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Modified viral envelope polypeptide
• •• said products (GF Okasinski and DG Fry, US). Abbott Laboratories W WO 96/33279. PCT A repertoire cloning process for producing mammalian monoclonal antibodies. Also provided are methods for using these monoclonal antibodies, and kits which contain these monoclonal antibodies.
Vaccins > Vaccine for the immunoprophylaxis of the infection from feline immunodeficiency virus in the domestic cat (M Bendinelli et ai, IT). Istituto Superiore di Sanita' , Universita' Degli Studi di Pisa and the inventors W WO 96/30045. PCT It is disclosed an immunizing vaccine for prophylaxis of the infection from feline immunodeficiency virus and/or the pathological syndrome know as feline AIDS induced by said virus ... > A pluripotent vaccine against enveloped viruses (DL Morton, US). John Wayne Cancer Institute W WO 96/33734. PCT
> Malaria peptides and vaccines (01 Baruch et ai, US). Affymax Technologies NV and the inventors W WO 96/33736. PCT The present invention generally relates to novel proteins, and fragments thereof, as well as nucleic acids which encode these proteins and methods of making and using these proteins in both diagnostic and therapeutic applications...
Maladies qene t i qu es > Single chain insulin with high bioactivity (RE Chance et ai, US). Eli Lilly and Co W 741188, EP The instant invention provides polypeptide compounds of the formula b-BPa having significant insulin activity...
i r 1IS > Bispecific reagents for
44 BIOFUTUR 163 • Janvier 1997
AIDS therapy (MW Fanger etal, US). Medarex Inc W 739904, EP Bispecific molecules which react both with the high-affinity Fe receptor of human effector cells and with a virus or virus component arc disclosed ... > Induction of protection against viral infection (M Girard et ai, FR). Institut Pasteur W 742229. EP. This invention relates to monoclonal or polyclonal antibodies having neutralizing properties regarding the infection bv a determined virus, obtained after administration to a host. .. The invention further relates to the use of these antibodies as serotherapeuric drug. > Fragments d'acide nuclelque derives du genome du virus VIH-1, peptides correspondants et leurs applications en tant que reactifs d'evaluation du risque de transmission materno-fcetal du VIH-1 (R Narwa et P Roques, FR). Commissariat l'enerqie atomique W 743364 EP. Fragments d'acide nucleique derives du genome du virus de l'imrnunodeficience humaine de type 1 (VIH-l) ainsi que peptides correspendants et leurs applications en rant que reactits de de pi stage et devaluation du risque de transmission rnaterno-foerale du VIH-l.
a
> Modified viral envelope polypeptide (W Anderson et ai, US). Genetic Therapy Inc, University of Southern California and the inventors N° WO 96/30504, PCT A retroviral vector particle having a modified envelope polypeptide wherein a portion of the receptor binding region of the envelope is replaced with a targeting polypeptide which binds to a ligand or a receptor on the targeted cells ... > Gene therapy for transplantation and inflammatory or thrombotic conditions (FH Bach and S Robson, US). Sandoz Ltd, New England
Deaconess Hospital Corp and the inventors W WO 96/30532, PCl A method to render in particular endothelial cells capable of inhibiting platelet and leukocyte-mediated injury and inflammation IS described... > Novel anti-AIDS immunotoxins (GB Kitto, US). Research Development Foundation W WO 96/32416. PCT ... The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptasc...
> Lignees immortalisees de cellules issues du tissu adipeux humain, leur procede de preparation et leurs applications (AD Strosberg et V Zilberfarb, FR). CNRS et les inventeurs N° WO 96/34100, PCT
SystEnne
mmuntt ai e > Composition destinee a I'induction d'une reponse immunitaire mucosaIe (B Guy et ai, FR). Pasteur Merieux Serums & Vaccins et les inventeurs W WO 96/31235, PCT Linvention a pour objet une composition pharmaceutique destinee a induire chez un rnamrnifere hore, une reponse immunitaire protectrice l'enconrre d'un anrigene, au niveau dun site mucosa! effecteur...
a
Apup tus e > Intracellular signaling proteins and methods of use (DV Goeddel and H Hsu, US). Tularik Inc N° WO 96/30404. PCI A novel family of intracellular signaling proteins, exemplified by a tumor necrosis factor-receptor 1 associated death domain protein (TRADD), share a common TRADD sequence and include transducers of signals that modulate cell growth, differenciation and apoprosis.c.
> Apoptosis regulating gene (HS Shin et ai, KR). Korea Green Cross Corp,
Postech Foundation and the inventors N° WO 96/30513. PCI A new Bcl-2 related gene BfI-l, a polypeptide encoded by said gene, and a plasmid and a transformant comprising said gene are disclosed. The gene can be used to detect cancer.
Therapies qeniqu e et cellu lair e > Gene therapy by secretory gland expression (M German et ai, US). The Regents of the University of California N° WO 96/30050, PCI Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein ... > Adenovirus vectors for gene therapy (0 Armentano et ai, US). Genzyme Corp W WO 96/30534, PCI The present invention relates to a novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replicationcompetent adenovirus (RCA) during in vitro propagation and clinical use ...
Bioconversions > Precede de production de vanilline par bioconversion de precurseurs benzeniques (B Audras et J More, FR). Orsan SA N" 2733763, FR. > Hydantoinase from Agrobacterium tumefaciens and its use for the preparation of optically pure N-carbamyl-D-amino acids from racemic hydantoins (JE Weber and DR Durham et ai, US). WR Grace & Co-Conn W 739978. EP. A novel hydantoinase exhibiting high activity and sta-
Vaccins > Vaccine for the immunoprophylaxis of the infection from feline immunodeficiency virus in the domestic cat (M Bendinelli et ai, IT). Istituto Superiore di Sanita' , Universita' Degli Studi di Pisa and the inventors W WO 96/30045. PCT It is disclosed an immunizing vaccine for prophylaxis of the infection from feline immunodeficiency virus and/or the pathological syndrome know as feline AIDS induced by said virus ... > A pluripotent vaccine against enveloped viruses (DL Morton, US). John Wayne Cancer Institute W WO 96/33734. PCT
> Malaria peptides and vaccines (01 Baruch et ai, US). Affymax Technologies NV and the inventors W WO 96/33736. PCT The present invention generally relates to novel proteins, and fragments thereof, as well as nucleic acids which encode these proteins and methods of making and using these proteins in both diagnostic and therapeutic applications...
Maladies qene t i qu es > Single chain insulin with high bioactivity (RE Chance et ai, US). Eli Lilly and Co W 741188, EP The instant invention provides polypeptide compounds of the formula b-BPa having significant insulin activity...
i r 1IS > Bispecific reagents for
44 BIOFUTUR 163 • Janvier 1997
AIDS therapy (MW Fanger etal, US). Medarex Inc W 739904, EP Bispecific molecules which react both with the high-affinity Fe receptor of human effector cells and with a virus or virus component arc disclosed ... > Induction of protection against viral infection (M Girard et ai, FR). Institut Pasteur W 742229. EP. This invention relates to monoclonal or polyclonal antibodies having neutralizing properties regarding the infection bv a determined virus, obtained after administration to a host. .. The invention further relates to the use of these antibodies as serotherapeuric drug. > Fragments d'acide nuclelque derives du genome du virus VIH-1, peptides correspondants et leurs applications en tant que reactifs d'evaluation du risque de transmission materno-fcetal du VIH-1 (R Narwa et P Roques, FR). Commissariat l'enerqie atomique W 743364 EP. Fragments d'acide nucleique derives du genome du virus de l'imrnunodeficience humaine de type 1 (VIH-l) ainsi que peptides correspendants et leurs applications en rant que reactits de de pi stage et devaluation du risque de transmission rnaterno-foerale du VIH-l.
a
> Modified viral envelope polypeptide (W Anderson et ai, US). Genetic Therapy Inc, University of Southern California and the inventors N° WO 96/30504, PCT A retroviral vector particle having a modified envelope polypeptide wherein a portion of the receptor binding region of the envelope is replaced with a targeting polypeptide which binds to a ligand or a receptor on the targeted cells ... > Gene therapy for transplantation and inflammatory or thrombotic conditions (FH Bach and S Robson, US). Sandoz Ltd, New England
Deaconess Hospital Corp and the inventors W WO 96/30532, PCl A method to render in particular endothelial cells capable of inhibiting platelet and leukocyte-mediated injury and inflammation IS described... > Novel anti-AIDS immunotoxins (GB Kitto, US). Research Development Foundation W WO 96/32416. PCT ... The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against viral reverse transcriptasc...
> Lignees immortalisees de cellules issues du tissu adipeux humain, leur procede de preparation et leurs applications (AD Strosberg et V Zilberfarb, FR). CNRS et les inventeurs N° WO 96/34100, PCT
SystEnne
mmuntt ai e > Composition destinee a I'induction d'une reponse immunitaire mucosaIe (B Guy et ai, FR). Pasteur Merieux Serums & Vaccins et les inventeurs W WO 96/31235, PCT Linvention a pour objet une composition pharmaceutique destinee a induire chez un rnamrnifere hore, une reponse immunitaire protectrice l'enconrre d'un anrigene, au niveau dun site mucosa! effecteur...
a
Apup tus e > Intracellular signaling proteins and methods of use (DV Goeddel and H Hsu, US). Tularik Inc N° WO 96/30404. PCI A novel family of intracellular signaling proteins, exemplified by a tumor necrosis factor-receptor 1 associated death domain protein (TRADD), share a common TRADD sequence and include transducers of signals that modulate cell growth, differenciation and apoprosis.c.
> Apoptosis regulating gene (HS Shin et ai, KR). Korea Green Cross Corp,
Postech Foundation and the inventors N° WO 96/30513. PCI A new Bcl-2 related gene BfI-l, a polypeptide encoded by said gene, and a plasmid and a transformant comprising said gene are disclosed. The gene can be used to detect cancer.
Therapies qeniqu e et cellu lair e > Gene therapy by secretory gland expression (M German et ai, US). The Regents of the University of California N° WO 96/30050, PCI Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein ... > Adenovirus vectors for gene therapy (0 Armentano et ai, US). Genzyme Corp W WO 96/30534, PCI The present invention relates to a novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replicationcompetent adenovirus (RCA) during in vitro propagation and clinical use ...
Bioconversions > Precede de production de vanilline par bioconversion de precurseurs benzeniques (B Audras et J More, FR). Orsan SA N" 2733763, FR. > Hydantoinase from Agrobacterium tumefaciens and its use for the preparation of optically pure N-carbamyl-D-amino acids from racemic hydantoins (JE Weber and DR Durham et ai, US). WR Grace & Co-Conn W 739978. EP. A novel hydantoinase exhibiting high activity and sta-