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MON-LB026: Vitamin-D Receptor Gene Polymorphism in Celiac Disease
S260
Late Breaking Abstracts
MON-LB025 AGREEMENT BETWEEN PG-SGA SHORT FORM, MUST AND SNAQ IN HOSPITAL PATIENTS
MON-LB026 VITAMIN-D RECEPTOR GENE POLYMORPHISM IN CELIAC DISEASE
K. Angerman1 , B. de Boer1 , F.D. Ottery2 , A. Bielderman3 , J.L. Roodenburg4 , W.P. Krijnen3 , B.F. van der Laan5 , P. Jutte6 , H. Jager-Wittenaar3,4 . 1 Nutrition and Dietetics, Hanze University of Applied Sciences, Groningen, Netherlands; 2 Ottery & Associates, LLC., Vernon Hills, United States; 3 Research Group Healthy Ageing, Allied Health Care and Nursing, Hanze University of Applied Sciences, 4 Department of Oral and Maxillofacial Surgery, 5 Department of Otorhinolaryngology/Head & Neck Surgery, 6 Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
H. Yuksekkaya1 , A. Yucel2 , M. Gumus2 . 1 Pediatric Gastroenterology, 2 N. Erbakan University, Konya, Turkey
Rationale: The Patient-Generated Subjective Global Assessment (PG-SGA) is a validated instrument to assess malnutrition and its risk factors in clinical populations. Its patient component, PG-SGA Short Form (SF), can be used as screening instrument. In this cross-sectional study we aimed to assess agreement between the PG-SGA SF, Malnutrition Universal Screening Tool (MUST), and Short Nutritional Assessment Questionnaire (SNAQ) in patients at the University Medical Center Groningen, The Netherlands. Methods: Malnutrition risk was assessed by PG-SGA SF, MUST, and SNAQ in 81 patients from the Departments Ear Nose Throat (ENT), Oral and Maxillofacial Surgery (OMS) and Orthopedics. Point scores of PG-SGA SF = 4 8, MUST = 1, and SNAQ = 2 were classified as ‘medium malnutrition risk’, and PG-SGA SF 9, MUST 2, and SNAQ 3 as ‘high malnutrition risk’. Agreement in classification for malnutrition risk was assessed by weighted kappa (ú) and intra-class correlation coefficient (ICC). A p-value of <0.05 was considered statistically significant. Results: According to the PG-SGA SF, MUST and SNAQ, respectively 65%, 81%, and 80% of all patients were classified as ‘low malnutrition risk’; 24%, 8% and 6% as ‘medium malnutrition risk’; 11%, 10% and 14% as ‘high malnutrition risk’. Agreement between PG-SGA SF and MUST (ú = 0.452, ICC = 0.448; p < 0.001), and between PG-SGA SF and SNAQ (ú = 0.395, ICC = 0.395; p < 0.001) were both fair. In patients from the Departments ENT and OMS, PG-SGA SF classified more patients at medium/high malnutrition risk (n = 26) as compared to the MUST (n = 12) or SNAQ (n = 14). Conclusion: We found only fair agreement between the PG-SGA SF and MUST and SNAQ, respectively. The PG-SGA SF classified three and four times more patients at medium malnutrition risk, compared to MUST and SNAQ respectively, due to its scoring on symptoms and activities/functioning. Hence, the PG-SGA SF may help facilitate proactive prevention of malnutrition. Disclosure of Interest: K. Angerman: None declared, B. de Boer: None declared, F. Ottery Other: Copyright holder of the Patient-Generated Subjective Global Assessment (PG-SGA), co-owner and co-developer of the PG-SGA based Pt-Global app, A. Bielderman: None declared, J. Roodenburg: None declared, W. Krijnen: None declared, B. van der Laan: None declared, P. Jutte: None declared, H. Jager-Wittenaar Other: Co-developer of the PG-SGA based Pt-Global app
Rationale: The pathogenesis of celiac disease still remains unknown, and the role of genetics can only be described as genetic predisposition, outside of HLA alleles are required investigations. Methods: Followed up due to celiac disease, 105 patients and 100 healthy controls were included into the study. Bsm-I and Fok-I genotypes in both groups, and vitamin-D levels, bone-mineral density, Z scores, stages of the disease and the association of Bsm-1/Fok-1 alleles were analyzed in patients group at the time of diagnosis. Results: The age and gender characteristics were similar between the two groups. In patients and control groups, the distributions of Bsm-I and Fok-I genotypes were similar (p = 0.43 and p = 0.97, respectively). Mean Z-scores of bone mineral density in patients at diagnosis were 1.5+0.88 SD, and in 61% of patients, the rate was at osteopenic ve osteoporotic levels. Mean the vitamin-D levels were 19.5+12.4 ng/ml, and significantly lower in 24% of patients (<10 ng/dl). Between those with normal and low levels of vitamin D, Bsm-I/Fok-I allelles showed a similar distribution (p > 0.05). In cases with and without osteopenia (Z-score), Bsm-I/Fok-I allelles showed a similar distribution (p > 0.05). Between to stages-III and stages-IV of celiac disease, there were no difference as to Bsm-I/Fok-I allelles (p > 0.05). Conclusion: In children with celiac disease, genotypical distribution of vitamin-D receptor genes (Bsm-I/Fok-I) were found to be similar to those in healthy children. Vitamin-D receptor genes seem to have no role in the development of celiac disease. Disclosure of Interest: None declared
MON-LB027 WATERCRESS IN BREAST CANCER PATIENTS UNDERGOING RADIOTHERAPY: RELEVANCE IN DNA DAMAGE OF DERMATITIS? P. Ravasco1 , D. Jo˜ ao1,2 , M. Jorge2 , I. Rowland3 , 3 N. Giallourou , J. Swann3 , L.M. Dias4 , J. Sain4 , S. Rothwell5 , M. Fogarty6 , N. Harbourne7 . 1 Laborat´ orio de Nutri¸ca ˜o, Faculdade de Medicina de Lisboa, 2 Hospital de Santa Maria CHLN, Lisboa, Portugal; 3 University of Reading, Reading, United Kingdom; 4 Vitacress, Odemira, Portugal; 5 Watercress Alliance, Hampshire, 6 University of Hull, Hull, United Kingdom; 7 Ireland Global University, Dublin, Ireland Rationale: Radiotherapy (RT) is a critical component of breast cancer treatment, but it can induce skin reactions and lesions. Several watercress components have been suggested to have antigenotoxic effects in vitro with reduced DNA damage. These cell effects of watercress may prove useful in the prevention of RT induced skin dermatitis. This study intended to evaluate the effect of a nutrition intervention supplemented with watercress (IG) vs a control group (CG) that maintained their ad libitum diet, on acute RT dermatitis. Methods: 29 breast cancer patients referred for RT with curative intent were randomized (IG n = 16; CG n = 13) by
Late Breaking Abstracts
MON-LB025 AGREEMENT BETWEEN PG-SGA SHORT FORM, MUST AND SNAQ IN HOSPITAL PATIENTS
MON-LB026 VITAMIN-D RECEPTOR GENE POLYMORPHISM IN CELIAC DISEASE
K. Angerman1 , B. de Boer1 , F.D. Ottery2 , A. Bielderman3 , J.L. Roodenburg4 , W.P. Krijnen3 , B.F. van der Laan5 , P. Jutte6 , H. Jager-Wittenaar3,4 . 1 Nutrition and Dietetics, Hanze University of Applied Sciences, Groningen, Netherlands; 2 Ottery & Associates, LLC., Vernon Hills, United States; 3 Research Group Healthy Ageing, Allied Health Care and Nursing, Hanze University of Applied Sciences, 4 Department of Oral and Maxillofacial Surgery, 5 Department of Otorhinolaryngology/Head & Neck Surgery, 6 Department of Orthopedics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
H. Yuksekkaya1 , A. Yucel2 , M. Gumus2 . 1 Pediatric Gastroenterology, 2 N. Erbakan University, Konya, Turkey
Rationale: The Patient-Generated Subjective Global Assessment (PG-SGA) is a validated instrument to assess malnutrition and its risk factors in clinical populations. Its patient component, PG-SGA Short Form (SF), can be used as screening instrument. In this cross-sectional study we aimed to assess agreement between the PG-SGA SF, Malnutrition Universal Screening Tool (MUST), and Short Nutritional Assessment Questionnaire (SNAQ) in patients at the University Medical Center Groningen, The Netherlands. Methods: Malnutrition risk was assessed by PG-SGA SF, MUST, and SNAQ in 81 patients from the Departments Ear Nose Throat (ENT), Oral and Maxillofacial Surgery (OMS) and Orthopedics. Point scores of PG-SGA SF = 4 8, MUST = 1, and SNAQ = 2 were classified as ‘medium malnutrition risk’, and PG-SGA SF 9, MUST 2, and SNAQ 3 as ‘high malnutrition risk’. Agreement in classification for malnutrition risk was assessed by weighted kappa (ú) and intra-class correlation coefficient (ICC). A p-value of <0.05 was considered statistically significant. Results: According to the PG-SGA SF, MUST and SNAQ, respectively 65%, 81%, and 80% of all patients were classified as ‘low malnutrition risk’; 24%, 8% and 6% as ‘medium malnutrition risk’; 11%, 10% and 14% as ‘high malnutrition risk’. Agreement between PG-SGA SF and MUST (ú = 0.452, ICC = 0.448; p < 0.001), and between PG-SGA SF and SNAQ (ú = 0.395, ICC = 0.395; p < 0.001) were both fair. In patients from the Departments ENT and OMS, PG-SGA SF classified more patients at medium/high malnutrition risk (n = 26) as compared to the MUST (n = 12) or SNAQ (n = 14). Conclusion: We found only fair agreement between the PG-SGA SF and MUST and SNAQ, respectively. The PG-SGA SF classified three and four times more patients at medium malnutrition risk, compared to MUST and SNAQ respectively, due to its scoring on symptoms and activities/functioning. Hence, the PG-SGA SF may help facilitate proactive prevention of malnutrition. Disclosure of Interest: K. Angerman: None declared, B. de Boer: None declared, F. Ottery Other: Copyright holder of the Patient-Generated Subjective Global Assessment (PG-SGA), co-owner and co-developer of the PG-SGA based Pt-Global app, A. Bielderman: None declared, J. Roodenburg: None declared, W. Krijnen: None declared, B. van der Laan: None declared, P. Jutte: None declared, H. Jager-Wittenaar Other: Co-developer of the PG-SGA based Pt-Global app
Rationale: The pathogenesis of celiac disease still remains unknown, and the role of genetics can only be described as genetic predisposition, outside of HLA alleles are required investigations. Methods: Followed up due to celiac disease, 105 patients and 100 healthy controls were included into the study. Bsm-I and Fok-I genotypes in both groups, and vitamin-D levels, bone-mineral density, Z scores, stages of the disease and the association of Bsm-1/Fok-1 alleles were analyzed in patients group at the time of diagnosis. Results: The age and gender characteristics were similar between the two groups. In patients and control groups, the distributions of Bsm-I and Fok-I genotypes were similar (p = 0.43 and p = 0.97, respectively). Mean Z-scores of bone mineral density in patients at diagnosis were 1.5+0.88 SD, and in 61% of patients, the rate was at osteopenic ve osteoporotic levels. Mean the vitamin-D levels were 19.5+12.4 ng/ml, and significantly lower in 24% of patients (<10 ng/dl). Between those with normal and low levels of vitamin D, Bsm-I/Fok-I allelles showed a similar distribution (p > 0.05). In cases with and without osteopenia (Z-score), Bsm-I/Fok-I allelles showed a similar distribution (p > 0.05). Between to stages-III and stages-IV of celiac disease, there were no difference as to Bsm-I/Fok-I allelles (p > 0.05). Conclusion: In children with celiac disease, genotypical distribution of vitamin-D receptor genes (Bsm-I/Fok-I) were found to be similar to those in healthy children. Vitamin-D receptor genes seem to have no role in the development of celiac disease. Disclosure of Interest: None declared
MON-LB027 WATERCRESS IN BREAST CANCER PATIENTS UNDERGOING RADIOTHERAPY: RELEVANCE IN DNA DAMAGE OF DERMATITIS? P. Ravasco1 , D. Jo˜ ao1,2 , M. Jorge2 , I. Rowland3 , 3 N. Giallourou , J. Swann3 , L.M. Dias4 , J. Sain4 , S. Rothwell5 , M. Fogarty6 , N. Harbourne7 . 1 Laborat´ orio de Nutri¸ca ˜o, Faculdade de Medicina de Lisboa, 2 Hospital de Santa Maria CHLN, Lisboa, Portugal; 3 University of Reading, Reading, United Kingdom; 4 Vitacress, Odemira, Portugal; 5 Watercress Alliance, Hampshire, 6 University of Hull, Hull, United Kingdom; 7 Ireland Global University, Dublin, Ireland Rationale: Radiotherapy (RT) is a critical component of breast cancer treatment, but it can induce skin reactions and lesions. Several watercress components have been suggested to have antigenotoxic effects in vitro with reduced DNA damage. These cell effects of watercress may prove useful in the prevention of RT induced skin dermatitis. This study intended to evaluate the effect of a nutrition intervention supplemented with watercress (IG) vs a control group (CG) that maintained their ad libitum diet, on acute RT dermatitis. Methods: 29 breast cancer patients referred for RT with curative intent were randomized (IG n = 16; CG n = 13) by