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Mouse models of human diseases: what can we learn?
TRENDS in Genetics, Vol.17 No.10, October 2001
A TRENDS Guide to Mouse Models of Human Diseases
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Editorial
Mouse models of human diseases: what can we learn? Heightened interest in disease models is one very clear outcome of the Human Genome Project. Teams are now racing to identify the genes that cause disease, enabling the study of their function in mouse models for subsequent research into prevention and therapy. The simultaneous evolution of gene knockout and mutation technology in mice has provided the prime opportunity to facilitate the elucidation of genetic etiology of inherited disorders in humans. In this online supplement, leading scientists review such work by disease type, from Alzheimer’s disease to DiGeorge syndrome. This valuable collection provides readers with timely, comprehensive reviews of mouse knockout and mutation research, including focus on single candidate gene knockouts to complex transgenics. We hope that you will find this supplement enjoyable and informative reading.
Editorial team
MKMD information
Editor-in-Chief
Richard R. Behringer (MD Anderson Cancer Center, University of Texas, TX, USA) Guest Editors
Ted Abel (University of Pennsylvania, Philadelphia, PA, USA) Hans-Henning Arnold (University of Braunschweig, Germany) Nadia Rosenthal (Harvard University, Gloucester, MA, USA) Richard P. Harvey (Victor Chang Cardiac Research Institute, Sydney, Australia) Roberto Montes de Oca Luna (Universidad Autonoma de Nuevo Leon, Mexico) Greg Barsh (Howard Hughes Medical Institute, CA, USA) Julia Dorin (Medical Research Centre, Edinburgh, UK) Cathy Abbott (Medical Research Centre, Edinburgh, UK) Fred Levine (University of California at San Diego, La Jolla, CA, USA)
Mouse Knockout and Mutation Database (MKMD; http://research. bmn.com/mkmd) is BioMedNet’s fully searchable database of phenotypic information related to knockout and classical mutations in mice.Visit the database to gain rapid access to existing literature on specific knockouts and mutations in areas of neurobiology, immunology, embryonic development, skeleton and musculature, tumorigenesis and behavioural patterns. It includes extensive links to MEDLINE on BioMedNet. Now your institute can subscribe to the enhanced MKMD featuring a new reviews section on ‘Mouse Models of Human Diseases’. MKMD is available on an institute-wide basis. Institutes interested in subscribing can experience the full functionality of the service with a trial. Ask your Information Officer/Librarian to contact their local Elsevier Science Account Manager or e-mail us at: [email protected] For more details, visit the site at:
MKMD Editor
Clare Rathbone Assistant Editor
Joanna Milburn
http://research.bmn.com/mkmd
Production
Naomi Wright Publishing Manager
Claire Moulton
0168-9525/01/$ – see front matter © 2001 Elsevier Science Ltd. All rights reserved. PII: S0168-9525(01)02490-8
S1
A TRENDS Guide to Mouse Models of Human Diseases
|
Editorial
Mouse models of human diseases: what can we learn? Heightened interest in disease models is one very clear outcome of the Human Genome Project. Teams are now racing to identify the genes that cause disease, enabling the study of their function in mouse models for subsequent research into prevention and therapy. The simultaneous evolution of gene knockout and mutation technology in mice has provided the prime opportunity to facilitate the elucidation of genetic etiology of inherited disorders in humans. In this online supplement, leading scientists review such work by disease type, from Alzheimer’s disease to DiGeorge syndrome. This valuable collection provides readers with timely, comprehensive reviews of mouse knockout and mutation research, including focus on single candidate gene knockouts to complex transgenics. We hope that you will find this supplement enjoyable and informative reading.
Editorial team
MKMD information
Editor-in-Chief
Richard R. Behringer (MD Anderson Cancer Center, University of Texas, TX, USA) Guest Editors
Ted Abel (University of Pennsylvania, Philadelphia, PA, USA) Hans-Henning Arnold (University of Braunschweig, Germany) Nadia Rosenthal (Harvard University, Gloucester, MA, USA) Richard P. Harvey (Victor Chang Cardiac Research Institute, Sydney, Australia) Roberto Montes de Oca Luna (Universidad Autonoma de Nuevo Leon, Mexico) Greg Barsh (Howard Hughes Medical Institute, CA, USA) Julia Dorin (Medical Research Centre, Edinburgh, UK) Cathy Abbott (Medical Research Centre, Edinburgh, UK) Fred Levine (University of California at San Diego, La Jolla, CA, USA)
Mouse Knockout and Mutation Database (MKMD; http://research. bmn.com/mkmd) is BioMedNet’s fully searchable database of phenotypic information related to knockout and classical mutations in mice.Visit the database to gain rapid access to existing literature on specific knockouts and mutations in areas of neurobiology, immunology, embryonic development, skeleton and musculature, tumorigenesis and behavioural patterns. It includes extensive links to MEDLINE on BioMedNet. Now your institute can subscribe to the enhanced MKMD featuring a new reviews section on ‘Mouse Models of Human Diseases’. MKMD is available on an institute-wide basis. Institutes interested in subscribing can experience the full functionality of the service with a trial. Ask your Information Officer/Librarian to contact their local Elsevier Science Account Manager or e-mail us at: [email protected] For more details, visit the site at:
MKMD Editor
Clare Rathbone Assistant Editor
Joanna Milburn
http://research.bmn.com/mkmd
Production
Naomi Wright Publishing Manager
Claire Moulton
0168-9525/01/$ – see front matter © 2001 Elsevier Science Ltd. All rights reserved. PII: S0168-9525(01)02490-8
S1