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National Trends in Acute Pancreatitis in United States: 2000- 2014
comorbidity, diabetes status and alcoholic etiology, HTG ≥ 1000 mg/dl was independently associated with organ failure, pancreatic necrosis, ICU need and mortality. Conclusion: HTG was observed in 2.3% of AP episodes. More than half of the patients with Tg serum levels ≥ 1000 mg/dl were alcoholic. HTG ≥ 1000 mg/dl is independently associated with greater organ failure, pancreatic necrosis, ICU admission and mortality. Results (demographics and clinical characteristics)
Sa1340 OUTCOMES OF WEEKEND VERSUS WEEKDAY ADMISSION FOR ACUTE PANCREATITIS: A NATIONWIDE ANALYSIS Huafeng Shen, Maen M. Masadeh, Kaartik Soota, Randhir Jesudoss, Suthat Liangpunsakul
AGA Abstracts
Background and Aims: Day of admission may affect the outcomes in patients with acute pancreatitis (AP). A Japanese study revealed no weekend effect in severe AP admissions. The aim of this study was to investigate the impact of weekend versus weekday admission on in-hospital mortality and other outcomes of patients with AP by using a US nationwide database. Method: We performed a retrospective study collecting data from the National Inpatient Sample (2009-2011). We compared the outcomes including in-hospital mortality, length of stay, and total hospitalization charges between weekend and weekday admissions. Results: A total of 265,381 discharges with AP were identified, of which 197,944 (75%) were weekday admissions and 67,437 (25%) were weekend admissions. Compared with patients admitted on weekdays, those admitted on weekends had similar in-hospital mortality rates ((odds ratio [OR] 0.99; 95% confidence interval [CI], 0.93-1.06), but lower lengths of hospital stay (mean decrease, 0.25 days, P < 0.01) and lower hospitalization charges (mean decrease, $1,512, P < 0.01). Conclusion: Compared to patients admitted on weekdays, patients with AP admitted on weekends had similar in-hospital mortality rates, but lower lengths of stay and hospitalization charges.
Sa1339 NATIONAL TRENDS IN ACUTE PANCREATITIS IN UNITED STATES: 20002014 Ru Min Lee, Manoj A. Shirodkar Purpose: Acute pancreatitis is one of the most frequent gastrointestinal causes for hospital admission in the US. The incidence of acute pancreatitis (AP) has increased over time. This study aims to estimate the characteristics, outcomes, and cost burden of patients hospitalized for AP by using a large national database. Methods: The Nationwide Inpatient Sample (NIS) database was used to obtain data from 2000-2014. The NIS contains data from over 7 million hospital stays in the US per year generalizable to the American population. The NIS was queried for ICD-9 codes for primary diagnosis of acute pancreatitis (577.0). Information for demographic data, length of stay (LOS), mortality, and hospital charges was evaluated. Results: (Table 1 summaries epidemiological data) There were 3,784,981 total discharges from 2000-2014 with AP as the primary diagnosis. The number of hospitalizations for AP increased from 204,077 in 2000 to 279,145 in 2014. Mean length of stay decreased from 6.0 days to 4.6 during this period. The mean charges per hospitalization increased from $17,727 to $35,728. Aggregate charges increased from $3.66 billion to $9.98 billion annually. Inpatient mortality of acute pancreatitis has decreased from 1.82% to 0.66%. The proportion of males to females with AP was almost equivalent from 2000-2005, but the proportion of males with pancreatitis compared to females is trending upwards. In 2014, 52.6% of patients admitted for AP were male. Conclusion: This study demonstrates that the number of hospitalizations for AP has increased by 37% from 2000 to 2014. However, inpatient mortality of acute pancreatitis has decreased from 1.82% to 0.66%, likely from improvements in intensive and supportive care. These findings affirm that AP remains a significant source of morbidity and mortality with substantial hospitalization and cost burden. Further investigation is needed regarding the reasons behind the increasing numbers of AP hospitalizations and efforts must be made to prevent the continued increase of AP cases. Table 1. Epidemiological and Economic Data for Acute Pancreatitis, Nationwide Inpatient Sample, 2000-2014 (Q3 years and 2000)
Table 1. Selected characteristics of the study participants, according to day of admission; NIS, 2009 - 2011.* Abbreviations: NIS, national inpatient sample * Values are percentages ± standard errors (SE) for categorical variables and means ± SE for continuous variables £ From Student t-test for continuous variables and chi square test for categorical variables
Table 2 and 3
Sa1341 DIFFERENT DEMOGRAPHIC, CLINICAL AND SEVERITY PROFILE BETWEEN PATIENTS WITH RECURRENT AND FIRST ATTACK OF ACUTE PANCREATITIS (AP) Jorge D. Machicado, Amir Gougol, Mohannad Dugum, Carl E. Manzo, Gong Tang, David C. Whitcomb, Dhiraj Yadav, Adam Slivka, Georgios I. Papachristou Background: Few studies have studied the differences between a first attack of AP and subsequent attacks of recurrent acute pancreatitis (RAP). Our aim was to compare the demographic factors, clinical profile, and outcomes between patients with a first and recurrent AP attack. Methods: We used data from a single-center prospective cohort that has enrolled
AGA Abstracts
S-282
Sa1340 OUTCOMES OF WEEKEND VERSUS WEEKDAY ADMISSION FOR ACUTE PANCREATITIS: A NATIONWIDE ANALYSIS Huafeng Shen, Maen M. Masadeh, Kaartik Soota, Randhir Jesudoss, Suthat Liangpunsakul
AGA Abstracts
Background and Aims: Day of admission may affect the outcomes in patients with acute pancreatitis (AP). A Japanese study revealed no weekend effect in severe AP admissions. The aim of this study was to investigate the impact of weekend versus weekday admission on in-hospital mortality and other outcomes of patients with AP by using a US nationwide database. Method: We performed a retrospective study collecting data from the National Inpatient Sample (2009-2011). We compared the outcomes including in-hospital mortality, length of stay, and total hospitalization charges between weekend and weekday admissions. Results: A total of 265,381 discharges with AP were identified, of which 197,944 (75%) were weekday admissions and 67,437 (25%) were weekend admissions. Compared with patients admitted on weekdays, those admitted on weekends had similar in-hospital mortality rates ((odds ratio [OR] 0.99; 95% confidence interval [CI], 0.93-1.06), but lower lengths of hospital stay (mean decrease, 0.25 days, P < 0.01) and lower hospitalization charges (mean decrease, $1,512, P < 0.01). Conclusion: Compared to patients admitted on weekdays, patients with AP admitted on weekends had similar in-hospital mortality rates, but lower lengths of stay and hospitalization charges.
Sa1339 NATIONAL TRENDS IN ACUTE PANCREATITIS IN UNITED STATES: 20002014 Ru Min Lee, Manoj A. Shirodkar Purpose: Acute pancreatitis is one of the most frequent gastrointestinal causes for hospital admission in the US. The incidence of acute pancreatitis (AP) has increased over time. This study aims to estimate the characteristics, outcomes, and cost burden of patients hospitalized for AP by using a large national database. Methods: The Nationwide Inpatient Sample (NIS) database was used to obtain data from 2000-2014. The NIS contains data from over 7 million hospital stays in the US per year generalizable to the American population. The NIS was queried for ICD-9 codes for primary diagnosis of acute pancreatitis (577.0). Information for demographic data, length of stay (LOS), mortality, and hospital charges was evaluated. Results: (Table 1 summaries epidemiological data) There were 3,784,981 total discharges from 2000-2014 with AP as the primary diagnosis. The number of hospitalizations for AP increased from 204,077 in 2000 to 279,145 in 2014. Mean length of stay decreased from 6.0 days to 4.6 during this period. The mean charges per hospitalization increased from $17,727 to $35,728. Aggregate charges increased from $3.66 billion to $9.98 billion annually. Inpatient mortality of acute pancreatitis has decreased from 1.82% to 0.66%. The proportion of males to females with AP was almost equivalent from 2000-2005, but the proportion of males with pancreatitis compared to females is trending upwards. In 2014, 52.6% of patients admitted for AP were male. Conclusion: This study demonstrates that the number of hospitalizations for AP has increased by 37% from 2000 to 2014. However, inpatient mortality of acute pancreatitis has decreased from 1.82% to 0.66%, likely from improvements in intensive and supportive care. These findings affirm that AP remains a significant source of morbidity and mortality with substantial hospitalization and cost burden. Further investigation is needed regarding the reasons behind the increasing numbers of AP hospitalizations and efforts must be made to prevent the continued increase of AP cases. Table 1. Epidemiological and Economic Data for Acute Pancreatitis, Nationwide Inpatient Sample, 2000-2014 (Q3 years and 2000)
Table 1. Selected characteristics of the study participants, according to day of admission; NIS, 2009 - 2011.* Abbreviations: NIS, national inpatient sample * Values are percentages ± standard errors (SE) for categorical variables and means ± SE for continuous variables £ From Student t-test for continuous variables and chi square test for categorical variables
Table 2 and 3
Sa1341 DIFFERENT DEMOGRAPHIC, CLINICAL AND SEVERITY PROFILE BETWEEN PATIENTS WITH RECURRENT AND FIRST ATTACK OF ACUTE PANCREATITIS (AP) Jorge D. Machicado, Amir Gougol, Mohannad Dugum, Carl E. Manzo, Gong Tang, David C. Whitcomb, Dhiraj Yadav, Adam Slivka, Georgios I. Papachristou Background: Few studies have studied the differences between a first attack of AP and subsequent attacks of recurrent acute pancreatitis (RAP). Our aim was to compare the demographic factors, clinical profile, and outcomes between patients with a first and recurrent AP attack. Methods: We used data from a single-center prospective cohort that has enrolled
AGA Abstracts
S-282