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Multiphase analysis of radiation morbidity
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MULTIPHASE ANALYSIS OF RADIATION MORBIDITY Donald L. Eads, M.D., M.Sc., B.Sc. * Director of Radiation Oncology Desert Hospital 1151 Via Miraleste Palm Springs, California 92262 Jerome M. Vaeth, 11. D. St. Mary's Hospital and Medical Center 2200 Hayes Street San Francisco, California 94117
IOC and NSD iso-effect formulae were used to evaluate clinical cases of acute moist dessuamation produced by a cobalt-60 unit at Mt. Zion Hospital, San Francisco, and chronic subcutaneous fibrosis produced by a 6 MEV linear accelerator at Stanford, Palo Alto, California. IOC was found to be 2900 rec. and NSD 2100 ret for the radiation tolerance moist reaction and 2730 ret and 1900 ret for the chronic fibrosis reaction. Moist reactions always resulted in fibrosis with cobalt-60, but seldom preceeded fibrosis with 6 MEV linear accelerator. Fibrosis ma,v occur without preceeding moist reaction with cobalt-60.
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CARCINOMA OF THE PENIS AND MALE URETHRA
*Kenneth E. Ellingwood, M.D., Radiation Therapy Div.; Richard B. Berry, Senior Medical Student; Rodney R. Million, M.D., Radiation Therapy Div.; Francis A. Deture, M.D., Urology Div.; and David M. Drylie, M.D., Urology Div., University of Florida, Gainesville, FL 32610
This report is an analysis of the University of Florida experience with carcinoma of the penis and male urethra. Twenty-three patients with carcinoma of the penis (17) or male urethra (6) have been treated since the present treatment policies were established in 1964. Fourteen cases have been managed with surgery, 6 with radiation therapy, and 1 with a combination of surgery and radiation therapy. Two received only palliative treatment. Of the 17 patients with penile cancer, 7 were Stage I, 5 Stage II, 4 Stage III, and 1 Stage IV (Jackson clinical staging). Control of the primary was achieved in 12/13 patients managed with surgery, but 4 patients (2 Stage I and 2 Stage III) died from uncontrolled recurrence in the regional nodes. All of 3 patients treated with radiation therapy have remained free of recurrence. Three of the 5 patients with carcinoma of the Wethra were treated with radiation therapy, and all have remained continuously free of disease. One of the 2 patients managed with surgery developed local recurrence.
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MULTIPHASE ANALYSIS OF RADIATION MORBIDITY Donald L. Eads, M.D., M.Sc., B.Sc. * Director of Radiation Oncology Desert Hospital 1151 Via Miraleste Palm Springs, California 92262 Jerome M. Vaeth, 11. D. St. Mary's Hospital and Medical Center 2200 Hayes Street San Francisco, California 94117
IOC and NSD iso-effect formulae were used to evaluate clinical cases of acute moist dessuamation produced by a cobalt-60 unit at Mt. Zion Hospital, San Francisco, and chronic subcutaneous fibrosis produced by a 6 MEV linear accelerator at Stanford, Palo Alto, California. IOC was found to be 2900 rec. and NSD 2100 ret for the radiation tolerance moist reaction and 2730 ret and 1900 ret for the chronic fibrosis reaction. Moist reactions always resulted in fibrosis with cobalt-60, but seldom preceeded fibrosis with 6 MEV linear accelerator. Fibrosis ma,v occur without preceeding moist reaction with cobalt-60.
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CARCINOMA OF THE PENIS AND MALE URETHRA
*Kenneth E. Ellingwood, M.D., Radiation Therapy Div.; Richard B. Berry, Senior Medical Student; Rodney R. Million, M.D., Radiation Therapy Div.; Francis A. Deture, M.D., Urology Div.; and David M. Drylie, M.D., Urology Div., University of Florida, Gainesville, FL 32610
This report is an analysis of the University of Florida experience with carcinoma of the penis and male urethra. Twenty-three patients with carcinoma of the penis (17) or male urethra (6) have been treated since the present treatment policies were established in 1964. Fourteen cases have been managed with surgery, 6 with radiation therapy, and 1 with a combination of surgery and radiation therapy. Two received only palliative treatment. Of the 17 patients with penile cancer, 7 were Stage I, 5 Stage II, 4 Stage III, and 1 Stage IV (Jackson clinical staging). Control of the primary was achieved in 12/13 patients managed with surgery, but 4 patients (2 Stage I and 2 Stage III) died from uncontrolled recurrence in the regional nodes. All of 3 patients treated with radiation therapy have remained free of recurrence. Three of the 5 patients with carcinoma of the Wethra were treated with radiation therapy, and all have remained continuously free of disease. One of the 2 patients managed with surgery developed local recurrence.
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