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MP31-08 IS OSTEOPOROSIS AN INDEPENDENT RISK FACTOR FOR URINARY INCONTINENCE? RESULTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY
THE JOURNAL OF UROLOGYâ
Vol. 197, No. 4S, Supplement, Saturday, May 13, 2017
MP31-07
MP31-08
URINARY STEM CELL FACTOR MAY BECOME THE DIAGNOSABLE BIOMARKER OF OVERACTIVE BLADDER IN WOMEN
IS OSTEOPOROSIS AN INDEPENDENT RISK FACTOR FOR URINARY INCONTINENCE? RESULTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY
Takashi Hamakawa*, Yasue Kubota, Yuya Ota, Naoko Unno, Rika Banno, Masa Takada, Shoichi Sasaki, Kenjiro Kohri, Takahiro Yasui, Nagoya, Japan INTRODUCTION AND OBJECTIVES: C-kit, as known a receptor tyrosine kinase protein and a receptor of stem cell factor (SCF), not only acts as a marker of interstitial cells of Cajal, but also plays a significant role in the control of bladder spontaneous activity. And it could be an interesting target for the clinical treatment of overactive bladder (OAB). Although SCF binding to c-kit is associated with various biologic phases, the distribution and role of SCF in the urinary bladder remain unknown. Thus, we speculated that c-kit and its ligand SCF could play an important role in the control of bladder function. The objective of this study was to investigate whether SCF affects the biological behaviour of OAB. METHODS: Differentiation between OAB and control was based on symptoms and a questionnaire of Overactive Bladder Symptom Score (OABSS). Urinary SCF levels were measured in patients with OAB and in control subjects by enzyme-linked immunosorbent assay (ELISA). The urinary SCF levels were compared among controls and OAB groups, and also between OAB patients ?75 years and <75 years. RESULTS: A total of 93 women with OAB and 71 controls were enrolled. The mean age was 74.1 13.0 years for the OAB groups and 67.1 15.6 years for the control group. The average urinary SCF/creatinine levels in OAB patients was 1.589 2.837, and in the control group was 0.558 0.773 (p<0.001) (Fig.1). Analysis of urinary SCF/Cr levels among OAB group and controls by age showed no significant differences. CONCLUSIONS: Urinary SCF levels were significantly higher in women with OAB. The urinary SCF level was not associated with ageing in OAB patients and controls. These results suggested that the SCF/C-kit pathway has a potential of contribution to the onset of OAB, and urinary stem cell factor might become the evaluable biomarker of OAB in women, objectively.
e401
Sarah Mozafarpour*, Boston, MA; Jessica Lloyd, Cleveland, OH; Farsad Afshinnia, Ann Arbor, MI; Libing Hu, Boston, MA; Howard Goldman, Cleveland, OH INTRODUCTION AND OBJECTIVES: A higher prevalence of urinary incontinence has been reported in women with low bone mineral density (BMD). However, there are conflicting reports in the literature regarding whether stress or urgency incontinence predominates in this population. We examined the National Health and Nutrition Examination Survey (NHANES) to investigate the association of osteoporosis and different types of urinary incontinence. METHODS: A retrospective review of all female subjects in the NHANES database between 2009-2010 was performed. Bone mineral density data was reviewed, along with the subjects’ responses to questions regarding stress and urgency urinary incontinence. Osteoporosis is defined as BMD of 2.5 SD below the mean peak bone mass of young, healthy adults. Analysis took into account the hidden variance and the weighting methodology pertinent to analysis of NHANES. A variety of clinical confounders, such as age, ethnicity, smoking, number of vaginal deliveries and body mass index were also collected. Descriptive statistics were calculated and a multivariable logistic regression was performed to assess the association of BMD with urinary incontinence. RESULTS: Overall, 95,886,461 individuals were included with a diverse racial background including 64.2% non-Hispanic white, 12.7 % non-Hispanic black and 9.8% Mexican American. The mean age was 47.03 (SE¼0.4). The prevalence of osteoporosis was 0.4% and 3.2% among non-Hispanic black and non-Hispanic white individuals, respectively. Stress urinary incontinence (SUI) and urgency urinary incontinence (UUI) were present in 33.6% and 35.5% of osteoporotic women, respectively. After adjusting for potential covariates, osteoporosis was found to be significantly associated with SUI (OR 1.5, confidence interval 1.1-2.3). No significant independent association was found between osteoporosis and UUI. CONCLUSIONS: In the large, administrative NHANES dataset, we identified an independent association of osteoporosis with SUI in a diverse cohort of women. As connective tissue weakness is considered an underlying etiology for both osteoporosis and SUI, this study may serve as a guide for future investigation of the basic underlying mechanism. Source of Funding: None
MP31-09 ASSOCIATION BETWEEN POSTOPERATIVE URETHRAL AND VESICAL ANATOMICAL FEATURES ON MRI AND LOWER TRACT URINARY SYMPTOMS AFTER RADICAL PROSTATECTOMY. Nobuhiro Haga*, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima, Fukushima, Japan
Source of Funding: none
INTRODUCTION AND OBJECTIVES: To elucidate the etiology of lower urinary tract symptoms (LUTS) after radical prostatectomy (RP), the present study investigated association between postoperative urethral and vesical anatomical features on magnetic resonance imaging (MRI) and LUTS. METHODS: Fifty-three consecutive patients undergoing RP also underwent pre- and postoperative MRI. Preoperative MRI only evaluated preoperative membranous urethral length (MUL). Postoperative MRI evaluated postoperative MUL, posterior-urethral vesical angle, depth of the urethrovesical junction (UVJ), and urinary pooling inside the urethra and bladder neck configuration (Figure 1 and 2). At the same time as postoperative MRI, International Prostate Symptom
Vol. 197, No. 4S, Supplement, Saturday, May 13, 2017
MP31-07
MP31-08
URINARY STEM CELL FACTOR MAY BECOME THE DIAGNOSABLE BIOMARKER OF OVERACTIVE BLADDER IN WOMEN
IS OSTEOPOROSIS AN INDEPENDENT RISK FACTOR FOR URINARY INCONTINENCE? RESULTS FROM THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY
Takashi Hamakawa*, Yasue Kubota, Yuya Ota, Naoko Unno, Rika Banno, Masa Takada, Shoichi Sasaki, Kenjiro Kohri, Takahiro Yasui, Nagoya, Japan INTRODUCTION AND OBJECTIVES: C-kit, as known a receptor tyrosine kinase protein and a receptor of stem cell factor (SCF), not only acts as a marker of interstitial cells of Cajal, but also plays a significant role in the control of bladder spontaneous activity. And it could be an interesting target for the clinical treatment of overactive bladder (OAB). Although SCF binding to c-kit is associated with various biologic phases, the distribution and role of SCF in the urinary bladder remain unknown. Thus, we speculated that c-kit and its ligand SCF could play an important role in the control of bladder function. The objective of this study was to investigate whether SCF affects the biological behaviour of OAB. METHODS: Differentiation between OAB and control was based on symptoms and a questionnaire of Overactive Bladder Symptom Score (OABSS). Urinary SCF levels were measured in patients with OAB and in control subjects by enzyme-linked immunosorbent assay (ELISA). The urinary SCF levels were compared among controls and OAB groups, and also between OAB patients ?75 years and <75 years. RESULTS: A total of 93 women with OAB and 71 controls were enrolled. The mean age was 74.1 13.0 years for the OAB groups and 67.1 15.6 years for the control group. The average urinary SCF/creatinine levels in OAB patients was 1.589 2.837, and in the control group was 0.558 0.773 (p<0.001) (Fig.1). Analysis of urinary SCF/Cr levels among OAB group and controls by age showed no significant differences. CONCLUSIONS: Urinary SCF levels were significantly higher in women with OAB. The urinary SCF level was not associated with ageing in OAB patients and controls. These results suggested that the SCF/C-kit pathway has a potential of contribution to the onset of OAB, and urinary stem cell factor might become the evaluable biomarker of OAB in women, objectively.
e401
Sarah Mozafarpour*, Boston, MA; Jessica Lloyd, Cleveland, OH; Farsad Afshinnia, Ann Arbor, MI; Libing Hu, Boston, MA; Howard Goldman, Cleveland, OH INTRODUCTION AND OBJECTIVES: A higher prevalence of urinary incontinence has been reported in women with low bone mineral density (BMD). However, there are conflicting reports in the literature regarding whether stress or urgency incontinence predominates in this population. We examined the National Health and Nutrition Examination Survey (NHANES) to investigate the association of osteoporosis and different types of urinary incontinence. METHODS: A retrospective review of all female subjects in the NHANES database between 2009-2010 was performed. Bone mineral density data was reviewed, along with the subjects’ responses to questions regarding stress and urgency urinary incontinence. Osteoporosis is defined as BMD of 2.5 SD below the mean peak bone mass of young, healthy adults. Analysis took into account the hidden variance and the weighting methodology pertinent to analysis of NHANES. A variety of clinical confounders, such as age, ethnicity, smoking, number of vaginal deliveries and body mass index were also collected. Descriptive statistics were calculated and a multivariable logistic regression was performed to assess the association of BMD with urinary incontinence. RESULTS: Overall, 95,886,461 individuals were included with a diverse racial background including 64.2% non-Hispanic white, 12.7 % non-Hispanic black and 9.8% Mexican American. The mean age was 47.03 (SE¼0.4). The prevalence of osteoporosis was 0.4% and 3.2% among non-Hispanic black and non-Hispanic white individuals, respectively. Stress urinary incontinence (SUI) and urgency urinary incontinence (UUI) were present in 33.6% and 35.5% of osteoporotic women, respectively. After adjusting for potential covariates, osteoporosis was found to be significantly associated with SUI (OR 1.5, confidence interval 1.1-2.3). No significant independent association was found between osteoporosis and UUI. CONCLUSIONS: In the large, administrative NHANES dataset, we identified an independent association of osteoporosis with SUI in a diverse cohort of women. As connective tissue weakness is considered an underlying etiology for both osteoporosis and SUI, this study may serve as a guide for future investigation of the basic underlying mechanism. Source of Funding: None
MP31-09 ASSOCIATION BETWEEN POSTOPERATIVE URETHRAL AND VESICAL ANATOMICAL FEATURES ON MRI AND LOWER TRACT URINARY SYMPTOMS AFTER RADICAL PROSTATECTOMY. Nobuhiro Haga*, Tomohiko Yanagida, Ken Aikawa, Yoshiyuki Kojima, Fukushima, Japan
Source of Funding: none
INTRODUCTION AND OBJECTIVES: To elucidate the etiology of lower urinary tract symptoms (LUTS) after radical prostatectomy (RP), the present study investigated association between postoperative urethral and vesical anatomical features on magnetic resonance imaging (MRI) and LUTS. METHODS: Fifty-three consecutive patients undergoing RP also underwent pre- and postoperative MRI. Preoperative MRI only evaluated preoperative membranous urethral length (MUL). Postoperative MRI evaluated postoperative MUL, posterior-urethral vesical angle, depth of the urethrovesical junction (UVJ), and urinary pooling inside the urethra and bladder neck configuration (Figure 1 and 2). At the same time as postoperative MRI, International Prostate Symptom