- Email: [email protected]
MP40-06 LONGITUDINAL INVESTIGATION ON PREDICTORS OF CONTINENCE OUTCOMES IN PATIENTS UNDERGOING ROBOT-ASSISTED RADICAL PROSTATECTOMY
THE JOURNAL OF UROLOGYâ
e552
undergoing sRARP was 69 (65-73) years. The 11 (16.9%) patients had positive surgical margins, 14 (21.6%) extraprostatic extension and 16 (24.6%) seminal vesicle invasion (pT3b). There were no cases of rectal injury or any intraoperative complications. 16 (25%) patients had a biochemical failure after a median follow-up of 16.5 (6-56) months and 10 (15%) required adjuvant hormone therapy. 85% of patients that had sRALP were free of additional therapy at a median of 16.5 months. All 65 patients were continent prior to salvage RARP and 34 (52.3%) of them reported full continence after surgery (no pad used). The 29 (44.6%) of them partial continence1-2 pads and 5 (3.1%) 3 pads, respectively. 19 (29.2%) patients were considered potent before sRARP and 9 (47.4%) of them retained potency after the sRARP. Tumor stage pT3b (seminal vesicle invasion), pre-op Gleason >7, and positive surgical margins were predictive of biochemical recurrence. CONCLUSIONS: Our series supports the feasibility of sRARP as a suitable treatment option for patients who have experienced local recurrence of prostate cancer. Our outcomes for biochemical recurrence, potency, and continence are reasonable, maintaining a reasonable balance between cancer control data, quality of life issues and risk of complications. Longer follow-up will be necessary in determining the full extent of sRARP in providing adequate cancer control and quality of life issues.
Vol. 195, No. 4S, Supplement, Sunday, May 8, 2016
significant for predicting continence after RARP (p ¼ 0.039). Multitiple logistic regression model for recovery of continence showed statistical significance in age (¼ 66 years) at 3 and 6 months after surgery (p ¼ 0.047 and p ¼ 0.049, respectively), prostate weight (< 40g) at 3 months, and presence of OAB related symptoms at 12 months (p ¼ 0.017). CONCLUSIONS: Present findings suggested that the most powerful predictors of recovery of continence differ at each period after RARP. Age was a significant predictor at 3 and 6 months, and presence of OAB related symptoms at 12 months.
Source of Funding: None
MP40-06 LONGITUDINAL INVESTIGATION ON PREDICTORS OF CONTINENCE OUTCOMES IN PATIENTS UNDERGOING ROBOT-ASSISTED RADICAL PROSTATECTOMY Yuta Yamada*, Tetsuya Fujimura, Hiroshi Fukuhara, Toru Sugihara, Takamasa Horiuchi, Tohru Nakagawa, Haruki Kume, Yukio Homma, Tokyo, Japan INTRODUCTION AND OBJECTIVES: Incontinence is a common complication that occurs after radical prostatectomy. Various factors are reported to be associated with the recovery of continence after surgery. However, there are few reports regarding longitudinal data. Herein, we investigated predictors of continence outcomes at 3, 6, and 12 months after robot assisted radical prostatectomy. METHODS: Clinical records of 243 patients who underwent robot assisted radical prostatectomy (RARP) were investigated. Self reported questionnaires as well as clinico-pathological factors were investigated, and relationship between factors and recovery of continence were assessed at 3, 6, and 12 months after RARP. RESULTS: Age (< 67 years) and presence of overactive bladder (OAB) related symptoms were significantly associated with recovery of continence at 3 months after robot-assisted radical prostatectomy (RARP) (p ¼ 0.024 and p ¼ 0.032). At 6 months after RARP, age (< 67 years), presence of OAB related symptoms, and prostate weight (< 40) were significantly associated with recovery of continence (p ¼ 0.015, p ¼ 0.025, and p ¼ 0.046, respectively). At 12 months, presence of OAB related symptoms was the only factor associated with recovery of continence (p ¼ 0.0006). Presence of OAB related symptoms in Kaplan-Meier curves was statistically
Source of Funding: None
e552
undergoing sRARP was 69 (65-73) years. The 11 (16.9%) patients had positive surgical margins, 14 (21.6%) extraprostatic extension and 16 (24.6%) seminal vesicle invasion (pT3b). There were no cases of rectal injury or any intraoperative complications. 16 (25%) patients had a biochemical failure after a median follow-up of 16.5 (6-56) months and 10 (15%) required adjuvant hormone therapy. 85% of patients that had sRALP were free of additional therapy at a median of 16.5 months. All 65 patients were continent prior to salvage RARP and 34 (52.3%) of them reported full continence after surgery (no pad used). The 29 (44.6%) of them partial continence1-2 pads and 5 (3.1%) 3 pads, respectively. 19 (29.2%) patients were considered potent before sRARP and 9 (47.4%) of them retained potency after the sRARP. Tumor stage pT3b (seminal vesicle invasion), pre-op Gleason >7, and positive surgical margins were predictive of biochemical recurrence. CONCLUSIONS: Our series supports the feasibility of sRARP as a suitable treatment option for patients who have experienced local recurrence of prostate cancer. Our outcomes for biochemical recurrence, potency, and continence are reasonable, maintaining a reasonable balance between cancer control data, quality of life issues and risk of complications. Longer follow-up will be necessary in determining the full extent of sRARP in providing adequate cancer control and quality of life issues.
Vol. 195, No. 4S, Supplement, Sunday, May 8, 2016
significant for predicting continence after RARP (p ¼ 0.039). Multitiple logistic regression model for recovery of continence showed statistical significance in age (¼ 66 years) at 3 and 6 months after surgery (p ¼ 0.047 and p ¼ 0.049, respectively), prostate weight (< 40g) at 3 months, and presence of OAB related symptoms at 12 months (p ¼ 0.017). CONCLUSIONS: Present findings suggested that the most powerful predictors of recovery of continence differ at each period after RARP. Age was a significant predictor at 3 and 6 months, and presence of OAB related symptoms at 12 months.
Source of Funding: None
MP40-06 LONGITUDINAL INVESTIGATION ON PREDICTORS OF CONTINENCE OUTCOMES IN PATIENTS UNDERGOING ROBOT-ASSISTED RADICAL PROSTATECTOMY Yuta Yamada*, Tetsuya Fujimura, Hiroshi Fukuhara, Toru Sugihara, Takamasa Horiuchi, Tohru Nakagawa, Haruki Kume, Yukio Homma, Tokyo, Japan INTRODUCTION AND OBJECTIVES: Incontinence is a common complication that occurs after radical prostatectomy. Various factors are reported to be associated with the recovery of continence after surgery. However, there are few reports regarding longitudinal data. Herein, we investigated predictors of continence outcomes at 3, 6, and 12 months after robot assisted radical prostatectomy. METHODS: Clinical records of 243 patients who underwent robot assisted radical prostatectomy (RARP) were investigated. Self reported questionnaires as well as clinico-pathological factors were investigated, and relationship between factors and recovery of continence were assessed at 3, 6, and 12 months after RARP. RESULTS: Age (< 67 years) and presence of overactive bladder (OAB) related symptoms were significantly associated with recovery of continence at 3 months after robot-assisted radical prostatectomy (RARP) (p ¼ 0.024 and p ¼ 0.032). At 6 months after RARP, age (< 67 years), presence of OAB related symptoms, and prostate weight (< 40) were significantly associated with recovery of continence (p ¼ 0.015, p ¼ 0.025, and p ¼ 0.046, respectively). At 12 months, presence of OAB related symptoms was the only factor associated with recovery of continence (p ¼ 0.0006). Presence of OAB related symptoms in Kaplan-Meier curves was statistically
Source of Funding: None