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Molecular biology of bacterial infection: Current status and future perspectives
382
Book Reviews
lation of amino groups to Schiff bases is reversible in low/normal glucose levels, but if the level of glucose remains high, these Schiff bases become irreversible advanced glycosylation end products, which may cause collagen cross-linking and arterial hardening. Receptors in tke CNS-Edited by C. T. DOURISH,S. J. COOPER,S. D. IVERSENand L. L. IVERSEN. 553~~. 1992. Oxford Scientific Publications, Oxford. E60.
Multiple C~i~ystokinin
Most of the cholecystokinin (CCK) in the body is present in the CNS, being present in large amounts in the neurons in the cerebral cortex. The receptors in the brain are of subtype CCK, whilst those in the gut are CCK,. Non-peptide antagonists of subtypes A and B are now available. This book deals with: synthesis of non-peptide CCK antagonists; distribution of brain neuronal CCK; characterization of B receptors; agonist and antagonist pharmacology; gastrin/CCK receptors; blood brain transfer of ~-365, 260 and devasepide; CGK and anxiety; modmation of GABA release bv CCK; CCK and satiety; gastric mechanism and satiety; A and B receptors and- control of feeding in rodents; hypolocomotion; CCK-monoamine interactions and satiety; CCK and 5HY interaction in feeding; hunger and gastric emptying; CCK and dopamine (DA) interactions; coexistence of CCK and DA; CCK-DA implications for schizophrenia and dyskinesia; movement disorders; CCK and opioid analgesia; CCK and acupuncture toierance; opioid control of CCK release from rat spinal cord; blockade of B receptors by ~-365, 260 induces analgesia in the squirrel monkey, Molecular Biology of Bacterial Infection: Current Status and Future Perspectives--Edited by C. E. HORMAECHE, C. W. PENN and C. J. SMYTH. Society for General Microbiology
Symposium 49, 329pp. 1992. Cambridge University Press. f55. What is the molecular basis of bacterial-host interactions in infections? This book deals with: intestinal microflora and host colonization resistance; evolution of pathogenic bacteria; understanding bacterial pathogenesis; epithelial invasion by Shigella Jesneri; antigenic variation in bacterial
pathogens; Haemophilus injfuenzae lipopolysaccharide, the biochemistry and biology of a virulence factor; life within phagocytic cells; chronic infection, latency and the carrier state; bacterial enterotoxin interactions; superantigenic activities of bacterial toxins; use of mutants for defining the role of virulence factors in viva; gfobai regulation of gene expression; Yersiniae, finely tuned pathogens; bacterial timbrae; Salmonella genetics and vaccine development. M. tuberculosis is the number one killer, with 3 million deaths a year. However, one-third of the world population (1.6-2.4 billion) is infected with this agent so the death frequency is l/650 infected people. About 60 million people fail to develop protection and so the death rate amongst these is l/35. So in the vast majority of cases (l/650 to i/3.5) there is a balanced relationship between the pathogen and man. PRC: Clinical Diagnosis and Research--Edited by A. ROLFS, I. SCHULLER,U. FINCKHand I. WEBER-ROLFS. 367~~. 1992. Springer Verlag, Berlin. DM88. The polymerase chain reaction (PCR) uses two oligonucleotide sequences, oppositely orientated, and a DNA potymerase enzyme to double the number of DNA targets, Each target becomes the target for the next reaction and so on, with exponential increasing amplification of the DNA. In this way adequate amounts of a specific DNA sequence can be obtained (from one original molecule) to allow sequence anaiysis. This is a practical laboratory book that gives background information and also full practical details. It deals with: PCR, principles and reaction components; optimization strategies; general applications of PCR; inhibition or enhancement; contamination and false interpreted results: biological material amenable to PCR; isolation of DNA from cells and tissues for PC; isolation of RNA from cells and tissues for PCR; reverse transcription PCR; identi~cation of amplified PCR products; restriction fragment analysis; multiplex PCR; detection of single base changes; non-radioactive direct solid phase sequencing of genomic DNA; quantification; characterization of oncogenes: detection of infectious agents; basic methodology and research applications. A new and important industry is based on PCR and this book will provide valuable information to ail those using PCR.
Book Reviews
lation of amino groups to Schiff bases is reversible in low/normal glucose levels, but if the level of glucose remains high, these Schiff bases become irreversible advanced glycosylation end products, which may cause collagen cross-linking and arterial hardening. Receptors in tke CNS-Edited by C. T. DOURISH,S. J. COOPER,S. D. IVERSENand L. L. IVERSEN. 553~~. 1992. Oxford Scientific Publications, Oxford. E60.
Multiple C~i~ystokinin
Most of the cholecystokinin (CCK) in the body is present in the CNS, being present in large amounts in the neurons in the cerebral cortex. The receptors in the brain are of subtype CCK, whilst those in the gut are CCK,. Non-peptide antagonists of subtypes A and B are now available. This book deals with: synthesis of non-peptide CCK antagonists; distribution of brain neuronal CCK; characterization of B receptors; agonist and antagonist pharmacology; gastrin/CCK receptors; blood brain transfer of ~-365, 260 and devasepide; CGK and anxiety; modmation of GABA release bv CCK; CCK and satiety; gastric mechanism and satiety; A and B receptors and- control of feeding in rodents; hypolocomotion; CCK-monoamine interactions and satiety; CCK and 5HY interaction in feeding; hunger and gastric emptying; CCK and dopamine (DA) interactions; coexistence of CCK and DA; CCK-DA implications for schizophrenia and dyskinesia; movement disorders; CCK and opioid analgesia; CCK and acupuncture toierance; opioid control of CCK release from rat spinal cord; blockade of B receptors by ~-365, 260 induces analgesia in the squirrel monkey, Molecular Biology of Bacterial Infection: Current Status and Future Perspectives--Edited by C. E. HORMAECHE, C. W. PENN and C. J. SMYTH. Society for General Microbiology
Symposium 49, 329pp. 1992. Cambridge University Press. f55. What is the molecular basis of bacterial-host interactions in infections? This book deals with: intestinal microflora and host colonization resistance; evolution of pathogenic bacteria; understanding bacterial pathogenesis; epithelial invasion by Shigella Jesneri; antigenic variation in bacterial
pathogens; Haemophilus injfuenzae lipopolysaccharide, the biochemistry and biology of a virulence factor; life within phagocytic cells; chronic infection, latency and the carrier state; bacterial enterotoxin interactions; superantigenic activities of bacterial toxins; use of mutants for defining the role of virulence factors in viva; gfobai regulation of gene expression; Yersiniae, finely tuned pathogens; bacterial timbrae; Salmonella genetics and vaccine development. M. tuberculosis is the number one killer, with 3 million deaths a year. However, one-third of the world population (1.6-2.4 billion) is infected with this agent so the death frequency is l/650 infected people. About 60 million people fail to develop protection and so the death rate amongst these is l/35. So in the vast majority of cases (l/650 to i/3.5) there is a balanced relationship between the pathogen and man. PRC: Clinical Diagnosis and Research--Edited by A. ROLFS, I. SCHULLER,U. FINCKHand I. WEBER-ROLFS. 367~~. 1992. Springer Verlag, Berlin. DM88. The polymerase chain reaction (PCR) uses two oligonucleotide sequences, oppositely orientated, and a DNA potymerase enzyme to double the number of DNA targets, Each target becomes the target for the next reaction and so on, with exponential increasing amplification of the DNA. In this way adequate amounts of a specific DNA sequence can be obtained (from one original molecule) to allow sequence anaiysis. This is a practical laboratory book that gives background information and also full practical details. It deals with: PCR, principles and reaction components; optimization strategies; general applications of PCR; inhibition or enhancement; contamination and false interpreted results: biological material amenable to PCR; isolation of DNA from cells and tissues for PC; isolation of RNA from cells and tissues for PCR; reverse transcription PCR; identi~cation of amplified PCR products; restriction fragment analysis; multiplex PCR; detection of single base changes; non-radioactive direct solid phase sequencing of genomic DNA; quantification; characterization of oncogenes: detection of infectious agents; basic methodology and research applications. A new and important industry is based on PCR and this book will provide valuable information to ail those using PCR.