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Month of birth and family history in schizophrenia
Poster session m
wittllhe PANSS. From this we conclude that correlationals studies between c:ognitive deficlts and clinical features. are definitively possible. Our new research projects consists In specific studies about selective attention and Hormalion extraction from context which seem to be particularly disturbed ~ IChizophrenlc patients.
[65- 164 1Month of birth and family history In schizophrenia A. Farga8. R. DuM. G. Garcia. R. Guillaml. Consorcl Hospitalarl Parr; Taull. S;JbBd6II, Spain
w. study retrospectively the monthly/seasonal distribution of births in 420
SIOL. PSYCHIATRY 1997;42:1S-297S
In NSS scores. However. high NSS scores were associated with poorer clinical response to risperidone In chronic nonresponders. NSS total score was negatively related to degree of smoking as measured by Fagestrom Tolerance Scale (FTS). and stability of NSS was positively correlated with FTS. Our finding that total NSS score was relatively stable over time and did not vary with psychopathology or treatment with atypical neuroleptlcs. supports the suggestion that this measure may represent a trait characteristic in chronically hospitalized schizophrenics.
165-1671
croniC schizophrenic patients visited in our Hospital. 241 men and 179
women
fulfillng DSM IV schizophrenia criteria. compose the sample. Their The aim of the study Is to analise the relationship between birth distribution and family history of psychiatric disturbance. We examined tl8 psychlalr1C records and taked Into account the month/season of birth and ltle first degree family history. In order to elude the age incidence effect. Ienglh of Illness must be equal or greater than two years. We compare the monthlY/seasonal birth dislr1bution 01 he cronic schizophrenic patients with that of a control group, stratified according to the age, using a Chi-square tell Finally we compare the birth distribution of the sample with that of bipOl8J' group of subjects. Results do not support the existence of a ~ pattem In the birth of schizophrenic patients In our environment. The prevalence of first degree relatives with psychiatric disturbance has no deP8fldeOC8 on seasonality. We diseuse the limitations of our findings.
mean age is 37 a
(65-16~ Verbal learning task and regional cerebral blood
flow In normal controls and schizophrenic patients S Not\aI'a. M. Suzuki. M. Matsui. I. Yamashita. K. Matsumoto, O. Saitoh,
M.
Kurachl. Department of Neuropsychiatry. Toyama Medical and Ph/Jf'ITIIJeeuticaJ University. Toyama, Japan
To clarifY the mechanism underlying memory dysfunction in schizophrenia. regional cerebral blood flow (rCBF) durlng a verbal leamlng task was mea• and using 89mTe-ECD and single photon emission computed tomography (SPECT) in 8 normal controls and 4 schizophrenic patients. The verbal Jeatnlng task was made according to the report by Gold et al. (1992), and fie erbal repetition was used as a control taSk. In the normal controls. tCB~ ~ the anterior clngulate, olbita-frontal, superior fron~l, and middle tontaJ areas In both hemispheres and rCBF In the left Infenor frontal area inCI'eased during the velballeaming task compared with the repetition In addition, rCBF in the basal ganglia and thalamic areas In the left hemisphere were decreased during the verbal leaming task. In contrast to c;ontrols there was no significant frontal lobe activation by velballeaming lhlI schiZ~renlc patients. Only the rCBF in the posterior cingulate was ~ during this task In the patients. The results indicate that memory tion may be related to the distributed networks of various frontal ~. thalamus, and basal ganglia, and their functions may be impaired il patieIltS wi1h schizophrenia.
=
@S-16§J
Stability of neurological soft signs In chronic schizophrenics treated with typical and atypical neuroleptlcs
R.C Smith, M.I. HussaJn. SA Chowdhury. S.M. Jalri. Dept Psychiatry. NYU ~ SC/1OOI & Manhattan Psychiatric Center, New York, New York, USA
. studY assessed the stability of neurological soft signs (NSS) In patients
with a series of typical and atypical neuroleptics. and assessed t'~ationShIP of changes In NSS to changes In NSS to changesin lhlI th010gy and to smokJng history.
ThiS
=
~.. Thirty-seven chronically hospitalized schizophrenic patients ted iwo or more occasions over the course of 3 yrs wi1h standard
~ psychOpathology scales. and smoking history was obtained with
...-trnrn Tolerance scale. lhlI FaV"v:T~ta1 NSS scores were highly correlated (r's '"' 0.76 to 0.86 P < ReSlJ)~ changes In NSS scores at two time points were not significantly ~ cha/lges In psychopathology scores. Component NSS subseale tomotor sequencing and motor coordination tasks showed moderate ~ of er time. In patients rated when they were treated with traditional ~~~cs and later with risperidone and/or clozapine, there were no ;r~ effects of atypical neuroleptics to produce a significant difference
1935
Retrospective study of 6,988 Involuntary schizophrenic admissions and readmissIons over a decade (1980-1990)
D.G. Hachem. P.J. Vivian. E.F. Azourl. Psychiatric Hospital of the Cross, Jall-Eddib, Lebanon ObJective: This study Is aimed at assessing the prevalence rete. profiles. clinical features and subtypes of schizophrenia In Lebanon. Procedure: This study was based on records of 6.988 schizophrenic In-patients admitted between 1980 and 1990. Results: The findings were: Diagnosis of schizophrenia (45.5% of all ad· missions). type of schizophrenia (55% paranoid). age of onset (20.5 years). sex (male to female ratio: 2.44). marital status (82.18% single). religion (24.24% Maronite). soclo-economlc status (46% lower-middle class), Intel· lectual level (840/0 average 10). educational level (36% secondary school). place of origin (33.33% North Lebanon). health care (46.8% govemment health care plan). length of hospitalization (62 days. SO .. 42.4). refractory period (12to 14 months. SO .. 4.3 months), number 01 admissions (average 5.50 ... 2.3). Conclusion: This Is the first descriptive study of schizophrenic In-patients In Lebanon. It Is important to have sufficient knowledge of schizophrenia. as It is a common pathology In psychiatry. This study Is Intended as a contribution to the awareness of schizophrenia In Lebanon.
165-1681
A 6-year follow-up of DSM-III-R schlzophrenlform disorder with good prognostic features
F. Senazz!. Dept of Psychiatry. Public Hospital "MorgagnJ",
Forn. Italy
Clinical course and outcome of DSM-III-R schlzophrenlform disorder with good prognostic features (SFD with GPF) Is unclear. A follow-up of 20 first episode SFD with GPF patients was carried out. They were Interviewed with the Comprehensive Assessment of Symptoms and History on three occasions. 1-year apart. The first follow-up was retrospective. the other two were prospective. GAF and Strauss-Carpenter scale were used as measures 01 functioning. Results: Mean length of follow-up was 6.6 years. Mean age at onset first SFD with GPF was 33.1 years. 75% were females. 70% had major affective disorders or major affective disorders and schizophreniform disorder. 5% had schizophreniform disorder only. 15% had no disorders. 10% became schizophrenics. Mean level of functioning was good. These findings suggest that OSM-III-R schizophrenlform disorder with good prognostic features Is more related to affective illness than to schizophrenia.
165-1691
T2 relaxation time measurements In selected brain regions In schizophrenia
M. Jarema, M. Choma. R. Poniatowska. R. Krawczyk. P. Kozlowski. Institute of Psychiatry and Neurology, Warsaw, Poland The study was aimed at the measurement of T2 relaxation time In selected brain structures from "dorsa-lateral prefrontal cortex" in patients suffering from schizophrenia. Methods: In 70 schizophrenic patients the T2 relaxation time was mea· sured from MRI scans in both white and grey matter of medial and Inferior frontal gyrus. medial temporal gyrus as well as in amygdala. Measurements were compared with the severity of schizophrenic symptoms (inclUding positiVe/negative division) and some other clinical data before and after neuroleptic treatment Results: The significant correlations were found between clinical data and T2 changes In right hemisphere. The T2 values measured In both white and grey matter of right medial frontal gyrus were significantly higher in patients with less severe schizophrenic symptomatology. T2 values of gray matter In right inferior frontal gyrus correlated positively with patients' age. T2 values In right amygdala correlated positively with the severity of
wittllhe PANSS. From this we conclude that correlationals studies between c:ognitive deficlts and clinical features. are definitively possible. Our new research projects consists In specific studies about selective attention and Hormalion extraction from context which seem to be particularly disturbed ~ IChizophrenlc patients.
[65- 164 1Month of birth and family history In schizophrenia A. Farga8. R. DuM. G. Garcia. R. Guillaml. Consorcl Hospitalarl Parr; Taull. S;JbBd6II, Spain
w. study retrospectively the monthly/seasonal distribution of births in 420
SIOL. PSYCHIATRY 1997;42:1S-297S
In NSS scores. However. high NSS scores were associated with poorer clinical response to risperidone In chronic nonresponders. NSS total score was negatively related to degree of smoking as measured by Fagestrom Tolerance Scale (FTS). and stability of NSS was positively correlated with FTS. Our finding that total NSS score was relatively stable over time and did not vary with psychopathology or treatment with atypical neuroleptlcs. supports the suggestion that this measure may represent a trait characteristic in chronically hospitalized schizophrenics.
165-1671
croniC schizophrenic patients visited in our Hospital. 241 men and 179
women
fulfillng DSM IV schizophrenia criteria. compose the sample. Their The aim of the study Is to analise the relationship between birth distribution and family history of psychiatric disturbance. We examined tl8 psychlalr1C records and taked Into account the month/season of birth and ltle first degree family history. In order to elude the age incidence effect. Ienglh of Illness must be equal or greater than two years. We compare the monthlY/seasonal birth dislr1bution 01 he cronic schizophrenic patients with that of a control group, stratified according to the age, using a Chi-square tell Finally we compare the birth distribution of the sample with that of bipOl8J' group of subjects. Results do not support the existence of a ~ pattem In the birth of schizophrenic patients In our environment. The prevalence of first degree relatives with psychiatric disturbance has no deP8fldeOC8 on seasonality. We diseuse the limitations of our findings.
mean age is 37 a
(65-16~ Verbal learning task and regional cerebral blood
flow In normal controls and schizophrenic patients S Not\aI'a. M. Suzuki. M. Matsui. I. Yamashita. K. Matsumoto, O. Saitoh,
M.
Kurachl. Department of Neuropsychiatry. Toyama Medical and Ph/Jf'ITIIJeeuticaJ University. Toyama, Japan
To clarifY the mechanism underlying memory dysfunction in schizophrenia. regional cerebral blood flow (rCBF) durlng a verbal leamlng task was mea• and using 89mTe-ECD and single photon emission computed tomography (SPECT) in 8 normal controls and 4 schizophrenic patients. The verbal Jeatnlng task was made according to the report by Gold et al. (1992), and fie erbal repetition was used as a control taSk. In the normal controls. tCB~ ~ the anterior clngulate, olbita-frontal, superior fron~l, and middle tontaJ areas In both hemispheres and rCBF In the left Infenor frontal area inCI'eased during the velballeaming task compared with the repetition In addition, rCBF in the basal ganglia and thalamic areas In the left hemisphere were decreased during the verbal leaming task. In contrast to c;ontrols there was no significant frontal lobe activation by velballeaming lhlI schiZ~renlc patients. Only the rCBF in the posterior cingulate was ~ during this task In the patients. The results indicate that memory tion may be related to the distributed networks of various frontal ~. thalamus, and basal ganglia, and their functions may be impaired il patieIltS wi1h schizophrenia.
=
@S-16§J
Stability of neurological soft signs In chronic schizophrenics treated with typical and atypical neuroleptlcs
R.C Smith, M.I. HussaJn. SA Chowdhury. S.M. Jalri. Dept Psychiatry. NYU ~ SC/1OOI & Manhattan Psychiatric Center, New York, New York, USA
. studY assessed the stability of neurological soft signs (NSS) In patients
with a series of typical and atypical neuroleptics. and assessed t'~ationShIP of changes In NSS to changes In NSS to changesin lhlI th010gy and to smokJng history.
ThiS
=
~.. Thirty-seven chronically hospitalized schizophrenic patients ted iwo or more occasions over the course of 3 yrs wi1h standard
~ psychOpathology scales. and smoking history was obtained with
...-trnrn Tolerance scale. lhlI FaV"v:T~ta1 NSS scores were highly correlated (r's '"' 0.76 to 0.86 P < ReSlJ)~ changes In NSS scores at two time points were not significantly ~ cha/lges In psychopathology scores. Component NSS subseale tomotor sequencing and motor coordination tasks showed moderate ~ of er time. In patients rated when they were treated with traditional ~~~cs and later with risperidone and/or clozapine, there were no ;r~ effects of atypical neuroleptics to produce a significant difference
1935
Retrospective study of 6,988 Involuntary schizophrenic admissions and readmissIons over a decade (1980-1990)
D.G. Hachem. P.J. Vivian. E.F. Azourl. Psychiatric Hospital of the Cross, Jall-Eddib, Lebanon ObJective: This study Is aimed at assessing the prevalence rete. profiles. clinical features and subtypes of schizophrenia In Lebanon. Procedure: This study was based on records of 6.988 schizophrenic In-patients admitted between 1980 and 1990. Results: The findings were: Diagnosis of schizophrenia (45.5% of all ad· missions). type of schizophrenia (55% paranoid). age of onset (20.5 years). sex (male to female ratio: 2.44). marital status (82.18% single). religion (24.24% Maronite). soclo-economlc status (46% lower-middle class), Intel· lectual level (840/0 average 10). educational level (36% secondary school). place of origin (33.33% North Lebanon). health care (46.8% govemment health care plan). length of hospitalization (62 days. SO .. 42.4). refractory period (12to 14 months. SO .. 4.3 months), number 01 admissions (average 5.50 ... 2.3). Conclusion: This Is the first descriptive study of schizophrenic In-patients In Lebanon. It Is important to have sufficient knowledge of schizophrenia. as It is a common pathology In psychiatry. This study Is Intended as a contribution to the awareness of schizophrenia In Lebanon.
165-1681
A 6-year follow-up of DSM-III-R schlzophrenlform disorder with good prognostic features
F. Senazz!. Dept of Psychiatry. Public Hospital "MorgagnJ",
Forn. Italy
Clinical course and outcome of DSM-III-R schlzophrenlform disorder with good prognostic features (SFD with GPF) Is unclear. A follow-up of 20 first episode SFD with GPF patients was carried out. They were Interviewed with the Comprehensive Assessment of Symptoms and History on three occasions. 1-year apart. The first follow-up was retrospective. the other two were prospective. GAF and Strauss-Carpenter scale were used as measures 01 functioning. Results: Mean length of follow-up was 6.6 years. Mean age at onset first SFD with GPF was 33.1 years. 75% were females. 70% had major affective disorders or major affective disorders and schizophreniform disorder. 5% had schizophreniform disorder only. 15% had no disorders. 10% became schizophrenics. Mean level of functioning was good. These findings suggest that OSM-III-R schizophrenlform disorder with good prognostic features Is more related to affective illness than to schizophrenia.
165-1691
T2 relaxation time measurements In selected brain regions In schizophrenia
M. Jarema, M. Choma. R. Poniatowska. R. Krawczyk. P. Kozlowski. Institute of Psychiatry and Neurology, Warsaw, Poland The study was aimed at the measurement of T2 relaxation time In selected brain structures from "dorsa-lateral prefrontal cortex" in patients suffering from schizophrenia. Methods: In 70 schizophrenic patients the T2 relaxation time was mea· sured from MRI scans in both white and grey matter of medial and Inferior frontal gyrus. medial temporal gyrus as well as in amygdala. Measurements were compared with the severity of schizophrenic symptoms (inclUding positiVe/negative division) and some other clinical data before and after neuroleptic treatment Results: The significant correlations were found between clinical data and T2 changes In right hemisphere. The T2 values measured In both white and grey matter of right medial frontal gyrus were significantly higher in patients with less severe schizophrenic symptomatology. T2 values of gray matter In right inferior frontal gyrus correlated positively with patients' age. T2 values In right amygdala correlated positively with the severity of