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Multimodal evoked responses compared to CSF occurrence of oligoclonal bands in patients with multiple sclerosis
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FI02
ELECTROPHYSIOLOGICALSTUDY OF E.A.E. IN GUINEA PIG
GAMBI D, ONOFRJ M, DI CESARE N, MARCHIONNOL, CESARIO G, DI STEFANO E, FEBBO A.~ C l i n i c a Neurologica, Universit~ di Chieti, Italy A f t e r inoculation of homologous spinal cord homogenate with Freund's adjuvant, a number of guinea pigs developed EAE. The onset of the disease was characterized by symptoms referred to peripheral lesion of both s c i a t i c nerves. In these animals motor conduction v e l o c i t i e s (MCV) and somatosensory evoked p o t e n t i a l s were studied from 7 to 150 days a f t e r i n o c u l a t i o n . S c i a t i c MCV decremented par a l l e l e l y to the development of peripheral hind limb paraparesis: mean MCV values were 50 + 2 m/sec before and 22 + 2 m/sec a f t e r the appearance of the paraparesis. In-the acute monophasic form, the N14-P18 components of somatosensory c o r t i c a l evoked p o t e n t i a l s did not t e s t i f y any a l t e r a t i o n of central conduction time. The MCV and EP f i n d i n g s were compared to the neuropathological specimens obtained in each animal in order to study the r e l a t i v e correspondence of e l e c t r o physiological and neuropathological data.
FI03 MULTIMODALEVOKED RESPONSES COMPAREDTO CSF OCCURRENCEOF OLIGOCLONAL BANDS IN PATIENTS WITH MULTIPLE SCLEROSIS GANES,T., BRAUTASET,N.J. and NYBERG-HANSEN,R., Lab. C l i n i c a l Neurophysiology, R i k s h o s p i t a l e t , Oslo, Norway Visual, brainstem and somatosensory evoked responses were recorded and compared to the r e s u l t of agarose gel electrophoresis in 81 patients with MS. The somatosensory evoked responses included determination also of the central conduction time. The patients were c l a s s i f i e d according to the c r i t e r i a of McAlpine and McDonald and Halliday. In the group of possible MS 65% had oligoclonal bands in the CSF and one or more of the evoked response tests were pathological in 65%. The group with probable MS showed 91% with oligoclonal bands and 87 percent with one or more of the evoked response tests pathological. Of the patients with a d e f i n i t e MS diagnosis, 93% had oligoclonal bands and 93% had one or several of the evoked response tests p o s i t i v e . The single most p o s i t i v e test for MS thus seems to be CSF examination on oligoclonal bands. When combined however, v i s u a l , brainstem and somatosensory evoked responses had an almost i d e n t i c a l diagnost i c y i e l d . Somatosensory evoked response when recorded simultaneously from Erb's p o i n t , neck and skull and thereby obtaining the a f f e r e n t conduction times seems to be the most s e n s i t i v e evoked response t e s t .
FI04 HIGH THRESHOLD MOTORUNIT DISCHARGES DURING PROLONGEDVOLUNTARYCONTRACTION IN MAN GATEV,P., IVANOVA,T., GANTCHEV,G.N., I n s t i t u t e of Physiology, Bulgarian Academy of Sciences, Sofia l l 3 , Bulgaria Considering the modification of the i n t e r s p i k e i n t e r v a l s ( I S I ) v a r i a b i l i t y of the motor units (MU) at f a t i g u i n g contraction (Gantchev, 1967, 1978; Ivanova, Gantchev, Popivanov, 1982), the discharge v a r i a b i l i t y of high threshold MU during prolonged voluntary contraction was studied.
FI02
ELECTROPHYSIOLOGICALSTUDY OF E.A.E. IN GUINEA PIG
GAMBI D, ONOFRJ M, DI CESARE N, MARCHIONNOL, CESARIO G, DI STEFANO E, FEBBO A.~ C l i n i c a Neurologica, Universit~ di Chieti, Italy A f t e r inoculation of homologous spinal cord homogenate with Freund's adjuvant, a number of guinea pigs developed EAE. The onset of the disease was characterized by symptoms referred to peripheral lesion of both s c i a t i c nerves. In these animals motor conduction v e l o c i t i e s (MCV) and somatosensory evoked p o t e n t i a l s were studied from 7 to 150 days a f t e r i n o c u l a t i o n . S c i a t i c MCV decremented par a l l e l e l y to the development of peripheral hind limb paraparesis: mean MCV values were 50 + 2 m/sec before and 22 + 2 m/sec a f t e r the appearance of the paraparesis. In-the acute monophasic form, the N14-P18 components of somatosensory c o r t i c a l evoked p o t e n t i a l s did not t e s t i f y any a l t e r a t i o n of central conduction time. The MCV and EP f i n d i n g s were compared to the neuropathological specimens obtained in each animal in order to study the r e l a t i v e correspondence of e l e c t r o physiological and neuropathological data.
FI03 MULTIMODALEVOKED RESPONSES COMPAREDTO CSF OCCURRENCEOF OLIGOCLONAL BANDS IN PATIENTS WITH MULTIPLE SCLEROSIS GANES,T., BRAUTASET,N.J. and NYBERG-HANSEN,R., Lab. C l i n i c a l Neurophysiology, R i k s h o s p i t a l e t , Oslo, Norway Visual, brainstem and somatosensory evoked responses were recorded and compared to the r e s u l t of agarose gel electrophoresis in 81 patients with MS. The somatosensory evoked responses included determination also of the central conduction time. The patients were c l a s s i f i e d according to the c r i t e r i a of McAlpine and McDonald and Halliday. In the group of possible MS 65% had oligoclonal bands in the CSF and one or more of the evoked response tests were pathological in 65%. The group with probable MS showed 91% with oligoclonal bands and 87 percent with one or more of the evoked response tests pathological. Of the patients with a d e f i n i t e MS diagnosis, 93% had oligoclonal bands and 93% had one or several of the evoked response tests p o s i t i v e . The single most p o s i t i v e test for MS thus seems to be CSF examination on oligoclonal bands. When combined however, v i s u a l , brainstem and somatosensory evoked responses had an almost i d e n t i c a l diagnost i c y i e l d . Somatosensory evoked response when recorded simultaneously from Erb's p o i n t , neck and skull and thereby obtaining the a f f e r e n t conduction times seems to be the most s e n s i t i v e evoked response t e s t .
FI04 HIGH THRESHOLD MOTORUNIT DISCHARGES DURING PROLONGEDVOLUNTARYCONTRACTION IN MAN GATEV,P., IVANOVA,T., GANTCHEV,G.N., I n s t i t u t e of Physiology, Bulgarian Academy of Sciences, Sofia l l 3 , Bulgaria Considering the modification of the i n t e r s p i k e i n t e r v a l s ( I S I ) v a r i a b i l i t y of the motor units (MU) at f a t i g u i n g contraction (Gantchev, 1967, 1978; Ivanova, Gantchev, Popivanov, 1982), the discharge v a r i a b i l i t y of high threshold MU during prolonged voluntary contraction was studied.