Negative Regulation of Mutant P53 by MicroRNA-101 (miR-101) in Pancreatic Ductal Adenocarcinoma (PDAC)

ASSOCIATION FOR ACADEMIC SURGERY AND SOCIETY OF UNIVERSITY SURGEONS—ABSTRACTS

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57.11. The Dominant Role of TBK1 Over IKKe In KRas Transformed Tumors in Regulating Cellular Proliferation. R. S. Sweeting,1 A. S. Baldwin,2 H. J. Kim1,2; 1University of North Carolina - Department of Surgery, Chapel Hill, NC; 2 Lineberger Cancer Center, Chapel Hill, NC

58.2. Clinical Significance of Normal Baseline Intraoperative PTH When Compared to Preoperative PTH in Patients Undergoing Parathyroid Surgery. S. Dhar, J. B. Ogilvie, K. S. Heller, K. N. Patel; NYU Langone Medical Center, New York, NY

57.12. Identifying Constraints on a Set of Putative Mechanisms Affecting the Dynamics of Oligo- Versus Poly-metastases Using Agent-based Modeling. A. Uppal, S. Wightman, S. Ganai, N. N. Khodarev, R. R. Weichselbaum, G. An; University of Chicago Pritzker School of Medicine, Chicago, IL

58.3. Surgeon Performed Ultrasound in the Assessment of Hrthle Cell Neoplasms of the Thyroid. P. Parikh,1 B. Allan,1 J. I. Lew2; 1University of Miami Department of Surgery, Miami, Fl; 2University of Miami Surgical Endocrinology, Miami, Fl

57.13. EDC-1: A New Targeted Drug With Anti-Proliferative Effects on Late Stage Thyroid Cancers. K. Ahmed,1 X. Yu,1 A. Dammalapati,1 D. Marshall,2 J. Prudent,2 R. Jaskula-Sztul,1 H. Chen1; 1Department of Surgery, University of Wisconsin, Madison, WI; 2Centrose LLC, Madison, WI 57.14. A Bicistronic Retroviral Vector Expressing IL-15 and Herpes Simplex Virus Thymidine Kinase for the Transduction of Human T Lymphocytes for Adoptive Cell Transfer Therapies. C. Hsu,1 J. D. Abad,2 R. A. Morgan3; 1 David Geffen School of Medicine At UCLA, Los Angeles, CA; 2Indiana University Health Goshen Center For Cancer Care, Goshen, IN; 3Surgery Branch, National Cancer Institute, Bethesda, MD 57.15. Negative Regulation of Mutant P53 by MicroRNA-101 (miR-101) in Pancreatic Ductal Adenocarcinoma (PDAC). R. B. Batchu,1,2 O. Gruzdyn,1,2 A. Qazi,1 S. T. King,1,2 D. W. Weaver,1 S. A. Gruber1,2; 1Laboratory of Surgical Oncology & Developmental Therapeutics, Department of Surgery, Wayne State University, Detroit, Michigan; 2John D. Dingell VA Medical Center, Detroit, Michigan 57.16. Combined CDK4 Inhibition and Doxorubicin Restores Smad3 Tumor Suppression and Induces Apoptosis Via a Survivin-Associated Mechanism. R. Hamdan,1,2 E. Tarasewicz,1,2 O. Nunez,1,2 J. Straehla,1,2 A. Hardy,1,2 S. Zelivianski,1,2 J. Jeruss1,2; 1Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; 2Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 57.17. Homozygous Loss of 5-Lipoxygenase Suppresses Pancreatic Neoplasia in EL-Kras and Pdx-Cre/LSLKras Mice. L. M. Knab,1 M. J. Heiferman,1 A. Samiei,1 J. D. Phillips,1 J. R. Heiferman,1 D. J. Bentrem,1,2,3 K. Adrian,2 P. J. Grippo2; 1Department of Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL; 2Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; 3Jesse Brown VA Medical Center, Chicago, IL

ONCOLOGY 5: ENDOCRINE 58.1. A Comparison of Outcomes From Laparoscopic Vs Open Adrenalectomy Using Data From the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). D. M. Elfenbein, J. E. Scarborough, P. Speicher, R. P. Scheri; Duke University Medical Center, Durham, NC

58.4. Differences in Presentation and Clinical Behavior Between Duodenal, Jejunal and Ileal Small Bowel Carcinoids. K. Coan, R. J. Gray, R. T. Schlinkert, B. A. Pockaj, N. Wasif; Mayo Clinic In Arizona, Phoenix, AZ 58.5. Lymphovascular Invasion Strongly Predicts Central Compartment Lymph Node Status in Papillary Thyroid Cancer. R. Pace, J. B. Ogilvie, K. S. Heller, K. N. Patel; NYU Langone Medical Center, New York, NY 58.6. Significance of Rebounding Parathyroid Hormone Levels During Parathyroidectomy. D. F. Schneider, K. A. Ojomo, H. Mazeh, S. C. Oltmann, R. S. Sippel, H. Chen; University of Wisconsin - Madison, Madison, WI 58.7. The Accuracy and Benefits of Surgeon-Performed Ultrasound-Guided Fine-Needle Aspiration in the Diagnosis of Thyroid Nodules. C. Hambleton, L. Yao, J. Buell, E. Kandil; Tulane University Department of Surgery, New Orleans, LA 58.8. Clinical Significance of Parathyroid Histology in Patients With Primary Hyperparathyroidism. S. Dhar, J. B. Ogilvie, K. S. Heller, K. N. Patel; NYU Langone Medical Center, New York, NY 58.9. Outcome of Patients Undergoing Lateral Compartment Neck Dissection for Thyroid Cancer. K. C. Welch1 C. R. McHenry2,3; 1Northeast Ohio Medical University, Rootstown, OH; 2MetroHealth Medical Center, Cleveland, OH; 3Case Western Reserve University School of Medicine, Cleveland, OH 58.10. Doses of I-131 Used for RAI Ablation Following Surgery for Papillary Thyroid Cancer (PTC) in a Large Metropolitan Area. B. Cohen, K. N. Patel, J. B. Ogilvie, K. S. Heller; NYU Langone Medical Center, New York, NY 58.11. PAASS: A Novel Prognostic Scale Specific for Pediatric Well Differentiated Thyroid Cancer: A PopulationBased SEER Outcomes Study. B. J. Shayota,1,2 S. Pawar,1 R. S. Chamberlain1,2,3; 1Department of Surgery, Saint Barnabas Medical Center, Livingston, NJ, Livingston, NJ; 2Saint George’s University School of Medicine, Saint George’s, Saint George’s; 3Department of Surgery, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 58.12. Chronic Thyroiditis May Contribute to the Development of Multifocal Papillary Thyroid Cancer. R. Pace, L. Dultz, J. B. Ogilvie, K. S. Heller, K. N. Patel; NYU Langone Medical Center, New York, NY