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N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVELS IS ASSOCIATED WITH ENDOTHELIAL PROGENITOR CELL MOBILIZATION AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
A100.E935 JACC March 9, 2010 Volume 55, issue 10A
MYOCARDIAL ISCHEMIA AND INFARCTION N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVELS IS ASSOCIATED WITH ENDOTHELIAL PROGENITOR CELL MOBILIZATION AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ACC Poster Contributions Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m.-10:30 a.m.
Session Title: Acute Myocardial Infarction--Cell Based Therapy and Cellular Manipulations Abstract Category: Acute Myocardial Infarction--Therapy Presentation Number: 1043-259 Authors: Youngkeun Ahn, Seo Na Hong, Keun Ho Park, Nam Sik Yoon, Do Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea, Seonam University Hospital, Namwon, South Korea Background: Circulating endothelial progenitor cells (EPCs) are known to be mobilized after acute myocardial infarction (AMI). We investigated the relation between the EPC mobilization and improvement of left ventricular (LV) function and predictor for EPC mobilization. Methods: A total of 37 patients (63.2±12.7 years, male 72.1 %) with AMI who underwent percutaneous coronary intervention (PCI) were enrolled. The number of EPC was measured in the peripheral blood before PCI and after 5days of PCI. LV ejection fraction (LVEF) was measured before and after PCI, and at one- month after PCI. According to the mobilization of EPC, patients were divided into 2 groups [group I: mobilized group (n=19), group II: non-mobilized group (n=18)]. Results: The group I was older and had lower N-terminal pro-B-type natriuretic peptide levels (NT-proBNP) than the group II (60.1±13.7 vs. 69.4±11.2 years, p=0.030; 1641.0±3026.5 vs. 1829.7±1470.7 pg/mL, p=0.039, respectively). Baseline CD45lowCD34+VEGFR2+ cells were higher in the group II than the group I (63.9±95.7 vs. 273.9±342.8/106 leukocyte, p=0.021). The change of CD45lowCD34+VEGFR2+ cells were significantly higher in the group I than the group II (305.7±514.9 vs. -219.6±320.6/106 leukocyte, p=0,001). Baseline LVEF, post-procedure LVEF, and LVEF at one- month after PCI had no significant differences. In multi-variate analyses, the level of NT-proBNP was an independent predictor of EPC mobilization (OR, 13.36, 95% CI 1.43-124.2, p=0.001). Conclusions: The EPC mobilization after PCI in patients with AMI was not related to the improvement of LVEF during short-term. The level of NTproBNP was an independent predictor of EPC mobilization in patients with AMI treated with PCI.
MYOCARDIAL ISCHEMIA AND INFARCTION N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE LEVELS IS ASSOCIATED WITH ENDOTHELIAL PROGENITOR CELL MOBILIZATION AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ACC Poster Contributions Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m.-10:30 a.m.
Session Title: Acute Myocardial Infarction--Cell Based Therapy and Cellular Manipulations Abstract Category: Acute Myocardial Infarction--Therapy Presentation Number: 1043-259 Authors: Youngkeun Ahn, Seo Na Hong, Keun Ho Park, Nam Sik Yoon, Do Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea, Seonam University Hospital, Namwon, South Korea Background: Circulating endothelial progenitor cells (EPCs) are known to be mobilized after acute myocardial infarction (AMI). We investigated the relation between the EPC mobilization and improvement of left ventricular (LV) function and predictor for EPC mobilization. Methods: A total of 37 patients (63.2±12.7 years, male 72.1 %) with AMI who underwent percutaneous coronary intervention (PCI) were enrolled. The number of EPC was measured in the peripheral blood before PCI and after 5days of PCI. LV ejection fraction (LVEF) was measured before and after PCI, and at one- month after PCI. According to the mobilization of EPC, patients were divided into 2 groups [group I: mobilized group (n=19), group II: non-mobilized group (n=18)]. Results: The group I was older and had lower N-terminal pro-B-type natriuretic peptide levels (NT-proBNP) than the group II (60.1±13.7 vs. 69.4±11.2 years, p=0.030; 1641.0±3026.5 vs. 1829.7±1470.7 pg/mL, p=0.039, respectively). Baseline CD45lowCD34+VEGFR2+ cells were higher in the group II than the group I (63.9±95.7 vs. 273.9±342.8/106 leukocyte, p=0.021). The change of CD45lowCD34+VEGFR2+ cells were significantly higher in the group I than the group II (305.7±514.9 vs. -219.6±320.6/106 leukocyte, p=0,001). Baseline LVEF, post-procedure LVEF, and LVEF at one- month after PCI had no significant differences. In multi-variate analyses, the level of NT-proBNP was an independent predictor of EPC mobilization (OR, 13.36, 95% CI 1.43-124.2, p=0.001). Conclusions: The EPC mobilization after PCI in patients with AMI was not related to the improvement of LVEF during short-term. The level of NTproBNP was an independent predictor of EPC mobilization in patients with AMI treated with PCI.