0 ( 1 6 men, 4 women), 5 5 - 6 4 : 2 4 (18 men, 6 women), over 6 5 : 3 7 (26 men, 11 women), D. Permanent residence: City of Trikala: 29, rural areas: 62, areas out of the county of Trikala: 7. E. Cause of death: acute myocardial infarction: 62 (64%), acute cardiac failure: 10 (10%), heart failure: 7 (7%), diseases of aorta 3 (3%), drug ingestion 4 (4%), others: 3 (3%). F. Analysis of S C D daily periodicity showed: a. in the morning 8:00-11:00 (max 10:00), b. at meridian hours 13:00-14:00 and c. in the evening 16:00-20:00 (max 18:00). These peaks were of similar magnitude. Conclusions: The frequency of SCDs is higher in m e n and is increased according to age, in both sexes. In rural areas a statistically significant increased n u m b e r of SCDs is observed. The m a j o r cause of SCDs is acute myocardial infarction due to atherosclerosis. O u r data support the daily d r c a d i a n variation of SCDs.Variability was independent of sex and age
IM o - P 1 : 8 3 1
I I
OBESITY, A D I P O N E C T I N A N D T H E P R E V A L E N C E O F THE METABOLIC SYNDROME AMONG JAPANESE M E N A N D W O M E N IN J A P A N A N D HAWAII: T H E INTERLIPID STUDY
Y. N a k a m u r a , N. O k u d a ~, A. H i g a s h i y a m a ~, Y. Kita ~ , T. O k a m u r a 2, A. O k a y a m a 3 , S. C h o u d h u r y 4 , B. Rodri~uez 5 , D. Curb 5, H. L eshima ~.
1Kyoto Wonwn's Universi~, Kyoto, Japan." 2Shiga Universi~ of Medical Science, Otsu, Japan: 3National Cardiovascular Center; Suita, Japan: 4National Heart Foundation Hospital & Research Institute, Dhakzt, Bangladesh." 5Pacific Health Research Institute, Honolulu, USA B a c k g r o u n d : A novel adipose-specific protein, adiponectin has been suggested to play an important role in modulation of the metabolic s y n d r o m e (MetSx). We c o m p a r e d the prevalence of MetSx and the p l a s m a adiponectin concentrations a m o n g Japanese m e n and w o m e n in Japan and Hawaii. M e t h o d s a n d Results: In between 1997 and 1998, c o m m u n i t y - b a s e d men and w o m e n a g e d 40-59 years were examined b y c o m m o n standardized methods - a sample in Japan (130 m e n and 129 w o m e n ) and a J a p a n e s e - A m e r i c a n sample in Hawaii (136 men and 131 women). M e t S x was defined as the co-occurrence of any 3 or more of the following 5 abnormalities: b o d y mass index (BMI) > 30 k g / m 2, h e m o g l o b i n A l c > 5.6%, b l o o d pressure 130/85 m m H g or use of antihypertensive therapy, triglycerides _> 150 mg/dl, H D L = < 40 mg/dl. The m e a n B M I was 23.4-t-2.8 and 28.1-t-4.7 k g / m 2 for m e n in Japan and Hawaii ( P < 0 . 0 0 0 1 ) ; 23.4-4-3.0 and 25.9-4-5.4 k g / m 2 for w o m e n in Japan and Hawaii ( P < 0.0001). Although, the prevalence of MetSx was higher in Japanese men and w o m e n in Hawaii (men: 3.9% in Japan vs 22.8% in Hawaii, P < 0 . 0 0 0 1 ; women: 2.3% in Japan vs 9.9% in Hawaii, P=0.011), the prevalence of M e t S x a m o n g those w h o with BMI _>28 k g / m - was not different between the two regions (P=0.23 for m e n and P=0.29 for women). The m e a n adiponectin was higher in those w h o live in Japan (men: 8.1-t-3.9 vs 6.6-t-3.2 I~g/ml, P=0.002; w o m e n 12.9-4-6.1 vs 9.3-4-4.2 I~g/ml, P < 0 . 0 0 0 1 ) , however,
Objective: Myocardial Infaxction (MI) is a complex and potentially lethal diease caused b y interaction of some genetic and environment factors.This disease has reached epidemic proportions in some A s i a n and African countries. It is responsible for one of the highest mortality causes in IRAN. The a i m of our study was to survey epidemiology of MI spatially in y o u n g age in south of IRAN. M e t h o d s : The study population consisted of 295 patients (mean age 62-t-12.5 years, Range 33-92 years) that admitted in cardiac care unit at the P y m a n i e h Hospital, JaJarom, I R A N between 2002-2005 with the diagnosis of MI according to W H O criteria. Results: our patients were 61.4% male vs 36.8% female. Overall, the prevalence of premature MI ( < 5 0 y/o) was 20.7% (47 male vs 14 female). Prevalence of risk factors in patients with premature MI consisted of high L D L (50.8%), D M (47.5%), low H D L (45.9%), s m o c k i n g (39.3%), H T N (34.4%) and family history of MI (17.8%). Overall, low H D L level were detected in w o m e n with cleax sex difference (p=0.028). In contrast, s m o c k i n g was more prevalent in men (p=0.000). A l s o a non significant sex difference in mortality was detected (15.7% in female vs 10.4% in male). C o n d u s i o n : These data indicate that premature MI is a growing hazard in IRAN. C o m p a r e d to developed countries, I R A N has a considerably high prevalence of this disease. Concerted effort are needed to prevent epidemic of c o r o n a r y artery disease spatially in y o u n g age in I R A N with focusing on difinie and probable risk factors.
I Mo-P1:85
I
I R I S K S T R A T I F I C A T I O N F O R C A R D I A C E V E N T S IN AN ALBANIAN POPULATION WITH UNSTABLE CORONARY DISEASE
i
M. Cafka, A. Doko, D. Teferid, N. Kasemi, N. ~ene, A. Goda. Universi~
Hospital Center; Tirane, Albania B a c k g r o u n d : Patients with unstable c o r o n a r y disease have a heterogenous risk profile for short term adverse outcomes. M e t h o d s : In a prospective study we r a n d o m l y assigned 1222 patients with acute coronary s y n d r o m without ST elevation to receive either s/c Calciparine 12500 IU twice daily plus Aspirine 250 m g / d (556pts), or Fraxipaxine 0.6 ml s/c twice daily plus Aspirine 250 m g / d (484pts), or Aspirine 250 m g / d (98pts). Study treatment was continued for 6-8 days and follow up was 30days. Risk stratification was made using TIMI score. Results: Using score factors such as more than three risk factors for C A D , ST segment depression on the E C G on the admission and age more than 65 years old for the three treatment groups these are the results. Group Calciparine valid
Fraxiparine valid
Aspirine valid
0.00 1.00 2.00 3.00 Total 0.00 1.00 2.00 3.(:)(:) Total 0.00 1.0 0 2.(:)(:) Total
Frequency
Percent
Valid percent
Cumulative percent
310 185 54 7 556 290 137 52 5 484 62 21 15 98
55.8 33.3 9.7 1.3 100.0 59.9 28.3 10.7 1.0 100.0 63.3 21.4 15.3 100.0
55.8 33.3 9.7 1.3 100.0 59.9 28.3 10.7 1.0 100.0 63.3 21.4 15.3 100.0
55.8 89.0 98.7 100.0 59.9 88.2 99.0 100.0 63.3 84.7 1(:)(:).(:)
C o n d u s i o n : It is evident that this albanian population has low risk for short t e r m adverse outcomes after an acute c o r o n a r y syndrom.
XIV InterTtational Symposium on Atherosclerosis, Rome, Italy, June 18-22, 2006
64
Mon&ty, June 19, 2006: Poster Session Epidemiology of cardiovascular disease
Results: During the survey period, the age-adjusted event rate for A M I / C D per 100,000 persons/yeax in this area was 68 (101 in m e n and 32 in women). This was approximately two-fold increase c o m p a r e d to the incident rate for a comparable rural area of J a p a n surveyed f r o m 1989 to 97. In addition, the 28-day case-fatality rate for the present survey was clearly higher than that of the previous report (55% versus 40%). Conclusion: The current incidence and case-fatality of A M I / C D axe considerably increased in a rural area of northern Japan. These data suggest that changes in life style and population composition m a y have a clear i m p a c t on the clinical and epidemiological features of AMI/CD.
the difference was not significant b y multivariate analysis of variance adjusted for BMI and age (P=0.71 for m e n and P=0.32 for women). C o n d u s i o n : BMI has a significant effect on MetSx and adiponectin in Japanese.
I
Mo-P1:84 [ PREMATURE MYOCARDIAL INFARCTION AS A i S E R I O U S P U B L I C H E A L T H IN I R A N . A N EPIDEMILOGIC SURVEY OF PREMATURE M Y O C A R D I A L I N F A R C T I O N IN S O U T H O F I R A N M. Shoiaie. Cardiology Department, Jahrom Medical School, h'an
IM o - P 1 : 8 2 1
I i
ANALYSIS AND STUDY OF SUDDEN CARDIAC D E A T H S IN A R E G I O N O F C E N T R A L G R E E C E
T. Galeas I , T. Potsis I , K. Koutrakis I , S. Betsimeas I , A. Xifoli I , V. G a l e a I , S. Mylonas i E. Z a g g e h d o u ~ , R. L e o n t a n ~ . General Hospztal of Trikala,
Trikala, Greece: 2 Forensic Medicine Sen,ice, lxlrisa, Greece Objective: 1)To analyse and study the cases of sudden cardiac deaths (SCDs) that occured in an area of Central Greece during the period 2000-2004 2)To examine the effects of gender and age on circadian variability in SCDs. M a t e r i a l a n d M e t h o d s : We recorded 98 cases of out-of-hospital SCDs, in subjects over 18 years. The 5-year material was classified according to the year of death, gender, age group, p e r m a n e n t residence of the necrotomized, cause of death and was distributed according to the time of death in 24 hourly intervals. Results: A. Year of death: 2000: 33, 2001: 27, 2002: 10, 2003: 14, 2004: 14. B. Sex: 73 men (75,5%) and 25 w o m e n (20%). C. A g e group: 1 5 - 2 4 : 4 men, 2 5 - 3 4 : 5 (3 men, 2 women), 3 5 - 4 4 : 8 (6 men, 2 women), 4 5 - 5 4 : 2 0 ( 1 6 men, 4 women), 5 5 - 6 4 : 2 4 (18 men, 6 women), over 6 5 : 3 7 (26 men, 11 women), D. Permanent residence: City of Trikala: 29, rural areas: 62, areas out of the county of Trikala: 7. E. Cause of death: acute myocardial infarction: 62 (64%), acute cardiac failure: 10 (10%), heart failure: 7 (7%), diseases of aorta 3 (3%), drug ingestion 4 (4%), others: 3 (3%). F. Analysis of S C D daily periodicity showed: a. in the morning 8:00-11:00 (max 10:00), b. at meridian hours 13:00-14:00 and c. in the evening 16:00-20:00 (max 18:00). These peaks were of similar magnitude. Conclusions: The frequency of SCDs is higher in m e n and is increased according to age, in both sexes. In rural areas a statistically significant increased n u m b e r of SCDs is observed. The m a j o r cause of SCDs is acute myocardial infarction due to atherosclerosis. O u r data support the daily d r c a d i a n variation of SCDs.Variability was independent of sex and age
IM o - P 1 : 8 3 1
I I
OBESITY, A D I P O N E C T I N A N D T H E P R E V A L E N C E O F THE METABOLIC SYNDROME AMONG JAPANESE M E N A N D W O M E N IN J A P A N A N D HAWAII: T H E INTERLIPID STUDY
Y. N a k a m u r a , N. O k u d a ~, A. H i g a s h i y a m a ~, Y. Kita ~ , T. O k a m u r a 2, A. O k a y a m a 3 , S. C h o u d h u r y 4 , B. Rodri~uez 5 , D. Curb 5, H. L eshima ~.
1Kyoto Wonwn's Universi~, Kyoto, Japan." 2Shiga Universi~ of Medical Science, Otsu, Japan: 3National Cardiovascular Center; Suita, Japan: 4National Heart Foundation Hospital & Research Institute, Dhakzt, Bangladesh." 5Pacific Health Research Institute, Honolulu, USA B a c k g r o u n d : A novel adipose-specific protein, adiponectin has been suggested to play an important role in modulation of the metabolic s y n d r o m e (MetSx). We c o m p a r e d the prevalence of MetSx and the p l a s m a adiponectin concentrations a m o n g Japanese m e n and w o m e n in Japan and Hawaii. M e t h o d s a n d Results: In between 1997 and 1998, c o m m u n i t y - b a s e d men and w o m e n a g e d 40-59 years were examined b y c o m m o n standardized methods - a sample in Japan (130 m e n and 129 w o m e n ) and a J a p a n e s e - A m e r i c a n sample in Hawaii (136 men and 131 women). M e t S x was defined as the co-occurrence of any 3 or more of the following 5 abnormalities: b o d y mass index (BMI) > 30 k g / m 2, h e m o g l o b i n A l c > 5.6%, b l o o d pressure 130/85 m m H g or use of antihypertensive therapy, triglycerides _> 150 mg/dl, H D L = < 40 mg/dl. The m e a n B M I was 23.4-t-2.8 and 28.1-t-4.7 k g / m 2 for m e n in Japan and Hawaii ( P < 0 . 0 0 0 1 ) ; 23.4-4-3.0 and 25.9-4-5.4 k g / m 2 for w o m e n in Japan and Hawaii ( P < 0.0001). Although, the prevalence of MetSx was higher in Japanese men and w o m e n in Hawaii (men: 3.9% in Japan vs 22.8% in Hawaii, P < 0 . 0 0 0 1 ; women: 2.3% in Japan vs 9.9% in Hawaii, P=0.011), the prevalence of M e t S x a m o n g those w h o with BMI _>28 k g / m - was not different between the two regions (P=0.23 for m e n and P=0.29 for women). The m e a n adiponectin was higher in those w h o live in Japan (men: 8.1-t-3.9 vs 6.6-t-3.2 I~g/ml, P=0.002; w o m e n 12.9-4-6.1 vs 9.3-4-4.2 I~g/ml, P < 0 . 0 0 0 1 ) , however,
Objective: Myocardial Infaxction (MI) is a complex and potentially lethal diease caused b y interaction of some genetic and environment factors.This disease has reached epidemic proportions in some A s i a n and African countries. It is responsible for one of the highest mortality causes in IRAN. The a i m of our study was to survey epidemiology of MI spatially in y o u n g age in south of IRAN. M e t h o d s : The study population consisted of 295 patients (mean age 62-t-12.5 years, Range 33-92 years) that admitted in cardiac care unit at the P y m a n i e h Hospital, JaJarom, I R A N between 2002-2005 with the diagnosis of MI according to W H O criteria. Results: our patients were 61.4% male vs 36.8% female. Overall, the prevalence of premature MI ( < 5 0 y/o) was 20.7% (47 male vs 14 female). Prevalence of risk factors in patients with premature MI consisted of high L D L (50.8%), D M (47.5%), low H D L (45.9%), s m o c k i n g (39.3%), H T N (34.4%) and family history of MI (17.8%). Overall, low H D L level were detected in w o m e n with cleax sex difference (p=0.028). In contrast, s m o c k i n g was more prevalent in men (p=0.000). A l s o a non significant sex difference in mortality was detected (15.7% in female vs 10.4% in male). C o n d u s i o n : These data indicate that premature MI is a growing hazard in IRAN. C o m p a r e d to developed countries, I R A N has a considerably high prevalence of this disease. Concerted effort are needed to prevent epidemic of c o r o n a r y artery disease spatially in y o u n g age in I R A N with focusing on difinie and probable risk factors.
I Mo-P1:85
I
I R I S K S T R A T I F I C A T I O N F O R C A R D I A C E V E N T S IN AN ALBANIAN POPULATION WITH UNSTABLE CORONARY DISEASE
i
M. Cafka, A. Doko, D. Teferid, N. Kasemi, N. ~ene, A. Goda. Universi~
Hospital Center; Tirane, Albania B a c k g r o u n d : Patients with unstable c o r o n a r y disease have a heterogenous risk profile for short term adverse outcomes. M e t h o d s : In a prospective study we r a n d o m l y assigned 1222 patients with acute coronary s y n d r o m without ST elevation to receive either s/c Calciparine 12500 IU twice daily plus Aspirine 250 m g / d (556pts), or Fraxipaxine 0.6 ml s/c twice daily plus Aspirine 250 m g / d (484pts), or Aspirine 250 m g / d (98pts). Study treatment was continued for 6-8 days and follow up was 30days. Risk stratification was made using TIMI score. Results: Using score factors such as more than three risk factors for C A D , ST segment depression on the E C G on the admission and age more than 65 years old for the three treatment groups these are the results. Group Calciparine valid
Fraxiparine valid
Aspirine valid
0.00 1.00 2.00 3.00 Total 0.00 1.00 2.00 3.(:)(:) Total 0.00 1.0 0 2.(:)(:) Total
Frequency
Percent
Valid percent
Cumulative percent
310 185 54 7 556 290 137 52 5 484 62 21 15 98
55.8 33.3 9.7 1.3 100.0 59.9 28.3 10.7 1.0 100.0 63.3 21.4 15.3 100.0
55.8 33.3 9.7 1.3 100.0 59.9 28.3 10.7 1.0 100.0 63.3 21.4 15.3 100.0
55.8 89.0 98.7 100.0 59.9 88.2 99.0 100.0 63.3 84.7 1(:)(:).(:)
C o n d u s i o n : It is evident that this albanian population has low risk for short t e r m adverse outcomes after an acute c o r o n a r y syndrom.
XIV InterTtational Symposium on Atherosclerosis, Rome, Italy, June 18-22, 2006