- Email: [email protected]
MS496 EFFICACY OF PERCUTANEOUS SHUNT CLOSURE FOR HEART SEPTUM DEFECTS
210
Atherosclerosis Supplements 11, no. 2 (2010) 109–222
include the fruit of the cornus mas (2 g/daily). Diabetic rats were treated either with the cornus or glibenclamide daily for 4 weeks. Result: Fasting blood sugar, decreased meaningfully in diabetic rats treated with plant and diabetic rats treated with glibenclamide (P < 0.05). Concurrent histological studies of the pancreas of these animals, demonstrated the same result. On the base of histologic result, cornus mas have a significant effect on increasing the size of pancreatic islets in diabetic rats. Conclusion: The observations of this study indicate that antioxidant present in Cornus mas can exert antihyperglycemic effect in alloxan-induced diabetic rats. Keywords: Cornus mas, diabetes, alloxan, rat MS496 EFFICACY OF PERCUTANEOUS SHUNT CLOSURE FOR HEART SEPTUM DEFECTS T. Emami Meybodi1 , M. Emami2 , M. Dehghani3 , M. Behjati3 . 1 Cardiovascular Research Center, 2 Afshar Heart Center, 3 Yazd University of Medical Science, Yazd, Iran Introduction: Surgical repair of cardiac defects (ASD and VSD) is a safe, widely accepted procedure with negligible mortality. However, it is associated with morbidity, discomfort and a thoracotomy scar. As an alternative to surgery, a variety of devices for transcatheter closure of these defects have been developed. The immediate and short-term results of theirs deployment have been reported frequently. Objective was to describe the midterm efficacy and safety of percutaneous closure. Methods: 135 Occluder devices were used in 127 patients to close ASDs (116), VSD (11) between March 2002 and July 2008 Detailed data were collected at implantation and they have been followed clinically and investigated with electrocardiogram and echocardiogram at a mean of 48 (76 month to 1 week) months after implantation. Results: The ages at implantation ranged from 7 to 70 years. Of few residual shunts noted early after implantation, no one persisted at latest follow-up. There were no new shunts. There were no new ECG abnormalities. There were no cases of frame fracture. There has been only one mortality (in VSD group). There were 5 device emboli in ASD and 2 in VSD devices. TIA is seen in one ASD closure 16 months after implantation. Hemolysis was detected in 2 VSD patients. Finally, in statistic analysis result were acceptable (P-value <0.05). Conclusion: At midterm follow-up the percutaneous shunt closure is durable and effective, with an acceptable adverse sequel. So we can conclude that this procedure is safe and can help patient with these defects. Keyword(s): VSD-ASD- septum defect-shunt MS497 ASSOCIATION BETWEEN FOOD INSECURITY, AND CVD AND ITS RISK FACTORS IN IRAN M. Rafiei1 , H. Entezari2 , M. Boshtam3 . 1 Medical Education Development Center/Isfahan University of Medical Sciences, 2 Nutrition, Health Center Faculty/Isfahan University of Medical Sciences, 3 Cardiovascular Research Center/Isfahan University of Medical Sciences, Isfahan, Iran Objective: Researches report high obesity and other nutritional CVD risk factors prevalence as the first mortality cause in Iran. Household food security is an index reflecting access of families to food. This study tries to investigate this index regarding food security and food insecurity and its different social classifications as well as the statue of CVD and their nutritional risk factors in each of these groups to define the association between economic aspect of food access and CVD. Methods: At first a standardized scale for food security was made. Food security was investigated among 3000 families in Isfahan. The statistical approach chosen was the Racsh model, a concise one- factor non-linear Item Response Theory (IRT), a model that first obtained data using a specialized software estimating the measurement scale and computing an “item calibration” value for each question in the scale. The item calibration score indicates the relative severity of the food insecurity by each question as well as the whole questionnaire. In addition, the questions on CVD and their risk factor were asked from the samples. Results: The findings of this study showed that although food consumption patterns and dietary quality are highly income − depended dietary choices, particularly in higher- income groups are also driven by non- economic forces. Also, there is direct correlation between food insecurity and CVD risk factors. Conclusion: We conclude that food insecurity can cause of high prevalence of CVD risk factors in our society. MS498 ARTERIAL PULSE IMPACT ON BLOOD FLOW M. Beraia1 , G. Nebieridze2 . 1 MRI, Institute of Clinical Medicine, 2 Medical Center, Health, Tbilisi, Georgia Objective: At the present it is impossible to describe blood flow only by the Navier-Stokes equations because blood flow in the large arteries is unsteady, with the flow separation and waveform propagation of the viscoelastic mass. The purpose of this paper is to study impact of the arterial pulse on blood flow and initial factors of atherogenesis.
Memory Stick Presentations
Methods: In 12 healthy man (25−39 years of age) mean, peak velocity, mean, net flow has been investigated by MR angiography. Results: Initial velocity is registered after 43msec of the ECG-R wave, and it is differing from zero at all sites of the aorta, although net flow is equal to zero. Womersley number from the ascending to the abdominal aorta decreases from −13 to 5, flow is modified from inertial to viscous. In the aortic arch in protodiastole blood flow separated into opposite directed streams resulting to wave superposition with the high net flow. At the isthmus area antegrade directed waves interference. Here flow acceleration in protodiastole 6 times higher than that in systole. At the boundary reflection wave can shift the vessel wall. Conclusions: Pulse wave increases stain rate to the contiguous flow layers. At the circular sites in protodiastola flow separation/recirculation and wave superposition promotes high net flow, but wave interference constrains the vessel wall to shift. MS499 MYTH OR FACT; IS THERE A ROLE FOR PERSONALITY IN ATHEROSCLEROTIC PLAQUE PROGRESSION? PRESENTING A PROSPECTIVE COHORT STUDY P.M.C. Mommersteeg1,2 , W.H. Aarnoudse2 , J. Denollet1 , J.W. Widdershoven2 . 1 CoRPS, Tilburg University, 2 Cardiology, TweeSteden Hospital, Tilburg, The Netherlands Objective: The present study aims to identify the risk of negative affectivity and social inhibition, components of the Type D personality type, in the progression of vascular irregularities and mild stenosis. We hypothesize that in addition to behavioral risk factors, biological mechanisms may mediate the relation between personality and cardiovascular disease progression. This hypothesis is plausible as on one side a significant part of the variance in systemic IL6, CRP and fibrinogen, involved in the development of atherosclerotic disease, is due to shared genetic influences. On the other side negative affectivity as Type D personality and depression have been related to an overall increased pro-inflammatory cytokine pattern and a decreased antiinflammatory pattern. Recent findings support the existence of a genetic profile related to pro-inflammatory cytokines in both healthy subjects and patients affected by mood disorders. Methods: 500 patients with angiographically confirmed vascular irregularities will be included at the TweeSteden Hospital Tilburg. Baseline and one year measurements will include questionnaires on negative affect components as depression, exhaustion, hostility and Type D personality, as well as health status and angina complaints. Routine cardiovascular risk markers, and metabolic syndome components are measured. Blood samples are being collected for hsCRP, fibrinogen, DNA storage, and pro- and anti-inflammatory cytokine assessment. Two year follow-up health status, angina complaints and major adverse cardiac outcomes will serve as outcome variables. Results: data collection has started in 2009. Preliminary findings will investigate the relation between routine cardiovascular risk factors, vascular irregularities and the negative affect markers. MS500 ASSOCIATION STUDY OF ABCB1 AND 5HT2C GENETIC POLYMORPHISMS AND METABOLIC SYNDROME IN FEMALE PATIENTS WITH SCHIZOPHRENIA T. Boˇzina1 , H. Ljubi´c1 , M. Rojnic Kuzman2 , N. Boˇzina2 , J. Serti´c1 . 1 Zagreb University School of Medicine and University Hospital Zagreb, 2 University Hospital Zagreb, Zagreb, Croatia Background: Second generation antipsychotic (SGAs) drugs have brought significant progress in treatment of schizophrenia. However, among patients who respond to treatment well, there is a significant number of those who develop metabolic syndrome (about 50%). Interindividual differences in responses to SGAs point out that genetic factor may be relevant. The objective of this study was to determine the association of genetic polymorphism of 5-HT2c and ABCB1 and metabolic abnormalities among female patients with DSM IV schizophrenia spectrum disorders treated with SGAs. Methods: We recruited 121 female schizophrenic patients following DSM-IV criteria, who were acutely psychotic and treated with olanzapine or risperidone for up to 3 months. Metabolic syndrome developement (which included assessment of the increase of fasting glucose levels in blood, fasting total cholesterol, LDL, HDL and triglyceride levels, blood pressure and waist and hip circumferences and body mass index) was assessed. Genomic DNA was isolated from a whole blood sample of patients and exon 21 2677G>T/A and exon 26 3435C>T gene variants of ABCB1 were identified by Real time PCR method in Roche LightCycler® . −759C>T of 5-HT2c gene was analysed by PCR-RFLP method. Results: We found a significant association of −759CT 5-HT2c and the increase of waist circumference, fasting glucose and triglycerides in blood after a 3-month period. 2677GT ABCB1 variants were significantly associated with the increase of fasting glucose in SGA-treated patients. Our data indicate a possible influence of −759CT 5-HT2c and ABCB1 2677GT genetic polymorphisms on the development of metabolic abnormalities among female patients treated with SGAs.
Atherosclerosis Supplements 11, no. 2 (2010) 109–222
include the fruit of the cornus mas (2 g/daily). Diabetic rats were treated either with the cornus or glibenclamide daily for 4 weeks. Result: Fasting blood sugar, decreased meaningfully in diabetic rats treated with plant and diabetic rats treated with glibenclamide (P < 0.05). Concurrent histological studies of the pancreas of these animals, demonstrated the same result. On the base of histologic result, cornus mas have a significant effect on increasing the size of pancreatic islets in diabetic rats. Conclusion: The observations of this study indicate that antioxidant present in Cornus mas can exert antihyperglycemic effect in alloxan-induced diabetic rats. Keywords: Cornus mas, diabetes, alloxan, rat MS496 EFFICACY OF PERCUTANEOUS SHUNT CLOSURE FOR HEART SEPTUM DEFECTS T. Emami Meybodi1 , M. Emami2 , M. Dehghani3 , M. Behjati3 . 1 Cardiovascular Research Center, 2 Afshar Heart Center, 3 Yazd University of Medical Science, Yazd, Iran Introduction: Surgical repair of cardiac defects (ASD and VSD) is a safe, widely accepted procedure with negligible mortality. However, it is associated with morbidity, discomfort and a thoracotomy scar. As an alternative to surgery, a variety of devices for transcatheter closure of these defects have been developed. The immediate and short-term results of theirs deployment have been reported frequently. Objective was to describe the midterm efficacy and safety of percutaneous closure. Methods: 135 Occluder devices were used in 127 patients to close ASDs (116), VSD (11) between March 2002 and July 2008 Detailed data were collected at implantation and they have been followed clinically and investigated with electrocardiogram and echocardiogram at a mean of 48 (76 month to 1 week) months after implantation. Results: The ages at implantation ranged from 7 to 70 years. Of few residual shunts noted early after implantation, no one persisted at latest follow-up. There were no new shunts. There were no new ECG abnormalities. There were no cases of frame fracture. There has been only one mortality (in VSD group). There were 5 device emboli in ASD and 2 in VSD devices. TIA is seen in one ASD closure 16 months after implantation. Hemolysis was detected in 2 VSD patients. Finally, in statistic analysis result were acceptable (P-value <0.05). Conclusion: At midterm follow-up the percutaneous shunt closure is durable and effective, with an acceptable adverse sequel. So we can conclude that this procedure is safe and can help patient with these defects. Keyword(s): VSD-ASD- septum defect-shunt MS497 ASSOCIATION BETWEEN FOOD INSECURITY, AND CVD AND ITS RISK FACTORS IN IRAN M. Rafiei1 , H. Entezari2 , M. Boshtam3 . 1 Medical Education Development Center/Isfahan University of Medical Sciences, 2 Nutrition, Health Center Faculty/Isfahan University of Medical Sciences, 3 Cardiovascular Research Center/Isfahan University of Medical Sciences, Isfahan, Iran Objective: Researches report high obesity and other nutritional CVD risk factors prevalence as the first mortality cause in Iran. Household food security is an index reflecting access of families to food. This study tries to investigate this index regarding food security and food insecurity and its different social classifications as well as the statue of CVD and their nutritional risk factors in each of these groups to define the association between economic aspect of food access and CVD. Methods: At first a standardized scale for food security was made. Food security was investigated among 3000 families in Isfahan. The statistical approach chosen was the Racsh model, a concise one- factor non-linear Item Response Theory (IRT), a model that first obtained data using a specialized software estimating the measurement scale and computing an “item calibration” value for each question in the scale. The item calibration score indicates the relative severity of the food insecurity by each question as well as the whole questionnaire. In addition, the questions on CVD and their risk factor were asked from the samples. Results: The findings of this study showed that although food consumption patterns and dietary quality are highly income − depended dietary choices, particularly in higher- income groups are also driven by non- economic forces. Also, there is direct correlation between food insecurity and CVD risk factors. Conclusion: We conclude that food insecurity can cause of high prevalence of CVD risk factors in our society. MS498 ARTERIAL PULSE IMPACT ON BLOOD FLOW M. Beraia1 , G. Nebieridze2 . 1 MRI, Institute of Clinical Medicine, 2 Medical Center, Health, Tbilisi, Georgia Objective: At the present it is impossible to describe blood flow only by the Navier-Stokes equations because blood flow in the large arteries is unsteady, with the flow separation and waveform propagation of the viscoelastic mass. The purpose of this paper is to study impact of the arterial pulse on blood flow and initial factors of atherogenesis.
Memory Stick Presentations
Methods: In 12 healthy man (25−39 years of age) mean, peak velocity, mean, net flow has been investigated by MR angiography. Results: Initial velocity is registered after 43msec of the ECG-R wave, and it is differing from zero at all sites of the aorta, although net flow is equal to zero. Womersley number from the ascending to the abdominal aorta decreases from −13 to 5, flow is modified from inertial to viscous. In the aortic arch in protodiastole blood flow separated into opposite directed streams resulting to wave superposition with the high net flow. At the isthmus area antegrade directed waves interference. Here flow acceleration in protodiastole 6 times higher than that in systole. At the boundary reflection wave can shift the vessel wall. Conclusions: Pulse wave increases stain rate to the contiguous flow layers. At the circular sites in protodiastola flow separation/recirculation and wave superposition promotes high net flow, but wave interference constrains the vessel wall to shift. MS499 MYTH OR FACT; IS THERE A ROLE FOR PERSONALITY IN ATHEROSCLEROTIC PLAQUE PROGRESSION? PRESENTING A PROSPECTIVE COHORT STUDY P.M.C. Mommersteeg1,2 , W.H. Aarnoudse2 , J. Denollet1 , J.W. Widdershoven2 . 1 CoRPS, Tilburg University, 2 Cardiology, TweeSteden Hospital, Tilburg, The Netherlands Objective: The present study aims to identify the risk of negative affectivity and social inhibition, components of the Type D personality type, in the progression of vascular irregularities and mild stenosis. We hypothesize that in addition to behavioral risk factors, biological mechanisms may mediate the relation between personality and cardiovascular disease progression. This hypothesis is plausible as on one side a significant part of the variance in systemic IL6, CRP and fibrinogen, involved in the development of atherosclerotic disease, is due to shared genetic influences. On the other side negative affectivity as Type D personality and depression have been related to an overall increased pro-inflammatory cytokine pattern and a decreased antiinflammatory pattern. Recent findings support the existence of a genetic profile related to pro-inflammatory cytokines in both healthy subjects and patients affected by mood disorders. Methods: 500 patients with angiographically confirmed vascular irregularities will be included at the TweeSteden Hospital Tilburg. Baseline and one year measurements will include questionnaires on negative affect components as depression, exhaustion, hostility and Type D personality, as well as health status and angina complaints. Routine cardiovascular risk markers, and metabolic syndome components are measured. Blood samples are being collected for hsCRP, fibrinogen, DNA storage, and pro- and anti-inflammatory cytokine assessment. Two year follow-up health status, angina complaints and major adverse cardiac outcomes will serve as outcome variables. Results: data collection has started in 2009. Preliminary findings will investigate the relation between routine cardiovascular risk factors, vascular irregularities and the negative affect markers. MS500 ASSOCIATION STUDY OF ABCB1 AND 5HT2C GENETIC POLYMORPHISMS AND METABOLIC SYNDROME IN FEMALE PATIENTS WITH SCHIZOPHRENIA T. Boˇzina1 , H. Ljubi´c1 , M. Rojnic Kuzman2 , N. Boˇzina2 , J. Serti´c1 . 1 Zagreb University School of Medicine and University Hospital Zagreb, 2 University Hospital Zagreb, Zagreb, Croatia Background: Second generation antipsychotic (SGAs) drugs have brought significant progress in treatment of schizophrenia. However, among patients who respond to treatment well, there is a significant number of those who develop metabolic syndrome (about 50%). Interindividual differences in responses to SGAs point out that genetic factor may be relevant. The objective of this study was to determine the association of genetic polymorphism of 5-HT2c and ABCB1 and metabolic abnormalities among female patients with DSM IV schizophrenia spectrum disorders treated with SGAs. Methods: We recruited 121 female schizophrenic patients following DSM-IV criteria, who were acutely psychotic and treated with olanzapine or risperidone for up to 3 months. Metabolic syndrome developement (which included assessment of the increase of fasting glucose levels in blood, fasting total cholesterol, LDL, HDL and triglyceride levels, blood pressure and waist and hip circumferences and body mass index) was assessed. Genomic DNA was isolated from a whole blood sample of patients and exon 21 2677G>T/A and exon 26 3435C>T gene variants of ABCB1 were identified by Real time PCR method in Roche LightCycler® . −759C>T of 5-HT2c gene was analysed by PCR-RFLP method. Results: We found a significant association of −759CT 5-HT2c and the increase of waist circumference, fasting glucose and triglycerides in blood after a 3-month period. 2677GT ABCB1 variants were significantly associated with the increase of fasting glucose in SGA-treated patients. Our data indicate a possible influence of −759CT 5-HT2c and ABCB1 2677GT genetic polymorphisms on the development of metabolic abnormalities among female patients treated with SGAs.