- Email: [email protected]
N-myc genomic content and DNA ploidy in stage IVS neuroblastoma
study demonstrates that resection alone provides acceptable survival for those patients with low grade sarcoma. However, adjuvant treatment should be considered for those with high-grade sarco-
N-myc Genomic Content and DNA Ploidy in Stage IVS Neuroblastoma. J. Bowhis, C. Dominici, H. McDowell, et al. J Clin Oncol
9:1371-1375, (August), 1991. This review of DNA index (DI) analyses of 12 stage IVS neuroblastoma from three European cancer centers gave some new insight on the importance of DI and N-myc amplification on prognosis. Of the 12 tumors studied, 9 were aneuploid and 2 were diploid. Two had N-myc amplification. The aneuploid tumors were all in near-triploid range. The 9 aneuploid (near triploid) tumors all were disease-free during follow-up. The poorest prognosis was associated with diploidy and N-myc amplification, which suggested the need for aggressive adjuvant chemotherapy in these patients.Michuel P. Hirsh and Ian T. Cohen Soft Tissue Sarcomas of the Chest Wall: Results of Surgical Resection. MS. Gordon, XI. Hajdu, MS. Bains, et al. J Thorac
Cardiovasc Surg 101:843-854. (May), 1991. This report reviews the 40-year experience of a single center with 189 patients admitted for primary soft tissue sarcoma of the chest wall. Pathological specimens were available for review in 149 cases (79%). Ages of patients ranged from 3 weeks to 86 years (median, 38 years). The initial complaint was mass or pain in 97% of the cases. Sixty percent were high-grade sarcomas; 40% were low grade. Histological subtypes were desmoid tumor (32), liposarcoma (23) rhabdomyosarcoma (18). fibrosarcoma (17). embryonal rhabdomyosarcoma (14). malignant peripheral nerve tumor (13) malignant fibrous histiocytoma (11) spindle cell sarcoma (4). tenosynovial sarcoma (3). hemangiopericytoma (3) alveolar soft part sarcoma (3). and other types (12). Resection was the primary treatment in 94% of cases with a local recurrence rate of 27%. Metastases occurred in 35%. commonly with high-grade tumors. Overall, 5-year survival was 66%. 49% for high-grade sarcomas. 90% for low grade. Tumor size and age were not prognostic. This
ANNOUNCEMENTS
mas.-Thomas
F. Tracy, Jr
The Contribution of Salvage Surgery to the Management of Childhood Osteosarcoma. U. Pastotino, M. Gasparini, L. Tuvecchio, etal. J Clin Oncol9:1357-1362, (August). 1991.
This review of an 18-year experience with osteogenic sarcoma in 174 patients at Istituto Gaetano Pini, Milan, Italy, shows the benefits of aggressive “salvage surgery” for pulmonary metastases. The authors believe that an increase in 5-year survival from 35%’ in the period from 1970 to 1981 to 58% from 1982 to 1988 is a reflection of the increase in patients undergoing complete resection of pulmonary metastases from 17% to 55% in the two periods. The survival of patients with pulmonary metastases went from 0% to 28% over the same period. Therefore, the authors conclude that aggressive bilateral pulmonary resection plays an important role in survival for this disease.-Michael P. Hirsh and Ian T Cohen Childhood Ki-1 Lymphoma: Presentation as a Buttock Mass. S.S. Winter. M.H. Duncan, E. Foucar, et al. Am J Pediatr Hematol
Oncol 13:334-337, 1991. This case report from University of New Mexico School of Medicine discusses a rare anaplastic large cell non-Hodgkin’s lymphoma (NHL) presenting as a buttock mass in an g-year-old girl. This type of lymphoma with Ki-1 antigen had previously been thought to affect older adolescents and young adults and usually presents as subcutaneous lesions with regional lymph node involvement. This mass presented like a hematoma with a necrotic center that precluded closure of biopsy site. It responded well to chemotherapy, and the patient is now in remission with excellent wound healing.-Michael P. Hirsh and Ian T. Cohen
OF FUTURE MEETINGS
April 2-4, 1992
Philadelphia
PEDIATRIC RADIOLOGY 1992 For information: Henrietta Rosenberg, MD, Department of Radiology, The Children’s Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA. Tel: (215) 590-2575.
Hospital
of
Dallas 6TH INTERNATIONAL FETAL CARDIOLOGY SYMPOSIUM For information: Terry Slade Young, Division of Pediatric Cardiology, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA. Tel: (301) 328-2399; Fax: (301) 328-0501.
April lo-11,1992
Iowa City INTERNATIONAL WORKSHOP IN PEDIATRIC SURGERY “What’s New in Pediatric Surgery” For information: Ken Kimura, MD, Department of Surgery, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. Tel: (319) 356-1884; Fax: (319) 356-8378. May lo-11,1992
Journal of Pediatric Surgery, Vol27, No 3 (March), 1992: pp 409-412
409
N-myc Genomic Content and DNA Ploidy in Stage IVS Neuroblastoma. J. Bowhis, C. Dominici, H. McDowell, et al. J Clin Oncol
9:1371-1375, (August), 1991. This review of DNA index (DI) analyses of 12 stage IVS neuroblastoma from three European cancer centers gave some new insight on the importance of DI and N-myc amplification on prognosis. Of the 12 tumors studied, 9 were aneuploid and 2 were diploid. Two had N-myc amplification. The aneuploid tumors were all in near-triploid range. The 9 aneuploid (near triploid) tumors all were disease-free during follow-up. The poorest prognosis was associated with diploidy and N-myc amplification, which suggested the need for aggressive adjuvant chemotherapy in these patients.Michuel P. Hirsh and Ian T. Cohen Soft Tissue Sarcomas of the Chest Wall: Results of Surgical Resection. MS. Gordon, XI. Hajdu, MS. Bains, et al. J Thorac
Cardiovasc Surg 101:843-854. (May), 1991. This report reviews the 40-year experience of a single center with 189 patients admitted for primary soft tissue sarcoma of the chest wall. Pathological specimens were available for review in 149 cases (79%). Ages of patients ranged from 3 weeks to 86 years (median, 38 years). The initial complaint was mass or pain in 97% of the cases. Sixty percent were high-grade sarcomas; 40% were low grade. Histological subtypes were desmoid tumor (32), liposarcoma (23) rhabdomyosarcoma (18). fibrosarcoma (17). embryonal rhabdomyosarcoma (14). malignant peripheral nerve tumor (13) malignant fibrous histiocytoma (11) spindle cell sarcoma (4). tenosynovial sarcoma (3). hemangiopericytoma (3) alveolar soft part sarcoma (3). and other types (12). Resection was the primary treatment in 94% of cases with a local recurrence rate of 27%. Metastases occurred in 35%. commonly with high-grade tumors. Overall, 5-year survival was 66%. 49% for high-grade sarcomas. 90% for low grade. Tumor size and age were not prognostic. This
ANNOUNCEMENTS
mas.-Thomas
F. Tracy, Jr
The Contribution of Salvage Surgery to the Management of Childhood Osteosarcoma. U. Pastotino, M. Gasparini, L. Tuvecchio, etal. J Clin Oncol9:1357-1362, (August). 1991.
This review of an 18-year experience with osteogenic sarcoma in 174 patients at Istituto Gaetano Pini, Milan, Italy, shows the benefits of aggressive “salvage surgery” for pulmonary metastases. The authors believe that an increase in 5-year survival from 35%’ in the period from 1970 to 1981 to 58% from 1982 to 1988 is a reflection of the increase in patients undergoing complete resection of pulmonary metastases from 17% to 55% in the two periods. The survival of patients with pulmonary metastases went from 0% to 28% over the same period. Therefore, the authors conclude that aggressive bilateral pulmonary resection plays an important role in survival for this disease.-Michael P. Hirsh and Ian T Cohen Childhood Ki-1 Lymphoma: Presentation as a Buttock Mass. S.S. Winter. M.H. Duncan, E. Foucar, et al. Am J Pediatr Hematol
Oncol 13:334-337, 1991. This case report from University of New Mexico School of Medicine discusses a rare anaplastic large cell non-Hodgkin’s lymphoma (NHL) presenting as a buttock mass in an g-year-old girl. This type of lymphoma with Ki-1 antigen had previously been thought to affect older adolescents and young adults and usually presents as subcutaneous lesions with regional lymph node involvement. This mass presented like a hematoma with a necrotic center that precluded closure of biopsy site. It responded well to chemotherapy, and the patient is now in remission with excellent wound healing.-Michael P. Hirsh and Ian T. Cohen
OF FUTURE MEETINGS
April 2-4, 1992
Philadelphia
PEDIATRIC RADIOLOGY 1992 For information: Henrietta Rosenberg, MD, Department of Radiology, The Children’s Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA. Tel: (215) 590-2575.
Hospital
of
Dallas 6TH INTERNATIONAL FETAL CARDIOLOGY SYMPOSIUM For information: Terry Slade Young, Division of Pediatric Cardiology, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201, USA. Tel: (301) 328-2399; Fax: (301) 328-0501.
April lo-11,1992
Iowa City INTERNATIONAL WORKSHOP IN PEDIATRIC SURGERY “What’s New in Pediatric Surgery” For information: Ken Kimura, MD, Department of Surgery, The University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. Tel: (319) 356-1884; Fax: (319) 356-8378. May lo-11,1992
Journal of Pediatric Surgery, Vol27, No 3 (March), 1992: pp 409-412
409